Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | voltage-gated potassium channel | 0.0044 | 0.0058 | 0.0058 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.1052 | 0.1678 | 0.1678 |
Brugia malayi | Pepsin A precursor | 0.0019 | 0.0017 | 0.0017 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0039 | 0.0039 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0039 | 0.0039 |
Schistosoma mansoni | amine oxidase | 0.0046 | 0.0061 | 0.0061 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0181 | 0.0277 | 0.0277 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0041 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.6223 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.6223 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.6223 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.6223 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0017 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0061 | 0.0061 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0019 | 0.0017 | 0.0017 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0046 | 0.0061 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.6223 | 1 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0027 | 0.003 | 0.003 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0012 | 0.0005 | 0.0005 |
Trichomonas vaginalis | set domain proteins, putative | 0.0261 | 0.0407 | 0.2346 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0046 | 0.0061 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0181 | 0.0277 | 0.0277 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0061 | 0.0061 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0027 | 0.003 | 0.003 |
Onchocerca volvulus | 0.0027 | 0.003 | 0.0178 | |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0041 | 0.0052 | 0.0052 |
Onchocerca volvulus | 0.0261 | 0.0407 | 0.2424 | |
Loa Loa (eye worm) | hypothetical protein | 0.1052 | 0.1678 | 0.1678 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.1052 | 0.1678 | 0.1678 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.0051 | 0.0051 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.1052 | 0.1678 | 1 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0051 | 0.5 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.1052 | 0.1678 | 0.1678 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0019 | 0.0017 | 0.0017 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0033 | 0.0039 | 0.5113 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1052 | 0.1678 | 0.1678 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0019 | 0.0017 | 0.0017 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0181 | 0.0277 | 0.0277 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0044 | 0.0058 | 0.0058 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0027 | 0.003 | 0.003 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0012 | 0.0005 | 0.0005 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0046 | 0.0061 | 0.0061 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.1052 | 0.1678 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.0051 | 0.0051 |
Onchocerca volvulus | 0.1052 | 0.1678 | 1 | |
Echinococcus multilocularis | acetylcholinesterase | 0.6223 | 1 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0655 | 0.1041 | 0.6057 |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.0019 | 0.0017 | 0.0017 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.1052 | 0.1678 | 0.1678 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0609 | 0.0966 | 0.5598 |
Echinococcus multilocularis | carboxylesterase 5A | 0.6223 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0051 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0038 | 0.0048 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.1052 | 0.1678 | 0.1678 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0038 | 0.0048 | 0.0183 |
Brugia malayi | Choline O-acetyltransferase | 0.0181 | 0.0277 | 0.0277 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0027 | 0.003 | 0.003 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.1052 | 0.1678 | 1 |
Onchocerca volvulus | 0.0046 | 0.0061 | 0.0361 | |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0406 | 0.064 | 0.064 |
Onchocerca volvulus | 0.1052 | 0.1678 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.6223 | 1 | 1 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0046 | 0.0061 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.1052 | 0.1678 | 0.1678 |
Loa Loa (eye worm) | hypothetical protein | 0.6223 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.003 | 0.003 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.1052 | 0.1678 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0181 | 0.0277 | 0.0277 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0277 | 0.0277 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.0005 | 0.0005 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0046 | 0.0061 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1052 | 0.1678 | 0.1678 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0406 | 0.064 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0019 | 0.0017 | 0.0017 |
Loa Loa (eye worm) | carboxylesterase | 0.1052 | 0.1678 | 0.1678 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0051 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0061 | 0.0061 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.1052 | 0.1678 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1052 | 0.1678 | 0.1678 |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.0019 | 0.0017 | 0.0017 |
Brugia malayi | Pre-SET motif family protein | 0.023 | 0.0356 | 0.0356 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0019 | 0.0017 | 0.0017 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0019 | 0.0017 | 0.0017 |
Brugia malayi | Carboxylesterase family protein | 0.1052 | 0.1678 | 0.1678 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0039 | 0.0039 |
Echinococcus multilocularis | 0.0046 | 0.0061 | 0.0061 | |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0046 | 0.0061 | 1 |
Onchocerca volvulus | 0.0019 | 0.0017 | 0.0102 | |
Onchocerca volvulus | 0.0027 | 0.003 | 0.0178 | |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0019 | 0.0017 | 0.0017 |
Onchocerca volvulus | 0.1052 | 0.1678 | 1 | |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.0019 | 0.0017 | 0.0017 |
Brugia malayi | Carboxylesterase family protein | 0.1052 | 0.1678 | 0.1678 |
Onchocerca volvulus | 0.1052 | 0.1678 | 1 | |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0012 | 0.0005 | 0.0005 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0027 | 0.003 | 0.003 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.0019 | 0.0017 | 0.0017 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.0019 | 0.0017 | 0.0017 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0476 | 0.0752 | 0.0752 |
Brugia malayi | hypothetical protein | 0.004 | 0.0051 | 0.0051 |
