Detailed information for compound 442478

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 425.547 | Formula: C22H27N5O2S
  • H donors: 3 H acceptors: 3 LogP: 3.23 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCCCn1c(NC(=O)c2cccs2)nc2c1ccc(c2)NC(=O)C1CCCCC1
  • InChi: 1S/C22H27N5O2S/c23-11-5-12-27-18-10-9-16(24-20(28)15-6-2-1-3-7-15)14-17(18)25-22(27)26-21(29)19-8-4-13-30-19/h4,8-10,13-15H,1-3,5-7,11-12,23H2,(H,24,28)(H,25,26,29)
  • InChiKey: WXXWTZZAPUCLIM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens IL2-inducible T-cell kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K07370 Bruton agammaglobulinemia tyrosine kinase, putative Get druggable targets OG5_129320 All targets in OG5_129320
Schistosoma japonicum Tyrosine-protein kinase BTK, putative Get druggable targets OG5_129320 All targets in OG5_129320
Echinococcus granulosus tyrosine protein kinase Btk29A Get druggable targets OG5_129320 All targets in OG5_129320
Echinococcus multilocularis tyrosine protein kinase Btk29A Get druggable targets OG5_129320 All targets in OG5_129320
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_129320 All targets in OG5_129320
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.018 0.1993 0.198
Loa Loa (eye worm) hypothetical protein 0.018 0.1993 0.3873
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0288 0.2754
Brugia malayi Plexin repeat family protein 0.0021 0.0103 0.0189
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0019 0.0084 0.0084
Brugia malayi conserved hypotetical protein 0.018 0.1993 0.3866
Brugia malayi protein-tyrosine kinase 0.002 0.0089 0.0162
Onchocerca volvulus 0.0038 0.0307 0.0593
Echinococcus multilocularis tyrosine kinase 0.002 0.0089 0.0074
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0416 0.0496
Loa Loa (eye worm) hypothetical protein 0.0081 0.0811 0.1576
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0044
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0307 0.0935
Brugia malayi beta-lactamase 0.0038 0.0307 0.0585
Brugia malayi Protein kinase domain containing protein 0.002 0.0089 0.0162
Echinococcus granulosus nuclear receptor 2DBD gamma 0.018 0.1993 0.2447
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.0811 0.4294
Loa Loa (eye worm) hypothetical protein 0.018 0.1993 0.3873
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0383 0.4385 0.8522
Onchocerca volvulus 0.0049 0.0432 0.0837
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0383 0.4385 0.8522
Loa Loa (eye worm) hypothetical protein 0.0041 0.0343 0.0666
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0479 0.1311
Brugia malayi nuclear receptor RXR 0.0202 0.2249 0.4365
Onchocerca volvulus 0.002 0.0089 0.0171
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0288 0.1016
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0307 0.0935
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0811 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0057 0.011
Schistosoma mansoni alpha glucosidase 0.0036 0.0288 0.0356
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0032 0.0229 0.0264
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0139 0.0414
Schistosoma mansoni hypothetical protein 0.0024 0.0136 0.0168
Echinococcus granulosus tyrosine kinase 0.002 0.0089 0.0091
Onchocerca volvulus 0.0447 0.5145 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0032 0.0229 0.0214
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0426 0.0411
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0084 0.0152
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0402 0.0387
Brugia malayi photoreceptor-specific nuclear receptor 0.0383 0.4385 0.8522
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0644 0.1779
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.002 0.0089 0.0091
Loa Loa (eye worm) TK/FER protein kinase 0.002 0.0089 0.0174
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0307 0.138
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0383 0.4385 0.5417
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0093 0.0215
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0024 0.014 0.0173
Echinococcus granulosus tyrosine protein kinase Fyn 0.0032 0.0229 0.0264
Echinococcus granulosus c src tyrosine kinase 0.0032 0.0229 0.0264
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0032 0.0229 0.0264
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.018 0.1993 0.3871
Entamoeba histolytica hypothetical protein 0.0073 0.0722 0.6984
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0465 0.0556
Echinococcus granulosus tyrosine protein kinase Fps85D 0.002 0.0089 0.0091
Echinococcus granulosus FTZ F1 alpha 0.0383 0.4385 0.5408
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0465 0.0556
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0084 0.0152
Mycobacterium ulcerans hypothetical protein 0.0024 0.0139 0.0414
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0465 0.0903
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0167 0.0325
Entamoeba histolytica SH2-protein kinase domain containing protein 0.002 0.0089 0.082
Schistosoma mansoni DNA helicase recq1 0.002 0.0093 0.0115
Echinococcus granulosus neuroglian 0.0019 0.0084 0.0084
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.0811 0.4294
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0375 0.1014
Trypanosoma brucei glucosidase, putative 0.0036 0.0288 0.0768
Onchocerca volvulus Bile acid receptor homolog 0.0383 0.4385 0.8523
Schistosoma mansoni hypothetical protein 0.0041 0.0342 0.0423
Loa Loa (eye worm) TK/FER protein kinase 0.002 0.0089 0.0174
Brugia malayi ecdysteroid receptor 0.0383 0.4385 0.8522
Loa Loa (eye worm) hypothetical protein 0.0029 0.0204 0.0397
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0288 0.0273
Schistosoma mansoni thyroid hormone receptor 0.0383 0.4385 0.5417
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0307 0.0821
Echinococcus granulosus tyrosine protein kinase Src64B 0.0032 0.0229 0.0264
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0383 0.4385 0.4376
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0288 0.1016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0402 0.0387
Echinococcus granulosus tyrosine protein kinase Fyn 0.0032 0.0229 0.0264
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.0482 0.159
Loa Loa (eye worm) hypothetical protein 0.018 0.1993 0.3873
Schistosoma mansoni hypothetical protein 0.0049 0.0432 0.0534
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0044
Schistosoma mansoni apoptosis regulator bax 0.0084 0.0845 0.1044
Echinococcus multilocularis NCK adaptor protein 0.0024 0.014 0.0124
Brugia malayi nuclear receptor NHR-67 0.018 0.1993 0.3866
Loa Loa (eye worm) hypothetical protein 0.0018 0.0068 0.0132
