Detailed information for compound 442808

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 274.317 | Formula: C18H14N2O
  • H donors: 0 H acceptors: 2 LogP: 3.91 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(C#N)cc(c1)c1ccc2c(c1)nc(cc2)C
  • InChi: 1S/C18H14N2O/c1-12-3-4-14-5-6-15(10-18(14)20-12)16-7-13(11-19)8-17(9-16)21-2/h3-10H,1-2H3
  • InChiKey: UYKOUDWFOWHINO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Metabotropic glutamate receptor 5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis metabotropic glutamate receptor 2 Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma mansoni metabotropic glutamate receptor Get druggable targets OG5_127095 All targets in OG5_127095
Loa Loa (eye worm) glutamate receptor Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) Get druggable targets OG5_127095 All targets in OG5_127095
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum Metabotropic glutamate receptor precursor, putative Get druggable targets OG5_127095 All targets in OG5_127095
Brugia malayi Metabotropic glutamate receptor precursor. Get druggable targets OG5_127095 All targets in OG5_127095
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus multilocularis metabotropic glutamate receptor 5 Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus granulosus metabotropic glutamate receptor 2 Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum ko:K04606 glutamate receptor, metabotropic 3, putative Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus granulosus metabotropic glutamate receptor 5 Get druggable targets OG5_127095 All targets in OG5_127095
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0019 0.0044
Brugia malayi conserved hypotetical protein 0.0107 0.1129 0.16
Brugia malayi M-phase phosphoprotein, mpp8 0.0112 0.1197 0.1696
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0019 0.0026
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0107 0.1129 0.1129
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0419 0.0949
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0083 0.025
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0052 0.0441 0.1042
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0343 0.0487
Loa Loa (eye worm) hypothetical protein 0.0107 0.1129 0.16
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0325 0.3887 0.6788
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0023 0.0064 0.0691
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0086 0.0261
Brugia malayi ecdysone receptor 0.0107 0.1129 0.16
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0019 0.0032
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0243 0.0831
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0044 0.0337 0.0478
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0014 0.0014
Echinococcus granulosus dna polymerase eta 0.0019 0.002 0.0035
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.1137 0.8822
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0705 0.0705
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0046
Schistosoma mansoni hypothetical protein 0.0036 0.023 0.0545
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0086 0.0086
Echinococcus granulosus lipoxygenase domain containing protein 0.0059 0.0523 0.0913
Brugia malayi Inositol-1 0.0037 0.0243 0.0344
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0227 0.2644 0.3746
Loa Loa (eye worm) hypothetical protein 0.0188 0.215 0.3045
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0019 0.0032
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0419 0.0949
Onchocerca volvulus Heterochromatin protein 1 homolog 0.005 0.0413 0.0717
Echinococcus multilocularis Polycystic kidney disease protein 0.0059 0.0523 0.0523
Schistosoma mansoni retinoic acid receptor RXR 0.0325 0.3887 0.9186
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0019 0.0026
Schistosoma mansoni retinoid-x-receptor (RXR) 0.012 0.1292 0.3053
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0064 0.0183
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.1364 0.2382
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0095 0.0214
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0536 0.0759
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0419 0.0991
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0227 0.2644 0.4617
Echinococcus multilocularis metabotropic glutamate receptor 5 0.006 0.0538 0.0538
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0405 0.0574
Schistosoma mansoni lipoxygenase 0.0228 0.2656 0.6276
Onchocerca volvulus 0.0236 0.2765 0.5129
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.1288 1
Brugia malayi Pre-SET motif family protein 0.0207 0.2401 0.3401
Echinococcus granulosus Ankyrin repeat domain containing protein 0.009 0.091 0.1589
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0019 0.0019
Brugia malayi photoreceptor-specific nuclear receptor 0.0227 0.2644 0.3746
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.1147 0.2596
Brugia malayi Thioredoxin reductase 0.0047 0.0373 0.0528
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.012 0.1292 0.1292
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0228 0.0777
Schistosoma mansoni zinc finger protein 0.002 0.0024 0.0056
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0243 0.055
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1147 0.4122
Schistosoma mansoni zinc finger protein 0.0107 0.1129 0.2669
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0107 0.1129 0.2669
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.002 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0228 0.0777
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0107 0.1129 0.1129
Trichomonas vaginalis chromobox protein, putative 0.0053 0.045 0.1587
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0147 0.1826
Echinococcus multilocularis lipoxygenase domain containing protein 0.0059 0.0523 0.0523
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0227 0.2644 0.6249
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.002 0.0046
Loa Loa (eye worm) hypothetical protein 0.0023 0.0064 0.0091
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0147 0.1826
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0147 0.0484
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0024 0.0035
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0243 0.0425
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0019 0.0044
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.1147 1
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0147 0.1175
Plasmodium vivax multidomain scavenger receptor, putative 0.0059 0.0523 0.6975
