Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dipeptidyl-peptidase 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0126 | 0.3435 | 0.5686 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.007 | 0.1709 | 0.1709 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0244 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0033 | 0.0054 |
Schistosoma mansoni | acylaminoacyl-peptidase (S09 family) | 0.0017 | 0.0033 | 0.0033 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0017 | 0.0033 | 0.0033 |
Echinococcus multilocularis | acylamino acid releasing enzyme | 0.0017 | 0.0033 | 0.0033 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0017 | 0.0033 | 0.5 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0017 | 0.0033 | 0.0054 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0017 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.006 | 0.0099 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0244 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.006 | 0.0099 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0244 | 0.0403 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.006 | 0.0099 |
Brugia malayi | RNA binding protein | 0.0126 | 0.3435 | 0.5686 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0244 | 0.1257 |
Loa Loa (eye worm) | TAR-binding protein | 0.0126 | 0.3435 | 0.5686 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.3435 | 0.3435 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0244 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.007 | 0.1709 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.3435 | 0.3435 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.003 | 0.0446 | 0.0446 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1046 | 0.1732 |
Schistosoma mansoni | hypothetical protein | 0.0336 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0244 | 0.0403 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0244 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0244 | 0.0403 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.006 | 0.139 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.007 | 0.1709 | 0.1709 |
Mycobacterium tuberculosis | Probable peptidase | 0.0017 | 0.0033 | 0.0136 |
Echinococcus granulosus | prolyl endopeptidase | 0.0017 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0033 | 0.0054 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0244 | 0.1257 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.0446 | 0.2464 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0446 | 0.0446 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0209 | 0.6041 | 0.6041 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0017 | 0.0033 | 0.0033 |
Echinococcus granulosus | acylamino acid releasing enzyme | 0.0017 | 0.0033 | 0.0033 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0244 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0244 | 0.0403 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.006 | 0.0099 |
Brugia malayi | hypothetical protein | 0.0054 | 0.1192 | 0.1974 |
Echinococcus multilocularis | tar DNA binding protein | 0.0126 | 0.3435 | 0.3435 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.006 | 0.5 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0017 | 0.0033 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0244 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.006 | 0.0648 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.0446 | 0.0446 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0209 | 0.6041 | 0.6041 |
Onchocerca volvulus | 0.0237 | 0.6898 | 1 | |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0209 | 0.6041 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0209 | 0.6041 | 0.6041 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0209 | 0.6041 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.007 | 0.1709 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0208 | 0.6002 | 0.9936 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.007 | 0.1709 | 0.1709 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1046 | 0.1732 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0017 | 0.0033 | 0.0136 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0446 | 0.0446 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0244 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0126 | 0.3435 | 0.5686 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0446 | 0.0738 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0017 | 0.0033 | 0.0033 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0017 | 0.0033 | 0.0054 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.3435 | 0.3435 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0244 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0244 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0446 | 0.0738 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.3435 | 0.3435 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0244 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0446 | 0.0446 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0446 | 0.0446 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.007 | 0.1709 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0412 | 0.0412 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.007 | 0.1709 | 1 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.007 | 0.1709 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1046 | 0.1732 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0244 | 0.0403 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0017 | 0.0033 | 0.0054 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0244 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.3435 | 0.3435 |
Brugia malayi | TAR-binding protein | 0.0126 | 0.3435 | 0.5686 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0126 | 0.3435 | 0.5686 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0244 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0208 | 0.6002 | 0.9936 |
Echinococcus granulosus | tar DNA binding protein | 0.0126 | 0.3435 | 0.3435 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0244 | 1 |
Onchocerca volvulus | 0.0023 | 0.0244 | 0.0307 | |
Brugia malayi | prolyl oligopeptidase family protein | 0.007 | 0.1709 | 0.283 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0017 | 0.0033 | 0.00000023243 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0562 | 0.093 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0244 | 0.0403 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0562 | 0.0562 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.006 | 0.0099 |
Schistosoma mansoni | hypothetical protein | 0.0336 | 1 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.007 | 0.1709 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.006 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0033 | 0.0054 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0209 | 0.6041 | 0.8751 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1046 | 0.1732 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0017 | 0.0033 | 0.00000023243 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.0446 | 0.0446 |
Trichomonas vaginalis | set domain proteins, putative | 0.0237 | 0.6898 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.0244 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0244 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0562 | 0.093 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0244 | 0.1257 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0017 | 0.0033 | 0.0054 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0446 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0017 | 0.006 | 0.1271 |
Echinococcus multilocularis | geminin | 0.0336 | 1 | 1 |
Onchocerca volvulus | 0.003 | 0.0446 | 0.0602 | |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1192 | 0.1974 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.