TDR Targets

Basic information

Technical information

TDR Targets ID: 442985
Name: (3aS,9R,9aR)-9-[(E)-2-[5-[3-(trifluoromethyl) phenyl]pyridin-2-yl]ethenyl]-3a,4,9,9a-tetrah ydro-1H-benzo[f][2]benzofuran-3-one
MW: 435.438 | Formula: C26H20F3NO2
H donors: 0 H acceptors: 2 LogP: 5.68 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C1OC[C@H]2[C@@H]1Cc1ccccc1[C@@H]2/C=C/c1ccc(cn1)c1cccc(c1)C(F)(F)F
InChi: 1S/C26H20F3NO2/c27-26(28,29)19-6-3-5-16(12-19)18-8-9-20(30-14-18)10-11-22-21-7-2-1-4-17(21)13-23-24(22)15-32-25(23)31/h1-12,14,22-24H,13,15H2/b11-10+/t22-,23-,24+/m0/s1
InChiKey: PBRFZUOCABCOOY-DJJNJRNKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(3aS,9R,9aR)-9-[(E)-2-[5-[3-(trifluoromethyl)phenyl]-2-pyridyl]vinyl]-3a,4,9,9a-tetrahydro-1H-benzo[f]isobenzofuran-3-one
(3aS,9R,9aR)-9-[(E)-2-[5-[3-(trifluoromethyl)phenyl]pyridin-2-yl]ethenyl]-3a,4,9,9a-tetrahydro-1H-naphtho[3,2-c]furan-3-one

