TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 455.426 | Formula: C25H20F3NO4
H donors: 1 H acceptors: 2 LogP: 5.51 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)Cn1ccc2c1ccc(c2)OCc1cccc(c1)COc1ccc(cc1)C(F)(F)F
InChi: 1S/C25H20F3NO4/c26-25(27,28)20-4-6-21(7-5-20)32-15-17-2-1-3-18(12-17)16-33-22-8-9-23-19(13-22)10-11-29(23)14-24(30)31/h1-13H,14-16H2,(H,30,31)
InChiKey: HPRZJTYQTBHRKL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	peroxisome proliferator-activated receptor delta	Starlite/ChEMBL	References
Homo sapiens	peroxisome proliferator-activated receptor gamma	Starlite/ChEMBL	References
Homo sapiens	peroxisome proliferator-activated receptor alpha	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	IPR008946,Nuclear receptor, ligand-binding,domain-containing	Get druggable targets OG5_137778	All targets in OG5_137778
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	Get druggable targets OG5_137778	All targets in OG5_137778
Schistosoma japonicum	ko:K08701 nuclear receptor, subfamily 1, invertebrate, putative	Get druggable targets OG5_137778	All targets in OG5_137778

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	ecdysone induced protein 78C	peroxisome proliferator-activated receptor gamma	477 aa	447 aa	28.2 %
Brugia malayi	ecdysteroid receptor	peroxisome proliferator-activated receptor delta	441 aa	369 aa	24.7 %
Brugia malayi	ecdysteroid receptor	peroxisome proliferator-activated receptor alpha	468 aa	397 aa	25.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0053	0.0241	0.0296
Brugia malayi	Protein kinase domain containing protein	0.0228	0.2505	0.3082
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0228	0.2505	0.3082
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0053	0.0241	0.0296
Trichomonas vaginalis	AGC family protein kinase	0.0662	0.8126	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0045	0.0136	0.0136
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0045	0.0136	0.0167
Entamoeba histolytica	protein kinase, putative	0.0228	0.2505	0.0289
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0228	0.2505	0.3082
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0045	0.0136	0.0167
Schistosoma mansoni	thyroid hormone receptor	0.0045	0.0136	0.0136
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0045	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0228	0.2505	0.3082
Entamoeba histolytica	protein kinase, putative	0.0662	0.8126	1
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0662	0.8126	1
Echinococcus multilocularis	nervana 2	0.0434	0.517	0.517
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0228	0.2505	0.2505
Echinococcus granulosus	FTZ F1 alpha	0.0045	0.0136	0.0136
Brugia malayi	steroid hormone receptor	0.0045	0.0136	0.0167
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0441	0.5259	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0241	0.0241
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0228	0.2505	0.2505
Schistosoma mansoni	serine/threonine protein kinase	0.0228	0.2505	0.2505
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0241	0.0241
Echinococcus multilocularis	ecdysone induced protein 78C	0.0045	0.0136	0.0136
Echinococcus multilocularis	Glutaredoxin protein 5	0.0434	0.517	0.517
Schistosoma mansoni	atypical protein kinase C	0.0228	0.2505	0.2505
Echinococcus granulosus	protein kinase c iota type	0.0228	0.2505	0.2505
Trichomonas vaginalis	AGC family protein kinase	0.0662	0.8126	1
Brugia malayi	Steroid receptor seven-up type 2	0.0045	0.0136	0.0167
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0241	0.0241
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0045	0.0136	0.0167
Trichomonas vaginalis	AGC family protein kinase	0.0662	0.8126	1
Schistosoma mansoni	serine/threonine-protein kinase	0.0441	0.5259	0.5259
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0221	0.2416	0.0135
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0045	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0136	0.0167
Trichomonas vaginalis	AGC family protein kinase	0.0228	0.2505	0.0289
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0441	0.5259	0.5259
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0045	0.0136	0.0136
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0228	0.2505	0.3082
Onchocerca volvulus		0.0045	0.0136	0.0432
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0045	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0136	0.0167
Echinococcus granulosus	Protein kinase C brain isozyme	0.0228	0.2505	0.2505
Echinococcus granulosus	protein kinase C gamma type	0.0228	0.2505	0.2505
Brugia malayi	p70 ribosomal S6 kinase beta	0.0662	0.8126	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0045	0.0136	0.0167
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0045	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0136	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0136	0.0167
Echinococcus multilocularis	microtubule associated protein 2	0.0807	1	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0136	0.0167
Brugia malayi	phosphoinositide-dependent protein kinase I	0.0215	0.2337	0.2876
Echinococcus granulosus	neuropeptide s receptor	0.0541	0.6552	0.6552
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0241	0.0241
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0045	0.0136	0.0136
