Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APH1B gamma secretase subunit | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K06172 anterior pharynx defective 1, putative | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Brugia malayi | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Echinococcus granulosus | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Aph-1 protein, putative | 0.0115 | 0.1049 | 0.5 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0115 | 0.1049 | 0.5 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0296 | 0.3895 | 0.3895 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0296 | 0.3895 | 0.3895 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0296 | 0.3895 | 0.406 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0115 | 0.1049 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0683 | 1 | 1 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0296 | 0.3895 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0657 | 0.9594 | 1 |
Onchocerca volvulus | 0.0049 | 0 | 0.5 | |
Brugia malayi | gamma-secretase subunit aph-1 | 0.0296 | 0.3895 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0049 | 0 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0049 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0049 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 15 nM | Inhibition of gamma secretase in APP-transfected CHO cells | ChEMBL. | 17502143 |
IC50 (binding) | = 15 nM | Inhibition of gamma secretase in APP-transfected CHO cells | ChEMBL. | 17502143 |
Ki (binding) | = 3.9 nM | Displacement of [3H]succinamide from gamma secretase in THP1 cell membranes | ChEMBL. | 17502143 |
Ki (binding) | = 3.9 nM | Displacement of [3H]succinamide from gamma secretase in THP1 cell membranes | ChEMBL. | 17502143 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.