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0046
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0076 0.0743 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0243 0.0344
Echinococcus granulosus RUN 0.0059 0.0523 0.0913
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0019 0.0032
Loa Loa (eye worm) hypothetical protein 0.0107 0.1129 0.16
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.002 0.0046
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0228 0.0516
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0343 0.06
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0083 0.025
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0243 0.0243
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0243 0.0575
Brugia malayi Protein cec-1. 0.0023 0.0064 0.0091
Plasmodium vivax heterochromatin protein 1, putative 0.0023 0.0064 0.0691
Onchocerca volvulus 0.0107 0.1129 0.2061
Brugia malayi Nuclear hormone receptor-like 1 0.0357 0.4298 0.6088
Echinococcus multilocularis musashi 0.0027 0.0117 0.0117
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0046
Onchocerca volvulus 0.0031 0.0163 0.0247
Echinococcus multilocularis zinc finger protein 0.002 0.0024 0.0024
Brugia malayi hypothetical protein 0.012 0.1292 0.183
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.011 0.0156
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0024 0.0035
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0357 0.4298 0.6088
Echinococcus granulosus chromobox protein 2 0.0023 0.0064 0.0113
Loa Loa (eye worm) CYP4Cod1 0.0026 0.011 0.0156
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0019 0.0017
Chlamydia trachomatis endonuclease IV 0.0076 0.0743 1
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0019 0.0032
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0368 0.087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0198 0.067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0228 0.0777
Leishmania major hypothetical protein, conserved 0.0212 0.2459 0.5564
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.012 0.1292 0.2256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0228 0.0777
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0419 0.0949
Brugia malayi Nuclear hormone receptor-like 1 0.0357 0.4298 0.6088
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0198 0.2668
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0343 0.0487
Loa Loa (eye worm) hypothetical protein 0.0029 0.0144 0.0205
Echinococcus granulosus FTZ F1 alpha 0.0227 0.2644 0.4617
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.011 0.0156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0198 0.067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0228 0.0777
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0147 0.1826
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0126 0.0406
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0147 0.0484
Brugia malayi PHD-finger family protein 0.0025 0.0091 0.0129
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0343 0.2907
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.1147 0.2596
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0086 0.0666
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0107 0.1129 0.2669
Trypanosoma brucei unspecified product 0.0019 0.002 0.0046
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0064 0.0183
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0019 0.0019
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0064 0.0445
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0064 0.0691
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.1137 0.8822
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0014 0.0122
Schistosoma mansoni chromobox protein 0.0081 0.0799 0.1888
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0368 0.0643
Leishmania major hypothetical protein, conserved 0.0025 0.0095 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0413 0.1451
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0031 0.0241
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0227 0.2644 0.3746
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0086 0.0194
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.002 0.0157
Schistosoma mansoni survival motor neuron protein 0.0048 0.0385 0.091
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0609 0.144
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0385 0.0545
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0064 0.0183
Schistosoma mansoni hypothetical protein 0.0029 0.0144 0.0341
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0147 0.0484
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.1147 0.2003
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0024 0.0035
Loa Loa (eye worm) hypothetical protein 0.0441 0.5361 0.7595
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0227 0.2644 0.3746
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0243 0.0243
Echinococcus granulosus metabotropic glutamate receptor 2 0.0041 0.0295 0.0515
Brugia malayi Bromodomain containing protein 0.0031 0.0174 0.0247
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0024 0.0058
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0014 0.0109
Brugia malayi Heterochromatin protein 1 0.0081 0.0799 0.1132
Echinococcus granulosus neuropeptide s receptor 0.047 0.5727 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0144 0.1944
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0373 0.0373
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0064 0.0445
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0019 0.0026
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0147 0.3285
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0086 0.0194
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0144 0.1944
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0064 0.0183
Schistosoma mansoni hypothetical protein 0.0023 0.0064 0.0152
Brugia malayi PXA domain containing protein 0.0019 0.0019 0.0026
Brugia malayi Doublecortin family protein 0.0059 0.0523 0.074
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0024 0.0058
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.023 0.0401
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0227 0.2644 0.2644
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0014 0.0032
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0343 0.0777
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.2758 0.4816
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0231 0.2012
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0014 0.0032
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0231 0.0327
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.1147 0.2711
