Detailed information for compound 440185

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 306.358 | Formula: C19H18N2O2
  • H donors: 2 H acceptors: 1 LogP: 3.56 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(c1ccccc1)Oc1ccc2c(c1)c1CCNC(=O)c1[nH]2
  • InChi: 1S/C19H18N2O2/c1-12(13-5-3-2-4-6-13)23-14-7-8-17-16(11-14)15-9-10-20-19(22)18(15)21-17/h2-8,11-12,21H,9-10H2,1H3,(H,20,22)
  • InChiKey: UMYVPNVCEGVNDJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Metabotropic glutamate receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus metabotropic glutamate receptor 2 Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum ko:K04606 glutamate receptor, metabotropic 3, putative Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus multilocularis metabotropic glutamate receptor 5 Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum Metabotropic glutamate receptor precursor, putative Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus multilocularis metabotropic glutamate receptor 2 Get druggable targets OG5_127095 All targets in OG5_127095
Brugia malayi Metabotropic glutamate receptor precursor. Get druggable targets OG5_127095 All targets in OG5_127095
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127095 All targets in OG5_127095
Loa Loa (eye worm) glutamate receptor Get druggable targets OG5_127095 All targets in OG5_127095
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma mansoni metabotropic glutamate receptor Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus granulosus metabotropic glutamate receptor 5 Get druggable targets OG5_127095 All targets in OG5_127095
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi olfactory channel protein osm-9 0.0021 0.0105 0.0105
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0056 0.1312 0.2444
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.002 0.0053 0.0053
Loa Loa (eye worm) AStacin protease 0.003 0.0417 0.0434
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0055
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.002 0.0053 0.0099
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0055
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.002 0.0053 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0192 0.0192
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0024 0.0192 0.2458
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0192 0.0309
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.002 0.0053 0.0681
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0192 0.0261
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0048 0.1051 0.1093
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.002 0.0053 0.0099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0192 0.0199
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0192 0.0357
Brugia malayi Matrixin family protein 0.0044 0.0907 0.0907
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0199
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.002 0.0053 0.0055
Schistosoma mansoni thyroid hormone receptor 0.0171 0.537 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0199
Schistosoma mansoni coup transcription factor 0.0024 0.0192 0.0357
Schistosoma mansoni hypothetical protein 0.002 0.0053 0.0099
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0041 0.0798 0.1402
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0043 0.088 0.1638
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.002 0.0053 0.0053
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0192 0.0261
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0055
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0053 0.0099
Leishmania major hypothetical protein, unknown function 0.002 0.0053 0.5
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0192 0.0261
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0055
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0055
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.002 0.0053 0.5
Toxoplasma gondii transporter, cation channel family protein 0.002 0.0053 0.5
Schistosoma mansoni thyroid hormone receptor 0.0171 0.537 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0053 0.0099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0192 0.0199
Loa Loa (eye worm) calcium channel 0.002 0.0053 0.0055
Toxoplasma gondii hypothetical protein 0.002 0.0053 0.5
Schistosoma mansoni transient receptor potential channel 0.002 0.0053 0.0099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0192 0.0199
Loa Loa (eye worm) ion channel NompC 0.002 0.0053 0.0055
Loa Loa (eye worm) ryanodine receptor 0.002 0.0053 0.0055
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0192 0.0199
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.002 0.0053 0.0053
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0022 0.0139 0.0139
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0192 0.0192
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.002 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0199
Mycobacterium leprae PROBABLE HYDROLASE 0.0022 0.0139 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0192 0.0261
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.002 0.0053 0.0099
Schistosoma mansoni metabotropic glutamate receptor 0.0024 0.0197 0.0367
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0192 0.0309
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0192 0.0261
Loa Loa (eye worm) matrixin family protein 0.0044 0.0907 0.0944
Toxoplasma gondii transporter, cation channel family protein 0.002 0.0053 0.5
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0192 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0192 0.0192
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.002 0.0053 0.5
Brugia malayi ecdysteroid receptor 0.0024 0.0192 0.0192
Echinococcus granulosus metabotropic glutamate receptor 2 0.0041 0.0798 0.1661
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0199