Echinococcus multilocularis zinc finger protein 0.002 0.009 0.0074
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.0096
Loa Loa (eye worm) TK/FER protein kinase 0.002 0.0089 0.0174
Brugia malayi Variant SH3 domain containing protein 0.0024 0.014 0.026
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0167 0.0426
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0402 0.0497
Brugia malayi nuclear receptor RXR 0.018 0.1993 0.3866
Schistosoma mansoni tyrosine kinase 0.0032 0.0229 0.0283
Echinococcus granulosus peregrin 0.0032 0.0233 0.0268
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0213 0.0263
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0019 0.0084 0.0068
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0288 0.1016
Loa Loa (eye worm) TK/FER protein kinase 0.002 0.0089 0.0174
Loa Loa (eye worm) hypothetical protein 0.018 0.1993 0.3873
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0204 0.2356
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0139 0.026
Loa Loa (eye worm) hypothetical protein 0.0038 0.0307 0.0596
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0402 0.0771
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0307 0.0935
Brugia malayi CHE-14 protein 0.0043 0.0361 0.069
Brugia malayi Sex muscle abnormal protein 5 0.0024 0.014 0.026
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0093 0.0338
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0383 0.4385 0.8524
Mycobacterium ulcerans hypothetical protein 0.0164 0.1798 1
Schistosoma mansoni tyrosine kinase 0.0103 0.1079 0.1333
Schistosoma mansoni cell adhesion molecule 0.0019 0.0084 0.0104
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0067 0.0649 0.0635
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0016 0.005 0.0034
Brugia malayi Nuclear hormone receptor-like 1 0.0202 0.2249 0.4365
Brugia malayi jmjC domain containing protein 0.0038 0.03 0.0573
Loa Loa (eye worm) nuclear receptor nhr-7B 0.018 0.1993 0.3873
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0288 0.0768
Brugia malayi beta-lactamase family protein 0.0038 0.0307 0.0585
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.005 0.0085
Brugia malayi Fibronectin type III domain containing protein 0.0017 0.0057 0.0099
Brugia malayi PHD-finger family protein 0.0029 0.0204 0.0386
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0811 1
Schistosoma mansoni survival motor neuron protein 0.0049 0.0432 0.0534
Loa Loa (eye worm) RecQ helicase 0.002 0.0093 0.0181
Schistosoma mansoni steroid hormone receptor ad4bp 0.0383 0.4385 0.5417
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0139 0.0347
Loa Loa (eye worm) runx1 0.0056 0.052 0.101
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0288 0.1016
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0307 0.036
Echinococcus multilocularis geminin 0.0179 0.1976 0.1963
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0057 0.0099
Schistosoma mansoni nephrin 0.0019 0.0084 0.0104
Loa Loa (eye worm) hypothetical protein 0.0038 0.0307 0.0596
Schistosoma mansoni peptidase Clp (S14 family) 0.0081 0.0811 0.1002
Echinococcus multilocularis Immunoglobulin 0.0014 0.0023 0.0007
Mycobacterium tuberculosis Conserved protein 0.0038 0.0307 0.0935
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.005 0.0085
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0032 0.0229 0.0214
Echinococcus multilocularis Nuclear hormone receptor HR96 0.018 0.1993 0.198
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0581 0.16
Echinococcus granulosus roundabout 2 0.0033 0.025 0.029
Loa Loa (eye worm) TK/FER protein kinase 0.002 0.0089 0.0174
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0032 0.0229 0.0214
Loa Loa (eye worm) TK/INSR protein kinase 0.0064 0.0615 0.1196
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0383 0.4385 0.5408
Loa Loa (eye worm) hypothetical protein 0.0018 0.0068 0.0132
Onchocerca volvulus 0.002 0.0089 0.0171
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0383 0.4385 0.4376
Brugia malayi N-terminal motif family protein 0.0182 0.2012 0.3903
Brugia malayi nuclear hormone receptor 0.0383 0.4385 0.8522
Loa Loa (eye worm) hypothetical protein 0.0202 0.2249 0.4371
Schistosoma mansoni ephrin receptor 0.0084 0.0856 0.1057
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.0482 0.0467
Echinococcus multilocularis tumor protein p63 0.0341 0.3891 0.3881
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0644 0.0778
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0465 0.1678
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0644 0.1779
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0465 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0068 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0383 0.4385 0.8522
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0581 0.0718
Brugia malayi hypothetical protein 0.018 0.1993 0.3866
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0167 0.0426
Echinococcus multilocularis tyrosine protein kinase shark 0.002 0.0089 0.0074
Echinococcus granulosus epidermal growth factor receptor 0.0187 0.2066 0.2537
Echinococcus granulosus lysosomal alpha glucosidase 0.0164 0.1801 0.221
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.018 0.1993 0.3866
Schistosoma mansoni zinc finger protein 0.018 0.1993 0.2461
Onchocerca volvulus 0.0038 0.0307 0.0593
Schistosoma mansoni tyrosine kinase 0.002 0.0089 0.011
Leishmania major hypothetical protein, conserved 0.0038 0.0307 0.0821
Brugia malayi hypothetical protein 0.018 0.1993 0.3866
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0383 0.4385 0.5417
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0093 0.0000000015008
Loa Loa (eye worm) hypothetical protein 0.005 0.0447 0.0868
Echinococcus granulosus Nuclear hormone receptor HR96 0.018 0.1993 0.2447
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0996 0.0982
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0312 0.0297
Echinococcus granulosus hemicentin 1 0.0016 0.005 0.0042
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0093 0.0095
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0375 0.1014
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.1601 0.4493
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0383 0.4385 0.8522
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0024 0.014 0.0271
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0139 0.031
Loa Loa (eye worm) MBCTL1 0.0055 0.0505 0.0981
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0139 0.026
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0505 0.097
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0402 0.0782
Schistosoma mansoni tyrosine kinase 0.0096 0.099 0.1223
