Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0848 | 0.1393 | 0.4558 |
Onchocerca volvulus | 0.0143 | 0 | 0.5 | |
Schistosoma mansoni | thyroid hormone receptor | 0.0991 | 0.1675 | 1 |
Onchocerca volvulus | 0.0143 | 0 | 0.5 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0848 | 0.1393 | 0.1393 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.1755 | 0.3183 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0848 | 0.1393 | 0.4375 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.169 | 0.3055 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1683 | 0.304 | 0.995 |
Schistosoma mansoni | hypothetical protein | 0.0854 | 0.1404 | 0.8383 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0143 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0848 | 0.1393 | 0.1393 |
Loa Loa (eye worm) | hypothetical protein | 0.0848 | 0.1393 | 0.4558 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0991 | 0.1675 | 0.1675 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0848 | 0.1393 | 0.8315 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0602 | 0.0906 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0854 | 0.1404 | 0.1404 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.056 | 0.0822 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.5207 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0848 | 0.1393 | 0.4558 |
Schistosoma mansoni | thyroid hormone receptor | 0.0991 | 0.1675 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.169 | 0.3055 | 0.9599 |
Echinococcus granulosus | acetylcholinesterase | 0.0848 | 0.1393 | 0.1393 |
Echinococcus multilocularis | acetylcholinesterase | 0.0848 | 0.1393 | 0.1393 |
Onchocerca volvulus | 0.0143 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0848 | 0.1393 | 0.1393 |
Onchocerca volvulus | 0.0143 | 0 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0143 | 0 | 0.5 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0854 | 0.1404 | 0.1404 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0848 | 0.1393 | 0.4558 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.169 | 0.3055 | 0.9599 |
Onchocerca volvulus | 0.0143 | 0 | 0.5 | |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0602 | 0.0906 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0848 | 0.1393 | 0.4375 |
Echinococcus granulosus | acetylcholinesterase | 0.0848 | 0.1393 | 0.1393 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | 0 | Neurotoxicity in Swiss Albino mouse at 30 mg/kg after 0.5 hrs by rotorod test | ChEMBL. | 17572089 |
Activity (ADMET) | 0 | Neurotoxicity in Swiss Albino mouse at 30 mg/kg after 4 hrs by rotorod test | ChEMBL. | 17572089 |
Activity (functional) | = 83.3 % | Anticonvulsant activity in Swiss Albino mouse at 30 mg/kg after 0.5 hrs by MES screen test | ChEMBL. | 17572089 |
Activity (functional) | = 83.3 % | Anticonvulsant activity in swiss Albino mouse at 30 mg/kg after 4 hrs by MES screen test | ChEMBL. | 17572089 |
Activity (functional) | = 83.3 % | Anticonvulsant activity in Swiss Albino mouse at 30 mg/kg after 0.5 hrs by MES screen test | ChEMBL. | 17572089 |
Activity (functional) | = 83.3 % | Anticonvulsant activity in swiss Albino mouse at 30 mg/kg after 4 hrs by MES screen test | ChEMBL. | 17572089 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.