Entamoeba histolytica hypothetical protein 0.0036 0.023 0.191
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0064 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0343 0.1198
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0064 0.0183
Brugia malayi phosphofructokinase 0.0108 0.1147 0.1625
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0076 0.0743 0.5768
Onchocerca volvulus 0.0112 0.1197 0.2188
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0014 0.0032
Brugia malayi Pre-SET motif family protein 0.003 0.0153 0.0217
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0064 0.0183
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.1147 1
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0243 0.0424
Entamoeba histolytica hypothetical protein 0.0019 0.0019 0.004
Loa Loa (eye worm) hypothetical protein 0.0076 0.0743 0.1053
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0194 0.1504
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0243 0.055
Brugia malayi MAP kinase sur-1 0.0051 0.0419 0.0594
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0064 0.0183
Loa Loa (eye worm) hypothetical protein 0.0227 0.2644 0.3746
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0157 0.052
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.2758 0.2758
Echinococcus multilocularis chromobox protein 1 0.0081 0.0799 0.0799
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0227 0.2644 0.6249
Loa Loa (eye worm) hypothetical protein 0.0112 0.1199 0.1699
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0373 0.0844
Onchocerca volvulus 0.0048 0.0385 0.0664
Loa Loa (eye worm) hypothetical protein 0.0026 0.0111 0.0157
Schistosoma mansoni intermediate filament proteins 0.0027 0.0117 0.0276
Echinococcus granulosus Nuclear hormone receptor HR96 0.0107 0.1129 0.1972
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0064 0.0183
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0227 0.2644 0.4617
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.1137 0.8822
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0064 0.0183
Trypanosoma brucei hypothetical protein, conserved 0.0212 0.2459 0.5564
Schistosoma mansoni hypothetical protein 0.0048 0.0385 0.091
Echinococcus multilocularis lamin dm0 0.0027 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0345 0.4135 0.5859
Echinococcus granulosus thyroid hormone receptor alpha 0.0107 0.1129 0.1972
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0243 0.0831
Mycobacterium tuberculosis Conserved protein 0.0024 0.0086 0.0666
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0019 0.0044
Loa Loa (eye worm) hypothetical protein 0.0236 0.2758 0.3907
Schistosoma mansoni chromobox protein 0.0023 0.0064 0.0152
Loa Loa (eye worm) hypothetical protein 0.0107 0.1129 0.16
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0014 0.002
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0019 0.0044
Echinococcus multilocularis nuclear receptor nhr 48 0.0107 0.1129 0.1129
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0228 0.0516
Brugia malayi 6-phosphofructokinase 0.0108 0.1147 0.1625
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0609 0.0863
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0405 0.0574
Mycobacterium ulcerans hypothetical protein 0.0024 0.0086 0.0748
Echinococcus granulosus peregrin 0.0031 0.0174 0.0304
Loa Loa (eye worm) hypothetical protein 0.012 0.1292 0.183
Schistosoma mansoni ap endonuclease 0.0019 0.0014 0.0033
Brugia malayi steroid hormone receptor 0.0227 0.2644 0.3746
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0609 0.0609
Brugia malayi hypothetical protein 0.0019 0.0019 0.0026
Onchocerca volvulus 0.0059 0.0523 0.0922
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0117 0.0166
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0343 0.0777
Brugia malayi Nuclear hormone receptor E75 0.0107 0.1129 0.16
Echinococcus multilocularis neuropeptide receptor A26 0.047 0.5727 0.5727
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1147 0.4122
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0064 0.0867
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0107 0.1129 0.1972
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0227 0.2644 0.2644
Plasmodium falciparum phd finger protein, putative 0.0029 0.0144 0.1789
Schistosoma mansoni rab6-interacting 0.0059 0.0523 0.1235
Entamoeba histolytica hypothetical protein 0.0023 0.0064 0.0445
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0019 0.0026
Mycobacterium leprae conserved hypothetical protein 0.002 0.0031 0.0241
Leishmania major DNA polymerase kappa, putative 0.0019 0.002 0.0046
Loa Loa (eye worm) hypothetical protein 0.0047 0.0368 0.0522
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0227 0.2644 0.3746
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0095 0.1274
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.053 0.0925
Echinococcus granulosus intermediate filament protein 0.0027 0.0117 0.0204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0115 0.0369
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.053 0.053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0083 0.025
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.011 0.025
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0045 0.0102
Brugia malayi chromobox protein homolog 3 0.005 0.0413 0.0585
Loa Loa (eye worm) hypothetical protein 0.0227 0.2644 0.3746
Brugia malayi jmjC domain containing protein 0.0095 0.0981 0.1389
Loa Loa (eye worm) hypothetical protein 0.0059 0.0523 0.074
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.002 0.0029
Echinococcus multilocularis Chromo domain 0.0023 0.0064 0.0064
Trichomonas vaginalis chromobox protein, putative 0.0053 0.045 0.1587
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.1288 1
Loa Loa (eye worm) hypothetical protein 0.012 0.1292 0.183
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0243 0.0833
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0064 0.0691
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0064 0.0183
Loa Loa (eye worm) hypothetical protein 0.0025 0.0095 0.0134
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0026
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0419 0.0949
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.039 0.0922
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0981 0.1713
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0343 0.0777
Echinococcus granulosus lamin dm0 0.0027 0.0117 0.0204
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0609 0.1064
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0046
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0095 0.0214
