Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0443 | 0.1532 | 1 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0482 | 0.1687 | 0.1687 |
Loa Loa (eye worm) | hypothetical protein | 0.0443 | 0.1532 | 0.1217 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0443 | 0.1532 | 0.1532 |
Brugia malayi | hypothetical protein | 0.0443 | 0.1532 | 0.1532 |
Echinococcus granulosus | neuroligin | 0.0443 | 0.1532 | 0.1532 |
Onchocerca volvulus | 0.0443 | 0.1532 | 0.5 | |
Echinococcus granulosus | BC026374 protein S09 family | 0.0443 | 0.1532 | 0.1532 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0049 | 0 | 0.5 |
Onchocerca volvulus | 0.0443 | 0.1532 | 0.5 | |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0049 | 0 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0141 | 0.0358 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0443 | 0.1532 | 0.1532 |
Loa Loa (eye worm) | carboxylesterase | 0.0443 | 0.1532 | 0.1217 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0443 | 0.1532 | 0.1532 |
Toxoplasma gondii | thioredoxin reductase | 0.0141 | 0.0358 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0443 | 0.1532 | 1 |
Leishmania major | trypanothione reductase | 0.0141 | 0.0358 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0443 | 0.1532 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0443 | 0.1532 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0443 | 0.1532 | 0.1217 |
Brugia malayi | Thioredoxin reductase | 0.0141 | 0.0358 | 0.0358 |
Echinococcus granulosus | acetylcholinesterase | 0.262 | 1 | 1 |
Onchocerca volvulus | 0.0443 | 0.1532 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0443 | 0.1532 | 0.1217 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0443 | 0.1532 | 0.1217 |
Brugia malayi | Carboxylesterase family protein | 0.0443 | 0.1532 | 0.1532 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0141 | 0.0358 | 0.0358 |
Brugia malayi | Carboxylesterase family protein | 0.0443 | 0.1532 | 0.1532 |
Loa Loa (eye worm) | hypothetical protein | 0.0443 | 0.1532 | 0.1217 |
Echinococcus granulosus | carboxylesterase 5A | 0.262 | 1 | 1 |
Echinococcus multilocularis | neuroligin | 0.0443 | 0.1532 | 0.1532 |
Echinococcus multilocularis | carboxylesterase 5A | 0.262 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0443 | 0.1532 | 0.1532 |
Brugia malayi | Carboxylesterase family protein | 0.0443 | 0.1532 | 0.1532 |
Brugia malayi | Carboxylesterase family protein | 0.262 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0141 | 0.0358 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.262 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0443 | 0.1532 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0141 | 0.0358 | 0.0358 |
Brugia malayi | Carboxylesterase family protein | 0.0443 | 0.1532 | 0.1532 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0443 | 0.1532 | 0.1532 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0141 | 0.0358 | 0.2341 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0443 | 0.1532 | 0.1532 |
Onchocerca volvulus | 0.0443 | 0.1532 | 0.5 | |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0049 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0443 | 0.1532 | 0.1217 |
Plasmodium vivax | glutathione reductase, putative | 0.0141 | 0.0358 | 1 |
Brugia malayi | glutathione reductase | 0.0141 | 0.0358 | 0.0358 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0443 | 0.1532 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0443 | 0.1532 | 0.1217 |
Schistosoma mansoni | gliotactin | 0.0443 | 0.1532 | 0.1532 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0443 | 0.1532 | 0.1532 |
Onchocerca volvulus | 0.0443 | 0.1532 | 0.5 | |
Schistosoma mansoni | acetylcholinesterase | 0.0443 | 0.1532 | 0.1532 |
Echinococcus multilocularis | acetylcholinesterase | 0.262 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0443 | 0.1532 | 0.1217 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0443 | 0.1532 | 0.1532 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.262 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0141 | 0.0358 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0141 | 0.0358 | 1 |
Treponema pallidum | NADH oxidase | 0.0049 | 0 | 0.5 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0443 | 0.1532 | 0.1532 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0443 | 0.1532 | 0.1532 |
Trypanosoma brucei | trypanothione reductase | 0.0141 | 0.0358 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.262 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.262 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.262 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.262 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.262 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | 0 mg kg-1 | Inhibition of cholera toxin induced intestinal fluid secretion in rat; I= Inactive | ChEMBL. | 2891854 |
Inhibition (functional) | 0 | Inhibition of increase in intestine potential difference caused by diarrhea-inducing secretagogues in rabbits using 'Ussing chamber'; Inactive | ChEMBL. | 2891854 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.