Detailed information for compound 44205

Basic information

Technical information
  • TDR Targets ID: 44205
  • Name: 3,3-bis(dimethoxyphosphoryl)propoxybenzene
  • MW: 352.257 | Formula: C13H22O7P2
  • H donors: 0 H acceptors: 2 LogP: 0.91 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COP(=O)(C(P(=O)(OC)OC)CCOc1ccccc1)OC
  • InChi: 1S/C13H22O7P2/c1-16-21(14,17-2)13(22(15,18-3)19-4)10-11-20-12-8-6-5-7-9-12/h5-9,13H,10-11H2,1-4H3
  • InChiKey: CRGQUXMDFWUZDE-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tar DNA binding protein 0.0064 0.3412 0.3412
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0305 0.0305
Brugia malayi hypothetical protein 0.0015 0.0305 0.0305
Brugia malayi steroid hormone receptor 0.0033 0.1413 0.1413
Brugia malayi nuclear receptor NHR-88 0.0033 0.1413 0.1413
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0487 0.0487
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.1413 0.1413
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.1413 0.1413
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0043 0.2085 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.1413 0.1413
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0487 0.0487
Brugia malayi nuclear hormone receptor 0.0015 0.0305 0.0305
Loa Loa (eye worm) hypothetical protein 0.0033 0.1413 0.1413
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0014 0.0196 0.0196
Mycobacterium leprae putative cytochrome p450 0.0018 0.0487 1
Echinococcus granulosus tar DNA binding protein 0.0064 0.3412 0.3412
Loa Loa (eye worm) hypothetical protein 0.0033 0.1413 0.1413
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.3412 0.3412
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.0487 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0018 0.0487 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.1413 0.1413
Onchocerca volvulus Peroxidasin homolog 0.0026 0.096 0.3683
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0043 0.2085 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.096 0.096
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.1413 0.1413
Loa Loa (eye worm) hypothetical protein 0.0026 0.096 0.096
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0166 1 1
Brugia malayi ecdysone receptor 0.0015 0.0305 0.0305
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.1413 0.1413
Loa Loa (eye worm) hypothetical protein 0.0026 0.096 0.096
Loa Loa (eye worm) hypothetical protein 0.0017 0.0423 0.0423
Schistosoma mansoni netrin receptor unc5 0.0028 0.1124 0.1124
Loa Loa (eye worm) hypothetical protein 0.0026 0.096 0.096
Loa Loa (eye worm) hypothetical protein 0.0026 0.096 0.096
Onchocerca volvulus 0.0026 0.096 0.3683
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.1413 0.1413
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0166 1 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0018 0.0487 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0039 0.1837 0.1837
Brugia malayi Animal haem peroxidase family protein 0.0026 0.096 0.096
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.2047 0.2047
Echinococcus granulosus nuclear factor of activated T cells 5 0.0144 0.8582 0.8582
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0305 0.0305
Schistosoma mansoni nuclear receptor nhr-48 0.0015 0.0305 0.0305
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.096 0.096
Loa Loa (eye worm) hypothetical protein 0.0035 0.1535 0.1535
Loa Loa (eye worm) hypothetical protein 0.0026 0.096 0.096
Schistosoma mansoni hypothetical protein 0.0028 0.1124 0.1124
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0166 1 1
Brugia malayi TAR-binding protein 0.0064 0.3412 0.3412
Brugia malayi Uncoordinated protein 44 0.0028 0.1124 0.1124
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0018 0.0487 1
Echinococcus granulosus fatty acid amide hydrolase 1 0.0114 0.6618 0.6618
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.0487 1
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0028 0.1124 0.1124
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0028 0.1124 0.1124
Loa Loa (eye worm) hypothetical protein 0.0017 0.0423 0.0423
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.1413 0.1413
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.1413 0.1413
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.1413 0.1413
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0305 0.0305
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0305 0.0305
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0423 0.0423
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0018 0.0487 1
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.0487 1
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.0305 0.0305
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.096 0.3683
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0114 0.6618 0.6618
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.1413 0.1413
Loa Loa (eye worm) hypothetical protein 0.0033 0.1413 0.1413
Loa Loa (eye worm) TAR-binding protein 0.0064 0.3412 0.3412
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.1413 0.1413
Schistosoma mansoni amidase 0.0114 0.6618 0.6618
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.0487 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0305 0.0305
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0166 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.1413 0.1413
Brugia malayi hypothetical protein 0.0026 0.096 0.096
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0487 0.154
Loa Loa (eye worm) hypothetical protein 0.0015 0.0305 0.0305
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.0487 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.1413 0.1413
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.0487 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.0305 0.0305
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.096 0.096
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0305 0.0305
Schistosoma mansoni coup transcription factor 0.0033 0.1413 0.1413
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.1413 0.1413
