Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Mus musculus | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0168 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0168 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0168 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0168 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0168 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0168 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0168 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0168 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0168 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0168 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0168 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0168 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0168 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0168 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0168 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0168 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0168 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0168 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0168 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0168 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0168 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0168 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0168 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0168 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0168 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0168 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0168 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0168 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0168 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0168 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0168 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0168 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0168 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0168 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0168 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0168 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0168 | 0.5 | 0.5 | |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0168 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0168 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0168 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0168 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0168 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0168 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0168 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0168 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0168 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0168 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0168 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0168 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0168 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0168 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0168 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0168 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0168 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0168 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0168 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0168 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0168 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0168 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0168 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0168 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0168 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AUC (ADMET) | = 3.2 ug.hr/ml | AUC in rat at 30 mg/kg, po | ChEMBL. | 17531479 |
CL (ADMET) | = 18.6 ml/min.kg | Total clearance in rat at 0.5 mg/kg, iv and 1 mg/kg, po | ChEMBL. | 17531479 |
CL (ADMET) | = 38.2 ml/min.kg | Total clearance in rat at 2 mg/kg, iv and 30 mg/kg, po | ChEMBL. | 17531479 |
ED50 (functional) | = 1.1 mg kg-1 | Analgesic activity against formalin-induced inflammatory pain in iv dosed mouse | ChEMBL. | 17531479 |
ED50 (functional) | = 1.1 mg kg-1 | Analgesic activity against formalin-induced inflammatory pain in iv dosed mouse | ChEMBL. | 17531479 |
ED50 (functional) | = 1.2 mg kg-1 | Analgesic activity against formalin-induced acute pain in iv dosed mouse | ChEMBL. | 17531479 |
ED50 (functional) | = 1.2 mg kg-1 | Analgesic activity against formalin-induced acute pain in iv dosed mouse | ChEMBL. | 17531479 |
ED50 (functional) | = 17.5 mg kg-1 | Analgesic activity against formalin-induced acute pain in po dosed mouse | ChEMBL. | 17531479 |
ED50 (functional) | = 17.5 mg kg-1 | Analgesic activity against formalin-induced inflammatory pain in po dosed mouse | ChEMBL. | 17531479 |
ED50 (functional) | = 17.5 mg kg-1 | Analgesic activity against formalin-induced acute pain in po dosed mouse | ChEMBL. | 17531479 |
ED50 (functional) | = 17.5 mg kg-1 | Analgesic activity against formalin-induced inflammatory pain in po dosed mouse | ChEMBL. | 17531479 |
F (ADMET) | = 24 % | Oral bioavailability in rat at 30 mg/kg | ChEMBL. | 17531479 |
F (ADMET) | = 32 % | Oral bioavailability in rat at 1 mg/kg | ChEMBL. | 17531479 |
Ki (binding) | = 0.8 nM | Binding affinity to human CB2 receptor | ChEMBL. | 17531479 |
Ki (binding) | = 0.8 nM | Binding affinity to human CB2 receptor | ChEMBL. | 17531479 |
Ki (binding) | = 1.2 nM | Binding affinity to mouse CB2 receptor | ChEMBL. | 17531479 |
Ki (binding) | = 1.2 nM | Binding affinity to mouse CB2 receptor | ChEMBL. | 17531479 |
Ki (binding) | = 80 nM | Binding affinity to mouse CB1 receptor | ChEMBL. | 17531479 |
Ki (binding) | = 80 nM | Binding affinity to mouse CB1 receptor | ChEMBL. | 17531479 |
Ki (binding) | = 122 nM | Binding affinity to human CB1 receptor | ChEMBL. | 17531479 |
Ki (binding) | = 122 nM | Binding affinity to human CB1 receptor | ChEMBL. | 17531479 |
t1/2 (ADMET) | = 2.5 hr | Half life in rat at 2 mg/kg, iv and 30 mg/kg, po | ChEMBL. | 17531479 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.