Brugia malayi CHD4 protein 0.0025 0.0089 0.0125
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0419 0.0732
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.1147 0.1625
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0086 0.0748
Mycobacterium ulcerans epimerase 0.002 0.0031 0.0271
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0019 0.0019
Brugia malayi orphan nuclear receptor NR2E1 0.0107 0.1129 0.16
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.002 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0046
Schistosoma mansoni ap endonuclease 0.0019 0.0014 0.0033
Schistosoma mansoni lipoxygenase 0.0121 0.1314 0.3104
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0243 0.0549
Schistosoma mansoni hypothetical protein 0.0169 0.1913 0.4521
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0227 0.2644 0.3746
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0107 0.1129 0.16
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0086 0.0748
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0019 0.0044
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0095 0.1106
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0227 0.2644 0.4617
Loa Loa (eye worm) hypothetical protein 0.0107 0.1129 0.16
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.023 0.0402
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0368 0.087
Brugia malayi Cytochrome P450 family protein 0.0056 0.0481 0.0682
Giardia lamblia DINP protein human, muc B family 0.0019 0.002 0.0153
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.009 0.091 0.2151
Loa Loa (eye worm) glutamate receptor 0.0019 0.002 0.0029
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0259 0.0452
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0061 0.0107
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0107 0.1129 0.1129
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0117 0.0166
Loa Loa (eye worm) hypothetical protein 0.0107 0.1129 0.16
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0198 0.067
Brugia malayi hypothetical protein 0.0112 0.1199 0.1699
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0107 0.1129 0.2061
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0019 0.0044
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0076 0.0743 1
Loa Loa (eye worm) phosphofructokinase 0.0108 0.1147 0.1625
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0609 0.1378
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0419 0.1474
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0981 0.0981
Schistosoma mansoni thyroid hormone receptor 0.0352 0.4231 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0153 0.2062
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0405 0.0574
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0343 0.0777
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0019 0.0017
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0095 0.1106
Loa Loa (eye worm) doublecortin family protein 0.0059 0.0523 0.074
Echinococcus granulosus single minded 2 0.0036 0.0231 0.0403
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0228 0.2656 0.4638
Trichomonas vaginalis Heterochromatin protein, putative 0.0023 0.0064 0.0183
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0064 0.0183
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0419 0.0419
Echinococcus multilocularis expressed protein 0.0372 0.4483 0.4483
Loa Loa (eye worm) hypothetical protein 0.012 0.1292 0.183
Brugia malayi jmjC domain containing protein 0.0037 0.0246 0.0348
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0064 0.0183
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0243 0.0425
Loa Loa (eye worm) hypothetical protein 0.0034 0.0207 0.0293
Brugia malayi Cytochrome P450 family protein 0.0026 0.011 0.0156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0082 0.0249
Schistosoma mansoni rab6-interacting 0.0059 0.0523 0.1235
Trypanosoma cruzi hypothetical protein, conserved 0.0212 0.2459 0.5564
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0064 0.0183
Loa Loa (eye worm) hypothetical protein 0.0227 0.2644 0.3746
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0609 0.1378
Schistosoma mansoni bromodomain containing protein 0.0063 0.0575 0.1358
Echinococcus granulosus chromobox protein 1 0.0081 0.0799 0.1395
Loa Loa (eye worm) hypothetical protein 0.0107 0.1129 0.16
Loa Loa (eye worm) hypothetical protein 0.0227 0.2644 0.3746
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0227 0.2644 0.3746
Brugia malayi nuclear receptor NHR-67 0.0107 0.1129 0.16
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.002 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0227 0.2644 0.3746
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0373 0.0651
Echinococcus multilocularis dna polymerase kappa 0.0019 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0112 0.1197 0.1696
Schistosoma mansoni nuclear receptor nhr-48 0.0107 0.1129 0.2669
Echinococcus multilocularis Protein lozenge 0.0055 0.0477 0.0477
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0246 0.0348
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.002 0.0055
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0144 0.1789
Onchocerca volvulus 0.0052 0.0441 0.0769
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0019 0.0017
Entamoeba histolytica hypothetical protein 0.0036 0.023 0.191
Loa Loa (eye worm) hypothetical protein 0.0227 0.2644 0.3746
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0064 0.0183
Brugia malayi hypothetical protein 0.0441 0.5361 0.7595
Loa Loa (eye worm) hypothetical protein 0.005 0.0413 0.0585
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0126 0.0406
Mycobacterium tuberculosis Probable reductase 0.0108 0.1137 0.8822
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.1147 1
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0419 0.0732
Leishmania major trypanothione reductase 0.0047 0.0373 0.0844
Schistosoma mansoni metabotropic glutamate receptor 0.0024 0.0078 0.0185
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0733 0.1733
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0243 0.0549
Loa Loa (eye worm) hypothetical protein 0.0023 0.0064 0.0091
Loa Loa (eye worm) hypothetical protein 0.012 0.1292 0.183
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0019 0.0019
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0419 0.1474
Loa Loa (eye worm) steroid hormone receptor 0.0227 0.2644 0.3746
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0112 0.0357
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0019 0.0026
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0373 0.0528
