Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 660 nM | Displacement of [3H]CP55940 from cloned human CB2 receptor | ChEMBL. | 17507224 |
Ki (binding) | = 660 nM | Displacement of [3H]CP55940 from cloned human CB2 receptor | ChEMBL. | 17507224 |
Ki (binding) | = 3900 nM | Displacement of [3H]CP55940 from cloned human CB1 receptor | ChEMBL. | 17507224 |
Ki (binding) | = 3900 nM | Displacement of [3H]CP55940 from cloned human CB1 receptor | ChEMBL. | 17507224 |
Ratio Ki (binding) | = 6 | Selectivity for human CB2 receptor over human CB1 receptor | ChEMBL. | 17507224 |
Ratio Ki (binding) | = 6 | Selectivity for human CB2 receptor over human CB1 receptor | ChEMBL. | 17507224 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.