Detailed information for compound 442685

Basic information

Technical information
  • TDR Targets ID: 442685
  • Name: propan-2-yl 4-(1-benzylimidazol-2-yl)-4-pheny lpiperidine-1-carboxylate
  • MW: 403.517 | Formula: C25H29N3O2
  • H donors: 0 H acceptors: 2 LogP: 4.55 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(OC(=O)N1CCC(CC1)(c1ccccc1)c1nccn1Cc1ccccc1)C
  • InChi: 1S/C25H29N3O2/c1-20(2)30-24(29)27-16-13-25(14-17-27,22-11-7-4-8-12-22)23-26-15-18-28(23)19-21-9-5-3-6-10-21/h3-12,15,18,20H,13-14,16-17,19H2,1-2H3
  • InChiKey: LFIFXAGOMGUFLO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • isopropyl 4-(1-benzylimidazol-2-yl)-4-phenyl-piperidine-1-carboxylate
  • 4-(1-benzyl-2-imidazolyl)-4-phenyl-1-piperidinecarboxylic acid isopropyl ester
  • propan-2-yl 4-phenyl-4-[1-(phenylmethyl)imidazol-2-yl]piperidine-1-carboxylate
  • 4-(1-benzylimidazol-2-yl)-4-phenyl-piperidine-1-carboxylic acid isopropyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens opioid receptor, mu 1 Starlite/ChEMBL References
Homo sapiens opioid receptor, kappa 1 Starlite/ChEMBL References
Homo sapiens opioid receptor, delta 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_139759 All targets in OG5_139759
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_139759 All targets in OG5_139759
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0019 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Brugia malayi hypothetical protein 0.001 0.0004 0.0012
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0124 0.0124
Schistosoma mansoni cpg binding protein 0.0028 0.0048 0.0048
Loa Loa (eye worm) nuclear receptor NHR-67 0.017 0.0391 0.1136
Brugia malayi Dopamine receptor protein 2 0.001 0.0004 0.0012
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0019 0.0039
Echinococcus multilocularis thyroid hormone receptor alpha 0.0361 0.0852 0.0893
Brugia malayi neuropeptide F receptor 0.001 0.0004 0.0012
Echinococcus multilocularis somatostatin receptor 0.001 0.0004 0.0004
Brugia malayi steroid hormone receptor 0.0361 0.0852 0.2478
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0004 0.0004
Loa Loa (eye worm) TYRA-2 protein 0.001 0.0004 0.001
Brugia malayi neuropeptide F receptor 0.001 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0004 0.001
Schistosoma mansoni nuclear hormone receptor 0.017 0.0391 0.0391
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.095 0.0996
Schistosoma mansoni neuropeptide receptor 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.017 0.0391 0.1136
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0054
Brugia malayi hypothetical protein 0.017 0.0391 0.1138
Onchocerca volvulus 0.0016 0.0019 0.0039
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.001 0.0004 0.0004
Brugia malayi Cathepsin L-like precursor 0.0016 0.0019 0.0056
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0004 0.0004
Schistosoma mansoni amine GPCR 0.001 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0019 1
Loa Loa (eye worm) hypothetical protein 0.0361 0.0852 0.2477
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0131 0.9614
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0004 0.0004
Schistosoma mansoni nuclear hormone receptor 0.017 0.0391 0.0391
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.019 0.044 0.0462
Echinococcus multilocularis G protein coupled receptor 139 0.001 0.0004 0.0004
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0635 0.1516 0.1589
Brugia malayi Nuclear hormone receptor E75 0.017 0.0391 0.1138
Brugia malayi nuclear receptor RXR 0.017 0.0391 0.1138
Echinococcus multilocularis neuropeptide s receptor 0.001 0.0004 0.0004
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.001 0.0004 0.001
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.001 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0019 0.0019
Onchocerca volvulus 0.0016 0.0019 0.0039
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0361 0.0852 0.0852
Loa Loa (eye worm) hypothetical protein 0.019 0.044 0.128
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0361 0.0852 0.2478
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0019 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0361 0.0852 0.2477
Echinococcus multilocularis g protein coupled receptor 0.001 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0019 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0019 1
Brugia malayi RE15519p 0.001 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0361 0.0852 0.0893
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.001 0.0004 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0019 1
Schistosoma mansoni neuropeptide f receptor 76f 0.001 0.0004 0.0004
Echinococcus multilocularis serotonin receptor 0.001 0.0004 0.0004
Brugia malayi Serotonin receptor 0.001 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.017 0.0391 0.1136
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0004 0.0004
Brugia malayi nuclear receptor RXR 0.019 0.044 0.1281
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0109 1
Loa Loa (eye worm) runx1 0.0055 0.0111 0.0322
Brugia malayi Nuclear hormone receptor-like 1 0.0361 0.0852 0.2478
Echinococcus multilocularis tachykinin peptides receptor 99D 0.001 0.0004 0.0004