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0227 0.2644 0.4617
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0243 0.0243
Onchocerca volvulus Alhambra homolog 0.0029 0.0144 0.0213
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0019 0.0044
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0228 0.0516
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0147 0.1175
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0061 0.0061
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0243 0.2114
Echinococcus granulosus neuropeptide receptor A26 0.047 0.5727 1
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0019 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0227 0.2644 0.3746
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0019 0.0032
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.002 0.0029
Schistosoma mansoni nuclear receptor 0.0107 0.1129 0.2669
Brugia malayi ecdysteroid receptor 0.0227 0.2644 0.3746
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.002 0.0046
Loa Loa (eye worm) hypothetical protein 0.0367 0.4419 0.626
Loa Loa (eye worm) DR-78 0.0107 0.1129 0.16
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.002 0.0046
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.1147 0.8904
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0227 0.2644 0.3746
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.002 0.0176
Onchocerca volvulus 0.0441 0.5361 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0246 0.0581
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0061 0.0144
Toxoplasma gondii exonuclease III APE 0.0019 0.0014 0.0189
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.1147 1
Schistosoma mansoni thyroid hormone receptor 0.0352 0.4231 1
Echinococcus multilocularis peregrin 0.0031 0.0174 0.0174
Schistosoma mansoni hypothetical protein 0.0034 0.0207 0.0488
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0046
Brugia malayi 6-phosphofructokinase 0.0108 0.1147 0.1625
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0243 0.0344
Loa Loa (eye worm) hypothetical protein 0.0023 0.0064 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0243 0.0833
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.002 0.0046
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0026
Schistosoma mansoni steroid hormone receptor ad4bp 0.0227 0.2644 0.6249
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0023 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0026
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0019 0.0026
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0024 0.0024
Brugia malayi nuclear receptor RXR 0.012 0.1292 0.183
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0227 0.2644 0.3746
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0227 0.2644 0.3746
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0609 0.1378
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0227 0.2644 0.3746
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0082 0.0249
Loa Loa (eye worm) hypothetical protein 0.0027 0.0117 0.0166
Brugia malayi nuclear hormone receptor 0.0107 0.1129 0.16
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0243 0.2022
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0026
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0194 0.1504
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0198 0.067
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.1147 0.1625
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0419 0.1474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0198 0.067
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1147 0.4122
Echinococcus multilocularis neuropeptide s receptor 0.047 0.5727 0.5727
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0082 0.0249
Schistosoma mansoni metabotropic glutamate receptor 0.0041 0.0295 0.0697
Loa Loa (eye worm) hypothetical protein 0.0227 0.2644 0.3746
Echinococcus multilocularis RUN 0.0059 0.0523 0.0523
Brugia malayi tailless protein 0.0107 0.1129 0.16
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0147 0.1826
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0343 0.0343
Brugia malayi hypothetical protein 0.0036 0.023 0.0327
Brugia malayi hypothetical protein 0.0236 0.2758 0.3907
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.1137 0.8822
Schistosoma mansoni lamin 0.0027 0.0117 0.0276
Echinococcus multilocularis geminin 0.0169 0.1913 0.1913
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0064 0.0183
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.002 0.0046
Schistosoma mansoni nuclear hormone receptor 0.0107 0.1129 0.2669
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0198 0.067
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0222 0.0222
Echinococcus multilocularis tumor protein p63 0.0337 0.4037 0.4037
Giardia lamblia GTOR 0.0045 0.0343 0.8129
Toxoplasma gondii endonuclease IV APN 0.0076 0.0743 1
Brugia malayi nuclear receptor RXR 0.0107 0.1129 0.16
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0609 0.0863
Loa Loa (eye worm) glutathione reductase 0.0047 0.0373 0.0528
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0343 0.2907
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0227 0.2644 0.3746
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0064 0.0183
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.1288 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0243 0.0831
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0205 0.2372 0.2372
Mycobacterium ulcerans hypothetical protein 0.0024 0.0086 0.0748
Loa Loa (eye worm) hypothetical protein 0.005 0.0405 0.0574
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0019 0.0044
Schistosoma mansoni chromobox protein 0.0023 0.0064 0.0152
Trichomonas vaginalis chromobox protein, putative 0.0081 0.0799 0.2855
Schistosoma mansoni hypothetical protein 0.0059 0.0523 0.1235
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0023 0.0064 0.0113
Brugia malayi hypoxia-induced factor 1 0.015 0.1675 0.2373
Echinococcus multilocularis Chromobox protein 3 0.0023 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0026
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.2401 0.3401
Trichomonas vaginalis set domain proteins, putative 0.0236 0.2763 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.023 0.0545
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0243 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0014 0.002
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0095 0.0214
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0419 0.0594
Schistosoma mansoni chromobox protein 0.0081 0.0799 0.1888
Entamoeba histolytica hypothetical protein 0.0019 0.0019 0.004
