TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 693.725 | Formula: C36H31N5O8S
H donors: 1 H acceptors: 6 LogP: 6 Rotable bonds: 14
Rule of 5 violations (Lipinski): 2
SMILES: CCOC(=O)COc1ccc(cc1)Oc1nc2n(nc(c2c(=O)n1C(=O)Nc1cccc(c1)C)S(=O)(=O)Cc1ccccc1)c1ccccc1
InChi: 1S/C36H31N5O8S/c1-3-47-30(42)22-48-28-17-19-29(20-18-28)49-36-38-32-31(34(43)40(36)35(44)37-26-14-10-11-24(2)21-26)33(39-41(32)27-15-8-5-9-16-27)50(45,46)23-25-12-6-4-7-13-25/h4-21H,3,22-23H2,1-2H3,(H,37,44)
InChiKey: CSXDYCMOJVGTEN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	opsin-like receptor	0.0032	0.0449	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0096	0.3477	0.3477
Schistosoma mansoni	biogenic amine receptor	0.0032	0.0449	0.0062
Echinococcus multilocularis	Niemann Pick C1 protein	0.0096	0.3477	0.3171
Brugia malayi	Dopamine receptor protein 1	0.0032	0.0449	0.0449
Schistosoma mansoni	biogenic amine receptor	0.0032	0.0449	0.0062
Schistosoma mansoni	NADPH flavin oxidoreductase	0.0032	0.0412	0.0024
Plasmodium vivax	flavodoxin domain containing protein	0.0055	0.1551	0.8159
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0449	0.0062
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.0063	0.1889	0.1889
Onchocerca volvulus		0.0032	0.0449	0.5
Schistosoma mansoni	histamine h1 receptor	0.0032	0.0449	0.0062
Schistosoma mansoni	patched 1	0.0096	0.3477	0.3213
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Loa Loa (eye worm)	flavodoxin family protein	0.0024	0.0051	0.0051
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0032	0.0449	0.0449
Giardia lamblia	3-hydroxy-3-methylglutaryl-coenzyme A reductase	0.0109	0.4114	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0449	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Brugia malayi	Dopamine receptor	0.0032	0.0449	0.0449
Plasmodium vivax	NADPH-cytochrome p450 reductase, putative	0.0063	0.1889	1
Echinococcus multilocularis	methionine synthase reductase	0.0039	0.0751	0.0316
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Schistosoma mansoni	opsin-like receptor	0.0032	0.0449	0.0062
Brugia malayi	neuropeptide F receptor	0.0032	0.0449	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Trypanosoma brucei	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0233	1	1
Schistosoma mansoni	5-methyl tetrahydrofolate-homocysteine methyltransferase reductase	0.0039	0.0751	0.0376
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0096	0.3477	0.3477
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0233	1	1
Echinococcus granulosus	hydroxymethylglutaryl coenzyme A reductase	0.0233	1	1
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0039	0.0751	0.0751
Schistosoma mansoni	myosin xvIII	0.0032	0.0449	0.0062
Schistosoma mansoni	hypothetical protein	0.0032	0.0449	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0032	0.0449	0.0062
Echinococcus multilocularis	NADPH cytochrome P450 reductase	0.0063	0.1889	0.1508
Brugia malayi	hypothetical protein	0.0032	0.0449	0.0449
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0449	0.0062
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.0063	0.1889	0.1889
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0547	0.1221
Brugia malayi	Serotonin receptor	0.0032	0.0449	0.0449
Brugia malayi	hypothetical protein	0.0032	0.0449	0.0449
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0032	0.0449	0.0062
Loa Loa (eye worm)	TYRA-2 protein	0.0032	0.0449	0.0449
Trypanosoma cruzi	Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative	0.0024	0.0051	0.0051
Brugia malayi	hypothetical protein	0.0032	0.0449	0.0449
Brugia malayi	CHE-14 protein	0.0096	0.3477	0.3477
Onchocerca volvulus		0.0032	0.0449	0.5
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Leishmania major	hypothetical protein, conserved	0.0024	0.0051	0.0051
Echinococcus granulosus	Niemann Pick C1 protein	0.0096	0.3477	0.3171
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0449	0.0062
Schistosoma mansoni	amine GPCR	0.0032	0.0449	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0032	0.0449	0.0449
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0032	0.0449	0.0062
