Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0156 | 0 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0156 | 0 | 0.5 |
Trypanosoma brucei | thymidine kinase | 0.0252 | 0.4334 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0156 | 0 | 0.5 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0252 | 0.4334 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0156 | 0 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0156 | 0 | 0.5 |
Onchocerca volvulus | 0.0156 | 0 | 0.5 | |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0156 | 0 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0156 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0156 | 0 | 0.5 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0252 | 0.4334 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0252 | 0.4334 | 1 |
Entamoeba histolytica | thymidine kinase, putative | 0.0252 | 0.4334 | 0.5 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0252 | 0.4334 | 0.5 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0252 | 0.4334 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0156 | 0 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0156 | 0 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0156 | 0 | 0.5 |
Leishmania major | thymidine kinase, putative | 0.0252 | 0.4334 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.1 uM | Inhibition of human cytomegalovirus DNA polymerase | ChEMBL. | 17513108 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.