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0136 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Echinococcus multilocularis cysteine protease 0.0016 0.0019 0.002
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.017 0.0391 0.1138
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.001 0.0004 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0019 1
Schistosoma mansoni thyroid hormone receptor 0.0361 0.0852 0.0852
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0361 0.0852 0.2478
Schistosoma mansoni hypothetical protein 0.0047 0.0094 0.0094
Schistosoma mansoni opsin-like receptor 0.001 0.0004 0.0004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.017 0.0391 0.041
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0004 0.0004
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0361 0.0852 0.0852
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0016
Schistosoma mansoni RAR-like nuclear receptor 0.0361 0.0852 0.0852
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0019 0.0019
Echinococcus granulosus neuropeptide receptor 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.017 0.0391 0.1136
Brugia malayi nuclear hormone receptor 0.1429 0.3437 1
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.007 0.0074
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0136 0.0395
Loa Loa (eye worm) hypothetical protein 0.0361 0.0852 0.2477
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0004 0.0004
Brugia malayi hypothetical protein 0.001 0.0004 0.0012
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.001 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0019 1
Loa Loa (eye worm) hypothetical protein 0.017 0.0391 0.1136
Schistosoma mansoni opsin-like receptor 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.017 0.0391 0.1136
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0019 1
Schistosoma mansoni hypothetical protein 0.001 0.0004 0.0004
Echinococcus multilocularis neuropeptide FF receptor 2 0.001 0.0004 0.0004
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.001 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.019 0.044 0.128
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0019 1
Loa Loa (eye worm) melatonin receptor type 1A 0.001 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.017 0.0391 0.1136
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0019 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0361 0.0852 0.0852
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0019 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.001 0.0004 0.0004
Schistosoma mansoni nuclear receptor nhr-48 0.017 0.0391 0.0391
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0019 0.1415
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0004 0.001
Brugia malayi nuclear receptor NHR-67 0.017 0.0391 0.1138
Echinococcus granulosus 7tm_1 domain containing protein 0.001 0.0004 0.0004
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0136 0.0396
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0004 0.0004
Brugia malayi hypothetical protein 0.017 0.0391 0.1138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0019 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0004 0.0004
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0131 0.9614
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0361 0.0852 0.0893
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0004 0.001
Brugia malayi G protein-coupled receptor 0.001 0.0004 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0361 0.0852 0.2478
Brugia malayi Serotonin/octopamine receptor family protein 7 0.001 0.0004 0.0012
Schistosoma mansoni adenoreceptor 0.001 0.0004 0.0004
Schistosoma mansoni nuclear hormone receptor 0.0361 0.0852 0.0852
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0435 0.1031 0.2998
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0019 1
Brugia malayi Melatonin receptor type 1A 0.001 0.0004 0.0012
Brugia malayi GnHR receptor homolog 0.001 0.0004 0.0012
Echinococcus multilocularis FTZ F1 alpha 0.0361 0.0852 0.0893
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.001 0.0004 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0004 0.0004
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0004 0.0004
Echinococcus granulosus thyrotropin releasing hormone receptor 0.001 0.0004 0.0004
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0136 1
Plasmodium vivax vivapain-2 0.0016 0.0019 1
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0004 0.001
Echinococcus granulosus hypothetical protein 0.001 0.0004 0.0004
Echinococcus granulosus sex peptide receptor 0.001 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0361 0.0852 0.2478
Echinococcus granulosus cathepsin l1 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0361 0.0852 0.0852
Loa Loa (eye worm) nuclear receptor nhr-7B 0.1429 0.3437 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0001 0.0001
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0004 0.0004
Brugia malayi hypothetical protein 0.001 0.0004 0.0012
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0004 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0004 0.0004
Echinococcus granulosus dro:myosuppressin receptor 0.001 0.0004 0.0004
Brugia malayi hypothetical protein 0.019 0.044 0.1281
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0004 0.0004
Brugia malayi Cathepsin L-like precursor 0.0016 0.0019 0.0056
