Detailed information for compound 443657

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 481.609 | Formula: C29H27N3O2S
  • H donors: 0 H acceptors: 3 LogP: 5.93 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCn1c(c2ccc3c(c2)ccc(c3)OC)c(nc1c1ccc(cc1)[S+](C)[O-])c1ccncc1
  • InChi: 1S/C29H27N3O2S/c1-4-17-32-28(24-6-5-23-19-25(34-2)10-7-22(23)18-24)27(20-13-15-30-16-14-20)31-29(32)21-8-11-26(12-9-21)35(3)33/h5-16,18-19H,4,17H2,1-3H3
  • InChiKey: MBYUZODCLRCMSS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TEK tyrosine kinase, endothelial Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0044 0.008 0.0087
Echinococcus multilocularis aldo keto reductase 0.0035 0.004 0.0059
Echinococcus granulosus lysine specific histone demethylase 1A 0.0091 0.0278 0.0383
Brugia malayi hypothetical protein 0.0099 0.0314 0.0437
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0044 0.008 0.0087
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0271 0.1044 0.153
Brugia malayi hypothetical protein 0.0044 0.008 0.0087
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0035 0.004 0.0449
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Schistosoma mansoni gamma-secretase subunit aph-1 0.0167 0.0604 0.0872
Loa Loa (eye worm) reprolysin 0.0113 0.0372 0.0345
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0271 0.1044 0.1557
Schistosoma mansoni opsin-like receptor 0.0044 0.008 0.0087
Echinococcus granulosus lipoxygenase domain containing protein 0.0099 0.0314 0.0437
Schistosoma mansoni neuropeptide receptor 0.0044 0.008 0.0087
Onchocerca volvulus 0.0271 0.1044 1
Onchocerca volvulus 0.0044 0.008 0.0504
Brugia malayi neuropeptide F receptor 0.0044 0.008 0.0087
Brugia malayi gamma-secretase subunit aph-1 0.0167 0.0604 0.0872
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0044 0.008 0.0051
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0079 0.0086
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0035 0.004 0.011
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0592 0.241 0.3575
Schistosoma mansoni acetylcholinesterase 0.0271 0.1044 0.153
Loa Loa (eye worm) oxidoreductase 0.0035 0.004 0.0011
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.008 0.0087
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.008 0.0119
Echinococcus granulosus neuropeptide FF receptor 2 0.0044 0.008 0.0087
Brugia malayi hypothetical protein 0.0044 0.008 0.0087
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0044 0.008 0.0119
Brugia malayi hypothetical protein 0.0044 0.008 0.0087
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0044 0.008 0.0087
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.008 0.0119
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0035 0.004 0.0059
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0044 0.008 0.0087
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0044 0.008 0.0087
Loa Loa (eye worm) melatonin receptor type 1A 0.0044 0.008 0.0051
Trichomonas vaginalis aldo/keto reductase, putative 0.0035 0.004 0.011
Entamoeba histolytica aldose reductase, putative 0.0035 0.004 1
Loa Loa (eye worm) hypothetical protein 0.0175 0.0639 0.0612
Brugia malayi follicle stimulating hormone receptor 0.0044 0.008 0.0087
Loa Loa (eye worm) oxidoreductase 0.0035 0.004 0.0011
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0113 0.0372 0.0525
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0044 0.008 0.0087
Brugia malayi AKH receptor 0.0044 0.008 0.0087
Trichomonas vaginalis aldo-keto reductase, putative 0.0035 0.004 0.011
Loa Loa (eye worm) hypothetical protein 0.0091 0.0278 0.025
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0091 0.0278 0.0467
Trypanosoma brucei prostaglandin f synthase 0.0035 0.004 0.0791
Loa Loa (eye worm) hypothetical protein 0.0175 0.0639 0.0612
Trichomonas vaginalis aldo/keto reductase, putative 0.0035 0.004 0.011
Loa Loa (eye worm) hypothetical protein 0.0091 0.0278 0.025
Onchocerca volvulus 0.0099 0.0314 0.2809