Loa Loa (eye worm)	neuropeptide F receptor	0.0032	0.0449	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Loa Loa (eye worm)	G-protein coupled receptor	0.0032	0.0449	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Schistosoma mansoni	biogenic amine receptor	0.0032	0.0449	0.0062
Onchocerca volvulus		0.0032	0.0449	0.5
Onchocerca volvulus		0.0032	0.0449	0.5
Schistosoma mansoni	growth hormone secretagogue receptor	0.0032	0.0449	0.0062
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0037	0.0663	0.0663
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Brugia malayi	hypothetical protein	0.0032	0.0449	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Echinococcus multilocularis	NADPH dependent diflavin oxidoreductase 1	0.0063	0.1889	0.1508
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0432	0.0432
Entamoeba histolytica	type A flavoprotein, putative	0.0024	0.0051	0.5
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0032	0.0449	0.0449
Echinococcus granulosus	NADPH cytochrome P450 reductase	0.0063	0.1889	0.1508
Schistosoma mansoni	neuropeptide f receptor 76f	0.0032	0.0449	0.0062
Brugia malayi	hypothetical protein	0.0032	0.0449	0.0449
Onchocerca volvulus		0.0032	0.0449	0.5
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Schistosoma mansoni	hypothetical protein	0.0032	0.0449	0.0062
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0823	0.0451
Echinococcus granulosus	methionine synthase reductase	0.0039	0.0751	0.0316
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0032	0.0449	0.0449
Onchocerca volvulus		0.0032	0.0449	0.5
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Brugia malayi	Cytochrome P450 family protein	0.0033	0.0489	0.0489
Trypanosoma cruzi	p450 reductase, putative	0.0063	0.1889	0.1889
Schistosoma mansoni	amine GPCR	0.0032	0.0449	0.0062
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0032	0.0449	0.5
Treponema pallidum	flavodoxin	0.0024	0.0051	0.5
Schistosoma mansoni	neuropeptide receptor	0.0032	0.0449	0.0062
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0063	0.1889	0.1889
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0547	0.1221
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0109	0.4114	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0032	0.0449	0.0062
Trypanosoma cruzi	NADPH-dependent FMN/FAD containing oxidoreductase, putative	0.0063	0.1889	0.1889
Mycobacterium ulcerans	hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase	0.0233	1	1
Toxoplasma gondii	flavodoxin domain-containing protein	0.0031	0.039	0.5
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0032	0.0449	0.0449
Echinococcus multilocularis	hydroxymethylglutaryl coenzyme A reductase	0.0233	1	1
Brugia malayi	GnHR receptor homolog	0.0032	0.0449	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Brugia malayi	G protein-coupled receptor	0.0032	0.0449	0.0449
Trypanosoma brucei	NADPH-cytochrome p450 reductase, putative	0.0063	0.1889	0.1889
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0449	0.0062
Trichomonas vaginalis	NADPH fad oxidoreductase, putative	0.0055	0.1551	0.369
Brugia malayi	Dopamine receptor protein 2	0.0032	0.0449	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0032	0.0449	0.0449
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0096	0.3477	0.3213
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase	0.0233	1	1
Brugia malayi	FAD binding domain containing protein	0.0063	0.1889	0.1889
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.0063	0.1889	0.1889
Schistosoma mansoni	neuropeptide receptor	0.0032	0.0449	0.0062
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0449	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1889	0.1889
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0109	0.4114	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0449	0.0062
Onchocerca volvulus		0.0032	0.0449	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0032	0.0449	0.0062
Trypanosoma cruzi	Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative	0.0024	0.0051	0.0051
Loa Loa (eye worm)	melatonin receptor type 1A	0.0032	0.0449	0.0449
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0032	0.0449	0.0062
Loa Loa (eye worm)	neuropeptide F receptor	0.0032	0.0449	0.0449