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0228	0.2505	0.2505
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0045	0.0136	0.0167
Schistosoma mansoni	serine/threonine protein kinase	0.0228	0.2505	0.2505
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0045	0.0136	0.0136
Echinococcus multilocularis	protein kinase c epsilon type	0.0228	0.2505	0.2505
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0045	0.0136	0.0167
Toxoplasma gondii	AGC kinase	0.0662	0.8126	1
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0662	0.8126	0.5
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0441	0.5259	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0228	0.2505	0.2505
Echinococcus granulosus	serine threonine protein kinase nrc	0.0441	0.5259	0.5259
Echinococcus multilocularis	rac serine:threonine kinase	0.0441	0.5259	0.5259
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0662	0.8126	1
Schistosoma mansoni	hypothetical protein	0.0198	0.2114	0.2114
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0045	0.0136	0.0167
Echinococcus granulosus	Glutaredoxin protein 5	0.0434	0.517	0.517
Echinococcus granulosus	ecdysone induced protein 78C	0.0045	0.0136	0.0136
Echinococcus granulosus	serine:threonine protein kinase N2	0.0228	0.2505	0.2505
Schistosoma mansoni	coup transcription factor	0.0045	0.0136	0.0136
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0045	0.0136	0.0167
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0045	0.0136	0.0136
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0045	0.0136	0.0167
Echinococcus multilocularis	3 phosphoinositide dependent protein kinase 1	0.0215	0.2337	0.2337
Schistosoma mansoni	serine/threonine protein kinase	0.0215	0.2337	0.2337
Brugia malayi	nuclear hormone receptor	0.0045	0.0136	0.0167
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0045	0.0136	0.0167
Echinococcus multilocularis	neuropeptide receptor A26	0.0541	0.6552	0.6552
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0045	0.0136	0.0167
Echinococcus multilocularis	neuropeptide s receptor	0.0541	0.6552	0.6552
Brugia malayi	Hr1 repeat family protein	0.0228	0.2505	0.3082
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0045	0.0136	0.0136
Echinococcus multilocularis	geminin	0.0198	0.2114	0.2114
Schistosoma mansoni	serine/threonine protein kinase	0.0228	0.2505	0.2505
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0228	0.2505	0.2505
Schistosoma mansoni	microtubule-associated protein tau	0.0807	1	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0136	0.0167
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0441	0.5259	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0228	0.2505	0.0289
Onchocerca volvulus	Bile acid receptor homolog	0.0045	0.0136	0.0432
Giardia lamblia	Kinase, AGC PKA	0.0441	0.5259	0.5
Trypanosoma cruzi	Protein kinase B	0.0441	0.5259	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0045	0.0136	0.0167
Trichomonas vaginalis	AGC family protein kinase	0.0228	0.2505	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0136	0.0167
Trichomonas vaginalis	AGC family protein kinase	0.0662	0.8126	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0045	0.0136	0.0136
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0045	0.0136	0.0136
Trichomonas vaginalis	AGC family protein kinase	0.0662	0.8126	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0045	0.0136	0.0136
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0228	0.2505	0.3082
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0228	0.2505	0.3082
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0045	0.0136	0.0136
Echinococcus multilocularis	protein kinase c iota type	0.0228	0.2505	0.2505
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0434	0.517	0.517
Trichomonas vaginalis	set domain proteins, putative	0.0277	0.3136	0.1379
Brugia malayi	Nuclear hormone receptor-like 1	0.0045	0.0136	0.0167
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0228	0.2505	0.2505
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0228	0.2505	0.2505
Schistosoma mansoni	thyroid hormone receptor	0.0045	0.0136	0.0136
Echinococcus granulosus	3-phosphoinositide-dependent protein kinase 1	0.0215	0.2337	0.2337
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0045	0.0136	0.0136
Brugia malayi	Protein kinase domain containing protein	0.0662	0.8126	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0045	0.0136	0.0136
Echinococcus granulosus	serine/threonine protein kinase	0.0441	0.5259	0.5259
Brugia malayi	Protein kinase domain containing protein	0.0215	0.2337	0.2876
Schistosoma mansoni	nuclear hormone receptor	0.0045	0.0136	0.0136
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0228	0.2505	0.2505
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0228	0.2505	0.2505
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0215	0.2337	0.2876
Loa Loa (eye worm)	steroid hormone receptor	0.0045	0.0136	0.0167
Entamoeba histolytica	protein kinase 2, putative	0.0441	0.5259	0.5046
Trichomonas vaginalis	AGC family protein kinase	0.0228	0.2505	0.0289
Schistosoma mansoni	RAR-like nuclear receptor	0.0045	0.0136	0.0136
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0228	0.2505	0.2505
Brugia malayi	Protein kinase domain containing protein	0.0228	0.2505	0.3082
