Detailed information for compound 440353

Basic information

Technical information
  • TDR Targets ID: 440353
  • Name: 2-[5-nitro-6-(trifluoromethyl)-1H-indol-2-yl] -1-propan-2-ylsulfanylpropan-2-ol
  • MW: 362.367 | Formula: C15H17F3N2O3S
  • H donors: 2 H acceptors: 3 LogP: 3.41 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(SCC(c1[nH]c2c(c1)cc(c(c2)C(F)(F)F)[N+](=O)[O-])(O)C)C
  • InChi: 1S/C15H17F3N2O3S/c1-8(2)24-7-14(3,21)13-5-9-4-12(20(22)23)10(15(16,17)18)6-11(9)19-13/h4-6,8,19,21H,7H2,1-3H3
  • InChiKey: HFQJOWOWKGJJBJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-isopropylsulfanyl-2-[5-nitro-6-(trifluoromethyl)-1H-indol-2-yl]propan-2-ol
  • 1-(isopropylthio)-2-[5-nitro-6-(trifluoromethyl)-1H-indol-2-yl]-2-propanol
  • 2-[5-nitro-6-(trifluoromethyl)-1H-indol-2-yl]-1-propan-2-ylsulfanyl-propan-2-ol
  • 1-(isopropylthio)-2-[5-nitro-6-(trifluoromethyl)-1H-indol-2-yl]propan-2-ol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0146 0.0707 0.1079
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Treponema pallidum sodium- and chloride- dependent transporter 0.0091 0.0371 0.5
Echinococcus granulosus g protein coupled receptor 0.0146 0.0707 0.0692
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Echinococcus multilocularis neuropeptide receptor 0.0146 0.0707 0.0614
Echinococcus granulosus tm gpcr rhodopsin 0.0146 0.0707 0.0692
Onchocerca volvulus 0.0606 0.3485 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Brugia malayi hypothetical protein 0.0146 0.0707 0.0661
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.0707 0.0701
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0606 0.3485 0.3453
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.1683 1 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.1683 1 1
Echinococcus granulosus g protein coupled receptor 0.0146 0.0707 0.0692
Schistosoma mansoni neuropeptide receptor 0.0146 0.0707 0.0701
Echinococcus granulosus rhodopsin orphan GPCR 0.0146 0.0707 0.0692
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Giardia lamblia Kinase, CMGC MAPK 0.1683 1 1
Brugia malayi neuropeptide F receptor 0.0146 0.0707 0.0661
Schistosoma mansoni neuropeptide F-like receptor 0.0146 0.0707 0.0701
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.0707 0.0614
Loa Loa (eye worm) hypothetical protein 0.0259 0.1385 0.1343
Schistosoma mansoni amine GPCR 0.0146 0.0707 0.0701
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.0707 0.0701
Echinococcus multilocularis fmrfamide receptor 0.0146 0.0707 0.0614
Echinococcus granulosus neuropeptides capa receptor 0.0146 0.0707 0.0692
Onchocerca volvulus 0.0146 0.0707 0.1079
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.0707 0.0614
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0146 0.0707 0.0661
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0146 0.0707 0.0614
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0146 0.0707 0.0614
Echinococcus granulosus serotonin transporter 0.0091 0.0371 0.0356
Echinococcus multilocularis mitogen activated protein kinase 0.1683 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0146 0.0707 0.0614
Echinococcus multilocularis neuropeptide receptor A26 0.0146 0.0707 0.0614
Leishmania major C-8 sterol isomerase-like protein 0.0371 0.2063 0.1983
Echinococcus multilocularis G protein coupled receptor 139 0.0146 0.0707 0.0614
Loa Loa (eye worm) hypothetical protein 0.0606 0.3485 0.3453
Brugia malayi follicle stimulating hormone receptor 0.0146 0.0707 0.0661
Onchocerca volvulus 0.0146 0.0707 0.1079
Brugia malayi hypothetical protein 0.0146 0.0707 0.0661
Toxoplasma gondii aldehyde dehydrogenase 0.0046 0.0099 0.0083
Onchocerca volvulus 0.0146 0.0707 0.1079
Echinococcus granulosus G protein coupled receptor 139 0.0146 0.0707 0.0692
Echinococcus granulosus alpha 1A adrenergic receptor 0.0146 0.0707 0.0692
Echinococcus multilocularis g protein coupled receptor 0.0146 0.0707 0.0614
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Onchocerca volvulus 0.0146 0.0707 0.1079
Echinococcus granulosus g protein coupled receptor 0.0146 0.0707 0.0692
Onchocerca volvulus 0.0146 0.0707 0.1079
Entamoeba histolytica acetyltransferase, GNAT family 0.0029 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.0707 0.0701
Onchocerca volvulus 0.0606 0.3485 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0146 0.0707 0.0614