Schistosoma mansoni vav2 0.0014 0.0019 0.0024
Schistosoma mansoni nuclear receptor nhr-48 0.018 0.1993 0.2461
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0068 0.0635
Schistosoma mansoni alpha-glucosidase 0.0141 0.1531 0.1891
Trichomonas vaginalis set domain proteins, putative 0.0239 0.2684 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0202 0.2249 0.2778
Loa Loa (eye worm) hypothetical protein 0.0017 0.0057 0.011
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0497 0.0614
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0307 0.0585
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0139 0.0347
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0644 0.063
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0307 0.0935
Loa Loa (eye worm) nuclear receptor NHR-67 0.018 0.1993 0.3873
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0762 0.0941
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0019 0.0084 0.0068
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.005 0.0085
Toxoplasma gondii hypothetical protein 0.0028 0.0185 0.1285
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0426 0.0507
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.005 0.0085
Loa Loa (eye worm) hypothetical protein 0.018 0.1993 0.3873
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0125 0.011
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0015 0.0031 0.0019
Echinococcus multilocularis polycomb protein SCMH1 0.0054 0.0497 0.0482
Onchocerca volvulus 0.0208 0.2323 0.4513
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0081 0.0811 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0307 0.0379
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0139 0.0414
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0465 0.1269
Loa Loa (eye worm) hypothetical protein 0.0039 0.0319 0.0621
Schistosoma mansoni zinc finger protein 0.002 0.009 0.0111
Echinococcus multilocularis c src tyrosine kinase 0.0032 0.0229 0.0214
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.0037
Brugia malayi Bromodomain containing protein 0.0032 0.0233 0.0441
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0307 0.3645
Onchocerca volvulus 0.0383 0.4385 0.8523
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0307 0.1086
Onchocerca volvulus Tyrosine kinase homolog 0.0223 0.2497 0.4852
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0383 0.4385 0.5417
Schistosoma mansoni vesicular amine transporter 0.0014 0.0023 0.0028
Schistosoma mansoni tyrosine kinase 0.0096 0.099 0.1223
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0383 0.4385 0.4376
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0465 0.1269
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0811 1
Echinococcus multilocularis expressed conserved protein 0.0093 0.096 0.0946
Brugia malayi hypothetical protein 0.0073 0.0722 0.1394
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0722 0.0874
Echinococcus multilocularis tyrosine protein kinase Fyn 0.002 0.0089 0.0074
Brugia malayi nuclear receptor NHR-88 0.0383 0.4385 0.8522
Onchocerca volvulus 0.002 0.0089 0.0171
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0239 0.2687 0.5223
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0465 0.0574
Loa Loa (eye worm) hypothetical protein 0.0383 0.4385 0.8524
Echinococcus multilocularis tyrosine protein kinase Abl 0.0032 0.0229 0.0214
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.018 0.1993 0.2461
Loa Loa (eye worm) hypothetical protein 0.018 0.1993 0.3873
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0479 0.5537
Schistosoma mansoni tyrosine kinase 0.0032 0.0229 0.0283
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0505 0.049
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.0096
Loa Loa (eye worm) beta-lactamase 0.0038 0.0307 0.0596
Brugia malayi ecdysone receptor 0.018 0.1993 0.3866
Schistosoma mansoni lozenge 0.0056 0.052 0.0642
Loa Loa (eye worm) hypothetical protein 0.0039 0.0314 0.0611
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.006 0.0044
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.005 0.0096
Echinococcus multilocularis Nuclear hormone receptor HR96 0.018 0.1993 0.198
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0479 0.5381
Brugia malayi mbt repeat family protein 0.0048 0.0426 0.0817
Schistosoma mansoni hypothetical protein 0.0084 0.0845 0.1044
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0383 0.4385 0.8522
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0288 0.2754
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0722 0.0892
Schistosoma mansoni nuclear receptor 0.018 0.1993 0.2461
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0081 0.0811 0.5
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.0482 0.5103
Echinococcus multilocularis epidermal growth factor receptor 0.0103 0.1079 0.1065
Brugia malayi Peroxidasin 0.0016 0.005 0.0085
Mycobacterium leprae Probable lipase LipE 0.0038 0.0307 0.2491
Loa Loa (eye worm) hypothetical protein 0.0038 0.0307 0.0596
Plasmodium falciparum flap endonuclease 1 0.0026 0.0167 0.1338
Schistosoma mansoni tyrosine kinase 0.0064 0.0615 0.076
Schistosoma mansoni flap endonuclease-1 0.0024 0.0137 0.017
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0202 0.2249 0.4371
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0383 0.4385 0.8524
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0341 0.0325
Loa Loa (eye worm) DR-78 0.018 0.1993 0.3873
Brugia malayi Protein kinase domain containing protein 0.002 0.0089 0.0162
Mycobacterium tuberculosis Conserved protein 0.0038 0.0307 0.0935
Loa Loa (eye worm) hypothetical protein 0.0383 0.4385 0.8524
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0093 0.0284
Onchocerca volvulus 0.002 0.0089 0.0171
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0497 0.0614
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0139 0.0414
Loa Loa (eye worm) hypothetical protein 0.0018 0.0068 0.0132
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0575 0.1118
Mycobacterium ulcerans lipase LipD 0.0038 0.0307 0.138
Toxoplasma gondii hypothetical protein 0.005 0.0451 0.4986
Schistosoma mansoni tyrosine kinase 0.0096 0.099 0.1223
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0383 0.4385 0.5408
Echinococcus granulosus defective proboscis extension response 0.0014 0.0023 0.0008
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0167 0.0563
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0361 0.0345
Giardia lamblia PHD finger protein 15 0.0029 0.0204 0.2998
Schistosoma mansoni hypothetical protein 0.0179 0.1976 0.2441
Echinococcus granulosus tyrosine kinase 0.002 0.0089 0.0091
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0288 0.0768
