Detailed information for compound 440624

Basic information

Technical information
  • TDR Targets ID: 440624
  • Name: 2-[4-[(3-phenoxyphenyl)methylamino]phenyl]cyc lopropane-1-carboxylic acid
  • MW: 359.418 | Formula: C23H21NO3
  • H donors: 2 H acceptors: 2 LogP: 4.64 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C1CC1c1ccc(cc1)NCc1cccc(c1)Oc1ccccc1
  • InChi: 1S/C23H21NO3/c25-23(26)22-14-21(22)17-9-11-18(12-10-17)24-15-16-5-4-8-20(13-16)27-19-6-2-1-3-7-19/h1-13,21-22,24H,14-15H2,(H,25,26)
  • InChiKey: ABFWFUAKPRLLAW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[4-[(3-phenoxyphenyl)methylamino]phenyl]cyclopropanecarboxylic acid
  • 2-[4-[(3-phenoxybenzyl)amino]phenyl]cyclopropanecarboxylic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens free fatty acid receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ATPase 0.0061 0.0283 0.0418
Schistosoma mansoni amidase 0.0639 0.6759 1
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.01 0.0717 0.0717
Onchocerca volvulus Peroxidasin homolog 0.0126 0.1009 0.309
Schistosoma mansoni z-protein (S1r protein) 0.0044 0.0088 0.013
Entamoeba histolytica hypothetical protein 0.0044 0.0088 0.0304
Plasmodium falciparum esterase, putative 0.0294 0.2894 1
Onchocerca volvulus Glycogen phosphorylase homolog 0.021 0.195 0.5968
Loa Loa (eye worm) hypothetical protein 0.0126 0.1009 0.1009
Brugia malayi hypothetical protein 0.0126 0.1009 0.1009
Brugia malayi RhoGEF domain containing protein 0.0046 0.0111 0.0111
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0046 0.0111 0.0111
Trichomonas vaginalis cation-transporting ATPase, putative 0.0061 0.0283 0.0977
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0927 1 1
Trypanosoma cruzi amidase, putative 0.0077 0.0459 0.0459
Schistosoma mansoni serine/threonine protein kinase 0.0257 0.2474 0.3661
Echinococcus granulosus fatty acid amide hydrolase 1 0.0639 0.6759 0.6759
Schistosoma mansoni voltage-gated cation channel 0.016 0.1389 0.2054
Loa Loa (eye worm) hypothetical protein 0.0126 0.1009 0.1009
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0061 0.0283 0.0283
Echinococcus multilocularis glycogen phosphorylase 0.021 0.195 0.195
Echinococcus multilocularis mitogen activated protein kinase 11 0.0927 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0363 0.0537
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.01 0.0717 0.0717
Loa Loa (eye worm) hypothetical protein 0.0046 0.0111 0.0111
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0363 0.1255
Schistosoma mansoni protein kinase C mu 0.0051 0.0165 0.0244
Loa Loa (eye worm) hypothetical protein 0.0046 0.0111 0.0111
Giardia lamblia Glycogen phosphorylase 0.021 0.195 1
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0363 0.1255
Onchocerca volvulus 0.01 0.0717 0.2195
Echinococcus multilocularis Glycosyl transferase, family 35 0.021 0.195 0.195
Loa Loa (eye worm) tyrosinase 1 0.01 0.0717 0.0717
Brugia malayi bZIP transcription factor family protein 0.0089 0.0596 0.0596
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0914 0.0914
Toxoplasma gondii AGC kinase 0.0068 0.0363 1
Entamoeba histolytica diacylglycerol kinase, putative 0.0046 0.0111 0.0384
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0294 0.2894 1
Brugia malayi hypothetical protein 0.007 0.0381 0.0381
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0363 0.1255
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0046 0.0111 0.0165
Loa Loa (eye worm) hypothetical protein 0.0046 0.0111 0.0111
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0068 0.0363 0.0363
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0142 0.021
Schistosoma mansoni regulator of G protein signaling 0.0044 0.0088 0.013
Brugia malayi Ras association domain family 1 isoform A 0.0046 0.0111 0.0111
Loa Loa (eye worm) amidase 0.0077 0.0459 0.0459
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0061 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0182 0.1641 0.1641
Loa Loa (eye worm) hypothetical protein 0.0396 0.4035 0.4035
Mycobacterium ulcerans amidase 0.0077 0.0459 0.1588
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0049 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0126 0.1009 0.1009
Loa Loa (eye worm) AGC/AKT protein kinase 0.0068 0.0363 0.0363
Loa Loa (eye worm) hypothetical protein 0.0126 0.1009 0.1009