Echinococcus multilocularis G-protein coupled receptor, putative 0.0146 0.0707 0.0614
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Schistosoma mansoni alpha-1 adrenergic receptor 0.0146 0.0707 0.0701
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0146 0.0707 0.0614
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0146 0.0707 0.0701
Echinococcus multilocularis neuropeptide FF receptor 2 0.0146 0.0707 0.0614
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0146 0.0707 0.0692
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Loa Loa (eye worm) neuropeptide F receptor 0.0146 0.0707 0.0661
Echinococcus granulosus neuropeptide s receptor 0.0146 0.0707 0.0692
Brugia malayi putative neuropeptide receptor 0.0146 0.0707 0.0661
Echinococcus granulosus dro:myosuppressin receptor 0.0146 0.0707 0.0692
Onchocerca volvulus 0.0146 0.0707 0.1079
Schistosoma mansoni amine GPCR 0.0146 0.0707 0.0701
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0606 0.3485 0.3453
Echinococcus granulosus biogenic amine 5HT receptor 0.0146 0.0707 0.0692
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0371 0.2063 0.2023
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0146 0.0707 0.0614
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0146 0.0707 0.0701
Onchocerca volvulus 0.0146 0.0707 0.1079
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0146 0.0707 0.0701
Echinococcus multilocularis g protein coupled receptor 0.0146 0.0707 0.0614
Echinococcus granulosus neuropeptide receptor 0.0146 0.0707 0.0692
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.0707 0.0614
Echinococcus granulosus sex peptide receptor 0.0146 0.0707 0.0692
Brugia malayi hypothetical protein 0.0146 0.0707 0.0661
Brugia malayi G protein-coupled receptor 0.0146 0.0707 0.0661
Loa Loa (eye worm) serotonin transporter b 0.0091 0.0371 0.0324
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.0707 0.0701
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.1683 1 1
Brugia malayi hypothetical protein 0.0146 0.0707 0.0661
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.1683 1 1
Brugia malayi Dopamine receptor 0.0146 0.0707 0.0661
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0109 0.0483 0.0388
Echinococcus multilocularis neuropeptide Y receptor 0.0146 0.0707 0.0614
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0146 0.0707 0.0614
Onchocerca volvulus 0.0606 0.3485 1
Echinococcus granulosus g-protein coupled receptor 0.0146 0.0707 0.0692
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.1683 1 1
Schistosoma mansoni opsin-like receptor 0.0146 0.0707 0.0701
Brugia malayi AKH receptor 0.0146 0.0707 0.0661
Schistosoma mansoni neuropeptide F-like receptor 0.0146 0.0707 0.0701
Echinococcus granulosus hypothetical protein 0.0146 0.0707 0.0692
Mycobacterium ulcerans aldehyde dehydrogenase 0.0046 0.0099 0.5
Echinococcus multilocularis serotonin receptor 0.0146 0.0707 0.0614
Brugia malayi hypothetical protein 0.0146 0.0707 0.0661
Schistosoma mansoni myosin xvIII 0.0146 0.0707 0.0701
Trypanosoma brucei protein kinase, putative 0.1683 1 1
Onchocerca volvulus 0.0146 0.0707 0.1079
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0146 0.0707 0.0614
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0146 0.0707 0.0701
Echinococcus multilocularis neuropeptide Y receptor 0.0146 0.0707 0.0614
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0146 0.0707 0.0661
Echinococcus granulosus rhodopsin orphan GPCR 0.0146 0.0707 0.0692
Echinococcus granulosus fmrfamide receptor 0.0146 0.0707 0.0692
Loa Loa (eye worm) hypothetical protein 0.0259 0.1385 0.1343
Onchocerca volvulus 0.0606 0.3485 1
Echinococcus granulosus mitogen activated protein kinase 0.1683 1 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0046 0.0099 0.5
Schistosoma mansoni biogenic amine receptor 0.0146 0.0707 0.0701
Loa Loa (eye worm) hypothetical protein 0.0347 0.1922 0.1882
Echinococcus multilocularis neuropeptides capa receptor 0.0146 0.0707 0.0614
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0146 0.0707 0.0692
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Schistosoma mansoni aldehyde dehydrogenase 0.0046 0.0099 0.0092
Brugia malayi Dopamine receptor protein 2 0.0146 0.0707 0.0661
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0146 0.0707 0.0701