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0534 0.2164 0.3206
Loa Loa (eye worm) animal heme peroxidase 0.0175 0.0639 0.0612
Loa Loa (eye worm) hypothetical protein 0.0271 0.1044 0.1018
Onchocerca volvulus 0.0044 0.008 0.0504
Onchocerca volvulus 0.0035 0.004 0.011
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Echinococcus multilocularis lipoxygenase domain containing protein 0.0099 0.0314 0.0468
Loa Loa (eye worm) hypothetical protein 0.0271 0.1044 0.1018
Echinococcus multilocularis neuropeptide s receptor 0.0044 0.008 0.0119
Loa Loa (eye worm) hypothetical protein 0.0099 0.0314 0.0286
Loa Loa (eye worm) neuropeptide F receptor 0.0044 0.008 0.0051
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0044 0.008 0.0087
Brugia malayi hypothetical protein 0.0044 0.008 0.0087
Onchocerca volvulus 0.0044 0.008 0.0504
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0035 0.004 0.0027
Echinococcus granulosus biogenic amine 5HT receptor 0.0044 0.008 0.0087
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0035 0.004 0.0059
Loa Loa (eye worm) animal heme peroxidase 0.0175 0.0639 0.0612
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.008 0.0087
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0044 0.008 0.0087
Echinococcus granulosus tm gpcr rhodopsin 0.0044 0.008 0.0087
Trichomonas vaginalis aldo-keto reductase, putative 0.0035 0.004 0.011
Schistosoma mansoni loxhd1 0.0099 0.0314 0.0437
Echinococcus multilocularis protoporphyrinogen oxidase 0.0091 0.0278 0.0414
Echinococcus granulosus gamma secretase subunit aph 1 0.0167 0.0604 0.0872
Schistosoma mansoni opsin-like receptor 0.0044 0.008 0.0087
Echinococcus multilocularis neuropeptides capa receptor 0.0044 0.008 0.0119
Echinococcus granulosus biogenic amine 5HT receptor 0.0044 0.008 0.0087
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.008 0.0087
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0044 0.008 0.0119
Onchocerca volvulus 0.0271 0.1044 1
Trypanosoma cruzi Aph-1 protein, putative 0.0065 0.017 0.5675
Leishmania major UDP-galactopyranose mutase 0.0091 0.0278 1
Schistosoma mansoni hypothetical protein 0.0044 0.008 0.0087
Echinococcus granulosus fmrfamide receptor 0.0044 0.008 0.0087
Trichomonas vaginalis aldo-keto reductase, putative 0.0035 0.004 0.011
Onchocerca volvulus Peroxidasin homolog 0.0175 0.0639 0.6011
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Schistosoma mansoni biogenic amine receptor 0.0044 0.008 0.0087
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0044 0.008 0.0087
Echinococcus multilocularis G protein coupled receptor 139 0.0044 0.008 0.0119
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.008 0.0119
Loa Loa (eye worm) hypothetical protein 0.0091 0.0278 0.025
Brugia malayi Dopamine receptor protein 1 0.0044 0.008 0.0087
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0044 0.008 0.0119
Brugia malayi G-protein coupled receptor 0.0044 0.008 0.0087
Schistosoma mansoni rab6-interacting 0.0099 0.0314 0.0437
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0044 0.008 0.0087
Trypanosoma brucei aldo-keto reductase, putative 0.0035 0.004 0.0791
Brugia malayi larval opioid receptor 0.0044 0.008 0.0087
Echinococcus multilocularis neuropeptide Y receptor 0.0044 0.008 0.0119
Echinococcus multilocularis neuropeptide receptor 0.0044 0.008 0.0119
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0091 0.0278 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0044 0.008 0.0087
Echinococcus multilocularis gamma secretase subunit aph 1 0.0167 0.0604 0.0901
Loa Loa (eye worm) hypothetical protein 0.0091 0.0278 0.025
Echinococcus granulosus carboxylesterase 5A 0.1602 0.6705 1
Brugia malayi Animal haem peroxidase family protein 0.0175 0.0639 0.0924
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0044 0.008 0.0119
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0044 0.008 0.0087
Schistosoma mansoni amine GPCR 0.0044 0.008 0.0087