Loa Loa (eye worm) hypothetical protein 0.018 0.1993 0.3873
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0127 0.1355 0.1342
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0044
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0067 0.0131
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0084 0.0845 0.1633
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0068 0.0043
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0581 0.0718
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0505 0.049
Schistosoma mansoni nuclear receptor 0.018 0.1993 0.2461
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0139 0.026
Loa Loa (eye worm) hypothetical protein 0.002 0.0089 0.0174
Echinococcus granulosus bloom syndrome protein 0.002 0.0093 0.0095
Brugia malayi plexin A 0.0025 0.0148 0.0277
Echinococcus multilocularis roundabout 2 0.0019 0.0084 0.0068
Echinococcus granulosus plexin a4 0.0025 0.0148 0.0164
Loa Loa (eye worm) hypothetical protein 0.003 0.0216 0.042
Entamoeba histolytica hypothetical protein 0.0073 0.0722 0.6984
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0383 0.4385 0.5417
Schistosoma mansoni hypothetical protein 0.0084 0.0845 0.1044
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0136 0.012
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0341 0.0402
Loa Loa (eye worm) hypothetical protein 0.0202 0.2249 0.4371
Trypanosoma cruzi ISWI complex protein 0.0015 0.0039 0.0062
Loa Loa (eye worm) TK/EGFR protein kinase 0.0187 0.2066 0.4016
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0084 0.0845 0.1026
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0016 0.005 0.0093
Echinococcus granulosus lachesin 0.0016 0.005 0.0042
Echinococcus multilocularis Protein lozenge 0.0056 0.052 0.0505
Brugia malayi Pre-SET motif family protein 0.021 0.2341 0.4544
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0084 0.0845 0.0831
Echinococcus granulosus zinc finger protein 0.002 0.009 0.0092
Echinococcus multilocularis insulin receptor 0.0064 0.0615 0.06
Schistosoma mansoni plexin 0.0021 0.0103 0.0127
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0479 0.1311
Echinococcus multilocularis lachesin 0.0016 0.005 0.0034
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0505 0.0623
Echinococcus granulosus flap endonuclease 1 0.0026 0.0167 0.0187
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0465 0.045
Loa Loa (eye worm) hypothetical protein 0.0084 0.0845 0.1642
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0426 0.0828
Brugia malayi SH2 domain containing protein 0.002 0.0089 0.0162
Brugia malayi tailless protein 0.018 0.1993 0.3866
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0307 0.1086
Brugia malayi Nuclear hormone receptor E75 0.018 0.1993 0.3866
Schistosoma mansoni growth factor receptor-bound protein 0.0024 0.014 0.0173
Loa Loa (eye worm) hypothetical protein 0.0447 0.5145 1
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.1536 0.1882
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.018 0.1993 0.2461
Brugia malayi steroid hormone receptor 0.0383 0.4385 0.8522
Schistosoma mansoni adapter molecule crk 0.0024 0.014 0.0173
Echinococcus granulosus tyrosine protein kinase Lyn 0.0032 0.0235 0.0271
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0581 0.6801
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0204 0.1552
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0416 0.0401
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.1032 1
Brugia malayi Bromodomain containing protein 0.0076 0.0752 0.1451
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0383 0.4385 0.5408
Loa Loa (eye worm) TK/FER protein kinase 0.002 0.0089 0.0174
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0139 0.0414
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0288 0.1016
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.005 0.0085
Onchocerca volvulus 0.018 0.1993 0.3871
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0167 0.1999
Echinococcus granulosus tyrosine protein kinase ABL1 0.002 0.0089 0.0091
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0167 0.0426
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0644 0.6227
Echinococcus multilocularis peregrin 0.0032 0.0233 0.0217
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0204 0.0252
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0139 0.1306
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0644 0.1779
Entamoeba histolytica recQ family helicase, putative 0.002 0.0093 0.0854
Loa Loa (eye worm) TK/ABL protein kinase 0.002 0.0089 0.0174
Brugia malayi MAP kinase sur-1 0.0051 0.0465 0.0893
Schistosoma mansoni coup transcription factor 0.0383 0.4385 0.5417
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0581 0.07
Echinococcus multilocularis neuroglian 0.0021 0.0107 0.0092
Schistosoma mansoni neuroglian 0.0019 0.0084 0.0104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0383 0.4385 0.8524
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.1601 0.4493
Loa Loa (eye worm) hypothetical protein 0.0038 0.0307 0.0596
Loa Loa (eye worm) hypothetical protein 0.0202 0.2249 0.4371
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0465 0.1269
Schistosoma mansoni hypothetical protein 0.0029 0.0204 0.0252
Loa Loa (eye worm) hypothetical protein 0.018 0.1993 0.3873
Echinococcus multilocularis tyrosine protein kinase Srms 0.002 0.0089 0.0074
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0465 0.1269
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0204 0.0397
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0213 0.1668
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.1032 0.1018
Loa Loa (eye worm) hypothetical protein 0.002 0.0093 0.0181
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0383 0.4385 0.8522
Loa Loa (eye worm) hypothetical protein 0.0052 0.0474 0.0922
Toxoplasma gondii ABC1 family protein 0.0038 0.0307 0.2977
Brugia malayi nuclear hormone receptor family member nhr-6 0.018 0.1993 0.3866
Schistosoma mansoni hypothetical protein 0.0073 0.0722 0.0892
Brugia malayi Glycosyl hydrolases family 31 protein 0.0164 0.1801 0.3494
Schistosoma mansoni growth factor receptor-bound protein 0.0024 0.014 0.0173
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0017 0.0115
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0016 0.005 0.0061
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.1801 0.1789
Loa Loa (eye worm) hypothetical protein 0.0024 0.014 0.0271
Entamoeba histolytica hypothetical protein 0.0013 0.0016 0.0102
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0383 0.4385 0.8522
Plasmodium vivax SET domain protein, putative 0.003 0.0213 0.2461
Loa Loa (eye worm) hypothetical protein 0.0048 0.0426 0.0828
