Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, alpha | 451 aa | 372 aa | 25.3 % |
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.0896 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | trans-2-enoyl-ACP reductase, FabK | 0.0424 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0176 | 0.0896 | 1 |
Mycobacterium ulcerans | 2-nitropropane dioxygenase | 0.0424 | 1 | 1 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0424 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0424 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.0896 | 1 |
Trichomonas vaginalis | 2-nitropropane dioxygenase precursor, putative | 0.0424 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0312 | 0.5886 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0301 | 0.5463 | 1 |
Mycobacterium tuberculosis | Possible alanine rich oxidoreductase | 0.0424 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 13 % | Activity against TRAFalpha1 expressed in CHOK1 cells by alkaline phosphatase reporter gene assay | ChEMBL. | 17543524 |
Activity (binding) | = 27 % | Activity against TRAFbeta expressed in CHOK1 cells by alkaline phosphatse reporter gene assay | ChEMBL. | 17543524 |
EC50 (binding) | = 170 nM | Activity against TRAFalpha1 expressed in CHOK1 cells by alkaline phosphatase reporter gene assay | ChEMBL. | 17543524 |
EC50 (binding) | = 1100 nM | Activity against TRAFbeta expressed in CHOK1 cells by alkaline phosphatse reporter gene assay | ChEMBL. | 17543524 |
IC50 (binding) | = 1500 nM | Binding affinity at human thyroid hormone receptor alpha 1 expressed in CHOK1 cells | ChEMBL. | 17543524 |
IC50 (binding) | = 1500 nM | Binding affinity at human thyroid hormone receptor alpha 1 expressed in CHOK1 cells | ChEMBL. | 17543524 |
IC50 (binding) | = 2600 nM | Binding affinity at human thyroid hormone receptor beta1 expressed in CHOK1 cells | ChEMBL. | 17543524 |
IC50 (binding) | = 2600 nM | Binding affinity at human thyroid hormone receptor beta1 expressed in CHOK1 cells | ChEMBL. | 17543524 |
Ratio IC50 (binding) | = 0.34 | Selectivity ratio of IC50 for thyroid hormone receptor alpha1 to IC50 for thyroid hormone receptor beta1 | ChEMBL. | 17543524 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.