Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-X-C motif) receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Peroxidasin homolog | 0.0139 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0139 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0139 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0139 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0139 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0139 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0139 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0139 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0139 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0139 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0139 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0139 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0139 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0139 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0139 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0139 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0139 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0139 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0139 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0139 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0139 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0139 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0139 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0139 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0139 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Fu (ADMET) | = 12 % | Protein binding in human plasma | ChEMBL. | 18240390 |
IC50 (binding) | = -7.5 | Displacement of [125I]IL8 from human CXCR2 expressed in HEK 293 by SPA | ChEMBL. | 17382543 |
IC50 (binding) | = 35 nM | Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 cells by SPA assay | ChEMBL. | 18240390 |
IC50 (binding) | = 35 nM | Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 cells by SPA assay | ChEMBL. | 18240390 |
Log IC50 (binding) | = 7.5 | Displacement of [125I]IL8 from human CXCR2 expressed in HEK 293 by SPA | ChEMBL. | 17382543 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.