Trichomonas vaginalis chromobox protein, putative 0.0081 0.0799 0.2855
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0419 0.0949
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0115 0.0369
Brugia malayi hypothetical protein 0.0163 0.1834 0.2599
Brugia malayi small heat shock protein 0.0576 0.7059 1
Echinococcus granulosus nuclear receptor nhr 48 0.0107 0.1129 0.1972
Echinococcus granulosus jumonji domain containing protein 0.004 0.0288 0.0504
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.012 0.1292 0.3053
Echinococcus granulosus Polycystic kidney disease protein 0.0059 0.0523 0.0913
Leishmania major DNA polymerase eta, putative 0.0019 0.002 0.0046
Echinococcus granulosus chromobox protein 1 0.0081 0.0799 0.1395
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0053 0.045 0.0787
Brugia malayi hypothetical protein 0.0107 0.1129 0.16
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0019 0.0019
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0019 0.0026
Brugia malayi hypothetical protein 0.0059 0.0523 0.074
Echinococcus multilocularis FTZ F1 alpha 0.0227 0.2644 0.2644
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.1137 0.8822
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.1147 0.8904
Echinococcus granulosus lipoxygenase domain containing protein 0.0059 0.0523 0.0913
Onchocerca volvulus 0.0107 0.1129 0.2061
Loa Loa (eye worm) helicase 0.0023 0.0064 0.0091
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0243 0.0243
Brugia malayi Nuclear hormone receptor-like 1 0.0464 0.565 0.8005
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0609 0.1378
Echinococcus granulosus dna polymerase kappa 0.0019 0.002 0.0035
Echinococcus granulosus Chromo domain 0.0023 0.0064 0.0113
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0023 0.0064 0.0091
Schistosoma mansoni nuclear hormone receptor 0.0227 0.2644 0.6249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0261 0.0897
Loa Loa (eye worm) inositol-1 0.0037 0.0243 0.0344
Loa Loa (eye worm) hypothetical protein 0.006 0.0538 0.0763
Loa Loa (eye worm) hypothetical protein 0.0107 0.1129 0.16
Leishmania major C-8 sterol isomerase-like protein 0.0367 0.4419 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0227 0.2644 0.2644
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.023 0.023
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0064 0.0152
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0064 0.0152
Brugia malayi hypothetical protein 0.012 0.1292 0.183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0198 0.067
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0368 0.0368
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0705 0.1232
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0227 0.2644 0.6249
Echinococcus multilocularis dna polymerase eta 0.0019 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0163 0.1834 0.2599
Loa Loa (eye worm) hypothetical protein 0.0107 0.1129 0.16
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0107 0.1129 0.16
Brugia malayi hypothetical protein 0.0025 0.0095 0.0134
Echinococcus granulosus tumor protein p63 0.0337 0.4037 0.7049
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0019 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0064 0.0183
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0031 0.0271
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0413 0.1451
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0024 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0115 0.0369
Schistosoma mansoni nuclear hormone receptor 0.0107 0.1129 0.2669
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0227 0.2644 0.2644
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0147 0.198
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0086 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0343 0.1198
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0019 0.0032
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0107 0.1129 0.2061
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.011 0.0963
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.1147 0.2596
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0227 0.2644 0.6249
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0064 0.0152
Trypanosoma brucei protein kinase, putative 0.0051 0.0419 0.0949
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0026
Brugia malayi nuclear hormone receptor family member odr-7 0.0107 0.1129 0.16
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0064 0.0867
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.009 0.091 0.091
Loa Loa (eye worm) runx1 0.0055 0.0477 0.0676
Loa Loa (eye worm) hypothetical protein 0.0227 0.2644 0.3746
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0243 0.5653
Schistosoma mansoni inositol monophosphatase 0.0037 0.0243 0.0573
Onchocerca volvulus 0.0227 0.2644 0.4903
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0609 0.5251
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0227 0.2644 0.4617
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0019 0.0032
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0373 0.4923
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0227 0.2644 0.2644
Brugia malayi Bromodomain containing protein 0.0075 0.0722 0.1023
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0227 0.2644 0.4903
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0014 0.0032
Schistosoma mansoni hypothetical protein 0.0021 0.0037 0.0088
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0019 0.0019
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0147 0.0484
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0246 0.0429
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0095 0.1106
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0076 0.0743 0.5768
Loa Loa (eye worm) hypothetical protein 0.0038 0.0261 0.0369
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0419 0.0419
Trypanosoma brucei trypanothione reductase 0.0047 0.0373 0.0844
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0419 1
Brugia malayi Associated with TFs and helicases family protein 0.0023 0.0064 0.0091
Loa Loa (eye worm) hypothetical protein 0.012 0.1292 0.183
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0086 0.0194
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0419 0.0949
Schistosoma mansoni coup transcription factor 0.0227 0.2644 0.6249
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0153 0.0153
Schistosoma mansoni polycystin 1-related 0.0059 0.0523 0.1235
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0343 0.1198
Brugia malayi intermediate filament protein 0.0027 0.0117 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0064 0.0183