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0068 0.0363 0.0363
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0051 0.0165 0.0165
Brugia malayi amidase 0.0639 0.6759 0.6759
Schistosoma mansoni diacylglycerol kinase theta 0.0046 0.0111 0.0165
Brugia malayi putative amidase 0.0077 0.0459 0.0459
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0088 0.0304
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0088 0.0304
Trichomonas vaginalis glycogen phosphorylase, putative 0.021 0.195 0.6739
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0088 0.0304
Loa Loa (eye worm) hypothetical protein 0.0046 0.0111 0.0111
Loa Loa (eye worm) acetylcholinesterase 1 0.0132 0.1071 0.1071
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0077 0.0459 0.0459
Schistosoma mansoni fatty-acid amide hydrolase 0.0639 0.6759 1
Loa Loa (eye worm) RGS-3 protein 0.0044 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0052 0.0177 0.0177
Mycobacterium ulcerans amidase 0.0077 0.0459 0.1588
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0363 0.1255
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0052 0.0177 0.0177
Onchocerca volvulus 0.0327 0.3267 1
Echinococcus granulosus beta-adrenergic receptor kinase 0.0049 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0044 0.0088 0.0088
Brugia malayi carbohydrate phosphorylase 0.021 0.195 0.195
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.016 0.1389 0.1389
Echinococcus multilocularis Regulator of G protein signaling 20 0.0044 0.0088 0.0088
Brugia malayi small heat shock protein 0.0613 0.6477 0.6477
Echinococcus granulosus axis inhibition protein axin 0.0044 0.0088 0.0088
Echinococcus granulosus expressed protein 0.0855 0.9189 0.9189
Echinococcus granulosus acetylcholinesterase 0.0132 0.1071 0.1071
Brugia malayi Amidase family protein 0.0077 0.0459 0.0459
Brugia malayi Amidase family protein 0.0077 0.0459 0.0459
Loa Loa (eye worm) hypothetical protein 0.01 0.0717 0.0717
Loa Loa (eye worm) hypothetical protein 0.0046 0.0111 0.0111
Echinococcus multilocularis regulator of G protein signaling 7 0.0044 0.0088 0.0088
Echinococcus granulosus jun protein 0.0089 0.0596 0.0596
Toxoplasma gondii transporter, cation channel family protein 0.0056 0.022 0.606
Echinococcus multilocularis acetylcholinesterase 0.0132 0.1071 0.1071
Loa Loa (eye worm) hypothetical protein 0.0126 0.1009 0.1009
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0044 0.0088 0.0088
Brugia malayi Carboxylesterase family protein 0.0132 0.1071 0.1071
Loa Loa (eye worm) hypothetical protein 0.0126 0.1009 0.1009
Echinococcus multilocularis voltage dependent calcium channel 0.016 0.1389 0.1389
Loa Loa (eye worm) carboxylesterase 0.0132 0.1071 0.1071
Schistosoma mansoni jun-related protein 0.0072 0.0408 0.0604
Brugia malayi diacylglycerol kinase 0.0046 0.0111 0.0111
Toxoplasma gondii hypothetical protein 0.0049 0.0145 0.3984
Brugia malayi PXA domain containing protein 0.0044 0.0088 0.0088
Brugia malayi protein kinase C3,putative 0.0051 0.0165 0.0165
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.016 0.1389 0.1389
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0054 0.0202 0.0202
Schistosoma mansoni glycogen phosphorylase 0.0091 0.0613 0.0908
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0044 0.0088 0.0088
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0077 0.0459 0.5
Onchocerca volvulus 0.0052 0.0177 0.0541
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0068 0.0363 0.0363
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0049 0.0142 0.0142
Echinococcus multilocularis N chimaerin 0.0046 0.0111 0.0111
Brugia malayi PXA domain containing protein 0.0044 0.0088 0.0088
Schistosoma mansoni vav2 0.0046 0.0111 0.0165
Schistosoma mansoni diacylglycerol kinase theta 0.0046 0.0111 0.0165
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0054 0.0202 0.0299
Brugia malayi hypothetical protein 0.0044 0.0088 0.0088
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0046 0.0111 0.0111
Mycobacterium ulcerans lysophospholipase 0.0294 0.2894 1
Onchocerca volvulus 0.0046 0.0111 0.034
Trypanosoma cruzi amidase, putative 0.0077 0.0459 0.0459
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0363 0.1255
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0061 0.0283 0.0977
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0077 0.0459 0.1588
Loa Loa (eye worm) animal heme peroxidase 0.0126 0.1009 0.1009