Loa Loa (eye worm) hypothetical protein 0.0017 0.0423 0.0423
Onchocerca volvulus 0.0026 0.096 0.3683
Schistosoma mansoni tar DNA-binding protein 0.0064 0.3412 0.3412
Onchocerca volvulus Bile acid receptor homolog 0.0033 0.1413 0.6223
Onchocerca volvulus Peroxidase homolog 0.0026 0.096 0.3683
Loa Loa (eye worm) RNA binding protein 0.0064 0.3412 0.3412
Loa Loa (eye worm) hypothetical protein 0.0026 0.096 0.096
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0487 0.154
Loa Loa (eye worm) hypothetical protein 0.0015 0.0305 0.0305
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.0487 1
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0018 0.0487 1
Onchocerca volvulus 0.0043 0.2085 1
Brugia malayi nuclear receptor NHR-88 0.0015 0.0305 0.0305
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0039 0.1837 0.1837
Loa Loa (eye worm) hypothetical protein 0.0033 0.1413 0.1413
Schistosoma mansoni nuclear receptor 0.0015 0.0305 0.0305
Loa Loa (eye worm) hypothetical protein 0.0026 0.096 0.096
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.1413 0.1413
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0487 0.154
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.2199 0.2199
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.1413 0.1413
Brugia malayi tailless protein 0.0015 0.0305 0.0305
Trypanosoma brucei cytochrome P450, putative 0.0018 0.0487 0.154
Brugia malayi Animal haem peroxidase family protein 0.0026 0.096 0.096
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0043 0.2085 0.2085
Echinococcus multilocularis 0.0018 0.0487 0.0487
Echinococcus multilocularis voltage gated potassium channel 0.0014 0.021 0.021
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0014 0.0196 0.0196
Brugia malayi RNA binding protein 0.0064 0.3412 0.3412
Loa Loa (eye worm) cytochrome P450 0.0018 0.0487 0.0487
Loa Loa (eye worm) hypothetical protein 0.0015 0.0305 0.0305
Schistosoma mansoni ankyrin 23/unc44 0.0028 0.1124 0.1124
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.096 0.096
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0166 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0039 0.1837 0.1837
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0043 0.2085 1
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0018 0.0487 1
Echinococcus granulosus Ankyrin 0.0028 0.114 0.114
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.1413 0.1413
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.0487 1
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0305 0.0305
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.1413 0.1413
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.2047 0.2047
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0423 0.0423
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0028 0.114 0.114
Loa Loa (eye worm) hypothetical protein 0.0015 0.0305 0.0305
Brugia malayi Animal haem peroxidase family protein 0.0026 0.096 0.096
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0166 1 1
Schistosoma mansoni fatty-acid amide hydrolase 0.0114 0.6618 0.6618
Schistosoma mansoni cytochrome P450 0.0018 0.0487 0.0487
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0043 0.2085 0.2085
Mycobacterium leprae Conserved hypothetical protein 0.0018 0.0487 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.1413 0.1413
Brugia malayi Death domain containing protein 0.0028 0.1124 0.1124
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0018 0.0487 1
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0123 0.723 0.723
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.1455 0.1455
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.096 0.096
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.1413 0.1413
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.1413 0.1413
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.0487 1
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0043 0.2085 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0305 0.0305
Onchocerca volvulus 0.0026 0.096 0.3683
Loa Loa (eye worm) hypothetical protein 0.0017 0.0423 0.0423
Loa Loa (eye worm) hypothetical protein 0.0028 0.114 0.114
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0487 0.154
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.1413 0.1413
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.1413 0.1413
Onchocerca volvulus Peroxidase homolog 0.0026 0.096 0.3683
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0487 0.154
Brugia malayi Blistered cuticle protein 3 0.0026 0.096 0.096
Loa Loa (eye worm) hypothetical protein 0.0028 0.1124 0.1124
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.1413 0.1413
Loa Loa (eye worm) hypothetical protein 0.0033 0.1413 0.1413
Loa Loa (eye worm) hypothetical protein 0.0015 0.0305 0.0305
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0305 0.0305
Onchocerca volvulus 0.0033 0.1413 0.6223
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0018 0.0487 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.3412 0.3412
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.0487 1
Brugia malayi ecdysteroid receptor 0.0033 0.1413 0.1413
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.2199 0.2199
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0166 1 1
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0018 0.0487 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0305 0.0305
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.1413 0.1413
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.0487 1
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.0487 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.1413 0.1413
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.2085 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.2199 0.2199
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.1413 0.1413
Leishmania major cytochrome p450-like protein 0.0018 0.0487 0.154
Leishmania major cytochrome p450-like protein 0.0018 0.0487 0.154
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0423 0.0423
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0043 0.2085 1