Schistosoma mansoni hypothetical protein 0.0146 0.0707 0.0701
Loa Loa (eye worm) TYRA-2 protein 0.0146 0.0707 0.0661
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.1683 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.0046 0.0099 0.0092
Onchocerca volvulus 0.0146 0.0707 0.1079
Echinococcus granulosus somatostatin receptor 0.0146 0.0707 0.0692
Onchocerca volvulus 0.0606 0.3485 1
Brugia malayi putative neuropeptide receptor NPR1 0.0146 0.0707 0.0661
Loa Loa (eye worm) hypothetical protein 0.0259 0.1385 0.1343
Echinococcus granulosus orexin receptor type 2 0.0146 0.0707 0.0692
Plasmodium falciparum histone acetyltransferase GCN5 0.0029 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Brugia malayi hypothetical protein 0.0347 0.1922 0.1882
Schistosoma mansoni neuropeptide receptor 0.0146 0.0707 0.0701
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0091 0.0371 0.0364
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.0707 0.0614
Onchocerca volvulus 0.0606 0.3485 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0146 0.0707 0.0692
Loa Loa (eye worm) hypothetical protein 0.0347 0.1922 0.1882
Echinococcus granulosus histone acetyltransferase KAT2B 0.0106 0.0464 0.0449
Echinococcus granulosus neuropeptide Y receptor 0.0146 0.0707 0.0692
Echinococcus granulosus biogenic amine 5HT receptor 0.0146 0.0707 0.0692
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0146 0.0707 0.0692
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0347 0.1922 0.1882
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0146 0.0707 0.0701
Trichomonas vaginalis CMGC family protein kinase 0.1683 1 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0146 0.0707 0.0661
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Echinococcus granulosus 7TM GPCR rhodopsin 0.0146 0.0707 0.0692
Brugia malayi neuropeptide F receptor 0.0146 0.0707 0.0661
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.0707 0.0614
Loa Loa (eye worm) hypothetical protein 0.0347 0.1922 0.1882
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0146 0.0707 0.0661
Echinococcus granulosus neuropeptides capa receptor 0.0146 0.0707 0.0692
Loa Loa (eye worm) hypothetical protein 0.0371 0.2063 0.2023
Brugia malayi RE15519p 0.0146 0.0707 0.0661
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Echinococcus multilocularis serotonin transporter 0.0091 0.0371 0.0275
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0146 0.0707 0.1079
Schistosoma mansoni biogenic amine receptor 0.0146 0.0707 0.0701
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0146 0.0707 0.0661
Echinococcus multilocularis allatostatin A receptor 0.0146 0.0707 0.0614
Echinococcus multilocularis neuropeptides capa receptor 0.0146 0.0707 0.0614
Onchocerca volvulus 0.0146 0.0707 0.1079
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Echinococcus granulosus tachykinin peptides receptor 99D 0.0146 0.0707 0.0692
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Schistosoma mansoni sodium/chloride dependent transporter 0.0091 0.0371 0.0364
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Echinococcus multilocularis fmrfamide receptor 0.0146 0.0707 0.0614
Schistosoma mansoni hypothetical protein 0.0146 0.0707 0.0701
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0032 0.0016 0.5
Echinococcus multilocularis somatostatin receptor 0.0146 0.0707 0.0614
Echinococcus granulosus serotonin receptor 0.0146 0.0707 0.0692
Echinococcus granulosus peptide allatostatin:somatostatin 0.0146 0.0707 0.0692
Schistosoma mansoni growth hormone secretagogue receptor 0.0146 0.0707 0.0701
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.0707 0.0701
Onchocerca volvulus 0.0606 0.3485 1
Onchocerca volvulus 0.0606 0.3485 1
Schistosoma mansoni amine GPCR 0.0146 0.0707 0.0701
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Brugia malayi sulfakinin receptor protein 0.0146 0.0707 0.0661
Loa Loa (eye worm) norepinephrine transporter 0.0091 0.0371 0.0324
Echinococcus multilocularis dro:myosuppressin receptor 0.0146 0.0707 0.0614
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0146 0.0707 0.0701
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Brugia malayi larval opioid receptor 0.0146 0.0707 0.0661
Brugia malayi Serotonin receptor 0.0146 0.0707 0.0661
Trichomonas vaginalis conserved hypothetical protein 0.0259 0.1385 0.1371