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0294 0.2894 1
Brugia malayi RhoGAP domain containing protein 0.0046 0.0111 0.0111
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0927 1 1
Echinococcus granulosus voltage dependent calcium channel 0.016 0.1389 0.1389
Echinococcus multilocularis protein kinase c iota type 0.0114 0.0879 0.0879
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0044 0.0088 0.0304
Trypanosoma brucei rac serine-threonine kinase, putative 0.0068 0.0363 0.0363
Loa Loa (eye worm) hypothetical protein 0.0613 0.6477 0.6477
Schistosoma mansoni serine/threonine protein kinase 0.0257 0.2474 0.3661
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0051 0.0165 0.0165
Echinococcus multilocularis protein kinase c epsilon type 0.0202 0.1862 0.1862
Trichomonas vaginalis conserved hypothetical protein 0.0294 0.2894 1
Echinococcus multilocularis expressed protein 0.0855 0.9189 0.9189
Echinococcus multilocularis raf serine:threonine protein kinase 0.0046 0.0111 0.0111
Echinococcus granulosus regulator of G protein signaling 7 0.0044 0.0088 0.0088
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.016 0.1389 0.1389
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.016 0.1389 0.1389
Brugia malayi RhoGAP domain containing protein 0.0046 0.0111 0.0111
Echinococcus multilocularis regulator of G protein signaling 3 0.0044 0.0088 0.0088
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0927 1 1
Loa Loa (eye worm) glycogen phosphorylase 0.021 0.195 0.195
Entamoeba histolytica glycogen phosphorylase, putative 0.021 0.195 0.6739
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0363 0.1255
Loa Loa (eye worm) hypothetical protein 0.0046 0.0111 0.0111
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0165 0.0244
Loa Loa (eye worm) hypothetical protein 0.0126 0.1009 0.1009
Loa Loa (eye worm) ShTK domain-containing protein 0.01 0.0717 0.0717
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0061 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0132 0.1071 0.1071
Echinococcus granulosus fatty acid amide hydrolase 1 0.0639 0.6759 0.6759
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0089 0.0596 0.0596
Onchocerca volvulus Dual oxidase homolog 0.0126 0.1009 0.309
Brugia malayi Regulator of G protein signaling domain containing protein 0.0044 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0145
Brugia malayi Carboxylesterase family protein 0.0132 0.1071 0.1071
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.016 0.1389 0.1389
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0363 0.0537
Onchocerca volvulus 0.01 0.0717 0.2195
Echinococcus multilocularis carboxylesterase 5A 0.0132 0.1071 0.1071
Schistosoma mansoni regulator of G protein signaling 0.0044 0.0088 0.013
Schistosoma mansoni glycogen phosphorylase 0.021 0.195 0.2885
Echinococcus multilocularis mitogen activated protein kinase 14 0.0927 1 1
Entamoeba histolytica protein kinase, putative 0.0068 0.0363 0.1255
Schistosoma mansoni axis inhibition protein axin 0.0044 0.0088 0.013
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0051 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0126 0.1009 0.1009
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0044 0.0088 0.0088
Loa Loa (eye worm) RasGEF domain-containing protein 0.0046 0.0111 0.0111
Schistosoma mansoni glycogen phosphorylase 0.021 0.195 0.2885
Toxoplasma gondii diacylglycerol kinase, putative 0.0046 0.0111 0.3064
Schistosoma mansoni fatty-acid amide hydrolase 0.0077 0.0459 0.068
Loa Loa (eye worm) hypothetical protein 0.0132 0.1071 0.1071
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0294 0.2894 1
Mycobacterium ulcerans amidase 0.0077 0.0459 0.1588
Trypanosoma brucei monoglyceride lipase, putative 0.0294 0.2894 0.2894
Brugia malayi Blistered cuticle protein 3 0.0126 0.1009 0.1009
Echinococcus multilocularis myotubularin protein 13 0.0046 0.0111 0.0111
Echinococcus granulosus glycogen phosphorylase 0.021 0.195 0.195
Echinococcus multilocularis axis inhibition protein axin 0.0044 0.0088 0.0088
Echinococcus granulosus mitogen activated protein kinase 14 0.0927 1 1
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0077 0.0459 0.0459
Onchocerca volvulus Peroxidasin homolog 0.0126 0.1009 0.309
Loa Loa (eye worm) amidase 0.0077 0.0459 0.0459
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0363 0.0537