Chlamydia trachomatis	sulfite reductase	0.0039	0.0751	0.5
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0037	0.0663	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Leishmania major	NADPH-cytochrome p450 reductase-like protein	0.0063	0.1889	0.1889
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0032	0.0449	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0032	0.0449	0.0449
Plasmodium falciparum	nitric oxide synthase, putative	0.0063	0.1889	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0032	0.0449	0.0449
Schistosoma mansoni	neuropeptide F-like receptor	0.0032	0.0449	0.0062
Echinococcus granulosus	Protein patched homolog 1	0.0096	0.3477	0.3171
Brugia malayi	ORL1-like opioid receptor	0.0032	0.0449	0.0449
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0032	0.0449	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Brugia malayi	FAD binding domain containing protein	0.0039	0.0751	0.0751
Brugia malayi	Serotonin receptor	0.0032	0.0449	0.0449
Brugia malayi	G-protein coupled receptor	0.0032	0.0449	0.0449
Loa Loa (eye worm)	cytochrome P450 family protein	0.0033	0.0489	0.0489
Entamoeba histolytica	type A flavoprotein, putative	0.0024	0.0051	0.5
Brugia malayi	hypothetical protein	0.0032	0.0449	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Brugia malayi	hypothetical protein	0.0032	0.0449	0.0449
Schistosoma mansoni	hydroxymethylglutaryl-CoA reductase (NADPH)	0.0233	1	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0032	0.0449	0.0062
Echinococcus multilocularis	protein patched	0.0096	0.3477	0.3171
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0032	0.0449	0.0062
Schistosoma mansoni	opsin-like receptor	0.0032	0.0449	0.0062
Trichomonas vaginalis	conserved hypothetical protein	0.0096	0.3477	0.8432
Schistosoma mansoni	neuropeptide receptor	0.0032	0.0449	0.0062
Toxoplasma gondii	flavodoxin domain-containing protein	0.0031	0.039	0.5
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Schistosoma mansoni	amine GPCR	0.0032	0.0449	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Leishmania major	p450 reductase, putative	0.0063	0.1889	0.1889
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0109	0.4114	1
Echinococcus multilocularis	protein dispatched 1	0.0096	0.3477	0.3171
Brugia malayi	AKH receptor	0.0032	0.0449	0.0449
Brugia malayi	sulfakinin receptor protein	0.0032	0.0449	0.0449
Trypanosoma brucei	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative	0.0024	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0233	1	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0032	0.0449	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Schistosoma mansoni	hypothetical protein	0.0032	0.0449	0.0062
Brugia malayi	hypothetical protein	0.0032	0.0449	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Leishmania major	cytochrome P450 reductase, putative	0.0055	0.1551	0.1551
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0032	0.0449	0.0062
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0449	0.0062
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0823	0.0451
Onchocerca volvulus		0.0032	0.0449	0.5
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Onchocerca volvulus		0.0032	0.0449	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0449	0.0062
Brugia malayi	Melatonin receptor type 1A	0.0032	0.0449	0.0449
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0032	0.0449	0.0062
Brugia malayi	follicle stimulating hormone receptor	0.0032	0.0449	0.0449
Brugia malayi	G protein-coupled receptor F59B2.13	0.0032	0.0449	0.0449
Mycobacterium ulcerans	formate dehydrogenase H FdhF	0.0063	0.1889	0.1889
Schistosoma mansoni	neuropeptide F-like receptor	0.0032	0.0449	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Onchocerca volvulus		0.0032	0.0449	0.5
Schistosoma mansoni	amine GPCR	0.0032	0.0449	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Brugia malayi	flavodoxin family protein	0.0063	0.1889	0.1889
Brugia malayi	RE15519p	0.0032	0.0449	0.0449
Trypanosoma brucei	NADPH-dependent diflavin oxidoreductase 1	0.0063	0.1889	0.1889
Echinococcus multilocularis	sterol regulatory element binding protein	0.0096	0.3477	0.3171
