Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calcium channel, voltage-dependent, N type, alpha 1B subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Peroxidase homolog | 0.01 | 0.3585 | 1 |
Brugia malayi | Peroxidasin | 0.01 | 0.3585 | 0.4648 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0116 | 0.4676 | 0.4725 |
Brugia malayi | Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog | 0.0116 | 0.4676 | 1 |
Onchocerca volvulus | 0.01 | 0.3585 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.01 | 0.3585 | 0.4648 |
Loa Loa (eye worm) | calcium channel | 0.0116 | 0.4676 | 1 |
Echinococcus multilocularis | peroxidasin | 0.01 | 0.3585 | 0.3622 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.3585 | 0.4648 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0116 | 0.4676 | 0.1701 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.3585 | 0.4648 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.3585 | 0.4648 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0071 | 0.1495 | 0.5 |
Onchocerca volvulus | 0.01 | 0.3585 | 1 | |
Brugia malayi | hypothetical protein | 0.01 | 0.3585 | 0.4648 |
Brugia malayi | Animal haem peroxidase family protein | 0.01 | 0.3585 | 0.4648 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.3585 | 0.4648 |
Loa Loa (eye worm) | animal heme peroxidase | 0.01 | 0.3585 | 0.4648 |
Brugia malayi | Animal haem peroxidase family protein | 0.01 | 0.3585 | 0.4648 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0116 | 0.4676 | 0.4725 |
Onchocerca volvulus | Dual oxidase homolog | 0.01 | 0.3585 | 1 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0116 | 0.4676 | 0.4725 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.3585 | 0.4648 |
Echinococcus granulosus | peroxidasin | 0.01 | 0.3585 | 0.3622 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.9895 | 0.9837 |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.0071 | 0.1495 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.3585 | 0.4648 |
Loa Loa (eye worm) | animal heme peroxidase | 0.01 | 0.3585 | 0.4648 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0116 | 0.4676 | 0.4725 |
Echinococcus multilocularis | geminin | 0.0191 | 0.9895 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.01 | 0.3585 | 0.4648 |
Schistosoma mansoni | voltage-gated cation channel | 0.0116 | 0.4676 | 0.1701 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.3585 | 0.4648 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.3585 | 0.4648 |
Brugia malayi | Blistered cuticle protein 3 | 0.01 | 0.3585 | 0.4648 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.3585 | 0.4648 |
Onchocerca volvulus | Peroxidase homolog | 0.01 | 0.3585 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.01 | 0.3585 | 0.4648 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0116 | 0.4676 | 0.4725 |
Onchocerca volvulus | Peroxidasin homolog | 0.01 | 0.3585 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.3585 | 0.4648 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0116 | 0.4676 | 0.4725 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0116 | 0.4676 | 0.4725 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.3585 | 0.4648 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.9895 | 0.9837 |
Onchocerca volvulus | 0.01 | 0.3585 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.3585 | 0.4648 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.3585 | 0.4648 |
Loa Loa (eye worm) | animal heme peroxidase | 0.01 | 0.3585 | 0.4648 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0116 | 0.4676 | 0.4725 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0116 | 0.4676 | 0.4725 |
Echinococcus granulosus | geminin | 0.0191 | 0.9895 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.01 | 0.3585 | 0.4648 |
Onchocerca volvulus | Peroxidasin homolog | 0.01 | 0.3585 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.3585 | 0.4648 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0116 | 0.4676 | 0.4725 |
Loa Loa (eye worm) | animal heme peroxidase | 0.01 | 0.3585 | 0.4648 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0116 | 0.4676 | 0.1701 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.4676 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.01 | 0.3585 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.5 uM | Inhibition of calcium channel Cav2.2 in IMR32 cells | ChEMBL. | 17134896 |
IC50 (binding) | = 0.5 uM | Inhibition of calcium channel Cav2.2 in IMR32 cells | ChEMBL. | 17134896 |
IC50 (binding) | = 3.08 uM | Inhibition of calcium channel L type in IMR32 cells | ChEMBL. | 17134896 |
Ratio IC50 (binding) | = 6.1 | Selectivity for calcium channel Cav2.2 over calcium channel L type | ChEMBL. | 17134896 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.