Loa Loa (eye worm) hypothetical protein 0.0175 0.0639 0.0612
Echinococcus granulosus neuropeptides capa receptor 0.0044 0.008 0.0087
Echinococcus granulosus 7tm_1 domain containing protein 0.0044 0.008 0.0087
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0035 0.004 0.0027
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0035 0.004 0.0449
Brugia malayi ADAMTS-like protease 0.0084 0.025 0.0341
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0035 0.004 0.0027
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0592 0.241 0.3595
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0035 0.004 0.0027
Schistosoma mansoni histamine h1 receptor 0.0044 0.008 0.0087
Echinococcus granulosus tachykinin peptides receptor 99D 0.0044 0.008 0.0087
Echinococcus granulosus alpha 1A adrenergic receptor 0.0044 0.008 0.0087
Echinococcus multilocularis acetylcholinesterase 0.1602 0.6705 1
Onchocerca volvulus 0.0035 0.004 0.011
Loa Loa (eye worm) hypothetical protein 0.0091 0.0278 0.025
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.071 0.2911 0.4324
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Onchocerca volvulus 0.0044 0.008 0.0504
Onchocerca volvulus 0.0044 0.008 0.0504
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Entamoeba histolytica aldose reductase, putative 0.0035 0.004 1
Brugia malayi hypothetical protein 0.0197 0.0729 0.1059
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0044 0.008 0.0087
Echinococcus granulosus acetylcholinesterase 0.1602 0.6705 1
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0091 0.0278 0.0383
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0079 0.0086
Echinococcus granulosus 7TM GPCR rhodopsin 0.0044 0.008 0.0087
Plasmodium vivax hypothetical protein, conserved 0.0091 0.0278 0.8739
Schistosoma mansoni opsin-like receptor 0.0044 0.008 0.0087
Trypanosoma cruzi UDP-galactopyranose mutase 0.0091 0.0278 1
Brugia malayi hypothetical protein 0.0044 0.008 0.0087
Schistosoma mansoni neuropeptide f receptor 76f 0.0044 0.008 0.0087
Schistosoma mansoni neuropeptide F-like receptor 0.0044 0.008 0.0087
Loa Loa (eye worm) blistered cuticle protein 3 0.0175 0.0639 0.0612
Echinococcus granulosus g protein coupled receptor 0.0044 0.008 0.0087
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0035 0.004 0.0027
Onchocerca volvulus 0.0044 0.008 0.0504
Loa Loa (eye worm) oxidoreductase 0.0035 0.004 0.0011
Loa Loa (eye worm) G-protein coupled receptor 0.0044 0.008 0.0051
Loa Loa (eye worm) hypothetical protein 0.0271 0.1044 0.1018
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0113 0.0372 0.0555
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.008 0.0087
Brugia malayi hypothetical protein 0.0099 0.0314 0.0437
Mycobacterium ulcerans oxidoreductase 0.0035 0.004 0.0021
Brugia malayi Serotonin receptor 0.0044 0.008 0.0087
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0044 0.008 0.0119
Brugia malayi hypothetical protein 0.0271 0.1044 0.153
Trichomonas vaginalis aldo-keto reductase, putative 0.0035 0.004 0.011
Loa Loa (eye worm) hypothetical protein 0.0271 0.1044 0.1018
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0011
Echinococcus granulosus somatostatin receptor 0.0044 0.008 0.0087
Brugia malayi RE15519p 0.0044 0.008 0.0087
Brugia malayi Animal haem peroxidase family protein 0.0175 0.0639 0.0924
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0079 0.0051
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0035 0.004 0.0059
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.008 0.0119
Brugia malayi Lipocalin / cytosolic fatty-acid binding protein family protein 0.1505 0.6291 0.9381
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.008 0.0087
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.008 0.0087
Echinococcus multilocularis aldo keto reductase 0.0035 0.004 0.0059
Loa Loa (eye worm) acetylcholinesterase 1 0.1602 0.6705 0.6695
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0079 0.0086
