Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melanocortin 4 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.5369 | 0.5 |
Trypanosoma cruzi | exopolyphosphatase | 0.0116 | 1 | 0.5 |
Trichomonas vaginalis | equilibrative nucleoside transporter, putative | 0.008 | 0.5369 | 0.5 |
Entamoeba histolytica | nucleoside transporter, putative | 0.008 | 0.5369 | 0.5 |
Trichomonas vaginalis | equilibrative nucleoside transporter, putative | 0.008 | 0.5369 | 0.5 |
Echinococcus multilocularis | equilibrative nucleoside transporter protein | 0.008 | 0.5369 | 1 |
Trypanosoma brucei | exopolyphosphatase | 0.0116 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.008 | 0.5369 | 0.5 |
Onchocerca volvulus | Equilibrative nucleoside transporter, putative homolog | 0.008 | 0.5369 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.5369 | 0.5 |
Trichomonas vaginalis | equilibrative nucleoside transporter, putative | 0.008 | 0.5369 | 0.5 |
Trichomonas vaginalis | equilibrative nucleoside transporter, putative | 0.008 | 0.5369 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.5369 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.008 | 0.5369 | 1 |
Echinococcus multilocularis | equilibrative nucleoside transporter 3 | 0.008 | 0.5369 | 1 |
Onchocerca volvulus | Equilibrative nucleoside transporter, putative homolog | 0.008 | 0.5369 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0116 | 1 | 0.5 |
Leishmania major | acidocalcisomal exopolyphosphatase, putative | 0.0116 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0116 | 1 | 0.5 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0039 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0116 | 1 | 0.5 |
Brugia malayi | Nucleoside transporter family protein | 0.008 | 0.5369 | 0.5 |
Trypanosoma cruzi | acidocalcisomal exopolyphosphatase, putative | 0.0116 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 340 nM | Antagonist activity at human MC4R expressed in HEK293 cells by cAMP acumulation assay | ChEMBL. | 17822895 |
IC50 (functional) | = 340 nM | Antagonist activity at human MC4R expressed in HEK293 cells by cAMP acumulation assay | ChEMBL. | 17822895 |
IC50 (ADMET) | = 25000 nM | Inhibition of microsomal CYP3A4 | ChEMBL. | 17822895 |
IC50 (ADMET) | = 25000 nM | Inhibition of microsomal CYP3A4 | ChEMBL. | 17822895 |
Ki (binding) | = 40 nM | Binding affinity at human MC4R | ChEMBL. | 17822895 |
Ki (binding) | = 40 nM | Binding affinity at human MC4R | ChEMBL. | 17822895 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.