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0347 0.1922 0.1882
Echinococcus granulosus neuropeptide receptor A26 0.0146 0.0707 0.0692
Echinococcus multilocularis mitogen activated protein kinase 3 0.1683 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0146 0.0707 0.0692
Echinococcus multilocularis neuropeptide receptor 0.0146 0.0707 0.0614
Loa Loa (eye worm) melatonin receptor type 1A 0.0146 0.0707 0.0661
Brugia malayi hypothetical protein 0.0259 0.1385 0.1343
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Brugia malayi GnHR receptor homolog 0.0146 0.0707 0.0661
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0146 0.0707 0.0701
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Schistosoma mansoni serine/threonine protein kinase 0.1683 1 1
Trichomonas vaginalis CMGC family protein kinase 0.1683 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0146 0.0707 0.0661
Brugia malayi hypothetical protein 0.0347 0.1922 0.1882
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.0707 0.0701
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.1683 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0146 0.0707 0.0701
Schistosoma mansoni adenoreceptor 0.0146 0.0707 0.0701
Brugia malayi Serotonin receptor 0.0146 0.0707 0.0661
Echinococcus granulosus rhodopsin orphan GPCR 0.0146 0.0707 0.0692
Loa Loa (eye worm) hypothetical protein 0.0189 0.0967 0.0922
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.0707 0.0614
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.0707 0.0614
Loa Loa (eye worm) acetyltransferase 0.0109 0.0483 0.0436
Brugia malayi G-protein coupled receptor 0.0146 0.0707 0.0661
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.0707 0.0701
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0146 0.0707 0.0614
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0146 0.0707 0.0614
Echinococcus multilocularis g protein coupled receptor 0.0146 0.0707 0.0614
Brugia malayi Dopamine receptor protein 1 0.0146 0.0707 0.0661
Schistosoma mansoni neuropeptide receptor 0.0146 0.0707 0.0701
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0046 0.0099 0.0083
Echinococcus granulosus neuropeptide receptor 0.0146 0.0707 0.0692
Onchocerca volvulus 0.0146 0.0707 0.1079
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Onchocerca volvulus 0.0146 0.0707 0.1079
Brugia malayi hypothetical protein 0.0146 0.0707 0.0661
Echinococcus granulosus rhodopsin orphan GPCR 0.0146 0.0707 0.0692
Schistosoma mansoni amine GPCR 0.0146 0.0707 0.0701
Mycobacterium ulcerans aldehyde dehydrogenase 0.0046 0.0099 0.5
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0347 0.1922 0.1882
Brugia malayi G-protein coupled receptor 0.0146 0.0707 0.0661
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0091 0.0371 0.0324
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Echinococcus multilocularis neuropeptide s receptor 0.0146 0.0707 0.0614
Schistosoma mansoni opsin-like receptor 0.0146 0.0707 0.0701
Brugia malayi ORL1-like opioid receptor 0.0146 0.0707 0.0661
Loa Loa (eye worm) hypothetical protein 0.0347 0.1922 0.1882
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0146 0.0707 0.0661
Brugia malayi acetyltransferase, GNAT family protein 0.0109 0.0483 0.0436
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0146 0.0707 0.0661
Onchocerca volvulus 0.0347 0.1922 0.498
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.0707 0.0701
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0146 0.0707 0.0692
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0109 0.0483 0.0476
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0347 0.1922 0.1882
Loa Loa (eye worm) G-protein coupled receptor 0.0146 0.0707 0.0661
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0146 0.0707 0.0701
Echinococcus multilocularis g-protein coupled receptor 0.0146 0.0707 0.0614
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0146 0.0707 0.0701
Brugia malayi Melatonin receptor type 1A 0.0146 0.0707 0.0661
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.1683 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0146 0.0707 0.0701
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Brugia malayi hypothetical protein 0.0146 0.0707 0.0661
Trichomonas vaginalis CMGC family protein kinase 0.1683 1 1