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0055
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.002 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0055
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0192 0.0261
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0192 0.0357
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0192 0.0357
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.002 0.0053 0.0055
Echinococcus multilocularis metabotropic glutamate receptor 5 0.006 0.1474 0.2672
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0055
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.002 0.0053 0.0099
Toxoplasma gondii transporter, cation channel family protein 0.002 0.0053 0.5
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0192 0.0357
Schistosoma mansoni transient receptor potential channel 0.0021 0.0105 0.0196
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0055
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.002 0.0053 0.0053
Onchocerca volvulus Matrix metalloproteinase homolog 0.004 0.0779 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0192 0.0192
Loa Loa (eye worm) voltage-gated potassium channel 0.002 0.0053 0.0055
Loa Loa (eye worm) hypothetical protein 0.0046 0.0982 0.1022
Onchocerca volvulus 0.0026 0.0267 0.3431
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.002 0.0053 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0192 0.0192
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0147 0.4539 1
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0053 0.0099
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.002 0.0053 0.0099
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.002 0.0053 0.0099
Onchocerca volvulus 0.002 0.0053 0.0681
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0053 0.0099
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.002 0.0053 0.5
Loa Loa (eye worm) hypothetical protein 0.0291 0.9561 0.9951
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.002 0.0053 0.0681
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0192 0.0192
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0192 0.0192
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0192 0.0192
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.002 0.0053 0.0055
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0053 0.0099
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0199
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0192 0.0357
Brugia malayi Cyclic-nucleotide gated cation channel 0.002 0.0053 0.0053
Loa Loa (eye worm) voltage-gated potassium channel 0.002 0.0053 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0192 0.0192
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0192 0.0309
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0053 0.0099
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0055
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0192 0.0192
Schistosoma mansoni 60S ribosomal protein L21 0.002 0.0053 0.0099
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.002 0.0053 0.0053
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0066 0.1687 0.3072
Schistosoma mansoni hypothetical protein 0.0026 0.0267 0.0498
Schistosoma mansoni metabotropic glutamate receptor 0.0041 0.0798 0.1487
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0044 0.0916 0.0916
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0066 0.1687 0.3642
Mycobacterium ulcerans hydrolase 0.0022 0.0139 0.5
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0053 0.0099
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0053 0.0099
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0053 0.0099
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0192 0.0309
Brugia malayi hypothetical protein 0.002 0.0053 0.0053
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0053 0.0099
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0053 0.0099
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0055
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0055
Brugia malayi Transient-receptor-potential like protein 0.002 0.0053 0.0053
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0192 0.0357
Brugia malayi cation channel family protein 0.002 0.0053 0.0053
Schistosoma mansoni transient receptor potential channel 0.002 0.0053 0.0099
Schistosoma mansoni voltage-gated ion channel 0.002 0.0053 0.0099
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.002 0.0053 0.0053
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0053 0.0099
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0199
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.002 0.0053 0.0099
Loa Loa (eye worm) voltage-gated calcium channel 0.002 0.0053 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0192 0.0192
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.002 0.0053 0.0053
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0048 0.1051 0.1956
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0053 0.0099
Brugia malayi cation channel family protein 0.002 0.0053 0.0053
Brugia malayi voltage-dependent calcium channel 0.002 0.0053 0.0053
Echinococcus multilocularis Tolloid protein 1 0.0048 0.1051 0.1876
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0192 0.0192
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.002 0.0053 0.0099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0192 0.0199
Brugia malayi steroid hormone receptor 0.0024 0.0192 0.0192
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0292 0.9608 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0192 0.0309
Schistosoma mansoni transient receptor potential channel 4 0.002 0.0053 0.0099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0192 0.0199
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0192 0.0309
Brugia malayi Nuclear hormone receptor-like 1 0.0292 0.9608 0.9608