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0363 0.1255
Echinococcus granulosus voltage dependent calcium channel 0.0056 0.022 0.022
Echinococcus granulosus serine:threonine protein kinase N2 0.0087 0.0567 0.0567
Leishmania major monoglyceride lipase, putative 0.0294 0.2894 0.2894
Mycobacterium ulcerans hypothetical protein 0.0294 0.2894 1
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0068 0.0363 0.0363
Echinococcus granulosus N chimaerin 0.0046 0.0111 0.0111
Echinococcus granulosus Diacylglycerol kinase theta 0.0046 0.0111 0.0111
Loa Loa (eye worm) calcium channel 0.016 0.1389 0.1389
Loa Loa (eye worm) hypothetical protein 0.0327 0.3267 0.3267
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0042 0.0072 0.0072
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0068 0.0363 0.0363
Brugia malayi Hr1 repeat family protein 0.0068 0.0363 0.0363
Schistosoma mansoni protein kinase C mu 0.0046 0.0111 0.0165
Echinococcus granulosus carboxylesterase 5A 0.0132 0.1071 0.1071
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0046 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0044 0.0088 0.0088
Plasmodium falciparum lysophospholipase, putative 0.0294 0.2894 1
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0046 0.0111 0.0111
Echinococcus granulosus glycogen phosphorylase 0.021 0.195 0.195
Brugia malayi Variant SH3 domain containing protein 0.0046 0.0111 0.0111
Echinococcus granulosus regulator of G protein signaling 3 0.0044 0.0088 0.0088
Echinococcus multilocularis Diacylglycerol kinase theta 0.0046 0.0111 0.0111
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0056 0.022 0.022
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0091 0.0613 0.212
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0363 0.1255
Brugia malayi protein kinase C II. 0.0202 0.1862 0.1862
Loa Loa (eye worm) animal heme peroxidase 0.0126 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0061 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0373 0.3783 0.3783
Loa Loa (eye worm) hypothetical protein 0.016 0.1389 0.1389
Echinococcus multilocularis mitogen activated protein kinase 14 0.0927 1 1
Loa Loa (eye worm) hypothetical protein 0.0327 0.3267 0.3267
Brugia malayi C1-like domain containing protein 0.0051 0.0165 0.0165
Brugia malayi p70 ribosomal S6 kinase beta 0.0068 0.0363 0.0363
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0639 0.6759 0.6759
Echinococcus multilocularis regulator of G protein signaling 0.0044 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.01 0.0717 0.0717
Loa Loa (eye worm) hypothetical protein 0.0037 0.0008 0.0008
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0136 0.1125 0.1125
Mycobacterium ulcerans peptide amidase, GatA 0.0077 0.0459 0.1588
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0089 0.0596 0.0596
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0068 0.0363 0.0363
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0363 0.1255
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0294 0.2894 1
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0202 0.1862 0.1862
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.01 0.0717 0.0717
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0088 0.0304
Brugia malayi Animal haem peroxidase family protein 0.0126 0.1009 0.1009
Schistosoma mansoni ATPase 0.0061 0.0283 0.0418
Schistosoma mansoni peroxidasin 0.0126 0.1009 0.1493
Echinococcus multilocularis beta adrenergic receptor kinase 0.0049 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0046 0.0111 0.0111
Entamoeba histolytica protein kinase, putative 0.0068 0.0363 0.1255
Trichomonas vaginalis cation-transporting ATPase, putative 0.0061 0.0283 0.0977
Loa Loa (eye worm) hypothetical protein 0.0126 0.1009 0.1009
Entamoeba histolytica glycogen phosphorylase, putative 0.0091 0.0613 0.212
Leishmania major hypothetical protein, conserved 0.0077 0.0459 0.0459
Loa Loa (eye worm) raf kinase 0.0046 0.0111 0.0111
Entamoeba histolytica glycogen phosphorylase, putative 0.0091 0.0613 0.212
Echinococcus multilocularis RNA directed DNA polymerase 0.0136 0.1125 0.1125
Onchocerca volvulus 0.0046 0.0111 0.034
Echinococcus multilocularis serine threonine protein kinase 0.0211 0.1958 0.1958
Echinococcus granulosus acetylcholinesterase 0.0132 0.1071 0.1071
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0077 0.0459 0.0957