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0227 0.2644 0.2644
Loa Loa (eye worm) hypothetical protein 0.0107 0.1129 0.16
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.1147 0.1147
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0227 0.2644 0.3746
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0227 0.2644 0.3746
Loa Loa (eye worm) hypothetical protein 0.0059 0.0523 0.074
Loa Loa (eye worm) hypothetical protein 0.0031 0.0163 0.0231
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0147 0.198
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0046
Brugia malayi nuclear hormone receptor family member nhr-6 0.0107 0.1129 0.16
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0243 0.0575
Echinococcus granulosus Chromobox protein 3 0.0023 0.0064 0.0113
Mycobacterium ulcerans endonuclease IV 0.0076 0.0743 0.6478
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0288 0.0288
Onchocerca volvulus Bile acid receptor homolog 0.0227 0.2644 0.4903
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0064 0.0183
Brugia malayi Valyl-tRNA synthetase 0.0023 0.0064 0.0091
Mycobacterium ulcerans hypothetical protein 0.002 0.0031 0.0271
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.04 0.0946
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0046
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0481 0.0682
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0046
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.009 0.091 0.2151
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0419 0.5642
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0029
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0064 0.0183
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.011 0.025
Schistosoma mansoni single-minded 0.0048 0.039 0.0922
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0145 0.0475
Loa Loa (eye worm) hypothetical protein 0.007 0.0669 0.0947
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0117 0.0166
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0076 0.0743 0.1053
Echinococcus granulosus zinc finger protein 0.002 0.0024 0.0041
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0243 0.0425
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0023 0.0064 0.0867
Onchocerca volvulus 0.0112 0.1197 0.2188
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.002 0.0046
Loa Loa (eye worm) glutamate receptor 0.0049 0.0395 0.056
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0243 0.0833
Trypanosoma brucei C-8 sterol isomerase, putative 0.0367 0.4419 1
Echinococcus multilocularis lamin 0.0027 0.0117 0.0117
Echinococcus granulosus expressed protein 0.0372 0.4483 0.7828
Loa Loa (eye worm) nuclear hormone receptor 0.0107 0.1129 0.16
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.1147 1
Echinococcus multilocularis chromobox protein 1 0.0081 0.0799 0.0799
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0064 0.0445
Brugia malayi nuclear hormone receptor 0.0227 0.2644 0.3746
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0147 0.0484
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0019 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0064 0.0183
Trypanosoma cruzi hypothetical protein, conserved 0.0212 0.2459 0.5564
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0243 0.055
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0086 0.0748
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0064 0.0691
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0367 0.4419 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.1137 0.8822
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0046
Loa Loa (eye worm) hypothetical protein 0.0041 0.0291 0.0412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0112 0.0357
Echinococcus multilocularis ecdysone induced protein 78C 0.0227 0.2644 0.2644
Onchocerca volvulus 0.0059 0.0523 0.0922
Brugia malayi PAS domain containing protein 0.0048 0.039 0.0553
Entamoeba histolytica hypothetical protein 0.0036 0.023 0.191
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0031 0.0044
Brugia malayi PHD-finger family protein 0.0029 0.0144 0.0205
Loa Loa (eye worm) hypothetical protein 0.005 0.0407 0.0577
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0147 0.0484
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0227 0.2644 0.3746
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0227 0.2644 0.6249
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0025 0.0089 0.0209
Loa Loa (eye worm) hypothetical protein 0.0107 0.1129 0.16
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0064 0.0183
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0227 0.2644 0.3746
Echinococcus granulosus lamin 0.0027 0.0117 0.0204
Loa Loa (eye worm) heterochromatin protein 1 0.0081 0.0799 0.1132
Plasmodium vivax glutathione reductase, putative 0.0047 0.0373 0.4923
Entamoeba histolytica hypothetical protein 0.0036 0.023 0.191
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.002 0.0023
Echinococcus granulosus Nuclear hormone receptor HR96 0.0107 0.1129 0.1972
Echinococcus granulosus geminin 0.0169 0.1913 0.3341
Brugia malayi PXA domain containing protein 0.0019 0.0019 0.0026
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1147 0.4122
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0144 0.0205
Brugia malayi metabotropic glutamate receptor type 2 0.0024 0.0078 0.0111
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.023 0.023
Plasmodium vivax SET domain protein, putative 0.003 0.0153 0.191
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0019 0.0017
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0019 0.0026
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0419 0.1474
Brugia malayi nuclear receptor NHR-88 0.0107 0.1129 0.16
Loa Loa (eye worm) CHromoDomain protein family member 0.0025 0.0089 0.0125
Schistosoma mansoni RAR-like nuclear receptor 0.0227 0.2644 0.6249
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0107 0.1129 0.1129
Loa Loa (eye worm) hypothetical protein 0.0049 0.04 0.0567
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0373 0.2895
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0153 0.0362
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0228 0.2656 0.2656
Schistosoma mansoni lozenge 0.0055 0.0477 0.1128
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0419 0.0949
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0019 0.0017
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0343 0.0777
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.002 0.0157
Schistosoma mansoni lamin 0.0027 0.0117 0.0276
Loa Loa (eye worm) hypoxia-induced factor 1 0.015 0.1675 0.2373