Brugia malayi Protein kinase domain containing protein 0.002 0.0089 0.0162
Schistosoma mansoni RAR-like nuclear receptor 0.0383 0.4385 0.5417
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0067 0.0649 0.0784
Onchocerca volvulus 0.0054 0.0497 0.0964
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0383 0.4385 0.5408
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0288 0.0337
Echinococcus multilocularis growth factor receptor bound protein 2 0.0024 0.014 0.0124
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0288 0.1016
Brugia malayi hypothetical protein 0.0238 0.268 0.5203
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0581 0.2967
Echinococcus multilocularis roundabout 2 0.0033 0.025 0.0235
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0361 0.1288
Brugia malayi jmjC domain containing protein 0.0096 0.0996 0.1927
Echinococcus granulosus roundabout 2 0.0019 0.0084 0.0084
Schistosoma mansoni nuclear hormone receptor 0.018 0.1993 0.2461
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.3543 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.1536 0.1523
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0811 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0068 0.0132
Schistosoma mansoni tyrosine kinase 0.0311 0.3543 0.4377
Loa Loa (eye worm) TK/FER protein kinase 0.002 0.0089 0.0174
Loa Loa (eye worm) hypothetical protein 0.0238 0.268 0.5209
Onchocerca volvulus 0.0077 0.0766 0.1487
Schistosoma mansoni titin 0.0016 0.005 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0383 0.4385 0.8522
Brugia malayi mbt repeat family protein 0.0048 0.0426 0.0817
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0383 0.4385 0.5408
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0312 0.0367
Schistosoma mansoni hypothetical protein 0.0041 0.0342 0.0423
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.105 0.1297
Schistosoma mansoni roundabout 0.0016 0.005 0.0061
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0084 0.0845 0.0831
Schistosoma mansoni nephrin 0.0024 0.0142 0.0175
Echinococcus multilocularis 0.0056 0.0516 0.0501
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0243 0.2734 1
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0465 0.1678
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0479 0.5821
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0182 0.2012 0.3908
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0139 0.0414
Loa Loa (eye worm) hypothetical protein 0.0024 0.0139 0.0271
Schistosoma mansoni patched 1 0.0043 0.0361 0.0446
Echinococcus granulosus polycomb protein SCMH1 0.0054 0.0497 0.0596
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0032 0.0229 0.0283
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0307 0.0821
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0081 0.0811 1
Brugia malayi PHD-finger family protein 0.0025 0.0154 0.0287
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.0096
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.0482 0.159
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0093 0.0284
Loa Loa (eye worm) hypothetical protein 0.0383 0.4385 0.8524
Leishmania major hypothetical protein, conserved 0.0015 0.0039 0.0062
Schistosoma mansoni DNA helicase recq5 0.002 0.0093 0.0115
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0093 0.0077
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.1032 0.1257
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0167 0.0152
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0081 0.0811 0.0796
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0383 0.4385 0.8522
Brugia malayi Prion-like- 0.0016 0.005 0.0085
Echinococcus granulosus endonuclease exonuclease phosphatase 0.019 0.2101 0.258
Echinococcus granulosus fibroblast growth factor receptor 4 0.0127 0.1355 0.1658
Mycobacterium ulcerans beta-lactamase 0.0038 0.0307 0.138
Leishmania major mitochondrial DNA polymerase beta 0.0311 0.3543 1
Schistosoma mansoni tyrosine kinase 0.0024 0.0139 0.0172
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0479 0.1311
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0204 0.0233
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.018 0.1993 0.198
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0402 0.0497
Schistosoma mansoni zinc finger protein 0.0015 0.0039 0.0048
Loa Loa (eye worm) hypothetical protein 0.0024 0.0139 0.0271
Echinococcus granulosus epidermal growth factor receptor 0.0103 0.1079 0.1316
Echinococcus granulosus geminin 0.0179 0.1976 0.2426
Loa Loa (eye worm) hypothetical protein 0.003 0.0216 0.042
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0032 0.0229 0.0214
Schistosoma mansoni thyroid hormone receptor 0.0383 0.4385 0.5417
Entamoeba histolytica hypothetical protein 0.0073 0.0722 0.6984
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0136 0.0148
Schistosoma mansoni cell adhesion molecule 0.0016 0.005 0.0061
Onchocerca volvulus 0.0024 0.0139 0.0268
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.03 0.0352
Brugia malayi hypothetical protein 0.0447 0.5145 1
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0127 0.1355 0.1342
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0103 0.0199
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0383 0.4385 0.5408
Loa Loa (eye worm) hypothetical protein 0.018 0.1993 0.3873
Onchocerca volvulus 0.018 0.1993 0.3871
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0644 0.1779
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0432 0.0829
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0285 0.027
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.2341 0.4551
Echinococcus multilocularis FTZ F1 alpha 0.0383 0.4385 0.4376
Onchocerca volvulus 0.0038 0.0307 0.0593
Brugia malayi Variant SH3 domain containing protein 0.0024 0.014 0.026
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0125 0.0155
Echinococcus granulosus thyroid hormone receptor alpha 0.018 0.1993 0.2447
Schistosoma mansoni tyrosine kinase 0.0103 0.1079 0.1333
Onchocerca volvulus 0.0239 0.2684 0.5216
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0361 0.0701
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0307 0.0821
Loa Loa (eye worm) hypothetical protein 0.0071 0.0701 0.1362
Brugia malayi Furin-like cysteine rich region family protein 0.0187 0.2066 0.4009
Echinococcus multilocularis hemicentin 1 0.0016 0.005 0.0034
Schistosoma mansoni nck2/grb4 0.0024 0.014 0.0173
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0202 0.2249 0.2764
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0383 0.4385 0.8522
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0307 0.0935
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0015 0.0031 0.0015
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0307 0.0379
