Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Peripheral-type benzodiazepine receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Peripheral-type benzodiazepine receptor | 169 aa | 156 aa | 25.6 % | |
Echinococcus granulosus | vacuolar h atpase | Peripheral-type benzodiazepine receptor | 169 aa | 137 aa | 25.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0322 | 0.5089 | 0.5 | |
Echinococcus granulosus | translocator protein | 0.0322 | 0.5089 | 1 |
Schistosoma mansoni | peripheral-type benzodiazepine receptor | 0.0322 | 0.5089 | 1 |
Brugia malayi | TspO/MBR family protein | 0.0322 | 0.5089 | 0.5089 |
Loa Loa (eye worm) | hypothetical protein | 0.0486 | 0.9445 | 0.9865 |
Mycobacterium ulcerans | tryptophan-rich sensory protein | 0.0322 | 0.5089 | 0.5 |
Onchocerca volvulus | 0.0322 | 0.5089 | 0.5 | |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0488 | 0.9504 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0286 | 0.4149 | 0.5281 |
Onchocerca volvulus | 0.0322 | 0.5089 | 0.5 | |
Schistosoma mansoni | thyroid hormone receptor | 0.0286 | 0.4149 | 0.5281 |
Schistosoma mansoni | thyroid hormone receptor | 0.0286 | 0.4149 | 0.5281 |
Onchocerca volvulus | 0.0322 | 0.5089 | 0.5 | |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0488 | 0.9504 | 0.9504 |
Echinococcus multilocularis | translocator protein | 0.0322 | 0.5089 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0488 | 0.9504 | 0.9504 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.215 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.169 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (binding) | = -6.78 | Displacement of [3H]-PK 11195 from rat peripheral (mitochondrial) benzodiazepine receptor | ChEMBL. | 7990110 |
IC50 (binding) | = 170 nM | Displacement of [3H]-PK 11195 from peripheral (mitochondrial) benzodiazepine receptor | ChEMBL. | 8182701 |
IC50 (binding) | = 170 nM | Displacement of [3H]-PK 11195 from peripheral (mitochondrial) benzodiazepine receptor | ChEMBL. | 8182701 |
Log IC50 (binding) | = 6.78 | Displacement of [3H]-PK 11195 from rat peripheral (mitochondrial) benzodiazepine receptor | ChEMBL. | 7990110 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.