Schistosoma mansoni	serine/threonine-protein kinase	0.0441	0.5259	0.5259
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0045	0.0136	0.0167
Echinococcus granulosus	geminin	0.0198	0.2114	0.2114
Onchocerca volvulus		0.0277	0.3136	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0045	0.0136	0.0136
Echinococcus granulosus	nervana 2	0.0434	0.517	0.517
Schistosoma mansoni	serine/threonine protein kinase	0.0228	0.2505	0.2505
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0045	0.0136	0.0167
Entamoeba histolytica	protein kinase, putative	0.0662	0.8126	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0045	0.0136	0.0136
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0243	0.27	0.3323
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0241	0.0241
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0045	0.0136	0.0136
Schistosoma mansoni	retinoic acid receptor RXR	0.0045	0.0136	0.0136
Schistosoma mansoni	serine/threonine protein kinase	0.0228	0.2505	0.2505
Onchocerca volvulus	Protein ultraspiracle homolog	0.0045	0.0136	0.0432
Trichomonas vaginalis	AGC family protein kinase	0.0662	0.8126	1
Brugia malayi	protein kinase C II.	0.0228	0.2505	0.3082
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0136	0.0167
Echinococcus granulosus	nervana 2	0.0434	0.517	0.517
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0045	0.0136	0.0167
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0045	0.0136	0.0136
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0438	0.5221	0.5221
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0045	0.0136	0.0167
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0241	0.0241
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0045	0.0136	0.0432
Schistosoma mansoni	serine/threonine protein kinase	0.0228	0.2505	0.2505
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0434	0.517	0.517
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0241	0.0241
Entamoeba histolytica	protein kinase, putative	0.0662	0.8126	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0045	0.0136	0.0167
Brugia malayi	nuclear receptor NHR-88	0.0045	0.0136	0.0167
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0045	0.0136	0.0136
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0441	0.5259	0.5259
Brugia malayi	photoreceptor-specific nuclear receptor	0.0045	0.0136	0.0167
Schistosoma mansoni	serine/threonine kinase	0.0228	0.2505	0.2505
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0045	0.0136	0.0167
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0228	0.2505	0.2505
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0045	0.0136	0.0167
Echinococcus granulosus	NDR protein kinase	0.0228	0.2505	0.2505
Echinococcus granulosus	neuropeptide receptor A26	0.0541	0.6552	0.6552
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0215	0.2337	0.2876
Schistosoma mansoni	hypothetical protein	0.0198	0.2114	0.2114
Echinococcus multilocularis	serine threonine protein kinase	0.0228	0.2505	0.2505
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0441	0.5259	0.5046
Echinococcus multilocularis	FTZ F1 alpha	0.0045	0.0136	0.0136
Echinococcus granulosus	protein kinase c epsilon type	0.0228	0.2505	0.2505
Echinococcus multilocularis	nervana 2	0.0434	0.517	0.517
Trichomonas vaginalis	AGC family protein kinase	0.0662	0.8126	1
Brugia malayi	Pre-SET motif family protein	0.0243	0.27	0.3323
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0441	0.5259	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0441	0.5259	0.5046
Brugia malayi	ecdysteroid receptor	0.0045	0.0136	0.0167
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0228	0.2505	0.3082
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0045	0.0136	0.0167

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 254 nM	Agonist activity at human PPARdelta in HepG2 cells by GAL4-luciferase reporter gene assay	ChEMBL.	17512197
EC50 (functional)	= 254 nM	Agonist activity at human PPARdelta in HepG2 cells by GAL4-luciferase reporter gene assay	ChEMBL.	17512197
IC50 (binding)	= 13 nM	Displacement of [3H]2-(4-(3-(4-acetyl-3-hydroxy-2 propyl-phenoxy)propoxy)phenoxy)acetic acid from human PPARdelta after 30 mins by SPA	ChEMBL.	17512197
IC50 (binding)	= 13 nM	Displacement of [3H]2-(4-(3-(4-acetyl-3-hydroxy-2 propyl-phenoxy)propoxy)phenoxy)acetic acid from human PPARdelta after 30 mins by SPA	ChEMBL.	17512197
IC50 (binding)	= 179 nM	Displacement of [3H]2-(4-(2-(3-(2,4-difluorophenyl)-1-heptylureido)ethyl)phenoxy)-2-methylbutanoic acid from human PPARalpha after 30 mins by SPA	ChEMBL.	17512197
IC50 (binding)	= 179 nM	Displacement of [3H]2-(4-(2-(3-(2,4-difluorophenyl)-1-heptylureido)ethyl)phenoxy)-2-methylbutanoic acid from human PPARalpha after 30 mins by SPA	ChEMBL.	17512197
IC50 (binding)	> 10000 nM	Displacement of [3H]5-(4-(3-(5-methyl-2-phenyloxazol-4-yl)propanoyl)benzyl)thiazolidine-2,4-dione from human PPARgamma after 2 hrs by SPA	ChEMBL.	17512197
IC50 (binding)	> 10000 nM	Displacement of [3H]5-(4-(3-(5-methyl-2-phenyloxazol-4-yl)propanoyl)benzyl)thiazolidine-2,4-dione from human PPARgamma after 2 hrs by SPA	ChEMBL.	17512197
Ratio IC50 (binding)	= 14	Selectivity for human PPARdelta over human PPARalpha	ChEMBL.	17512197

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL231689

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 442404