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0019 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0361 0.0852 0.2478
Echinococcus granulosus nuclear receptor 2DBD gamma 0.017 0.0391 0.0391
Echinococcus multilocularis fmrfamide receptor 0.001 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0361 0.0852 0.2478
Schistosoma mansoni opsin-like receptor 0.001 0.0004 0.0004
Brugia malayi putative neuropeptide receptor 0.001 0.0004 0.0012
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0136 0.0136
Echinococcus multilocularis cysteine protease 0.0016 0.0019 0.002
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Brugia malayi gonadotropin-releasing hormone receptor 2 0.001 0.0004 0.0012
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0131 0.9614
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0131 0.9614
Brugia malayi ecdysone receptor 0.017 0.0391 0.1138
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0004 0.0004
Brugia malayi nuclear receptor NHR-88 0.017 0.0391 0.1138
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0019 0.0054
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.017 0.0391 0.0391
Loa Loa (eye worm) hypothetical protein 0.019 0.044 0.128
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0016
Schistosoma mansoni neuropeptide receptor 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Brugia malayi hypothetical protein 0.001 0.0004 0.0012
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.017 0.0391 0.1136
Echinococcus multilocularis cpg binding protein 0.003 0.0052 0.0054
Loa Loa (eye worm) ctsf protein 0.0016 0.0019 0.0054
Schistosoma mansoni biogenic amine receptor 0.001 0.0004 0.0004
Brugia malayi AKH receptor 0.001 0.0004 0.0012
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0094 0.0274
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0361 0.0852 0.2478
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0004 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0131 0.9614
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0361 0.0852 0.0852
Echinococcus multilocularis alpha 1A adrenergic receptor 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.017 0.0391 0.1136
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0118 0.8649
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0136 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0131 0.9614
Onchocerca volvulus 0.0011 0.0006 0.0005
Echinococcus multilocularis sex peptide receptor 0.001 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0361 0.0852 0.2478
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.017 0.0391 0.1136
Echinococcus granulosus nuclear receptor nhr 48 0.017 0.0391 0.0391
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0361 0.0852 0.2477
Echinococcus granulosus thyroid hormone receptor alpha 0.017 0.0391 0.0391
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0361 0.0852 0.2478
Echinococcus multilocularis nuclear receptor nhr 48 0.017 0.0391 0.041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0019 1
Schistosoma mansoni coup transcription factor 0.0361 0.0852 0.0852
Echinococcus multilocularis neuropeptide receptor 0.001 0.0004 0.0004
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0019 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0004 0.0004
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0361 0.0852 0.0852
Schistosoma mansoni peptide (allatostatin)-like receptor 0.001 0.0004 0.0004
Onchocerca volvulus 0.0016 0.0019 0.0039
Schistosoma mansoni biogenic amine receptor 0.001 0.0004 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0131 0.9614
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0004 0.0004
Brugia malayi ORL1-like opioid receptor 0.001 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Echinococcus granulosus orexin receptor type 2 0.001 0.0004 0.0004
Brugia malayi hypothetical protein 0.001 0.0004 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0131 0.9614
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0019 1
Brugia malayi G-protein coupled receptor 0.001 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0361 0.0852 0.2477
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.017 0.0391 0.041
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Onchocerca volvulus 0.017 0.0391 0.0994
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Entamoeba histolytica cysteine protease, putative 0.0016 0.0019 0.1415
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0006 0.0006
Echinococcus granulosus neuropeptide FF receptor 2 0.001 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor 0.017 0.0391 0.1136
Schistosoma mansoni amine GPCR 0.001 0.0004 0.0004
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Schistosoma mansoni neuropeptide receptor 0.001 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0361 0.0852 0.2477
Schistosoma mansoni survival motor neuron protein 0.0047 0.0094 0.0094
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0004 0.0004
Brugia malayi nuclear receptor NHR-88 0.0361 0.0852 0.2478
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0361 0.0852 0.2477
Schistosoma mansoni steroid hormone receptor ad4bp 0.0361 0.0852 0.0852
Brugia malayi Serotonin receptor 0.001 0.0004 0.0012
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0361 0.0852 0.0893
