Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Bile acid receptor homolog | 0.0126 | 0.4968 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0036 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | 0.021 | 0.9653 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0036 | 0 | 0.5 |
Mycobacterium ulcerans | epoxide hydrolase EphA | 0.021 | 0.9653 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.0126 | 0.4968 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.4968 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0036 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 5.63 nmol | Effect on lipid peroxidation in rat gastric mucosa assessed as malondialdehyde level per 100 mg of tissue | ChEMBL. | 17576062 |
Inhibition (functional) | = 37.2 % | Analgesic activity in po dosed rat | ChEMBL. | 17576062 |
Inhibition (functional) | = 68.93 % | Antiinflammatory activity against carrageenan-induced paw edema in po dosed rat after 4 hrs | ChEMBL. | 17576062 |
UI (ADMET) | = 0.75 | Toxicity assessed as ulcerogenic activity in po dosed rat | ChEMBL. | 17576062 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.