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	coagulation factor II (thrombin) receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0658	1	1
Schistosoma mansoni	hypothetical protein	0.0059	0.0566	0.0986
Brugia malayi	RNA, U transporter 1	0.0086	0.0989	0.0989
Onchocerca volvulus	Slit protein homolog	0.0059	0.0566	0.2256
Schistosoma mansoni	hypothetical protein	0.0322	0.4708	1
Onchocerca volvulus		0.0059	0.0566	0.2256
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0137	0.1789	1
Mycobacterium ulcerans	endonuclease IV	0.0087	0.1013	0.638
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0054	0.0487	0.272
Echinococcus multilocularis	neurogenic locus notch protein	0.0059	0.0566	0.0986
Onchocerca volvulus		0.0059	0.0566	0.2256
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0566	0.0566
Echinococcus granulosus	protein jagged 1	0.0059	0.0566	0.0986
Entamoeba histolytica	phosphofructokinase, putative	0.0124	0.1588	1
Brugia malayi	notch-like transmembrane receptor	0.0059	0.0566	0.0566
Mycobacterium tuberculosis	Probable reductase	0.0123	0.1573	0.8793
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1013	0.1013
Loa Loa (eye worm)	hypothetical protein	0.0182	0.251	0.251
Brugia malayi	Animal haem peroxidase family protein	0.0182	0.251	0.251
Loa Loa (eye worm)	hypothetical protein	0.0182	0.251	0.251
Echinococcus multilocularis	protein jagged 2	0.0059	0.0566	0.0986
Loa Loa (eye worm)	hypothetical protein	0.0182	0.251	0.251
Leishmania major	trypanothione reductase	0.0054	0.0487	0.296
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0059	0.0566	0.2256
Plasmodium vivax	thioredoxin reductase, putative	0.0054	0.0487	0.4148
Trichomonas vaginalis	phosphofructokinase, putative	0.0124	0.1588	1
Schistosoma mansoni	notch	0.0059	0.0566	0.0986
Toxoplasma gondii	6-phosphofructokinase	0.0033	0.0165	0.0577
Plasmodium vivax	glutathione reductase, putative	0.0054	0.0487	0.4148
Echinococcus granulosus	thioredoxin glutathione reductase	0.0054	0.0487	0.0813
Schistosoma mansoni	hypothetical protein	0.0059	0.0566	0.0986
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0033	0.0165	0.0906
Mycobacterium tuberculosis	Probable oxidoreductase	0.0137	0.1789	1
Brugia malayi	EGF-like domain containing protein	0.0059	0.0566	0.0566
Onchocerca volvulus		0.0182	0.251	1
Loa Loa (eye worm)	animal heme peroxidase	0.0182	0.251	0.251
Onchocerca volvulus	Peroxidase homolog	0.0182	0.251	1
Schistosoma mansoni	laminin gamma-3 chain	0.0059	0.0566	0.0986
Echinococcus granulosus	slit 2 protein	0.0059	0.0566	0.0986
Loa Loa (eye worm)	glutathione reductase	0.0054	0.0487	0.0487
Brugia malayi	Peroxidasin	0.0182	0.251	0.251
Echinococcus multilocularis	protein jagged 1	0.0059	0.0566	0.0986
Plasmodium falciparum	glutathione reductase	0.0054	0.0487	0.4148
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0123	0.1573	0.8793
Schistosoma mansoni	septate junction protein	0.0059	0.0566	0.0986
Loa Loa (eye worm)	hypothetical protein	0.0182	0.251	0.251
Echinococcus granulosus	protein jagged 2	0.0059	0.0566	0.0986
Schistosoma mansoni	6-phosphofructokinase	0.0124	0.1588	0.321
Loa Loa (eye worm)	hypothetical protein	0.0361	0.5329	0.5329
Plasmodium falciparum	thioredoxin reductase	0.0054	0.0487	0.4148
Mycobacterium tuberculosis	Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase)	0.0087	0.1013	0.5664
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0566	0.0566
Echinococcus multilocularis	neural cadherin	0.0059	0.0566	0.0986
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0566	0.0566
Brugia malayi	Cadherin domain containing protein	0.0059	0.0566	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0566	0.0566
Plasmodium vivax	6-phosphofructokinase, putative	0.0033	0.0165	0.0577
Schistosoma mansoni	peroxidasin	0.0182	0.251	0.5216
Brugia malayi	Importin beta-1 subunit	0.003	0.0113	0.0113
Schistosoma mansoni	notch	0.0059	0.0566	0.0986
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0033	0.0165	0.0577
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0566	0.0566
Brugia malayi	Thioredoxin reductase	0.0054	0.0487	0.0487
Schistosoma mansoni	notch	0.0059	0.0566	0.0986
Onchocerca volvulus		0.0059	0.0566	0.2256
Mycobacterium ulcerans	6-phosphofructokinase	0.0124	0.1588	1
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0124	0.1588	1
Loa Loa (eye worm)	hypothetical protein	0.0182	0.251	0.251
Brugia malayi	EGF-like domain containing protein	0.0059	0.0566	0.0566
Brugia malayi	Calcium binding EGF domain containing protein	0.0059	0.0566	0.0566
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0124	0.1588	0.8877
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0566	0.0566
Echinococcus multilocularis	neurogenic locus protein delta	0.0059	0.0566	0.0986
Leishmania major	ATP-dependent phosphofructokinase	0.0124	0.1588	1
Echinococcus granulosus	notch	0.0059	0.0566	0.0986
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0566	0.0566
Brugia malayi	Delta serrate ligand family protein	0.0059	0.0566	0.0566