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0305 0.0305
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0014 0.021 0.021
Brugia malayi nuclear receptor NHR-67 0.0015 0.0305 0.0305
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.3412 0.3412
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.1413 0.1413
Brugia malayi nuclear hormone receptor 0.0033 0.1413 0.1413
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.1413 0.1413
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0043 0.2085 0.1927
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.0487 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0014 0.021 0.021
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0015 0.0305 0.0305
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0018 0.0487 1
Brugia malayi Animal haem peroxidase family protein 0.0026 0.096 0.096
Giardia lamblia Rab geranylgeranyltransferase 0.0166 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.2199 0.2199
Onchocerca volvulus Netrin receptor homolog 0.0028 0.1124 0.4603
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0166 1 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.6618 0.6618
Loa Loa (eye worm) hypothetical protein 0.0026 0.096 0.096
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.0487 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0305 0.0305
Echinococcus multilocularis Ankyrin 0.0028 0.114 0.114
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.2085 1
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0043 0.2085 0.2085
Brugia malayi Amidase family protein 0.0014 0.0196 0.0196
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.1413 0.1413
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0423 0.0423
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0423 0.0423
Onchocerca volvulus Peroxidasin homolog 0.0026 0.096 0.3683
Toxoplasma gondii hypothetical protein 0.0123 0.723 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.2199 0.2199
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.0487 1
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0014 0.0196 0.5
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.1413 0.1413
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0043 0.2085 0.2085
Loa Loa (eye worm) CYP4Cod1 0.0018 0.0487 0.0487
Echinococcus granulosus netrin receptor unc 5 0.0028 0.1124 0.1124
Schistosoma mansoni fatty-acid amide hydrolase 0.0014 0.0196 0.0196
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0015 0.0305 0.0305
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0305 0.0305
Schistosoma mansoni thyroid hormone receptor 0.0033 0.1413 0.1413
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0487 0.154
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0014 0.0196 0.5
Schistosoma mansoni tar DNA-binding protein 0.0064 0.3412 0.3412
Echinococcus granulosus peroxidasin 0.0026 0.096 0.096
Schistosoma mansoni tar DNA-binding protein 0.0064 0.3412 0.3412
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0014 0.0196 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.096 0.096
Loa Loa (eye worm) hypothetical protein 0.0026 0.096 0.096
Brugia malayi Protein kinase domain containing protein 0.0028 0.1124 0.1124
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.0487 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0487 0.0487
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0487 0.154
Loa Loa (eye worm) hypothetical protein 0.0015 0.0305 0.0305
Brugia malayi Cytochrome P450 family protein 0.0018 0.0487 0.0487
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0015 0.0305 0.0305
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0305 0.0305
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0018 0.0487 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.2199 0.2199
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.096 0.096
Echinococcus granulosus death domain containing protein 0.0028 0.1124 0.1124
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.021 0.021
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0014 0.0196 0.0196
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0018 0.0487 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.3412 0.3412
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.1413 0.1413
Schistosoma mansoni nuclear receptor 0.0015 0.0305 0.0305
Brugia malayi nuclear receptor RXR 0.0015 0.0305 0.0305
Echinococcus granulosus FTZ F1 alpha 0.0033 0.1413 0.1413
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0018 0.0487 1
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0043 0.2085 0.1927
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.1413 0.1413
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0305 0.0305
Loa Loa (eye worm) hypothetical protein 0.0014 0.021 0.021
Brugia malayi hypothetical protein 0.0015 0.0305 0.0305
Brugia malayi Cytochrome P450 family protein 0.0018 0.0487 0.0487
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.1455 0.1455
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0423 0.0423
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.0305 0.0305
Schistosoma mansoni thyroid hormone receptor 0.0033 0.1413 0.1413
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0305 0.0305
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0039 0.1837 0.1837
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0018 0.0487 1
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0043 0.2085 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.1413 0.1413
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.0487 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.1413 0.1413
Loa Loa (eye worm) hypothetical protein 0.0026 0.096 0.096
Echinococcus multilocularis thyroid hormone receptor alpha 0.0033 0.1413 0.1413
Loa Loa (eye worm) hypothetical protein 0.0033 0.1413 0.1413
Loa Loa (eye worm) hypothetical protein 0.0015 0.0305 0.0305
Brugia malayi cytochrome P450 0.0018 0.0487 0.0487
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0014 0.0196 0.0196
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0018 0.0487 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0305 0.0305