Loa Loa (eye worm) | hypothetical protein | 0.6223 | 1 | 1 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0019 | 0.0017 | 0.0017 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0033 | 0.0039 | 0.0039 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0017 | 0.0017 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0046 | 0.0061 | 0.5 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0037 | 0.0037 |
Schistosoma mansoni | amine oxidase | 0.0046 | 0.0061 | 0.0061 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0041 | 0.0052 | 0.0052 |
Onchocerca volvulus | 0.0027 | 0.003 | 0.0178 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1052 | 0.1678 | 0.1678 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.1052 | 0.1678 | 0.1678 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0027 | 0.003 | 0.003 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0655 | 0.1041 | 0.6057 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0046 | 0.0061 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0061 | 0.0061 |
Echinococcus granulosus | choline O acetyltransferase | 0.0181 | 0.0277 | 0.0277 |
Onchocerca volvulus | 0.0019 | 0.0017 | 0.0102 | |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0019 | 0.0017 | 0.0017 |
Schistosoma mansoni | gliotactin | 0.1052 | 0.1678 | 0.1678 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.023 | 0.0356 | 0.0356 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.1052 | 0.1678 | 0.1678 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1052 | 0.1678 | 0.1678 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0039 | 0.0039 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0027 | 0.003 | 0.003 |
Onchocerca volvulus | 0.1052 | 0.1678 | 1 | |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.0039 | 0.0039 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.0078 | 0.0078 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0046 | 0.0061 | 0.0061 |
Brugia malayi | Carboxylesterase family protein | 0.6223 | 1 | 1 |
Onchocerca volvulus | 0.0027 | 0.003 | 0.0178 | |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0019 | 0.0017 | 0.0017 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0046 | 0.0061 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.0051 | 0.0051 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0041 | 0.0052 | 0.0052 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0046 | 0.0061 | 0.0061 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0046 | 0.0061 | 0.0061 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0046 | 0.0061 | 0.0505 |
Plasmodium vivax | hypothetical protein, conserved | 0.0046 | 0.0061 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0017 | 0.0017 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0046 | 0.0061 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0046 | 0.0061 | 1 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0012 | 0.0005 | 0.0005 |
Plasmodium vivax | hypothetical protein, conserved | 0.0046 | 0.0061 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.032 | 0.032 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0005 | 0.0005 |
Echinococcus granulosus | acetylcholinesterase | 0.6223 | 1 | 1 |
Brugia malayi | SWIRM domain containing protein | 0.0046 | 0.0061 | 0.0061 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0046 | 0.0061 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.0039 | 0.5113 |
Loa Loa (eye worm) | hypothetical protein | 0.1052 | 0.1678 | 0.1678 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.064 | 0.064 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0017 | 0.0017 |
Echinococcus granulosus | voltage gated potassium channel | 0.0012 | 0.0005 | 0.0005 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0019 | 0.0017 | 0.0017 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0061 | 0.0061 |
Loa Loa (eye worm) | carboxylesterase | 0.1052 | 0.1678 | 0.1678 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0019 | 0.0017 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0061 | 0.0061 |
Echinococcus granulosus | BC026374 protein S09 family | 0.1052 | 0.1678 | 0.1678 |
Brugia malayi | hypothetical protein | 0.1052 | 0.1678 | 0.1678 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0046 | 0.0061 | 0.0061 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0046 | 0.0061 | 0.0505 |
Brugia malayi | hypothetical protein | 0.0046 | 0.0061 | 0.0061 |
Echinococcus granulosus | neuroligin | 0.1052 | 0.1678 | 0.1678 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0051 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0406 | 0.064 | 1 |
Echinococcus multilocularis | neuroligin | 0.1052 | 0.1678 | 0.1678 |
Brugia malayi | Carboxylesterase family protein | 0.1052 | 0.1678 | 0.1678 |
Onchocerca volvulus | 0.0033 | 0.0039 | 0.0235 | |
Leishmania major | UDP-galactopyranose mutase | 0.0046 | 0.0061 | 0.0505 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0017 | 0.0017 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0039 | 0.0039 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0051 | 0.0051 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0406 | 0.064 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0039 | 0.0039 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.1052 | 0.1678 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0027 | 0.003 | 0.003 |
Schistosoma mansoni | acetylcholinesterase | 0.1052 | 0.1678 | 0.1678 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0027 | 0.003 | 0.003 |
Brugia malayi | Carboxylesterase family protein | 0.1052 | 0.1678 | 0.1678 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0019 | 0.0017 | 0.0017 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.1052 | 0.1678 | 0.1678 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0027 | 0.003 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.1052 | 0.1678 | 0.1678 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0043 | 0.0043 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0019 | 0.0017 | 0.0017 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | NA 0 mg kg-1 | Dose required to produce an acute inflammatory response of the algal poly saccharide carrageenan into the pleural cavity of rat; IA is Inactive at 6 mg/kg | ChEMBL. | 3941408 |
Inhibition (functional) | < 5 % | Inhibition of lymphocyte-mediated cytolysis at a concentratioon of 100 uM in [51Cr]- labelled EL4 leukemia cells | ChEMBL. | 3941408 |
Inhibition (functional) | < 5 % | Inhibition of lymphocyte-mediated cytolysis at a concentratioon of 100 uM in [51Cr]- labelled EL4 leukemia cells | ChEMBL. | 3941408 |
Inhibition (functional) | = 6 % | Compound was tested for inhibition of mouse connective tissue cell (L) growth at a concentration of 100 uM | ChEMBL. | 3941408 |
Inhibition (functional) | = 6 % | Compound was tested for inhibition of mouse connective tissue cell (L) growth at a concentration of 100 uM | ChEMBL. | 3941408 |
Inhibition (functional) | = 18 % | Compound was tested for inhibition of human sternal marrow cell (D98) growth at a concentration of 100 uM | ChEMBL. | 3941408 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.