Loa Loa (eye worm)	6-phosphofructokinase	0.0124	0.1588	0.1588
Loa Loa (eye worm)	hypothetical protein	0.014	0.1836	0.1836
Toxoplasma gondii	endonuclease IV APN	0.0087	0.1013	1
Loa Loa (eye worm)	phosphofructokinase	0.0124	0.1588	0.1588
Echinococcus multilocularis	protein jagged 1	0.0059	0.0566	0.0986
Loa Loa (eye worm)	animal heme peroxidase	0.0182	0.251	0.251
Schistosoma mansoni	peroxidasin	0.0182	0.251	0.5216
Loa Loa (eye worm)	6-phosphofructokinase	0.0124	0.1588	0.1588
Echinococcus granulosus	protein jagged 1	0.0059	0.0566	0.0986
Trypanosoma cruzi	trypanothione reductase, putative	0.0054	0.0487	0.296
Toxoplasma gondii	phosphofructokinase PFKII	0.0033	0.0165	0.0577
Trichomonas vaginalis	phosphofructokinase, putative	0.0033	0.0165	0.0906
Brugia malayi	Animal haem peroxidase family protein	0.0182	0.251	0.251
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0054	0.0487	0.0813
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0566	0.0566
Brugia malayi	Calcium binding EGF domain containing protein	0.0059	0.0566	0.0566
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0322	0.4708	0.4708
Echinococcus granulosus	neural cadherin	0.0059	0.0566	0.0986
Brugia malayi	hypothetical protein	0.0182	0.251	0.251
Brugia malayi	GCC2 and GCC3 family protein	0.0059	0.0566	0.0566
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0033	0.0165	0.0577
Echinococcus multilocularis	notch	0.0059	0.0566	0.0986
Loa Loa (eye worm)	hypothetical protein	0.0182	0.251	0.251
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0123	0.1573	0.8793
Brugia malayi	hypothetical protein	0.0139	0.1822	0.1822
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0566	0.0566
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0124	0.1588	1
Brugia malayi	Cadherin domain containing protein	0.0059	0.0566	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0182	0.251	0.251
Trichomonas vaginalis	phosphofructokinase, putative	0.0124	0.1588	1
Giardia lamblia	High cysteine protein	0.0059	0.0566	1
Schistosoma mansoni	hypothetical protein	0.0059	0.0566	0.0986
Trypanosoma brucei	trypanothione reductase	0.0054	0.0487	0.2531
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0566	0.0566
Plasmodium vivax	apurinic/apyrimidinic endonuclease Apn1, putative	0.0087	0.1013	1
Schistosoma mansoni	hypothetical protein	0.0059	0.0566	0.0986
Loa Loa (eye worm)	animal heme peroxidase	0.0182	0.251	0.251
Trichomonas vaginalis	phosphofructokinase, putative	0.0033	0.0165	0.0906
Brugia malayi	Muscle positioning protein 4	0.0059	0.0566	0.0566
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0033	0.0165	0.0577
Echinococcus multilocularis	snurportin 1	0.0322	0.4708	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0033	0.0165	0.0906
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0123	0.1573	0.8793
Toxoplasma gondii	EGF family domain-containing protein	0.0059	0.0566	0.5031
Onchocerca volvulus	Putative cubilin	0.0059	0.0566	0.2256
Loa Loa (eye worm)	Notch2	0.0059	0.0566	0.0566
Onchocerca volvulus		0.0059	0.0566	0.2256
Brugia malayi	Animal haem peroxidase family protein	0.0182	0.251	0.251
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0566	0.0566
Plasmodium falciparum	apurinic/apyrimidinic endonuclease Apn1, putative	0.0087	0.1013	1
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0033	0.0165	0.0906
Trichomonas vaginalis	phosphofructokinase, putative	0.0033	0.0165	0.0906
Chlamydia trachomatis	endonuclease IV	0.0087	0.1013	1
Toxoplasma gondii	thioredoxin reductase	0.0054	0.0487	0.4148
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0566	0.0566
Brugia malayi	EGF-like domain containing protein	0.0059	0.0566	0.0566
Onchocerca volvulus	Peroxidasin homolog	0.0182	0.251	1
Brugia malayi	Blistered cuticle protein 3	0.0182	0.251	0.251
Echinococcus granulosus	neurogenic locus notch protein 4	0.0059	0.0566	0.0986
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0566	0.0566
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0137	0.1789	1
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0124	0.1588	0.8877
Onchocerca volvulus	Neurogenic locus notch homolog	0.0059	0.0566	0.2256
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0059	0.0566	0.0566
Mycobacterium tuberculosis	Probable dehydrogenase	0.0123	0.1573	0.8793
Loa Loa (eye worm)	hypothetical protein	0.0182	0.251	0.251
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0566	0.0566
Brugia malayi	Calcium binding EGF domain containing protein	0.0059	0.0566	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0182	0.251	0.251
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0059	0.0566	0.0986
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0059	0.0566	0.0986
Onchocerca volvulus	Chorion peroxidase homolog	0.0182	0.251	1
Echinococcus granulosus	delta-like protein 1	0.0059	0.0566	0.0986
Brugia malayi	hypothetical protein	0.014	0.1836	0.1836
Loa Loa (eye worm)	blistered cuticle protein 3	0.0182	0.251	0.251
Onchocerca volvulus	Peroxidase homolog	0.0182	0.251	1