Brugia malayi LBP/BPI 0.0259 0.1385 0.1343
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0146 0.0707 0.0701
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0606 0.3485 0.3453
Schistosoma mansoni histamine h1 receptor 0.0146 0.0707 0.0701
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0146 0.0707 0.0614
Onchocerca volvulus 0.0146 0.0707 0.1079
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.1683 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.0707 0.0701
Echinococcus multilocularis orexin receptor type 2 0.0146 0.0707 0.0614
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0347 0.1922 0.1882
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Loa Loa (eye worm) hypothetical protein 0.0091 0.0371 0.0324
Schistosoma mansoni hypothetical protein 0.0146 0.0707 0.0701
Schistosoma mansoni opsin-like receptor 0.0146 0.0707 0.0701
Mycobacterium ulcerans aldehyde dehydrogenase 0.0046 0.0099 0.5
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0146 0.0707 0.0661
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0606 0.3485 0.3453
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Echinococcus granulosus rhodopsin orphan GPCR 0.0146 0.0707 0.0692
Echinococcus granulosus allatostatin A receptor 0.0146 0.0707 0.0692
Loa Loa (eye worm) hypothetical protein 0.0091 0.0371 0.0324
Brugia malayi hypothetical protein 0.0146 0.0707 0.0661
Schistosoma mansoni hypothetical protein 0.0146 0.0707 0.0701
Schistosoma mansoni amine GPCR 0.0146 0.0707 0.0701
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Echinococcus granulosus mitogen activated protein kinase 3 0.1683 1 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0146 0.0707 0.0661
Loa Loa (eye worm) neuropeptide F receptor 0.0146 0.0707 0.0661
Loa Loa (eye worm) solute carrier family 6 member 4 0.0091 0.0371 0.0324
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0146 0.0707 0.0701
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0146 0.0707 0.0692
Schistosoma mansoni neuropeptide f receptor 76f 0.0146 0.0707 0.0701
Echinococcus granulosus 7tm_1 domain containing protein 0.0146 0.0707 0.0692
Schistosoma mansoni neuropeptide receptor 0.0146 0.0707 0.0701
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0146 0.0707 0.0614
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0146 0.0707 0.0701
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0146 0.0707 0.0692
Onchocerca volvulus 0.0146 0.0707 0.1079
Onchocerca volvulus 0.0146 0.0707 0.1079
Onchocerca volvulus 0.0146 0.0707 0.1079
Onchocerca volvulus 0.0347 0.1922 0.498
Brugia malayi hypothetical protein 0.0146 0.0707 0.0661
Brugia malayi Tachykinin-like peptides receptor 99D 0.0146 0.0707 0.0661
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0146 0.0707 0.0661
Echinococcus granulosus tm gpcr rhodopsin 0.0146 0.0707 0.0692
Echinococcus granulosus neuropeptide FF receptor 2 0.0146 0.0707 0.0692
Trichomonas vaginalis CMGC family protein kinase 0.1683 1 1
Loa Loa (eye worm) hypothetical protein 0.0347 0.1922 0.1882
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.0707 0.0614
Echinococcus granulosus tm gpcr rhodopsin 0.0146 0.0707 0.0692
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Loa Loa (eye worm) hypothetical protein 0.0259 0.1385 0.1343
Onchocerca volvulus 0.0259 0.1385 0.3256
Echinococcus multilocularis serotonin receptor 0.0146 0.0707 0.0614
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0146 0.0707 0.0614
Schistosoma mansoni biogenic amine receptor 0.0146 0.0707 0.0701
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661
Echinococcus multilocularis sex peptide receptor 0.0146 0.0707 0.0614
Loa Loa (eye worm) hypothetical protein 0.0091 0.0371 0.0324
Brugia malayi G protein-coupled receptor F59B2.13 0.0146 0.0707 0.0661
Onchocerca volvulus Neuropeptide F receptor homolog 0.0146 0.0707 0.1079
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0146 0.0707 0.0614
Brugia malayi hypothetical protein 0.0146 0.0707 0.0661
Echinococcus granulosus neuropeptide Y receptor 0.0146 0.0707 0.0692
Loa Loa (eye worm) hypothetical protein 0.0146 0.0707 0.0661

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 42 % Reduction of prostrate weight in orally dosed immature rat ChEMBL. 17337185

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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