Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 1, group H, member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.0298 | 0.2424 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0138 | 0.0724 | 0.0647 |
Toxoplasma gondii | hypothetical protein | 0.0104 | 0.0365 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0081 | 0.0117 | 0.322 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0081 | 0.0117 | 0.0117 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0081 | 0.0117 | 0.0117 |
Schistosoma mansoni | thyroid hormone receptor | 0.0081 | 0.0117 | 0.0117 |
Trypanosoma brucei | presenilin-like aspartic peptidase, putative | 0.0298 | 0.2424 | 0.5 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0298 | 0.2424 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0081 | 0.0117 | 0.322 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0081 | 0.0117 | 0.0485 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0081 | 0.0117 | 0.0117 |
Brugia malayi | nuclear receptor NHR-88 | 0.0081 | 0.0117 | 0.0485 |
Brugia malayi | Presenilin spe-4 | 0.0104 | 0.0365 | 0.1505 |
Brugia malayi | hypothetical protein | 0.0104 | 0.0365 | 0.1505 |
Brugia malayi | hypothetical protein | 0.0104 | 0.0365 | 0.1505 |
Onchocerca volvulus | 0.0081 | 0.0117 | 1 | |
Brugia malayi | Presenilin family protein | 0.0298 | 0.2424 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0117 | 0.322 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.0298 | 0.2424 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0117 | 0.322 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0117 | 0.322 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0081 | 0.0117 | 0.322 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0081 | 0.0117 | 0.0485 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0081 | 0.0117 | 0.0485 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0081 | 0.0117 | 0.0485 |
Schistosoma mansoni | lipoxygenase | 0.0138 | 0.0724 | 0.0724 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0117 | 0.322 |
Schistosoma mansoni | thyroid hormone receptor | 0.0081 | 0.0117 | 0.0117 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0081 | 0.0117 | 0.322 |
Brugia malayi | ecdysteroid receptor | 0.0081 | 0.0117 | 0.0485 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0138 | 0.0724 | 0.0614 |
Brugia malayi | Presenilin spe-4 | 0.0104 | 0.0365 | 0.1505 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0298 | 0.2424 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0081 | 0.0117 | 0.0117 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0081 | 0.0117 | 0.322 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.0298 | 0.2424 | 0.5 |
Brugia malayi | Presenilin-like protein At2g29900 | 0.0104 | 0.0365 | 0.1505 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0081 | 0.0117 | 0.0485 |
Brugia malayi | Presenilin spe-4 | 0.0104 | 0.0365 | 0.1505 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0081 | 0.0117 | 0.0117 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0298 | 0.2424 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0081 | 0.0117 | 0.0117 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0081 | 0.0117 | 0.0485 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0081 | 0.0117 | 0.0485 |
Echinococcus multilocularis | presenilin | 0.0298 | 0.2424 | 0.246 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0964 | 0.9496 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0081 | 0.0117 | 0.0485 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0081 | 0.0117 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0117 | 0.322 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0081 | 0.0117 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0081 | 0.0117 | 0.0485 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0081 | 0.0117 | 0.0485 |
Loa Loa (eye worm) | presenilin spe-4 | 0.0104 | 0.0365 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0081 | 0.0117 | 0.0485 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0117 | 0.322 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.1011 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0081 | 0.0117 | 0.0485 |
Brugia malayi | hypothetical protein | 0.0104 | 0.0365 | 0.1505 |
Schistosoma mansoni | coup transcription factor | 0.0081 | 0.0117 | 0.0117 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0117 | 0.322 |
Brugia malayi | steroid hormone receptor | 0.0081 | 0.0117 | 0.0485 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0081 | 0.0117 | 0.0485 |
Echinococcus granulosus | presenilin | 0.0298 | 0.2424 | 0.2334 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0117 | 0.322 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0081 | 0.0117 | 0.0485 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0081 | 0.0117 | 0.0485 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0081 | 0.0117 | 0.0117 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0081 | 0.0117 | 0.322 |
Schistosoma mansoni | lipoxygenase | 0.0097 | 0.0282 | 0.0282 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0081 | 0.0117 | 0.0485 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0081 | 0.0117 | 0.0485 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0081 | 0.0117 | 0.322 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0081 | 0.0117 | 0.0117 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0081 | 0.0117 | 0.0117 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.0298 | 0.2424 | 0.2424 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.0298 | 0.2424 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0081 | 0.0117 | 0.322 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0081 | 0.0117 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.49 uM | Agonist activity at human LXRbeta receptor after 1 hr by HTRF cofactor recruitment assay | ChEMBL. | 17587573 |
EC50 (functional) | = 0.49 uM | Agonist activity at human LXRbeta receptor after 1 hr by HTRF cofactor recruitment assay | ChEMBL. | 17587573 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.