Detailed information for compound 442698

Basic information

Technical information
  • TDR Targets ID: 442698
  • Name: tert-butyl 2-[3-[2-(benzenesulfonamido)ethyl] phenyl]indole-1-carboxylate
  • MW: 476.587 | Formula: C27H28N2O4S
  • H donors: 1 H acceptors: 3 LogP: 5.85 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(n1c(cc2c1cccc2)c1cccc(c1)CCNS(=O)(=O)c1ccccc1)OC(C)(C)C
  • InChi: 1S/C27H28N2O4S/c1-27(2,3)33-26(30)29-24-15-8-7-11-22(24)19-25(29)21-12-9-10-20(18-21)16-17-28-34(31,32)23-13-5-4-6-14-23/h4-15,18-19,28H,16-17H2,1-3H3
  • InChiKey: ITARVGIWSLJAAL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[3-[2-(benzenesulfonamido)ethyl]phenyl]-1-indolecarboxylic acid tert-butyl ester
  • tert-butyl 2-[3-[2-(phenylsulfonylamino)ethyl]phenyl]indole-1-carboxylate
  • 2-[3-[2-(benzenesulfonamido)ethyl]phenyl]indole-1-carboxylic acid tert-butyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear receptor subfamily 1, group H, member 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni zinc finger protein 0.0154 0.0408 0.0408
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0182 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0182 0.0487 0.1092
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0182 0.0487 0.0487
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0154 0.0408 0.0805
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0008 0.0008
Loa Loa (eye worm) runx1 0.0062 0.0149 0.0332
Brugia malayi Steroid receptor seven-up type 2 0.0336 0.0922 0.2071
Schistosoma mansoni RAR-like nuclear receptor 0.0336 0.0922 0.0922
Echinococcus multilocularis cpg binding protein 0.0034 0.0069 0.0073
Plasmodium vivax vivapain-2 0.0019 0.0026 1
Loa Loa (eye worm) hypothetical protein 0.1433 0.4019 0.9023
Onchocerca volvulus Bile acid receptor homolog 0.0336 0.0922 0.1843
Onchocerca volvulus 0.0054 0.0126 0.0237
Brugia malayi tailless protein 0.0154 0.0408 0.0915
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0336 0.0922 0.0972
Onchocerca volvulus 0.0019 0.0026 0.0035
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0074 0.0182 0.0182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0336 0.0922 0.2069
Schistosoma mansoni hypothetical protein 0.0459 0.127 0.127
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0074 0.0182 0.0409
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0336 0.0922 0.2071
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0126 0.0282
Brugia malayi Nuclear hormone receptor-like 1 0.0182 0.0487 0.1094
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0175 0.9614
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.1769 0.4969 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0154 0.0408 0.0408
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0175 0.9614
Loa Loa (eye worm) hypothetical protein 0.0336 0.0922 0.2069
Leishmania major cathepsin L-like protease 0.0072 0.0175 0.955
Schistosoma mansoni lozenge 0.0062 0.0149 0.0149
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0175 0.9614
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0001 0.0001
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0074 0.0182 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0175 0.9614
Brugia malayi nuclear hormone receptor 0.0336 0.0922 0.2071
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0026 0.0056
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0336 0.0922 0.0922
Brugia malayi hypothetical protein 0.0265 0.0723 0.1622
Loa Loa (eye worm) hypothetical protein 0.0154 0.0408 0.0914
Brugia malayi Cathepsin L-like precursor 0.0013 0.0008 0.0018
Loa Loa (eye worm) hypothetical protein 0.0154 0.0408 0.0914
Loa Loa (eye worm) hypothetical protein 0.0154 0.0408 0.0914
Brugia malayi Nuclear hormone receptor-like 1 0.0336 0.0922 0.2071
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0154 0.0408 0.0805
Echinococcus multilocularis cysteine protease 0.0019 0.0026 0.0027
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0026 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0336 0.0922 0.0922
Loa Loa (eye worm) hypothetical protein 0.0154 0.0408 0.0914
Schistosoma mansoni steroid hormone receptor ad4bp 0.0336 0.0922 0.0922
Brugia malayi Cathepsin L-like precursor 0.0013 0.0008 0.0018
Brugia malayi nuclear receptor NHR-88 0.0336 0.0922 0.2071
Echinococcus granulosus Nuclear hormone receptor HR96 0.0154 0.0408 0.0408
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0336 0.0922 0.0972
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0336 0.0922 0.0972
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0026 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.0408 0.0914
Leishmania major cathepsin L-like protease 0.0072 0.0175 0.955
Loa Loa (eye worm) hypothetical protein 0.0154 0.0408 0.0914
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0336 0.0922 0.0922