Plasmodium falciparum LCCL domain-containing protein 0.0099 0.0314 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Echinococcus granulosus serotonin receptor 0.0044 0.008 0.0087
Echinococcus multilocularis somatostatin receptor 0.0044 0.008 0.0119
Onchocerca volvulus 0.0044 0.008 0.0504
Brugia malayi Melatonin receptor type 1A 0.0044 0.008 0.0087
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0044 0.008 0.0051
Schistosoma mansoni polycystin 1-related 0.0099 0.0314 0.0437
Echinococcus multilocularis pyruvate kinase 0.0032 0.0029 0.0043
Schistosoma mansoni growth hormone secretagogue receptor 0.0044 0.008 0.0087
Echinococcus granulosus BC026374 protein S09 family 0.0271 0.1044 0.153
Onchocerca volvulus 0.0175 0.0639 0.6011
Trypanosoma cruzi Aph-1 protein, putative 0.0065 0.017 0.5675
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0044 0.008 0.0087
Brugia malayi hypothetical protein 0.0044 0.008 0.0087
Echinococcus multilocularis neuropeptide FF receptor 2 0.0044 0.008 0.0119
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0035 0.004 0.0059
Plasmodium vivax hypothetical protein, conserved 0.0091 0.0278 0.8739
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.008 0.0119
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1285 0.5359 1
Brugia malayi Carboxylesterase family protein 0.0271 0.1044 0.153
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0534 0.2164 0.3206
Schistosoma mansoni aldo-keto reductase 0.0035 0.004 0.0027
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0035 0.004 0.0449
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Brugia malayi Animal haem peroxidase family protein 0.0175 0.0639 0.0924
Onchocerca volvulus 0.0271 0.1044 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0035 0.004 0.0059
Brugia malayi SWIRM domain containing protein 0.0091 0.0278 0.0383
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0113 0.0372 0.0525
Brugia malayi hypothetical protein 0.0044 0.008 0.0087
Schistosoma mansoni biogenic amine receptor 0.0044 0.008 0.0087
Trichomonas vaginalis aldo-keto reductase, putative 0.0035 0.004 0.011
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0044 0.008 0.0504
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0035 0.004 0.0059
Echinococcus multilocularis fmrfamide receptor 0.0044 0.008 0.0119
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Schistosoma mansoni pyruvate kinase 0.0032 0.0029 0.0011
Echinococcus granulosus fatty acid binding protein FABP2 0.0187 0.0688 0.0997
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0044 0.008 0.0087
Mycobacterium tuberculosis Carboxylesterase LipT 0.0271 0.1044 0.2053
Onchocerca volvulus Chorion peroxidase homolog 0.0175 0.0639 0.6011
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0035 0.004 0.0027
Trichomonas vaginalis spcc417.12 protein, putative 0.0271 0.1044 1
Onchocerca volvulus 0.0271 0.1044 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.0029 0.0011
Trichomonas vaginalis aldo-keto reductase, putative 0.0035 0.004 0.011
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0044 0.008 0.0119
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Schistosoma mansoni amine GPCR 0.0044 0.008 0.0087
Echinococcus granulosus g protein coupled receptor 0.0044 0.008 0.0087
Entamoeba histolytica aldose reductase, putative 0.0035 0.004 1
Echinococcus multilocularis neuropeptide receptor A26 0.0044 0.008 0.0119
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0035 0.004 0.0027
Loa Loa (eye worm) hypothetical protein 0.1602 0.6705 0.6695
Echinococcus granulosus sex peptide receptor 0.0044 0.008 0.0087
Echinococcus granulosus peroxidasin 0.0175 0.0639 0.0924
Loa Loa (eye worm) TYRA-2 protein 0.0044 0.008 0.0051
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Echinococcus granulosus neuropeptide receptor 0.0044 0.008 0.0087
Echinococcus granulosus lysine specific histone demethylase 1A 0.0091 0.0278 0.0383