Mycobacterium leprae	PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE)	0.0087	0.1013	0.5664
Loa Loa (eye worm)	notch protein	0.0059	0.0566	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0566	0.0566
Schistosoma mansoni	6-phosphofructokinase	0.0124	0.1588	0.321
Brugia malayi	EGF-like domain containing protein	0.0059	0.0566	0.0566
Plasmodium vivax	6-phosphofructokinase, putative	0.0033	0.0165	0.0577
Brugia malayi	Animal haem peroxidase family protein	0.0182	0.251	0.251
Loa Loa (eye worm)	hypothetical protein	0.0182	0.251	0.251
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0124	0.1588	1
Onchocerca volvulus		0.0059	0.0566	0.2256
Loa Loa (eye worm)	animal heme peroxidase	0.0182	0.251	0.251
Schistosoma mansoni	slit	0.0059	0.0566	0.0986
Echinococcus granulosus	neurogenic locus notch protein	0.0059	0.0566	0.0986
Schistosoma mansoni	hypothetical protein	0.0059	0.0566	0.0986
Echinococcus granulosus	neurogenic locus notch protein	0.0059	0.0566	0.0986
Echinococcus granulosus	fibropellin Ia	0.0059	0.0566	0.0986
Echinococcus granulosus	peroxidasin	0.0182	0.251	0.5216
Brugia malayi	phosphofructokinase	0.0124	0.1588	0.1588
Echinococcus multilocularis	6 phosphofructokinase	0.0124	0.1588	0.321
Brugia malayi	EGF-like domain containing protein	0.0059	0.0566	0.0566
Echinococcus granulosus	snurportin 1	0.0322	0.4708	1
Echinococcus multilocularis	peroxidasin	0.0182	0.251	0.5216
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0059	0.0566	0.0986
Brugia malayi	6-phosphofructokinase	0.0124	0.1588	0.1588
Loa Loa (eye worm)	hypothetical protein	0.0182	0.251	0.251
Schistosoma mansoni	hypothetical protein	0.0059	0.0566	0.0986
Brugia malayi	6-phosphofructokinase	0.0124	0.1588	0.1588
Echinococcus granulosus	protein jagged 2	0.0059	0.0566	0.0986
Loa Loa (eye worm)	hypothetical protein	0.0182	0.251	0.251
Trichomonas vaginalis	phosphofructokinase, putative	0.0124	0.1588	1
Entamoeba histolytica	phosphofructokinase, putative	0.0124	0.1588	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0113	0.0113
Schistosoma mansoni	notch	0.0059	0.0566	0.0986
Loa Loa (eye worm)	hypothetical protein	0.0182	0.251	0.251
Echinococcus granulosus	neurogenic locus protein delta	0.0059	0.0566	0.0986
Schistosoma mansoni	cell polarity protein	0.0059	0.0566	0.0986
Onchocerca volvulus	Peroxidasin homolog	0.0182	0.251	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0566	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0566	0.0566
Brugia malayi	EGF-like domain containing protein	0.0059	0.0566	0.0566
Onchocerca volvulus		0.0182	0.251	1
Loa Loa (eye worm)	thioredoxin reductase	0.0054	0.0487	0.0487
Trichomonas vaginalis	phosphofructokinase, putative	0.0124	0.1588	1
Brugia malayi	EGF-like domain containing protein	0.0059	0.0566	0.0566
Loa Loa (eye worm)	hypothetical protein	0.014	0.1836	0.1836
Onchocerca volvulus		0.0182	0.251	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0566	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0566	0.0566
Schistosoma mansoni	notch	0.0059	0.0566	0.0986
Echinococcus granulosus	6 phosphofructokinase	0.0124	0.1588	0.321
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0123	0.1573	0.8793
Brugia malayi	DNA-(Apurinic or apyrimidinic site) lyase	0.0087	0.1013	0.1013
Echinococcus multilocularis	neurogenic locus notch protein	0.0059	0.0566	0.0986
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0566	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0182	0.251	0.251
Onchocerca volvulus	Huntingtin homolog	0.014	0.1836	0.7315
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0123	0.1573	0.8793
Trichomonas vaginalis	phosphofructokinase, putative	0.0033	0.0165	0.0906
Entamoeba histolytica	phosphofructokinase, putative	0.0124	0.1588	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0566	0.0566
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0137	0.1789	1
Echinococcus multilocularis	fibropellin Ia	0.0059	0.0566	0.0986
Onchocerca volvulus	Dual oxidase homolog	0.0182	0.251	1
Schistosoma mansoni	hypothetical protein	0.0059	0.0566	0.0986
Echinococcus multilocularis	neurogenic locus protein delta	0.0059	0.0566	0.0986
Trichomonas vaginalis	phosphofructokinase, putative	0.0033	0.0165	0.0906
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0566	0.0566
Brugia malayi	glutathione reductase	0.0054	0.0487	0.0487
Schistosoma mansoni	notch	0.0059	0.0566	0.0986
Echinococcus multilocularis	slit 2 protein	0.0059	0.0566	0.0986
Onchocerca volvulus	Huntingtin homolog	0.014	0.1836	0.7315
Brugia malayi	Animal haem peroxidase family protein	0.0182	0.251	0.251

Activities

Activity type	Activity value	Assay description	Source	Reference
AUC (ADMET)	< 300 ng.hr/ml	AUC in cynomolgus monkey at 3 mg/kg, po	ChEMBL.	17490877
IC50 (binding)	= 10 nM	Displacement of [3H]haTRAP from PAR1	ChEMBL.	17490877
IC50 (binding)	= 10 nM	Displacement of [3H]haTRAP from PAR1	ChEMBL.	17490877

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL234190
PubChem: 9889179

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 442985