Echinococcus multilocularis glycogen phosphorylase 0.021 0.195 0.195
Echinococcus granulosus regulator of G protein signaling 7 0.0044 0.0088 0.0088
Brugia malayi Animal haem peroxidase family protein 0.0126 0.1009 0.1009
Loa Loa (eye worm) AGC/NDR protein kinase 0.0068 0.0363 0.0363
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0111 0.0165
Brugia malayi regulator of G-protein signaling rgs-7 0.0044 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0327 0.3267 0.3267
Loa Loa (eye worm) voltage-dependent calcium channel 0.0056 0.022 0.022
Onchocerca volvulus 0.0126 0.1009 0.309
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0639 0.6759 0.6759
Trichomonas vaginalis glycogen phosphorylase, putative 0.021 0.195 0.6739
Loa Loa (eye worm) hypothetical protein 0.0126 0.1009 0.1009
Schistosoma mansoni hypothetical protein 0.0046 0.0111 0.0165
Brugia malayi Regulator of G protein signaling domain containing protein 0.0044 0.0088 0.0088
Entamoeba histolytica PH domain containing protein kinase, putative 0.0087 0.0567 0.196
Echinococcus multilocularis protein kinase c eta type 0.0046 0.0111 0.0111
Brugia malayi Common central domain of tyrosinase family protein 0.01 0.0717 0.0717
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0044 0.0088 0.013
Trypanosoma cruzi monoglyceride lipase, putative 0.0294 0.2894 0.2894
Brugia malayi MH2 domain containing protein 0.0118 0.0914 0.0914
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0051 0.0165 0.0165
Onchocerca volvulus 0.0126 0.1009 0.309
Onchocerca volvulus Peroxidase homolog 0.0126 0.1009 0.309
Schistosoma mansoni regulator of G protein signaling 0.0044 0.0088 0.013
Echinococcus multilocularis Rac GTPase activating protein 1 0.0046 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0056 0.022 0.022
Mycobacterium ulcerans amidase 0.0077 0.0459 0.1588
Schistosoma mansoni regulator of G protein signaling 0.0044 0.0088 0.013
Loa Loa (eye worm) hypothetical protein 0.0046 0.0111 0.0111
Echinococcus granulosus protein kinase c eta type 0.0046 0.0111 0.0111
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0363 0.1255
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0061 0.0283 0.03
Echinococcus granulosus peroxidasin 0.0126 0.1009 0.1009
Echinococcus multilocularis axis inhibition protein axin 0.0044 0.0088 0.0088
Mycobacterium tuberculosis Possible lysophospholipase 0.0294 0.2894 1
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0257 0.2474 0.2474
Schistosoma mansoni unc-13 (munc13) 0.0052 0.0177 0.0261
Brugia malayi diacylglycerol kinase 0.0046 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0145
Schistosoma mansoni serine/threonine protein kinase 0.0202 0.1862 0.2755
Plasmodium falciparum lysophospholipase, putative 0.0294 0.2894 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0088 0.0088
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0068 0.0363 0.0363
Echinococcus granulosus fatty acid amide hydrolase 1 0.0077 0.0459 0.0459
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0049 0.0142 0.0142
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0294 0.2894 1
Schistosoma mansoni serine/threonine kinase 0.0068 0.0363 0.0537
Brugia malayi Protein kinase domain containing protein 0.0068 0.0363 0.0363
Loa Loa (eye worm) hypothetical protein 0.0639 0.6759 0.6759
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0165 0.0244
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.016 0.1389 0.2054
Echinococcus granulosus calcium transporting atpase 0.0054 0.0202 0.0202
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0077 0.0459 0.0677
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.01 0.0717 0.0717
Onchocerca volvulus Chorion peroxidase homolog 0.0126 0.1009 0.309
Entamoeba histolytica hypothetical protein 0.0044 0.0088 0.0304
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.016 0.1389 0.1389
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.016 0.1389 0.1389
Loa Loa (eye worm) blistered cuticle protein 3 0.0126 0.1009 0.1009
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0044 0.0088 0.013
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.016 0.1389 0.1389
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0142 0.021
Echinococcus multilocularis voltage dependent calcium channel 0.016 0.1389 0.1389
Loa Loa (eye worm) AGC/PKN protein kinase 0.0068 0.0363 0.0363