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0018 0.0487 1
Brugia malayi conserved hypotetical protein 0.0015 0.0305 0.0305
Schistosoma mansoni hypothetical protein 0.0018 0.0487 0.0487
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.1124 0.1124
Leishmania major cytochrome p450-like protein 0.0018 0.0487 0.154
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0018 0.0487 1
Echinococcus granulosus voltage gated potassium channel 0.0014 0.021 0.021
Echinococcus granulosus fatty acid amide hydrolase 1 0.0114 0.6618 0.6618
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.0305 0.0305
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.0305 0.0305
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0305 0.0305
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.2199 0.2199
Loa Loa (eye worm) DR-78 0.0015 0.0305 0.0305
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.2085 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.1413 0.1413
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0144 0.8582 0.8582
Schistosoma mansoni peroxidasin 0.0026 0.096 0.096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.1413 0.1413
Brugia malayi hypothetical protein 0.0017 0.0423 0.0423
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0114 0.6618 0.6618
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.1413 0.1413
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.1413 0.1413
Brugia malayi Peroxidasin 0.0026 0.096 0.096
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0166 1 1
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0018 0.0487 1
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0043 0.2085 0.2085
Loa Loa (eye worm) amidase 0.0014 0.0196 0.0196
Echinococcus granulosus fatty acid amide hydrolase 1 0.0014 0.0196 0.0196
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0305 0.0305
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.1413 0.1413
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.021 0.021
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.0487 1
Brugia malayi amidase 0.0114 0.6618 0.6618
Loa Loa (eye worm) amidase 0.0014 0.0196 0.0196
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0043 0.2085 1
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0043 0.2085 0.2085
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.1413 0.1413
Brugia malayi Animal haem peroxidase family protein 0.0026 0.096 0.096
Loa Loa (eye worm) hypothetical protein 0.0026 0.096 0.096
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0423 0.0423
Brugia malayi Amidase family protein 0.0014 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0033 0.1413 0.1413
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.1413 0.1413
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.0487 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.1413 0.1413
Onchocerca volvulus Protein ultraspiracle homolog 0.0033 0.1413 0.6223
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0018 0.0487 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0305 0.0305
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.1413 0.1413
Loa Loa (eye worm) hypothetical protein 0.0033 0.1413 0.1413
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0018 0.0487 1
Toxoplasma gondii hypothetical protein 0.0043 0.2085 0.237
Loa Loa (eye worm) hypothetical protein 0.0026 0.096 0.096
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0043 0.2085 0.2085
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.1413 0.1413
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.1413 0.1413
Loa Loa (eye worm) hypothetical protein 0.0017 0.0423 0.0423
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.2199 0.2199
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0166 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0487 0.0487
Brugia malayi Cytochrome P450 family protein 0.0018 0.0487 0.0487
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.0487 1
Brugia malayi Cytochrome P450 family protein 0.0018 0.0487 0.0487
Schistosoma mansoni nuclear hormone receptor 0.0033 0.1413 0.1413
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0033 0.1413 0.6223
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0014 0.021 0.021
Brugia malayi putative amidase 0.0014 0.0196 0.0196
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.2199 0.2199
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0043 0.2085 0.2085
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0018 0.0487 1
Onchocerca volvulus Dual oxidase homolog 0.0026 0.096 0.3683
Brugia malayi hypothetical protein 0.0017 0.0423 0.0423
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.1413 0.1413
Schistosoma mansoni zinc finger protein 0.0015 0.0305 0.0305
Echinococcus multilocularis peroxidasin 0.0026 0.096 0.096
Brugia malayi nuclear receptor RXR 0.0017 0.0423 0.0423
Schistosoma mansoni peroxidasin 0.0026 0.096 0.096
Loa Loa (eye worm) hypothetical protein 0.0015 0.0305 0.0305
Loa Loa (eye worm) hypothetical protein 0.0166 1 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0305 0.0305
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.1413 0.1413
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0305 0.0305
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0028 0.1124 0.1124
Echinococcus multilocularis netrin receptor unc 5 0.0028 0.1124 0.1124

Activities

Activity type Activity value Assay description Source Reference
Control (functional) 0 % Activity to induce the elevation of triglycerides of male Wistar rats; No Data ChEMBL. 3612689
Control (functional) 0 % Activity to induce the elevation of phospholipids of male Wistar rats; No Data ChEMBL. 3612689
Control (functional) 0 % Activity to induce the elevation of alpha/beta cholesterol ratio of male Wistar rats; No Data ChEMBL. 3612689
Control (functional) 0 % Activity to induce the elevation of HDL(High Density Lipoproteins)-Cholesterol of male Wistar rats; No Data ChEMBL. 3612689

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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