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0175 0.9614
Onchocerca volvulus 0.0019 0.0026 0.0035
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0026 0.1415
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0026 0.0058
Brugia malayi steroid hormone receptor 0.0336 0.0922 0.2071
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0166 0.0166
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0175 0.9614
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0026 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0026 1
Schistosoma mansoni cpg binding protein 0.0032 0.0064 0.0064
Schistosoma mansoni retinoic acid receptor RXR 0.355 1 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.0408 0.0914
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0026 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0336 0.0922 0.2071
Brugia malayi Nuclear hormone receptor E75 0.0154 0.0408 0.0915
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0001 0.0001
Echinococcus granulosus nuclear receptor nhr 48 0.0154 0.0408 0.0408
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0065 0.0157 0.8649
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0026 1
Brugia malayi hypothetical protein 0.0154 0.0408 0.0915
Plasmodium vivax vivapain-2 0.0019 0.0026 1
Loa Loa (eye worm) ctsf protein 0.0019 0.0026 0.0056
Brugia malayi cathepsin L-like precursor 0.0013 0.0008 0.0018
Loa Loa (eye worm) steroid hormone receptor 0.0336 0.0922 0.2069
Echinococcus granulosus thyroid hormone receptor alpha 0.0154 0.0408 0.0408
Onchocerca volvulus 0.0154 0.0408 0.0805
Loa Loa (eye worm) nuclear hormone receptor 0.0154 0.0408 0.0914
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0336 0.0922 0.2071
Schistosoma mansoni hypothetical protein 0.0054 0.0126 0.0126
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0175 0.9614
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.0182 0.0487 0.1092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0008 0.3182
Brugia malayi Cathepsin L-like precursor 0.0019 0.0026 0.0058
Brugia malayi nuclear receptor RXR 0.0154 0.0408 0.0915
Brugia malayi Nuclear hormone receptor E75 0.0154 0.0408 0.0915
Loa Loa (eye worm) hypothetical protein 0.0336 0.0922 0.2069
Loa Loa (eye worm) hypothetical protein 0.0182 0.0487 0.1092
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0175 0.9614
Onchocerca volvulus 0.0019 0.0026 0.0035
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0182 1
Entamoeba histolytica cysteine proteinase, putative 0.0013 0.0008 0.045
Loa Loa (eye worm) hypothetical protein 0.0336 0.0922 0.2069
Brugia malayi orphan nuclear receptor NR2E1 0.0154 0.0408 0.0915
Echinococcus granulosus ecdysone induced protein 78C 0.0336 0.0922 0.0922
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0026 0.1415
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0336 0.0922 0.2071
Onchocerca volvulus 0.0497 0.1377 0.276
Onchocerca volvulus 0.0019 0.0026 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0336 0.0922 0.2069
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0336 0.0922 0.2071
Loa Loa (eye worm) hypothetical protein 0.0497 0.1377 0.3091
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0175 0.9614
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0026 1
Loa Loa (eye worm) hypothetical protein 0.0265 0.0723 0.162
Brugia malayi nuclear receptor NHR-67 0.0154 0.0408 0.0915
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0026 0.0027
Schistosoma mansoni thyroid hormone receptor 0.0336 0.0922 0.0922
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.0056
Loa Loa (eye worm) hypothetical protein 0.0336 0.0922 0.2069
Loa Loa (eye worm) hypothetical protein 0.0154 0.0408 0.0914
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0074 0.0182 0.0182
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0336 0.0922 0.2071
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0026 1
Loa Loa (eye worm) cysteine protease 0.0019 0.0026 0.0056
Loa Loa (eye worm) hypothetical protein 0.0154 0.0408 0.0914
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0336 0.0922 0.2071
Loa Loa (eye worm) hypothetical protein 0.0336 0.0922 0.2069
Brugia malayi Cathepsin L-like cysteine proteinase 0.0013 0.0008 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0026 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0182 0.0487 0.0487
Brugia malayi Cathepsin L-like precursor 0.0019 0.0026 0.0058
Loa Loa (eye worm) nuclear receptor nhr-7B 0.1587 0.4455 1
Brugia malayi Cathepsin L-like precursor 0.0019 0.0026 0.0058
Echinococcus granulosus survival motor neuron protein 1 0.0265 0.0723 0.0723
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0336 0.0922 0.0922
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0336 0.0922 0.2071
Brugia malayi hypothetical protein 0.0182 0.0487 0.1094