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0032	0.0449	0.0062
Trypanosoma cruzi	NADPH--cytochrome P450 reductase, putative	0.0024	0.0051	0.0051
Schistosoma mansoni	adenoreceptor	0.0032	0.0449	0.0062
Trichomonas vaginalis	sulfite reductase, putative	0.0063	0.1889	0.4523
Onchocerca volvulus		0.0032	0.0449	0.5
Schistosoma mansoni	neuropeptide receptor	0.0032	0.0449	0.0062
Brugia malayi	hypothetical protein	0.0032	0.0449	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0032	0.0449	0.5
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Onchocerca volvulus		0.0032	0.0449	0.5
Brugia malayi	flavodoxin family protein	0.0024	0.0051	0.0051
Entamoeba histolytica	type A flavoprotein, putative	0.0024	0.0051	0.5
Schistosoma mansoni	amine GPCR	0.0032	0.0449	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Leishmania major	3-hydroxy-3-methylglutaryl-CoA reductase	0.0233	1	1
Onchocerca volvulus		0.0032	0.0449	0.5
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0032	0.0449	0.0062
Echinococcus granulosus	sterol regulatory element binding protein	0.0096	0.3477	0.3171
Schistosoma mansoni	cytochrome P450 reductase	0.0063	0.1889	0.156
Entamoeba histolytica	type A flavoprotein, putative	0.0024	0.0051	0.5
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0032	0.0449	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Onchocerca volvulus		0.0032	0.0449	0.5
Brugia malayi	G-protein coupled receptor	0.0032	0.0449	0.0449
Schistosoma mansoni	hypothetical protein	0.0032	0.0449	0.0062
Echinococcus granulosus	NADPH dependent diflavin oxidoreductase 1	0.0063	0.1889	0.1508
Brugia malayi	larval opioid receptor	0.0032	0.0449	0.0449
Onchocerca volvulus		0.0032	0.0449	0.5
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.0063	0.1889	0.1889
Brugia malayi	hypothetical protein	0.0032	0.0449	0.0449
Onchocerca volvulus		0.0032	0.0449	0.5
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0032	0.0449	0.0062
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0032	0.0449	0.0062
Brugia malayi	putative neuropeptide receptor	0.0032	0.0449	0.0449
Onchocerca volvulus		0.0032	0.0449	0.5
Brugia malayi	putative neuropeptide receptor NPR1	0.0032	0.0449	0.0449
Loa Loa (eye worm)	G-protein coupled receptor	0.0032	0.0449	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449
Entamoeba histolytica	type A flavoprotein, putative	0.0024	0.0051	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0032	0.0449	0.0449
Brugia malayi	neuropeptide F receptor	0.0032	0.0449	0.0449
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0037	0.0663	0.0224
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0037	0.0663	0.0663
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0449	0.0449

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= -5.3 %	Herbicidal activity against barnyard grass assesed as inhibition of stalk growth at 10 mg/L relative to control	ChEMBL.	17337186
Inhibition (functional)	= 0 %	Herbicidal activity against barnyard grass assesed as inhibition of stalk growth at 100 mg/L relative to control	ChEMBL.	17337186
Inhibition (functional)	= 6.7 %	Herbicidal activity against rape assesed as inhibition of stalk growth at 100 mg/L relative to control	ChEMBL.	17337186
Inhibition (functional)	= 15.5 %	Herbicidal activity against rape assesed as inhibition of stalk growth at 10 mg/L relative to control	ChEMBL.	17337186
Inhibition (functional)	= 21.7 %	Herbicidal activity against rape assesed as inhibition of root growth at 10 mg/L relative to control	ChEMBL.	17337186
Inhibition (functional)	= 35.5 %	Herbicidal activity against barnyard grass assesed as inhibition of root growth at 10 mg/L relative to control	ChEMBL.	17337186
Inhibition (functional)	= 51.1 %	Herbicidal activity against rape assesed as inhibition of root growth at 100 mg/L relative to control	ChEMBL.	17337186
Inhibition (functional)	= 62.2 %	Herbicidal activity against barnyard grass assesed as inhibition of root growth at 100 mg/L relative to control	ChEMBL.	17337186

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL233860

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 440078