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0068 0.0363 0.0363
Schistosoma mansoni unc-13 (munc13) 0.0052 0.0177 0.0261
Echinococcus multilocularis regulator of G protein signaling 7 0.0044 0.0088 0.0088
Brugia malayi Peroxidasin 0.0126 0.1009 0.1009
Echinococcus granulosus Regulator of G protein signaling 20 0.0044 0.0088 0.0088
Schistosoma mansoni peroxidasin 0.0126 0.1009 0.1493
Brugia malayi hypothetical protein 0.0044 0.0088 0.0088
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0054 0.0202 0.0299
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0061 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0044 0.0088 0.0088
Echinococcus multilocularis serine:threonine protein kinase N2 0.0068 0.0363 0.0363
Plasmodium falciparum lysophospholipase, putative 0.0294 0.2894 1
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0147 0.1244 0.1244
Brugia malayi Animal haem peroxidase family protein 0.0126 0.1009 0.1009
Echinococcus multilocularis jun protein 0.0089 0.0596 0.0596
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0038 0.0025 0.0025
Mycobacterium ulcerans amidase 0.0077 0.0459 0.1588
Loa Loa (eye worm) PXA domain-containing protein 0.0044 0.0088 0.0088
Onchocerca volvulus 0.0126 0.1009 0.309
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.016 0.1389 0.2054
Loa Loa (eye worm) animal heme peroxidase 0.0126 0.1009 0.1009
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0142 0.021
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0294 0.2894 1
Trypanosoma brucei calcium-translocating P-type ATPase 0.0054 0.0202 0.0202
Echinococcus granulosus protein kinase C gamma type 0.0211 0.1958 0.1958
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0068 0.0363 0.0363
Onchocerca volvulus 0.01 0.0717 0.2195
Entamoeba histolytica hypothetical protein 0.0046 0.0111 0.0384
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0044 0.0088 0.013
Echinococcus granulosus RNA directed DNA polymerase 0.0136 0.1125 0.1125
Entamoeba histolytica protein kinase, putative 0.0068 0.0363 0.1255
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0294 0.2894 1
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0363 0.0537
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0294 0.2894 1
Echinococcus multilocularis serine:threonine protein kinase 38 0.0068 0.0363 0.0363
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0052 0.0177 0.0177
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0056 0.022 0.022
Loa Loa (eye worm) ShTK domain-containing protein 0.01 0.0717 0.0717
Loa Loa (eye worm) hypothetical protein 0.0126 0.1009 0.1009
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0077 0.0459 0.5
Schistosoma mansoni tyrosinase precursor 0.01 0.0717 0.1061
Brugia malayi Pleckstrin Homology Domain 0.0046 0.0111 0.0111
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0077 0.0459 0.068
Echinococcus granulosus Glycosyl transferase family 35 0.021 0.195 0.195
Schistosoma mansoni hypothetical protein 0.0072 0.0408 0.0604
Schistosoma mansoni regulator of G protein signaling 0.0044 0.0088 0.013
Plasmodium vivax PST-A protein 0.0294 0.2894 1
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0088 0.0304
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0294 0.2894 1
Brugia malayi ShTK domain containing protein 0.01 0.0717 0.0717
Brugia malayi Animal haem peroxidase family protein 0.0126 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0087 0.0568 0.0568
Echinococcus granulosus axis inhibition protein axin 0.0044 0.0088 0.0088
Loa Loa (eye worm) animal heme peroxidase 0.0126 0.1009 0.1009
Onchocerca volvulus 0.01 0.0717 0.2195
Echinococcus multilocularis unc 13 (munc13) 0.0052 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0136 0.1125 0.1125
Echinococcus granulosus Rac GTPase activating protein 1 0.0046 0.0111 0.0111
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0046 0.0111 0.0165
Schistosoma mansoni tyrosinase precursor 0.01 0.0717 0.1061
Schistosoma mansoni axis inhibition protein axin 0.0044 0.0088 0.013
Loa Loa (eye worm) hypothetical protein 0.0126 0.1009 0.1009
Chlamydia trachomatis glycogen phosphorylase 0.021 0.195 1
Onchocerca volvulus 0.007 0.0381 0.1166
Echinococcus granulosus mitogen activated protein kinase 11 0.0927 1 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0111 0.0111
Echinococcus granulosus raf serine:threonine protein kinase 0.0046 0.0111 0.0111