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0581 0.1961
Loa Loa (eye worm) hypothetical protein 0.0023 0.0131 0.0254
Schistosoma mansoni hypothetical protein 0.0015 0.0039 0.0048
Echinococcus granulosus NCK adaptor protein 0.0024 0.014 0.0153
Loa Loa (eye worm) apoptosis regulator protein 0.0084 0.0845 0.1642
Brugia malayi hypothetical protein 0.0053 0.0479 0.0921
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0505 0.0605
Schistosoma mansoni hypothetical protein 0.0179 0.1976 0.2441
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0019 0.0084 0.0068
Brugia malayi Protein kinase domain containing protein 0.0064 0.0615 0.1185
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0093 0.0169
Loa Loa (eye worm) hypothetical protein 0.018 0.1993 0.3873
Echinococcus granulosus insulin receptor 0.0064 0.0615 0.0742
Echinococcus granulosus tyrosine protein kinase shark 0.002 0.0089 0.0091
Brugia malayi Probable ClpP-like protease 0.0081 0.0811 0.1567
Echinococcus multilocularis ephrin type A receptor 4 A 0.0084 0.0856 0.0842
Leishmania major hypothetical protein, conserved 0.0053 0.0479 0.1311
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0204 0.0189
Brugia malayi Immunoglobulin I-set domain containing protein 0.0134 0.144 0.2791
Brugia malayi Nuclear hormone receptor-like 1 0.0202 0.2249 0.4365
Echinococcus granulosus microtubule associated protein 2 0.0696 0.8096 1
Echinococcus multilocularis protein patched 0.0043 0.0361 0.0345
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0167 0.1888
Loa Loa (eye worm) hypothetical protein 0.0055 0.0505 0.0981
Schistosoma mansoni hypothetical protein 0.0084 0.0845 0.1044
Loa Loa (eye worm) hypothetical protein 0.0017 0.0057 0.011
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0996 0.1214
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0722 0.0708
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.018 0.1993 0.198
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0278 0.0262
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0307 0.0935
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0416 0.0514
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0383 0.4385 0.8522
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0811 1
Brugia malayi Pre-SET motif family protein 0.003 0.0213 0.0402
Brugia malayi Protein kinase domain containing protein 0.002 0.0089 0.0162
Brugia malayi hypothetical protein 0.0202 0.2249 0.4365
Echinococcus granulosus roundabout 2 0.0019 0.0084 0.0084
Echinococcus multilocularis ecdysone induced protein 78C 0.0383 0.4385 0.4376
Loa Loa (eye worm) hypothetical protein 0.0038 0.0307 0.0596
Brugia malayi Nuclear hormone receptor E75 0.018 0.1993 0.3866
Loa Loa (eye worm) hypothetical protein 0.0202 0.2249 0.4371
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0139 0.031
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.03 0.0371
Echinococcus multilocularis tyrosine protein kinase Blk 0.002 0.0089 0.0074
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.018 0.1993 0.2447
Echinococcus multilocularis protein dispatched 1 0.0049 0.0432 0.0417
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0402 0.0479
Loa Loa (eye worm) hypothetical protein 0.0383 0.4385 0.8524
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.02 0.0227
Loa Loa (eye worm) hypothetical protein 0.0099 0.1032 0.2005
Schistosoma mansoni hypothetical protein 0.0041 0.0342 0.0423
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0139 0.0414
Loa Loa (eye worm) nuclear hormone receptor 0.018 0.1993 0.3873
Loa Loa (eye worm) TK protein kinase 0.002 0.0089 0.0174
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0323 0.3683 0.3673
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0383 0.4385 0.8523
Entamoeba histolytica hypothetical protein 0.0073 0.0722 0.6984
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0323 0.3683 0.4539
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0014 0.0019 0.0037
Schistosoma mansoni tyrosine kinase 0.0064 0.0615 0.076
Echinococcus granulosus Nuclear hormone receptor HR96 0.018 0.1993 0.2447
Schistosoma mansoni tyrosine kinase 0.0032 0.0229 0.0283
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0402 0.0479
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0139 0.1306
Brugia malayi ephrin receptor 1 precursor 0.0044 0.0375 0.0718
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.268 0.3297
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0288 0.0768
Echinococcus multilocularis hemicentin 1 0.0016 0.005 0.0034
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0288 0.2716
Brugia malayi nuclear hormone receptor 0.018 0.1993 0.3866
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0479 0.5537
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0288 0.1016
Echinococcus multilocularis microtubule associated protein 2 0.0696 0.8096 0.8093
Brugia malayi nuclear receptor NHR-88 0.018 0.1993 0.3866
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0285 0.0334
Schistosoma mansoni nuclear hormone receptor 0.018 0.1993 0.2461
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0383 0.4385 0.8524
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0288 0.056
Schistosoma mansoni cell adhesion molecule 0.0019 0.0084 0.0104
Brugia malayi orphan nuclear receptor NR2E1 0.018 0.1993 0.3866
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0383 0.4385 0.8524
Echinococcus granulosus Immunoglobulin 0.0014 0.0023 0.0008
Loa Loa (eye worm) hypothetical protein 0.0383 0.4385 0.8524
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0307 0.0935
Loa Loa (eye worm) TK/ROR protein kinase 0.0015 0.0031 0.006
Loa Loa (eye worm) TK/FER protein kinase 0.002 0.0089 0.0174
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0093 0.0181
Schistosoma mansoni nuclear hormone receptor 0.0383 0.4385 0.5417
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.1801 0.1789
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0383 0.4385 0.5417
Loa Loa (eye worm) hypothetical protein 0.0447 0.5145 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.0096
Mycobacterium tuberculosis Conserved hypothetical protein 0.0164 0.1798 0.6506
Echinococcus multilocularis tyrosine protein kinase otk 0.0016 0.005 0.0034
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.006 0.0055
Schistosoma mansoni retinoic acid receptor RXR 0.0383 0.4385 0.5417
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.268 0.2668
Brugia malayi hypothetical protein 0.0017 0.0057 0.0099
Echinococcus granulosus tyrosine protein kinase otk 0.0016 0.005 0.0042
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0023 0.0131 0.0143
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0307 0.0291
