TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 652.074 | Formula: C30H26ClN5O8S
H donors: 1 H acceptors: 6 LogP: 5.17 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: CCOC(=O)C(Oc1ccc(cc1)Oc1nc2n(nc(c2c(=O)n1C(=O)Nc1ccccc1Cl)S(=O)(=O)C)c1ccccc1)C
InChi: 1S/C30H26ClN5O8S/c1-4-42-28(38)18(2)43-20-14-16-21(17-15-20)44-30-33-25-24(26(45(3,40)41)34-36(25)19-10-6-5-7-11-19)27(37)35(30)29(39)32-23-13-9-8-12-22(23)31/h5-18H,4H2,1-3H3,(H,32,39)
InChiKey: DMRIPKYRMQDYPR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.003	0.6218	0.6218
Echinococcus multilocularis	neuropeptide receptor	0.003	0.6218	0.7022
Echinococcus multilocularis	neuropeptide receptor	0.003	0.6218	0.7022
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0015	0.1172	0.5
Schistosoma mansoni	neuropeptide receptor	0.003	0.6218	0.6218
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.003	0.6218	0.6218
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Schistosoma mansoni	alpha-1 adrenergic receptor	0.003	0.6218	0.6218
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.003	0.6218	0.7022
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.6218	0.6218
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0015	0.1172	0.5
Onchocerca volvulus		0.003	0.6218	0.5
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.003	0.6218	0.6218
Schistosoma mansoni	neuropeptide F-like receptor	0.003	0.6218	0.6218
Echinococcus multilocularis	sex peptide receptor	0.003	0.6218	0.7022
Onchocerca volvulus		0.003	0.6218	0.5
Brugia malayi	hypothetical protein	0.003	0.6218	0.7022
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.003	0.6218	0.6218
Schistosoma mansoni	amine GPCR	0.003	0.6218	0.6218
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.003	0.6218	0.7022
Onchocerca volvulus		0.003	0.6218	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.003	0.6218	0.6218
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.6218	0.7022
Loa Loa (eye worm)	melatonin receptor type 1A	0.003	0.6218	0.7022
Echinococcus granulosus	neuropeptide s receptor	0.003	0.6218	0.7022
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0038	0.8855	1
Echinococcus granulosus	tm gpcr rhodopsin	0.003	0.6218	0.7022
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.003	0.6218	0.7022
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0015	0.1172	0.5
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.003	0.6218	0.7022
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.003	0.6218	0.6218
Schistosoma mansoni	neuropeptide F-like receptor	0.003	0.6218	0.6218
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Trypanosoma cruzi	cytochrome P450, putative	0.0024	0.4133	1
Echinococcus granulosus	sex peptide receptor	0.003	0.6218	0.7022
Echinococcus granulosus	g protein coupled receptor	0.003	0.6218	0.7022
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.003	0.6218	0.6218
Echinococcus multilocularis	serotonin receptor	0.003	0.6218	0.7022
Echinococcus granulosus	alpha 1A adrenergic receptor	0.003	0.6218	0.7022
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.003	0.6218	0.7022
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.003	0.6218	0.7022
Schistosoma mansoni	hypothetical protein	0.003	0.6218	0.6218
Schistosoma mansoni	amine GPCR	0.003	0.6218	0.6218
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.6218	0.7022
Brugia malayi	neuropeptide F receptor	0.003	0.6218	0.7022
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.003	0.6218	0.7022
Brugia malayi	Cytochrome P450 family protein	0.0034	0.7621	0.8607
Loa Loa (eye worm)	cytochrome P450 family protein	0.0024	0.4133	0.4668
Echinococcus granulosus	neuropeptides capa receptor	0.003	0.6218	0.7022
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0035	0.8035	0.5
Brugia malayi	sulfakinin receptor protein	0.003	0.6218	0.7022
Echinococcus granulosus	neuropeptide receptor A26	0.003	0.6218	0.7022
Schistosoma mansoni	hypothetical protein	0.003	0.6218	0.6218
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.003	0.6218	0.6218
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0015	0.1172	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.003	0.6218	0.7022
Echinococcus granulosus	tachykinin peptides receptor 99D	0.003	0.6218	0.7022
Brugia malayi	RE15519p	0.003	0.6218	0.7022
Onchocerca volvulus		0.003	0.6218	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.003	0.6218	0.7022
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.6218	0.7022
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.003	0.6218	0.6218
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.003	0.6218	0.6218
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.6218	0.7022
Leishmania major	cytochrome p450-like protein	0.0024	0.4133	1
Echinococcus multilocularis	allatostatin A receptor	0.003	0.6218	0.7022
Onchocerca volvulus		0.003	0.6218	0.5
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.003	0.6218	0.7022