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.3952 0.9539 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0048 0.0139
Brugia malayi Nuclear hormone receptor-like 1 0.019 0.044 0.1281
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Schistosoma mansoni amine GPCR 0.001 0.0004 0.0004
Echinococcus multilocularis dro:myosuppressin receptor 0.001 0.0004 0.0004
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0001 0.0001
Echinococcus granulosus fmrfamide receptor 0.001 0.0004 0.0004
Schistosoma mansoni myosin xvIII 0.001 0.0004 0.0004
Schistosoma mansoni alpha-1 adrenergic receptor 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0361 0.0852 0.2477
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Brugia malayi photoreceptor-specific nuclear receptor 0.0361 0.0852 0.2478
Loa Loa (eye worm) DR-78 0.017 0.0391 0.1136
Echinococcus granulosus neuropeptide receptor A26 0.001 0.0004 0.0004
Schistosoma mansoni cpg binding protein 0.003 0.0052 0.0052
Echinococcus granulosus neuropeptide s receptor 0.001 0.0004 0.0004
Brugia malayi Cathepsin L-like precursor 0.0016 0.0019 0.0056
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0 0.0001
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Echinococcus multilocularis fmrfamide receptor 0.001 0.0004 0.0004
Echinococcus granulosus tachykinin peptides receptor 99D 0.001 0.0004 0.0004
Echinococcus granulosus g protein coupled receptor 0.001 0.0004 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0006 0.0018
Echinococcus multilocularis Protein lozenge 0.0055 0.0111 0.0117
Schistosoma mansoni cpg binding protein 0.003 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Echinococcus granulosus g protein coupled receptor 0.001 0.0004 0.0004
Brugia malayi hypothetical protein 0.0435 0.1031 0.2999
Schistosoma mansoni thyroid hormone receptor 0.0361 0.0852 0.0852
Echinococcus multilocularis neuropeptide receptor 0.001 0.0004 0.0004
Schistosoma mansoni amine GPCR 0.001 0.0004 0.0004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0361 0.0852 0.0893
Leishmania major cathepsin L-like protease 0.0063 0.0131 0.955
Echinococcus granulosus Nuclear hormone receptor HR96 0.017 0.0391 0.0391
Brugia malayi Tachykinin-like peptides receptor 99D 0.001 0.0004 0.0012
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0361 0.0852 0.0852
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0006 0.3182
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0004 0.0004
Onchocerca volvulus 0.017 0.0391 0.0994
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.001 0.0004 0.0004
Brugia malayi Cathepsin L-like precursor 0.0011 0.0006 0.0018
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.0541 0.0567
Loa Loa (eye worm) hypothetical protein 0.017 0.0391 0.1136
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0019 0.1415
Brugia malayi hypothetical protein 0.019 0.044 0.1281
Loa Loa (eye worm) fibroinase 0.0016 0.0019 0.0054
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0004 0.0004
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0004 0.0004
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0019 0.0054
Echinococcus granulosus cathepsin l1 0.0016 0.0019 0.0019
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0232 0.0541 0.1572
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0019 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0019 1
Echinococcus multilocularis g protein coupled receptor 0.001 0.0004 0.0004
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.019 0.044 0.128
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.001 0.0004 0.0004
Brugia malayi orphan nuclear receptor NR2E1 0.017 0.0391 0.1138
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0019 1
Echinococcus granulosus FTZ F1 alpha 0.0361 0.0852 0.0852
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0004 0.0004
Loa Loa (eye worm) steroid hormone receptor 0.0361 0.0852 0.2477
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0361 0.0852 0.2477
Leishmania major cathepsin L-like protease 0.0063 0.0131 0.955
Brugia malayi hypothetical protein 0.001 0.0004 0.0012
Brugia malayi tailless protein 0.017 0.0391 0.1138
Brugia malayi nuclear hormone receptor 0.0361 0.0852 0.2478
Loa Loa (eye worm) hypothetical protein 0.0435 0.1031 0.2998
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0048 0.0137
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.001 0.0004 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0019 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Onchocerca volvulus 0.0016 0.0019 0.0039
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0361 0.0852 0.0893
Echinococcus granulosus G protein coupled receptor 139 0.001 0.0004 0.0004
Onchocerca volvulus 0.0047 0.0094 0.0231
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.017 0.0391 0.0994
Brugia malayi nuclear hormone receptor family member nhr-6 0.017 0.0391 0.1138
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.001 0.0004 0.001
Brugia malayi hypothetical protein 0.001 0.0004 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0361 0.0852 0.2478
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0004 0.0004
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.0541 0.0541
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.001 0.0004 0.0004
