Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-C motif) receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | chemokine (C-C motif) receptor 1 | 355 aa | 289 aa | 21.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0146 | 0.6328 | 0.6328 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.6328 | 0.6328 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0146 | 0.6328 | 0.6328 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0204 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.01 | 0.3399 | 0.3399 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0204 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0204 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0204 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.3399 | 0.3399 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0204 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.3399 | 0.3399 |
Echinococcus granulosus | carboxylesterase 5A | 0.0204 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0204 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0204 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0204 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0146 | 0.6328 | 0.6328 |
Loa Loa (eye worm) | carboxylesterase | 0.0204 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | 0 | Plasma clearance in iv dosed dog | ChEMBL. | 17383873 |
CL (ADMET) | 0 | Plasma clearance in monkey | ChEMBL. | 17383873 |
CL (ADMET) | 0 | Plasma clearance in iv dosed rat | ChEMBL. | 17383873 |
CL (ADMET) | = 14 ml/min.kg | Metabolic stability in human liver microsomes | ChEMBL. | 17383873 |
CL (ADMET) | = 27 ml/min.kg | Metabolic stability in dog liver microsomes | ChEMBL. | 17383873 |
CL (ADMET) | = 40 ml/min.kg | Metabolic stability in monkey liver microsomes | ChEMBL. | 17383873 |
CL (ADMET) | = 63 ml/min.kg | Metabolic stability in rat liver microsomes | ChEMBL. | 17383873 |
F (ADMET) | 0 | Bioavailability in dog | ChEMBL. | 17383873 |
F (ADMET) | 0 | Bioavailability in rat | ChEMBL. | 17383873 |
F (ADMET) | 0 | Bioavailability in monkey | ChEMBL. | 17383873 |
IC50 (functional) | = 0.086 uM | Activity at CCL3 by chemotaxis asssay | ChEMBL. | 17383873 |
IC50 (binding) | = 0.86 uM | Binding Affinity at CCL3 | ChEMBL. | 17383873 |
IC50 (binding) | = 0.86 uM | Binding Affinity at CCL3 | ChEMBL. | 17383873 |
t1/2 (ADMET) | 0 | Half life in dog | ChEMBL. | 17383873 |
t1/2 (ADMET) | 0 | Half life in monkey | ChEMBL. | 17383873 |
t1/2 (ADMET) | 0 | Half life in rat | ChEMBL. | 17383873 |
Vdss (ADMET) | 0 | Volume of distribution at steady state in dog | ChEMBL. | 17383873 |
Vdss (ADMET) | 0 | Volume of distribution at steady state in monkey | ChEMBL. | 17383873 |
Vdss (ADMET) | 0 | Volume of distribution at steady state in rat | ChEMBL. | 17383873 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.