Loa Loa (eye worm)	TYRA-2 protein	0.003	0.6218	0.7022
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0015	0.1172	0.5
Brugia malayi	follicle stimulating hormone receptor	0.003	0.6218	0.7022
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Echinococcus granulosus	tm gpcr rhodopsin	0.003	0.6218	0.7022
Echinococcus granulosus	7TM GPCR rhodopsin	0.003	0.6218	0.7022
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0015	0.1172	0.5
Onchocerca volvulus		0.003	0.6218	0.5
Brugia malayi	hypothetical protein	0.003	0.6218	0.7022
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0015	0.1172	0.5
Echinococcus multilocularis	G-protein coupled receptor, putative	0.003	0.6218	0.7022
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.6218	0.7022
Schistosoma mansoni	hypothetical protein	0.0015	0.1172	0.1172
Schistosoma mansoni	neuropeptide receptor	0.003	0.6218	0.6218
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.003	0.6218	0.7022
Brugia malayi	larval opioid receptor	0.003	0.6218	0.7022
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.003	0.6218	0.7022
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.6218	0.6218
Schistosoma mansoni	voltage-gated potassium channel	0.0041	1	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Schistosoma mansoni	opsin-like receptor	0.003	0.6218	0.6218
Schistosoma mansoni	hypothetical protein	0.003	0.6218	0.6218
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.6218	0.6218
Brugia malayi	Dopamine receptor protein 1	0.003	0.6218	0.7022
Schistosoma mansoni	neuropeptide receptor	0.003	0.6218	0.6218
Brugia malayi	hypothetical protein	0.003	0.6218	0.7022
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.003	0.6218	0.7022
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.003	0.6218	0.6218
Onchocerca volvulus		0.003	0.6218	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.003	0.6218	0.6218
Schistosoma mansoni	neuropeptide f receptor 76f	0.003	0.6218	0.6218
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0015	0.1172	0.5
Echinococcus multilocularis	neuropeptide s receptor	0.003	0.6218	0.7022
Loa Loa (eye worm)	cytochrome P450	0.0015	0.1172	0.1324
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.003	0.6218	0.7022
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Onchocerca volvulus		0.003	0.6218	0.5
Echinococcus granulosus	g-protein coupled receptor	0.003	0.6218	0.7022
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.003	0.6218	0.7022
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.6218	0.7022
Brugia malayi	Cytochrome P450 family protein	0.0024	0.4133	0.4668
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0015	0.1172	0.5
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Echinococcus multilocularis	neuropeptide Y receptor	0.003	0.6218	0.7022
Loa Loa (eye worm)	cytochrome P450 family protein	0.0024	0.4133	0.4668
Echinococcus multilocularis	orexin receptor type 2	0.003	0.6218	0.7022
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0015	0.1172	0.5
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.003	0.6218	0.7022
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.6218	0.7022
Brugia malayi	hypothetical protein	0.003	0.6218	0.7022
Schistosoma mansoni	biogenic amine receptor	0.003	0.6218	0.6218
Brugia malayi	G protein-coupled receptor	0.003	0.6218	0.7022
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0015	0.1172	0.5
Brugia malayi	hypothetical protein	0.003	0.6218	0.7022
Onchocerca volvulus		0.003	0.6218	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.6218	0.6218
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Schistosoma mansoni	myosin xvIII	0.003	0.6218	0.6218
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0038	0.8855	1
Schistosoma mansoni	hypothetical protein	0.003	0.6218	0.6218
Echinococcus multilocularis	somatostatin receptor	0.003	0.6218	0.7022
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Brugia malayi	putative neuropeptide receptor NPR1	0.003	0.6218	0.7022
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.003	0.6218	0.7022
Brugia malayi	Melatonin receptor type 1A	0.003	0.6218	0.7022
Echinococcus granulosus	somatostatin receptor	0.003	0.6218	0.7022
Brugia malayi	G protein-coupled receptor F59B2.13	0.003	0.6218	0.7022
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.003	0.6218	0.7022
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0035	0.8035	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.6218	0.7022
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.003	0.6218	0.7022
Brugia malayi	G-protein coupled receptor	0.003	0.6218	0.7022
Echinococcus granulosus	hypothetical protein	0.003	0.6218	0.7022
Brugia malayi	neuropeptide F receptor	0.003	0.6218	0.7022
Onchocerca volvulus		0.003	0.6218	0.5
Echinococcus multilocularis	serotonin receptor	0.003	0.6218	0.7022
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.003	0.6218	0.7022