Entamoeba histolytica protein kinase, putative 0.0068 0.0363 0.1255
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0046 0.0111 0.0111
Echinococcus multilocularis acetylcholinesterase 0.0132 0.1071 0.1071
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0363 0.1255
Echinococcus granulosus Protein kinase C brain isozyme 0.0257 0.2474 0.2474
Echinococcus granulosus myotubularin protein 13 0.0046 0.0111 0.0111
Schistosoma mansoni atypical protein kinase C 0.0114 0.0879 0.13
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0927 1 1
Entamoeba histolytica glycogen phosphorylase, putative 0.021 0.195 0.6739
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0927 1 1
Brugia malayi Protein kinase domain containing protein 0.0051 0.0165 0.0165
Brugia malayi Protein kinase c protein 2 0.0193 0.176 0.176
Brugia malayi regulator of G-protein signaling egl-10 0.0044 0.0088 0.0088
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0064 0.0309 0.1069
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0088 0.0304
Echinococcus multilocularis calcium transporting atpase 0.0054 0.0202 0.0202
Entamoeba histolytica glycogenphosphorylase, putative 0.0091 0.0613 0.212
Trichomonas vaginalis conserved hypothetical protein 0.0294 0.2894 1
Echinococcus granulosus NDR protein kinase 0.0068 0.0363 0.0363
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0077 0.0459 0.0459
Trypanosoma brucei monoglyceride lipase, putative 0.0294 0.2894 0.2894
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0061 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0044 0.0088 0.0088
Schistosoma mansoni rac gtpase activating protein 0.0046 0.0111 0.0165
Echinococcus multilocularis serine:threonine protein kinase N2 0.015 0.1281 0.1281
Loa Loa (eye worm) hypothetical protein 0.0126 0.1009 0.1009
Brugia malayi Protein kinase domain containing protein 0.0068 0.0363 0.0363
Echinococcus granulosus protein kinase c epsilon type 0.0202 0.1862 0.1862
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0042 0.0072 0.0072
Brugia malayi A-kinase anchor protein 10, precursor 0.0044 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0044 0.0088 0.0088
Echinococcus granulosus unc 13 munc13 0.0052 0.0177 0.0177
Brugia malayi Protein kinase domain containing protein 0.0068 0.0363 0.0363
Echinococcus granulosus regulator of G protein signaling 3 0.0044 0.0088 0.0088
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0091 0.0613 0.0633
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0132 0.1071 0.1584
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0061 0.0283 0.7785
Leishmania major calcium-translocating P-type ATPase 0.0061 0.0283 0.0283
Echinococcus multilocularis mitogen activated protein kinase 11 0.0927 1 1
Onchocerca volvulus Peroxidase homolog 0.0126 0.1009 0.309
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0914 0.0914
Entamoeba histolytica diacylglycerol kinase, putative 0.0046 0.0111 0.0384
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0051 0.0165 0.0165
Brugia malayi Animal haem peroxidase family protein 0.0126 0.1009 0.1009
Echinococcus multilocularis peroxidasin 0.0126 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0126 0.1009 0.1009
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0077 0.0459 0.0459
Echinococcus granulosus protein kinase c iota type 0.0114 0.0879 0.0879
Echinococcus granulosus serine:threonine protein kinase N2 0.0068 0.0363 0.0363
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0054 0.0202 0.0299
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0068 0.0363 0.0363
Schistosoma mansoni protein kinase C 0.0052 0.0177 0.0261
Entamoeba histolytica hypothetical protein 0.0044 0.0088 0.0304
Echinococcus multilocularis regulator of G protein signaling 3 0.0044 0.0088 0.0088

Activities

Activity type Activity value Assay description Source Reference
%max (functional) = 74 % Agonist activity at GPR40 receptor expressed in CHO cells by reporter gene assay ChEMBL. 17240142
%max (functional) = 74 % Agonist activity at GPR40 receptor expressed in CHO cells by reporter gene assay ChEMBL. 17240142
EC50 (functional) = -7.3 Agonist activity at GPR40 receptor ChEMBL. 17240142
Log EC50 (functional) = 7.3 Agonist activity at GPR40 receptor ChEMBL. 17240142

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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