Loa Loa (eye worm) nuclear receptor NHR-67 0.0107 0.1129 0.16
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0227 0.2644 0.6249
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0207 0.0293
Loa Loa (eye worm) hypothetical protein 0.0576 0.7059 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0243 0.2017
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.002 0.0029
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0246 0.0581
Onchocerca volvulus 0.0036 0.0231 0.0375
Plasmodium falciparum thioredoxin reductase 0.0047 0.0373 0.4923
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0147 0.198
Loa Loa (eye worm) hypothetical protein 0.0043 0.0315 0.0446
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0083 0.025
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0144 0.0341
Brugia malayi Metabotropic glutamate receptor precursor. 0.0049 0.0395 0.056
Loa Loa (eye worm) hypothetical protein 0.0023 0.0064 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0227 0.2644 0.3746
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0367 0.4419 0.626
Plasmodium falciparum glutathione reductase 0.0047 0.0373 0.4923
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0025 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0023 0.0064 0.0091
Echinococcus granulosus ecdysone induced protein 78C 0.0227 0.2644 0.4617
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0227 0.2644 0.4617
Brugia malayi glutathione reductase 0.0047 0.0373 0.0528
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.002 0.0176
Brugia malayi SET domain containing protein 0.0024 0.0078 0.0111
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0056 0.048 0.1135
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.002 0.002
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0014 0.0024
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.002 0.0048
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0259 0.0259
Brugia malayi hypothetical protein 0.0107 0.1129 0.16
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0019 0.0044
Giardia lamblia PHD finger protein 15 0.0029 0.0144 0.3219
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0024 0.0058
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0041 0.0295 0.0295
Trichomonas vaginalis hypothetical protein 0.0023 0.0064 0.0183
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.002 0.0046
Onchocerca volvulus 0.0049 0.04 0.0693
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.002 0.0046
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0343 0.0812
Leishmania major cytochrome p450-like protein 0.0026 0.011 0.025
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0139 0.0243
Entamoeba histolytica hypothetical protein 0.0019 0.0019 0.004
Onchocerca volvulus 0.0027 0.0117 0.0161
Plasmodium falciparum LCCL domain-containing protein 0.0059 0.0523 0.6975
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0243 0.0549
Brugia malayi nuclear receptor NHR-88 0.0227 0.2644 0.3746
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0019 0.0044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0107 0.1129 0.1972
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0019 0.0019
Entamoeba histolytica hypothetical protein 0.0023 0.0064 0.0445
Echinococcus multilocularis thyroid hormone receptor alpha 0.0352 0.4231 0.4231
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.1364 0.1364
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0037 0.0052
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0144 0.0144
Onchocerca volvulus 0.0027 0.0117 0.0161
Loa Loa (eye worm) hypothetical protein 0.0441 0.5361 0.7595
Brugia malayi Bromodomain containing protein 0.0038 0.026 0.0368
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0012 0.0028
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0019 0.0032
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0343 0.0777
Schistosoma mansoni DNA polymerase eta 0.0019 0.002 0.0048
Brugia malayi Cytochrome P450 family protein 0.0026 0.011 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0227 0.2644 0.3746
Toxoplasma gondii thioredoxin reductase 0.0047 0.0373 0.5019
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0019 0.0019
Schistosoma mansoni nuclear receptor 0.0107 0.1129 0.2669
Echinococcus multilocularis lipoxygenase domain containing protein 0.0059 0.0523 0.0523
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.002 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0064 0.0183
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0243 0.3264
Brugia malayi hypothetical protein 0.0059 0.0523 0.074
Brugia malayi Nuclear hormone receptor E75 0.0107 0.1129 0.16
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0243 0.055
Plasmodium falciparum heterochromatin protein 1 0.0023 0.0064 0.0691
Schistosoma mansoni inositol monophosphatase 0.0037 0.0243 0.0573
Entamoeba histolytica hypothetical protein 0.0023 0.0064 0.0445
Echinococcus granulosus metabotropic glutamate receptor 5 0.006 0.0538 0.094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0227 0.2644 0.3746
Brugia malayi hypothetical protein 0.0019 0.0019 0.0026
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0044
Schistosoma mansoni hypothetical protein 0.0169 0.1913 0.4521
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0025 0.0089 0.0155
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0107 0.1129 0.16
Schistosoma mansoni hypothetical protein 0.0125 0.1364 0.3224
Echinococcus multilocularis chromobox protein 2 0.0023 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0107 0.1129 0.16
Onchocerca volvulus Protein ultraspiracle homolog 0.0227 0.2644 0.4903
Trypanosoma brucei cytochrome P450, putative 0.0026 0.011 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0064 0.0183
Loa Loa (eye worm) hypothetical protein 0.0227 0.2644 0.3746
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.1147 0.2711
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0019 0.0017
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.1288 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0147 0.0484
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0144 0.0252
Schistosoma mansoni loxhd1 0.0059 0.0523 0.1235
Brugia malayi Steroid receptor seven-up type 2 0.0227 0.2644 0.3746
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0243 0.0549

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.4 nM Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay ChEMBL. 17590335
IC50 (binding) = 2.4 nM Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assay ChEMBL. 17590335

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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