Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | dihydrofolate reductase | 0.0346 | 0.7211 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0346 | 0.7211 | 0.5 |
Onchocerca volvulus | 0.0149 | 0.0574 | 0.5 | |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0132 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0149 | 0.0574 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0149 | 0.0574 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0149 | 0.0574 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0346 | 0.7211 | 0.7041 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0346 | 0.7211 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0346 | 0.7211 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0346 | 0.7211 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0132 | 0 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.0346 | 0.7211 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0346 | 0.7211 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0346 | 0.7211 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0132 | 0 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0132 | 0 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0346 | 0.7211 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0132 | 0 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0132 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.