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0026 0.0026
Echinococcus multilocularis survival motor neuron protein 1 0.0265 0.0723 0.0762
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0182 0.0487 0.0487
Brugia malayi nuclear hormone receptor family member odr-7 0.0154 0.0408 0.0915
Schistosoma mansoni cpg binding protein 0.0034 0.0069 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0026 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0026 1
Brugia malayi hypothetical protein 0.0154 0.0408 0.0915
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0336 0.0922 0.0922
Schistosoma mansoni thyroid hormone receptor 0.0336 0.0922 0.0922
Onchocerca volvulus 0.0019 0.0026 0.0035
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0182 0.0487 0.1092
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0026 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0074 0.0182 0.0407
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0175 0.9614
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0336 0.0922 0.0972
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0175 0.9614
Brugia malayi ecdysteroid receptor 0.0336 0.0922 0.2071
Schistosoma mansoni nuclear receptor 0.0154 0.0408 0.0408
Trypanosoma cruzi major cysteine proteinase, putative 0.0056 0.0132 0.7234
Schistosoma mansoni survival motor neuron protein 0.0054 0.0126 0.0126
Schistosoma mansoni nuclear hormone receptor 0.0336 0.0922 0.0922
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0026 1
Brugia malayi Cathepsin L-like precursor 0.0019 0.0026 0.0058
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0026 0.0026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0175 0.9614
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0154 0.0408 0.0408
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0026 0.0027
Loa Loa (eye worm) hypothetical protein 0.0336 0.0922 0.2069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0026 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.026 0.0707 0.1586
Loa Loa (eye worm) hypothetical protein 0.0336 0.0922 0.2069
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0094 0.0094
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0026 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.0408 0.0914
Loa Loa (eye worm) hypothetical protein 0.0154 0.0408 0.0914
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0336 0.0922 0.2071
Loa Loa (eye worm) hypothetical protein 0.0336 0.0922 0.2069
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0074 0.0182 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0026 1
Echinococcus granulosus FTZ F1 alpha 0.0336 0.0922 0.0922
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0336 0.0922 0.2069
Leishmania major cathepsin L-like protease 0.0072 0.0175 0.955
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0008 0.3182
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0336 0.0922 0.0972
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0026 0.0056
Schistosoma mansoni nuclear receptor 0.0154 0.0408 0.0408
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0154 0.0408 0.043
Onchocerca volvulus 0.0032 0.0064 0.0112
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0336 0.0922 0.0922
Brugia malayi nuclear hormone receptor 0.1587 0.4455 1
Echinococcus multilocularis dnaJ subfamily B 0.0459 0.127 0.1339
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0336 0.0922 0.0922
Echinococcus granulosus cpg binding protein 0.0034 0.0069 0.0069
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0182 1
Echinococcus multilocularis cysteine protease 0.0019 0.0026 0.0027
Schistosoma mansoni nuclear hormone receptor 0.0154 0.0408 0.0408
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0026 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.0408 0.0914
Echinococcus multilocularis thyroid hormone receptor alpha 0.0336 0.0922 0.0972
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0026 0.1415
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0026 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0154 0.0408 0.0408
Brugia malayi conserved hypotetical protein 0.0154 0.0408 0.0915
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0094 0.0099
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0336 0.0922 0.0972
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0182 0.0487 0.0514
Brugia malayi nuclear receptor RXR 0.0182 0.0487 0.1094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0026 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0154 0.0408 0.043
Schistosoma mansoni coup transcription factor 0.0336 0.0922 0.0922
Loa Loa (eye worm) fibroinase 0.0019 0.0026 0.0056
Loa Loa (eye worm) nuclear receptor NHR-67 0.0154 0.0408 0.0914
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0336 0.0922 0.0922
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0026 0.0035