Brugia malayi G-protein coupled receptor 0.001 0.0004 0.0012
Echinococcus multilocularis biogenic amine (5HT) receptor 0.001 0.0004 0.0004
Echinococcus multilocularis allatostatin A receptor 0.001 0.0004 0.0004
Echinococcus granulosus allatostatin A receptor 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0361 0.0852 0.2477
Echinococcus multilocularis Nuclear hormone receptor HR96 0.017 0.0391 0.041
Echinococcus multilocularis g-protein coupled receptor 0.001 0.0004 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.001 0.0004 0.001
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0004 0.0004
Onchocerca volvulus 0.0016 0.0019 0.0039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0131 0.9614
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0361 0.0852 0.2478
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0019 0.0019
Brugia malayi putative neuropeptide receptor NPR1 0.001 0.0004 0.0012
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.019 0.044 0.044
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.001 0.0004 0.0004
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0019 0.002
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Echinococcus granulosus serotonin receptor 0.001 0.0004 0.0004
Brugia malayi hypothetical protein 0.001 0.0004 0.0012
Schistosoma mansoni hypothetical protein 0.0401 0.095 0.095
Loa Loa (eye worm) hypothetical protein 0.019 0.044 0.128
Loa Loa (eye worm) hypothetical protein 0.017 0.0391 0.1136
Onchocerca volvulus 0.0028 0.0048 0.0112
Echinococcus granulosus ecdysone induced protein 78C 0.0361 0.0852 0.0852
Brugia malayi nuclear hormone receptor family member odr-7 0.017 0.0391 0.1138
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0136 1
Brugia malayi cathepsin L-like precursor 0.0011 0.0006 0.0018
Onchocerca volvulus 0.0016 0.0019 0.0039
Echinococcus granulosus tm gpcr rhodopsin 0.0635 0.1516 0.1516
Schistosoma mansoni hypothetical protein 0.001 0.0004 0.0004
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0004 0.0004
Brugia malayi Cathepsin L-like precursor 0.0016 0.0019 0.0056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0131 0.9614
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0361 0.0852 0.2477
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0361 0.0852 0.0852
Echinococcus multilocularis neuropeptide receptor A26 0.001 0.0004 0.0004
Brugia malayi conserved hypotetical protein 0.017 0.0391 0.1138
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0019 0.0039
Brugia malayi Cathepsin L-like precursor 0.0016 0.0019 0.0056
Schistosoma mansoni nuclear receptor 0.017 0.0391 0.0391
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0361 0.0852 0.2477
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0019 1
Brugia malayi larval opioid receptor 0.001 0.0004 0.0012
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.001 0.0004 0.0004
Brugia malayi ecdysteroid receptor 0.0361 0.0852 0.2478
Echinococcus granulosus alpha 1A adrenergic receptor 0.001 0.0004 0.0004
Schistosoma mansoni amine GPCR 0.001 0.0004 0.0004
Plasmodium vivax vivapain-2 0.0016 0.0019 1
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0004 0.0004
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.001 0.0004 0.0004
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.017 0.0391 0.0391
Echinococcus granulosus 7TM GPCR rhodopsin 0.001 0.0004 0.0004
Echinococcus multilocularis g protein coupled receptor 0.001 0.0004 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.001 0.0004 0.0004
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0019 0.1415
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0019 1
Brugia malayi hypothetical protein 0.0232 0.0541 0.1573
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Brugia malayi Cathepsin L-like precursor 0.0016 0.0019 0.0056
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0236 0.055 0.1599
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.019 0.044 0.044
Loa Loa (eye worm) cysteine protease 0.0016 0.0019 0.0054
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0361 0.0852 0.2477
Echinococcus granulosus g-protein coupled receptor 0.001 0.0004 0.0004
Onchocerca volvulus Protein ultraspiracle homolog 0.0361 0.0852 0.2177
Brugia malayi Nuclear hormone receptor E75 0.017 0.0391 0.1138
Brugia malayi follicle stimulating hormone receptor 0.0236 0.055 0.16
Echinococcus granulosus transcription factor Dp 1 0.0037 0.007 0.007
Echinococcus granulosus somatostatin receptor 0.001 0.0004 0.0004
Schistosoma mansoni retinoid-x-receptor (RXR) 0.019 0.044 0.044
Brugia malayi hypothetical protein 0.001 0.0004 0.0012
Echinococcus granulosus peptide allatostatin:somatostatin 0.001 0.0004 0.0004
Onchocerca volvulus 0.0016 0.0019 0.0039
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0004 0.0004
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0006 0.045
Echinococcus multilocularis serotonin receptor 0.001 0.0004 0.0004
Onchocerca volvulus 0.0361 0.0852 0.2177
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0004 0.0004
Schistosoma mansoni histamine h1 receptor 0.001 0.0004 0.0004
Onchocerca volvulus Bile acid receptor homolog 0.0361 0.0852 0.2177
Schistosoma mansoni growth hormone secretagogue receptor 0.001 0.0004 0.0004
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0136 1