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0015	0.1172	0.5
Brugia malayi	AKH receptor	0.003	0.6218	0.7022
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.6218	0.6218
Schistosoma mansoni	adenoreceptor	0.003	0.6218	0.6218
Echinococcus multilocularis	fmrfamide receptor	0.003	0.6218	0.7022
Echinococcus granulosus	neuropeptide receptor	0.003	0.6218	0.7022
Onchocerca volvulus		0.003	0.6218	0.5
Echinococcus multilocularis	g protein coupled receptor	0.003	0.6218	0.7022
Onchocerca volvulus		0.003	0.6218	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.003	0.6218	0.7022
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.003	0.6218	0.7022
Schistosoma mansoni	amine GPCR	0.003	0.6218	0.6218
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0015	0.1172	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.6218	0.7022
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0015	0.1172	0.5
Echinococcus multilocularis	neuropeptide receptor A26	0.003	0.6218	0.7022
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.003	0.6218	0.7022
Echinococcus granulosus	neuropeptide FF receptor 2	0.003	0.6218	0.7022
Schistosoma mansoni	amine GPCR	0.003	0.6218	0.6218
Onchocerca volvulus		0.003	0.6218	0.5
Onchocerca volvulus	Neuropeptide F receptor homolog	0.003	0.6218	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.6218	0.7022
Schistosoma mansoni	histamine h1 receptor	0.003	0.6218	0.6218
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Schistosoma mansoni	opsin-like receptor	0.003	0.6218	0.6218
Echinococcus granulosus	allatostatin A receptor	0.003	0.6218	0.7022
Brugia malayi	Cytochrome P450 family protein	0.0024	0.4133	0.4668
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0024	0.4133	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.7208	0.8141
Echinococcus granulosus	G protein coupled receptor 139	0.003	0.6218	0.7022
Onchocerca volvulus		0.003	0.6218	0.5
Loa Loa (eye worm)	cytochrome P450 family protein	0.0034	0.7621	0.8607
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.6218	0.6218
Schistosoma mansoni	opsin-like receptor	0.003	0.6218	0.6218
Brugia malayi	hypothetical protein	0.003	0.6218	0.7022
Brugia malayi	putative neuropeptide receptor	0.003	0.6218	0.7022
Mycobacterium leprae	putative cytochrome p450	0.0015	0.1172	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.003	0.6218	0.7022
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0015	0.1172	0.5
Brugia malayi	G-protein coupled receptor	0.003	0.6218	0.7022
Echinococcus granulosus	dro:myosuppressin receptor	0.003	0.6218	0.7022
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Trypanosoma brucei	cytochrome P450, putative	0.0024	0.4133	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.6218	0.6218
Schistosoma mansoni	biogenic amine receptor	0.003	0.6218	0.6218
Echinococcus granulosus	g protein coupled receptor	0.003	0.6218	0.7022
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.6218	0.7022
Echinococcus multilocularis		0.0015	0.1172	0.1324
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Mycobacterium leprae	Conserved hypothetical protein	0.0015	0.1172	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.003	0.6218	0.7022
Onchocerca volvulus		0.003	0.6218	0.5
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Brugia malayi	Dopamine receptor protein 2	0.003	0.6218	0.7022
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.6218	0.7022
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.003	0.6218	0.7022
Echinococcus granulosus	cytochrome P450 2K1	0.0015	0.1172	0.1324
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0015	0.1172	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.003	0.6218	0.7022
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0038	0.8855	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.003	0.6218	0.6218
Echinococcus multilocularis	neuropeptides capa receptor	0.003	0.6218	0.7022
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.6218	0.7022
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.003	0.6218	0.7022
Echinococcus multilocularis	g protein coupled receptor	0.003	0.6218	0.7022
Brugia malayi	hypothetical protein	0.003	0.6218	0.7022
Echinococcus granulosus	serotonin receptor	0.003	0.6218	0.7022
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0015	0.1172	0.5
Echinococcus multilocularis	neuropeptide FF receptor 2	0.003	0.6218	0.7022
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.6218	0.7022
Brugia malayi	Serotonin receptor	0.003	0.6218	0.7022
Brugia malayi	hypothetical protein	0.003	0.6218	0.7022
Loa Loa (eye worm)	neuropeptide F receptor	0.003	0.6218	0.7022
Loa Loa (eye worm)	CYP4Cod1	0.0024	0.4133	0.4668
Echinococcus granulosus	neuropeptide Y receptor	0.003	0.6218	0.7022
Echinococcus granulosus	biogenic amine 5HT receptor	0.003	0.6218	0.7022
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.003	0.6218	0.7022