Brugia malayi SH2 domain containing protein 0.002 0.0089 0.0162
Echinococcus granulosus nuclear receptor nhr 48 0.018 0.1993 0.2447
Mycobacterium ulcerans hypothetical protein 0.0038 0.0307 0.138
Loa Loa (eye worm) hypothetical protein 0.0021 0.0103 0.0201
Echinococcus granulosus contactin 0.0019 0.0084 0.0084
Schistosoma mansoni tyrosine kinase 0.0187 0.2066 0.2552
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0139 0.0347
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0103 0.1079 0.1316
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0202 0.2249 0.2778
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0167 0.1035
Echinococcus multilocularis plexin a4 0.0025 0.0148 0.0133
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.1032 0.1996
Brugia malayi hypothetical protein 0.0202 0.2249 0.4365
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0093 0.0284
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0644 0.0796
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0307 0.1086
Brugia malayi hypothetical protein 0.002 0.0089 0.0162
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.3543 1
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0086 0.0106
Echinococcus granulosus tyrosine protein kinase Src42A 0.0032 0.0229 0.0264
Loa Loa (eye worm) hypothetical protein 0.0182 0.2012 0.391
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0644 0.1253
Echinococcus granulosus tyrosine protein kinase Fyn 0.0032 0.0229 0.0264
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0383 0.4385 0.4376
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.03 0.0371
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.005 0.0096
Onchocerca volvulus 0.002 0.0089 0.0171
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0383 0.4385 0.5417
Brugia malayi nuclear hormone receptor family member odr-7 0.018 0.1993 0.3866
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0185 0.158
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0014 0.0023 0.0028
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0383 0.4385 0.8524
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0447 0.0552
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.006 0.0074
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0416 0.0514
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.0096
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0361 0.0427
Schistosoma mansoni septate junction protein 0.0016 0.005 0.0061
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0213 0.0197
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0383 0.4385 0.4376
Onchocerca volvulus 0.0021 0.0103 0.0197
Loa Loa (eye worm) TK protein kinase 0.0134 0.144 0.2799
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0307 0.2491
Echinococcus multilocularis tyrosine protein kinase ABL1 0.002 0.0089 0.0074
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0093 0.0169
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.03 0.0584
Schistosoma mansoni bromodomain containing protein 0.0064 0.0612 0.0756
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0019 0.0084 0.0068
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0644 0.1242
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0164 0.1801 0.3502
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.006 0.0074
Onchocerca volvulus Alhambra homolog 0.0029 0.0204 0.0394
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0465 0.1269
Brugia malayi Protein kinase domain containing protein 0.002 0.0089 0.0162
Echinococcus multilocularis neuroglian 0.0019 0.0084 0.0068
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.0185 0.0683
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0402 0.0497
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0032 0.0229 0.0214
Loa Loa (eye worm) hypothetical protein 0.0043 0.0361 0.0701
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.0096
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0017 0.003
Echinococcus granulosus expressed conserved protein 0.0093 0.096 0.1169
Echinococcus granulosus tyrosine protein kinase Srms 0.002 0.0089 0.0091
Loa Loa (eye worm) SRC-1 0.0032 0.0229 0.0446
Onchocerca volvulus 0.002 0.0089 0.0171
Loa Loa (eye worm) hypothetical protein 0.0043 0.0365 0.071
Loa Loa (eye worm) hypothetical protein 0.0024 0.0139 0.0271
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0569 0.0685
Trypanosoma brucei ISWI complex protein 0.0015 0.0039 0.0062
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0014 0.0023 0.0028
Echinococcus multilocularis thyroid hormone receptor alpha 0.0383 0.4385 0.4376
Loa Loa (eye worm) TK/FER protein kinase 0.002 0.0089 0.0174
Echinococcus multilocularis epidermal growth factor receptor 0.0187 0.2066 0.2053
Echinococcus granulosus tyrosine protein kinase Blk 0.002 0.0089 0.0091
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0032 0.0229 0.0214
Schistosoma mansoni alpha-glucosidase 0.0141 0.1531 0.1891
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.005 0.0085
Trypanosoma cruzi ISWI complex protein 0.0015 0.0039 0.0062
Loa Loa (eye worm) hypothetical protein 0.0383 0.4385 0.8524
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0581 0.0566
Schistosoma mansoni hypothetical protein 0.0041 0.0342 0.0423
Onchocerca volvulus 0.005 0.0447 0.0865
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0307 0.0596
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0032 0.0229 0.0214
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0375 0.1014
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0139 0.0414
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0032 0.0229 0.0214
Trichomonas vaginalis esterase, putative 0.0038 0.0307 0.1086
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0093 0.0169
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0307 0.1086
Schistosoma mansoni microtubule-associated protein tau 0.0696 0.8096 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0239 0.2687 0.5217
Schistosoma mansoni tyrosine kinase 0.0127 0.1355 0.1674
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0288 0.0549
Echinococcus granulosus ecdysone induced protein 78C 0.0383 0.4385 0.5408
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0383 0.4385 0.5408
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0426 0.0825
Echinococcus multilocularis Immunoglobulin 0.0014 0.0023 0.0007
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0017 0.0022
Brugia malayi Flap endonuclease-1 0.0026 0.0167 0.0314
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0093 0.0077
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0013 0.0016 0.0019
Loa Loa (eye worm) hypothetical protein 0.005 0.0453 0.0881
Loa Loa (eye worm) hypothetical protein 0.0383 0.4385 0.8524