Onchocerca volvulus 0.0154 0.0408 0.0805
Entamoeba histolytica cysteine protease, putative 0.0019 0.0026 0.1415
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0074 0.0182 0.0192
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.0175 0.9614
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0336 0.0922 0.0922
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0026 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0336 0.0922 0.2069
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0026 1
Onchocerca volvulus 0.0336 0.0922 0.1843
Echinococcus multilocularis Protein lozenge 0.0062 0.0149 0.0157
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0064 0.0141
Schistosoma mansoni nuclear hormone receptor 0.0154 0.0408 0.0408
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0336 0.0922 0.0922
Echinococcus multilocularis ecdysone induced protein 78C 0.0336 0.0922 0.0972
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0026 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0336 0.0922 0.2071
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.3368 0.9485 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0026 0.0027
Loa Loa (eye worm) hypothetical protein 0.0182 0.0487 0.1092
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0336 0.0922 0.2071
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0336 0.0922 0.0922
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0154 0.0408 0.0408
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0336 0.0922 0.2071
Loa Loa (eye worm) DR-78 0.0154 0.0408 0.0914
Echinococcus granulosus dnaJ subfamily B 0.0459 0.127 0.127
Schistosoma mansoni cpg binding protein 0.0034 0.0069 0.0069
Brugia malayi nuclear hormone receptor family member nhr-6 0.0154 0.0408 0.0915
Brugia malayi nuclear receptor NHR-88 0.0154 0.0408 0.0915
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0026 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0026 1
Onchocerca volvulus 0.0019 0.0026 0.0035
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0026 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0336 0.0922 0.2069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0026 1
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0175 0.9614
Schistosoma mansoni nuclear receptor nhr-48 0.0154 0.0408 0.0408
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0017
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0145 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0154 0.0408 0.0408
Brugia malayi ecdysone receptor 0.0154 0.0408 0.0915
Loa Loa (eye worm) hypothetical protein 0.0182 0.0487 0.1092
Brugia malayi hypothetical protein 0.0497 0.1377 0.3092
Brugia malayi CXXC zinc finger family protein 0.0032 0.0064 0.0143
Brugia malayi Cathepsin L-like precursor 0.0019 0.0026 0.0058
Brugia malayi Cathepsin L-like precursor 0.0019 0.0026 0.0058
Loa Loa (eye worm) hypothetical protein 0.0497 0.1377 0.3091
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0336 0.0922 0.2069
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0336 0.0922 0.2071
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0336 0.0922 0.0922
Echinococcus granulosus cathepsin l1 0.0019 0.0026 0.0026
Brugia malayi Nuclear hormone receptor-like 1 0.0182 0.0487 0.1094
Onchocerca volvulus Protein ultraspiracle homolog 0.0336 0.0922 0.1843
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0026 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0026 1
Echinococcus multilocularis FTZ F1 alpha 0.0336 0.0922 0.0972
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0175 0.9614
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0336 0.0922 0.2069
Brugia malayi F/Y-rich N-terminus family protein 0.001 0 0.0001
Brugia malayi photoreceptor-specific nuclear receptor 0.0336 0.0922 0.2071
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0154 0.0408 0.043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0026 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.0408 0.0914
Brugia malayi follicle stimulating hormone receptor 0.026 0.0707 0.1587
Echinococcus granulosus cathepsin l1 0.0013 0.0008 0.0008
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0026 0.0026
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0154 0.0408 0.043
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0154 0.0408 0.043
Brugia malayi hypothetical protein 0.0182 0.0487 0.1094
Onchocerca volvulus 0.0019 0.0026 0.0035
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0154 0.0408 0.0915

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.42 uM Agonist activity at human LXRbeta receptor after 1 hr by HTRF cofactor recruitment assay ChEMBL. 17587573
EC50 (functional) = 0.42 uM Agonist activity at human LXRbeta receptor after 1 hr by HTRF cofactor recruitment assay ChEMBL. 17587573

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.