Echinococcus multilocularis	g protein coupled receptor	0.003	0.6218	0.7022
Loa Loa (eye worm)	neuropeptide F receptor	0.003	0.6218	0.7022
Echinococcus granulosus	neuropeptide Y receptor	0.003	0.6218	0.7022
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Echinococcus multilocularis	g-protein coupled receptor	0.003	0.6218	0.7022
Onchocerca volvulus		0.003	0.6218	0.5
Echinococcus granulosus	orexin receptor type 2	0.003	0.6218	0.7022
Brugia malayi	Cytochrome P450 family protein	0.0015	0.1172	0.1324
Brugia malayi	cytochrome P450	0.0015	0.1172	0.1324
Echinococcus granulosus	biogenic amine 5HT receptor	0.003	0.6218	0.7022
Brugia malayi	GnHR receptor homolog	0.003	0.6218	0.7022
Echinococcus multilocularis	fmrfamide receptor	0.003	0.6218	0.7022
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.003	0.6218	0.7022
Echinococcus multilocularis	G protein coupled receptor 139	0.003	0.6218	0.7022
Echinococcus granulosus	fmrfamide receptor	0.003	0.6218	0.7022
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.003	0.6218	0.7022
Brugia malayi	hypothetical protein	0.003	0.6218	0.7022
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0038	0.8855	1
Brugia malayi	hypothetical protein	0.003	0.6218	0.7022
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Brugia malayi	Tachykinin-like peptides receptor 99D	0.003	0.6218	0.7022
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.003	0.6218	0.7022
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0015	0.1172	0.5
Echinococcus granulosus	7tm_1 domain containing protein	0.003	0.6218	0.7022
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.003	0.6218	0.6218
Echinococcus multilocularis	dro:myosuppressin receptor	0.003	0.6218	0.7022
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0015	0.1172	0.5
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.003	0.6218	0.7022
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0015	0.1172	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.6218	0.6218
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.003	0.6218	0.5
Echinococcus granulosus	neuropeptide receptor	0.003	0.6218	0.7022
Brugia malayi	Serotonin receptor	0.003	0.6218	0.7022
Schistosoma mansoni	cytochrome P450	0.0015	0.1172	0.1172
Schistosoma mansoni	amine GPCR	0.003	0.6218	0.6218
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022
Brugia malayi	Dopamine receptor	0.003	0.6218	0.7022
Loa Loa (eye worm)	G-protein coupled receptor	0.003	0.6218	0.7022
Echinococcus granulosus	peptide allatostatin:somatostatin	0.003	0.6218	0.7022
Onchocerca volvulus		0.003	0.6218	0.5
Schistosoma mansoni	growth hormone secretagogue receptor	0.003	0.6218	0.6218
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0015	0.1172	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.6218	0.7022
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.6218	0.6218
Echinococcus granulosus	g protein coupled receptor	0.003	0.6218	0.7022
Echinococcus granulosus	tm gpcr rhodopsin	0.003	0.6218	0.7022
Schistosoma mansoni	neuropeptide receptor	0.003	0.6218	0.6218
Schistosoma mansoni	biogenic amine receptor	0.003	0.6218	0.6218
Trypanosoma cruzi	cytochrome P450, putative	0.0024	0.4133	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.003	0.6218	0.6218
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.003	0.6218	0.7022
Brugia malayi	ORL1-like opioid receptor	0.003	0.6218	0.7022
Loa Loa (eye worm)	hypothetical protein	0.003	0.6218	0.7022

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 5.1 %	Herbicidal activity against rape assesed as inhibition of stalk growth at 10 mg/L relative to control	ChEMBL.	17337186
Inhibition (functional)	= 29.4 %	Herbicidal activity against rape assesed as inhibition of root growth at 10 mg/L relative to control	ChEMBL.	17337186
Inhibition (functional)	= 37.9 %	Herbicidal activity against barnyard grass assesed as inhibition of stalk growth at 10 mg/L relative to control	ChEMBL.	17337186
Inhibition (functional)	= 47.9 %	Herbicidal activity against barnyard grass assesed as inhibition of stalk growth at 100 mg/L relative to control	ChEMBL.	17337186
Inhibition (functional)	= 48.7 %	Herbicidal activity against rape assesed as inhibition of stalk growth at 100 mg/L relative to control	ChEMBL.	17337186
Inhibition (functional)	= 63 %	Herbicidal activity against barnyard grass assesed as inhibition of root growth at 10 mg/L relative to control	ChEMBL.	17337186
Inhibition (functional)	= 81.4 %	Herbicidal activity against rape assesed as inhibition of root growth at 100 mg/L relative to control	ChEMBL.	17337186
Inhibition (functional)	= 89.1 %	Herbicidal activity against barnyard grass assesed as inhibition of root growth at 100 mg/L relative to control	ChEMBL.	17337186

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL390438

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 440072