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0465 0.1269
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0093 0.0215
Echinococcus granulosus tumor protein p63 0.0341 0.3891 0.4796
Onchocerca volvulus 0.0095 0.0981 0.1905
Loa Loa (eye worm) plexin A 0.0025 0.0148 0.0288
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0383 0.4385 0.8522
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.018 0.1993 0.3871
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.0096
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0505 0.0605
Mycobacterium tuberculosis Conserved protein 0.0038 0.0307 0.0935
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0024 0.014 0.0271
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0288 0.1016
Echinococcus multilocularis peroxidasin 0.0016 0.005 0.0034
Plasmodium falciparum phd finger protein, putative 0.0029 0.0204 0.1838
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0093 0.0338
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.019 0.2101 0.2088
Loa Loa (eye worm) hypothetical protein 0.0053 0.0479 0.0932
Loa Loa (eye worm) hypothetical protein 0.0047 0.0416 0.0809
Schistosoma mansoni septate junction protein 0.0016 0.005 0.0061
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0569 0.0554
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0465 0.5177
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0288 0.1016
Trypanosoma brucei protein kinase, putative 0.0051 0.0465 0.1269
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0383 0.4385 0.8522
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.0482 0.0577
Brugia malayi SRC-1 0.0032 0.0229 0.0435
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0383 0.4385 0.8524
Schistosoma mansoni hypothetical protein 0.0292 0.3318 0.4099
Schistosoma mansoni tyrosine kinase 0.0032 0.0229 0.0283
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0581 0.2967
Brugia malayi beta-lactamase family protein 0.0038 0.0307 0.0585
Loa Loa (eye worm) TK/FER protein kinase 0.002 0.0089 0.0174
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0465 0.1678
Brugia malayi Tyrosine-protein kinase abl-1 0.0032 0.0229 0.0435
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0147 0.1601 0.4493
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0202 0.2249 0.2237
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0019 0.0084 0.0163
Loa Loa (eye worm) hypothetical protein 0.018 0.1993 0.3873
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0426 0.0526
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0084 0.0845 0.1026
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0307 0.138
Echinococcus granulosus peroxidasin 0.0016 0.005 0.0042
Loa Loa (eye worm) TK/EPH protein kinase 0.0106 0.1106 0.2149
Schistosoma mansoni cell adhesion molecule 0.0026 0.0165 0.0204
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.002 0.0089 0.0074
Onchocerca volvulus Protein ultraspiracle homolog 0.0383 0.4385 0.8523
Onchocerca volvulus 0.003 0.0213 0.041
Loa Loa (eye worm) steroid hormone receptor 0.0383 0.4385 0.8524
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0213 0.0263
Brugia malayi Steroid receptor seven-up type 2 0.0383 0.4385 0.8522
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0127 0.1355 0.1658
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0465 0.1678
Loa Loa (eye worm) hypothetical protein 0.0038 0.0307 0.0596
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0019 0.0084 0.0104
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0307 0.1086
Schistosoma mansoni hypothetical protein 0.0021 0.0103 0.0127
Loa Loa (eye worm) hypothetical protein 0.018 0.1993 0.3873
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0167 0.1577
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0375 0.1014
Brugia malayi Nuclear hormone receptor-like 1 0.0383 0.4385 0.8522
Echinococcus granulosus twitchin 0.0022 0.0113 0.012
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0383 0.4385 0.4376
Echinococcus multilocularis nuclear receptor nhr 48 0.018 0.1993 0.198
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0084 0.0152
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0014 0.0023 0.0007
Brugia malayi hypothetical protein 0.0034 0.0258 0.0491
Echinococcus multilocularis bloom syndrome protein 0.002 0.0093 0.0077
Loa Loa (eye worm) hypothetical protein 0.0202 0.2249 0.4371
Brugia malayi Bromodomain containing protein 0.0039 0.0314 0.0599
Echinococcus granulosus growth factor receptor bound protein 2 0.0024 0.014 0.0153
Loa Loa (eye worm) hypothetical protein 0.018 0.1993 0.3873
Echinococcus granulosus ephrin type A receptor 4 A 0.0084 0.0856 0.104
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0139 0.1306
Loa Loa (eye worm) hypothetical protein 0.0383 0.4385 0.8524
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0084 0.0845 0.1044
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0488 0.1336
Brugia malayi Variant SH3 domain containing protein 0.0014 0.0019 0.0026
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0093 0.0215
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0465 0.045
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0093 0.0095
Echinococcus multilocularis roundabout 2 0.0019 0.0084 0.0068
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0581 0.2967
Loa Loa (eye worm) hypothetical protein 0.0019 0.0084 0.0163
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0811 1
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0361 0.0427
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0311 0.3543 1
Echinococcus granulosus neuroglian 0.0021 0.0107 0.0114
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0125 0.0136
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0081 0.0811 0.0984
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.002 0.0089 0.0174
Loa Loa (eye worm) hypothetical protein 0.0077 0.0766 0.149
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0204 0.1552
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0185 0.2114
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0465 0.1269
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0032 0.0229 0.0214

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.7 uM Effect on human ITK in DT40 cells assessed as induction of calcium influx by FLIPR assay ChEMBL. 17499505
IC50 (binding) = 1.7 uM Effect on human ITK in DT40 cells assessed as induction of calcium influx by FLIPR assay ChEMBL. 17499505
IC50 (binding) = 2.5 uM Inhibition of human ITK by DELFIA assay ChEMBL. 17499505
IC50 (binding) = 2.5 uM Inhibition of human ITK by DELFIA assay ChEMBL. 17499505

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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