Echinococcus multilocularis transient receptor potential cation channel 0.0021 0.0105 0.0098
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0055
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.002 0.0053 0.0099
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0055
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.002 0.0053 0.0053
Brugia malayi Nuclear hormone receptor-like 1 0.0292 0.9608 0.9608
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0053 0.0099
Echinococcus granulosus transient receptor potential cation channel 0.0021 0.0105 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0192 0.0192
Echinococcus granulosus Tolloid protein 1 0.0048 0.1051 0.2224
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0022 0.0139 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0055
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0192 0.0357
Schistosoma mansoni ryanodine receptor related 0.002 0.0053 0.0099
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0055
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0053 0.0099
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0199
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.002 0.0053 0.0053
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0192 0.0309
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.002 0.0053 0.0099
Loa Loa (eye worm) voltage-dependent calcium channel 0.002 0.0053 0.0055
Schistosoma mansoni vesicular amine transporter 0.002 0.0053 0.0099
Loa Loa (eye worm) hypothetical protein 0.006 0.1474 0.1534
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0147 0.4539 0.8436
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0024 0.0192 0.0199
Echinococcus multilocularis short transient receptor potential channel 6 0.0021 0.0105 0.0098
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0192 0.0357
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0055
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0055
Schistosoma mansoni calcium-activated potassium channel 0.002 0.0053 0.0099
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0053 0.5
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0192 0.0357
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0192 0.0261
Echinococcus granulosus metabotropic glutamate receptor 5 0.006 0.1474 0.3167
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.002 0.0053 0.0099
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.002 0.0053 0.0053
Echinococcus multilocularis transient receptor potential cation channel 0.0021 0.0105 0.0098
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0053 0.0099
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0053 0.0099
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.002 0.0053 0.0053
Echinococcus multilocularis thyroid hormone receptor alpha 0.0171 0.537 1
Schistosoma mansoni two-pore calcium channel 0.002 0.0053 0.0099
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0053 0.5
Leishmania major hypothetical protein, conserved 0.002 0.0053 0.5
Onchocerca volvulus Matrilysin homolog 0.004 0.0779 1
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0192 0.0199
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0053 0.0099
Loa Loa (eye worm) glutamate receptor 0.0019 0.0036 0.0037
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0192 0.0309
Brugia malayi Hemopexin family protein 0.0026 0.0267 0.0267
Loa Loa (eye worm) hypothetical protein 0.002 0.0049 0.0051
Onchocerca volvulus Protein ultraspiracle homolog 0.0024 0.0192 0.2458
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0055
Leishmania major calcium channel protein, putative,ion transporter, putative 0.002 0.0053 0.5
Schistosoma mansoni inositol 145-trisphosphate receptor 0.002 0.0053 0.0099
Onchocerca volvulus 0.0024 0.0192 0.2458
Echinococcus granulosus short transient receptor potential channel 6 0.0021 0.0105 0.0117
Onchocerca volvulus Bile acid receptor homolog 0.0024 0.0192 0.2458
Loa Loa (eye worm) hypothetical protein 0.0022 0.0139 0.0145
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0053 0.0099
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0053 0.0099
Schistosoma mansoni voltage-dependent calcium channel 0.002 0.0053 0.0099
Loa Loa (eye worm) glutamate receptor 0.0049 0.1077 0.1121
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.002 0.0053 0.5
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0192 0.0309
Brugia malayi metabotropic glutamate receptor type 2 0.0024 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0055
Brugia malayi ion channel NompC 0.002 0.0053 0.0053
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0053 0.0099
Brugia malayi nuclear receptor NHR-88 0.0024 0.0192 0.0192
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0053 0.0099
Brugia malayi Metabotropic glutamate receptor precursor. 0.0049 0.1077 0.1077
Schistosoma mansoni hypothetical protein 0.0147 0.4539 0.8452
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.002 0.0053 0.5
Toxoplasma gondii hypothetical protein 0.002 0.0053 0.5
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0192 0.0357
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0192 0.0261
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.002 0.0053 0.5
Schistosoma mansoni voltage-gated cation channel 0.002 0.0053 0.0099
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.002 0.0053 0.0053
Loa Loa (eye worm) matrixin family protein 0.004 0.0779 0.0811
Brugia malayi nuclear hormone receptor 0.0024 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0021 0.0105 0.011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0192 0.0199

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 380 nM Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay ChEMBL. 17276684
IC50 (functional) = 380 nM Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay ChEMBL. 17276684

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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