Brugia malayi Nuclear hormone receptor-like 1 0.019 0.044 0.1281
Schistosoma mansoni neuropeptide receptor 0.001 0.0004 0.0004
Echinococcus granulosus dnaJ subfamily B 0.0401 0.095 0.095
Schistosoma mansoni lozenge 0.0055 0.0111 0.0111
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0361 0.0852 0.0852
Loa Loa (eye worm) hypothetical protein 0.1259 0.3025 0.8803
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0099 0.7234
Echinococcus multilocularis ecdysone induced protein 78C 0.0361 0.0852 0.0893
Brugia malayi Dopamine receptor protein 1 0.001 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0361 0.0852 0.2477
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0136 0.0143
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0136 0.0136
Brugia malayi Steroid receptor seven-up type 2 0.0361 0.0852 0.2478
Schistosoma mansoni hypothetical protein 0.001 0.0004 0.0004
Onchocerca volvulus 0.0435 0.1031 0.2637
Echinococcus granulosus g protein coupled receptor 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.019 0.044 0.128
Brugia malayi sulfakinin receptor protein 0.001 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0131 0.9614
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.001 0.0004 0.0004
Brugia malayi Dopamine receptor 0.001 0.0004 0.0012
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.162 0.3897 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0131 0.9614
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0006 0.3182
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0131 0.9614
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.017 0.0391 0.1136
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0361 0.0852 0.0893
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0019 0.002
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0361 0.0852 0.0852
Loa Loa (eye worm) hypothetical protein 0.0361 0.0852 0.2477
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0019 1
Schistosoma mansoni biogenic amine receptor 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.017 0.0391 0.1136
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0004 0.0004
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0004 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0361 0.0852 0.0852
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.017 0.0391 0.0391
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0004 0.0004
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.017 0.0391 0.0994
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0361 0.0852 0.0852
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Leishmania major cathepsin L-like protease 0.0063 0.0131 0.955
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0019 0.0056
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0019 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0131 0.9614
Brugia malayi G protein-coupled receptor F59B2.13 0.001 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0361 0.0852 0.2478
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0004 0.0004
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0019 0.002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0019 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.001 0.0004 0.0004
Echinococcus granulosus cpg binding protein 0.003 0.0052 0.0052
Schistosoma mansoni retinoic acid receptor RXR 0.4143 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.017 0.0391 0.041
Echinococcus granulosus neuropeptide receptor 0.001 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0019 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Brugia malayi hypothetical protein 0.001 0.0004 0.0012
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0131 0.9614
Brugia malayi Cathepsin L-like precursor 0.0011 0.0006 0.0018
Echinococcus granulosus Nuclear hormone receptor HR96 0.017 0.0391 0.0391
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0019 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0019 1
Echinococcus multilocularis orexin receptor type 2 0.001 0.0004 0.0004
Schistosoma mansoni nuclear receptor 0.017 0.0391 0.0391
Schistosoma mansoni zinc finger protein 0.017 0.0391 0.0391
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0361 0.0852 0.2478
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0004 0.0004
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.001 0.0004 0.0012

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1.8 nM Displacement of [3H]DPDPE from cloned human delta opioid receptor ChEMBL. 17512730
Ki (binding) = 1.8 nM Displacement of [3H]DPDPE from cloned human delta opioid receptor ChEMBL. 17512730
Ki (binding) = 201 nM Displacement of [3H]U69593 from cloned human kappa opioid receptor ChEMBL. 17512730
Ki (binding) = 201 nM Displacement of [3H]U69593 from cloned human kappa opioid receptor ChEMBL. 17512730
Ki (binding) > 465 nM Displacement of [3H]DAMGO from cloned human mu opioid receptor ChEMBL. 17512730
Ki (binding) > 465 nM Displacement of [3H]DAMGO from cloned human mu opioid receptor ChEMBL. 17512730
Ratio Ki (binding) = 112 Selectivity for delta opioid receptor over kappa opioid receptor ChEMBL. 17512730
Ratio Ki (binding) > 258 Selectivity for delta opioid receptor over mu opioid receptor ChEMBL. 17512730

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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