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Loa Loa (eye worm) hypothetical protein 0.0175 0.0639 0.0612
Echinococcus granulosus tm gpcr rhodopsin 0.0044 0.008 0.0087
Loa Loa (eye worm) hypothetical protein 0.1602 0.6705 0.6695
Schistosoma mansoni neuropeptide receptor 0.0044 0.008 0.0087
Echinococcus multilocularis orexin receptor type 2 0.0044 0.008 0.0119
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0044 0.008 0.0087
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0044 0.008 0.0087
Echinococcus multilocularis dro:myosuppressin receptor 0.0044 0.008 0.0119
Giardia lamblia Aldose reductase 0.0035 0.004 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0035 0.004 0.011
Onchocerca volvulus 0.0175 0.0639 0.6011
Mycobacterium ulcerans monoamine oxidase 0.0091 0.0278 0.0467
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0091 0.0278 0.0383
Schistosoma mansoni neuropeptide receptor 0.0044 0.008 0.0087
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0035 0.004 0.0027
Loa Loa (eye worm) doublecortin family protein 0.0099 0.0314 0.0286
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.008 0.0119
Echinococcus granulosus disintegrin and metalloproteinase 0.0113 0.0372 0.0525
Schistosoma mansoni amine oxidase 0.0091 0.0278 0.0383
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Schistosoma mansoni myosin xvIII 0.0044 0.008 0.0087
Echinococcus multilocularis adam 17 protease 0.1131 0.4703 0.7014
Loa Loa (eye worm) oxidoreductase 0.0035 0.004 0.0011
Trichomonas vaginalis aldo/keto reductase, putative 0.0035 0.004 0.011
Mycobacterium ulcerans oxidoreductase 0.0091 0.0278 0.0467
Loa Loa (eye worm) neuropeptide F receptor 0.0044 0.008 0.0051
Loa Loa (eye worm) animal heme peroxidase 0.0175 0.0639 0.0612
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0044 0.008 0.0119
Brugia malayi angiogenesis inhibito 0.0084 0.025 0.0341
Mycobacterium tuberculosis Possible oxidoreductase 0.0091 0.0278 0.0504
Echinococcus multilocularis lipoxygenase domain containing protein 0.0099 0.0314 0.0468
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Schistosoma mansoni biogenic amine receptor 0.0044 0.008 0.0087
Plasmodium falciparum protoporphyrinogen oxidase 0.0091 0.0278 0.8739
Schistosoma mansoni pol-related 0.0035 0.004 0.0027
Echinococcus multilocularis g protein coupled receptor 0.0044 0.008 0.0119
Schistosoma mansoni rab6-interacting 0.0099 0.0314 0.0437
Loa Loa (eye worm) hypothetical protein 0.0175 0.0639 0.0612
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.1131 0.4703 0.7005
Mycobacterium ulcerans dehydrogenase 0.0091 0.0278 0.0467
Echinococcus granulosus acetylcholinesterase 0.1602 0.6705 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0099 0.0314 0.0437
Echinococcus multilocularis adam 0.0197 0.0729 0.1087
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0091 0.0278 0.0414
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Echinococcus granulosus neuropeptide receptor A26 0.0044 0.008 0.0087
Echinococcus multilocularis pyruvate kinase 0.0032 0.0029 0.0043
Echinococcus granulosus neuropeptide receptor 0.0044 0.008 0.0087
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.008 0.0119
Echinococcus granulosus aldo keto reductase 0.0035 0.004 0.0027
Echinococcus multilocularis carboxylesterase 5A 0.1602 0.6705 1
Onchocerca volvulus 0.0091 0.0278 0.2454
Echinococcus multilocularis RUN 0.0099 0.0314 0.0468
Loa Loa (eye worm) oxidoreductase 0.0035 0.004 0.0011
Schistosoma mansoni amine GPCR 0.0044 0.008 0.0087
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0035 0.004 0.0059
Loa Loa (eye worm) hypothetical protein 0.0271 0.1044 0.1018
Mycobacterium tuberculosis Conserved hypothetical protein 0.0091 0.0278 0.0504
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.008 0.0119
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0271 0.1044 0.2053
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0091 0.0278 0.8739
Schistosoma mansoni BC026374 protein (S09 family) 0.0271 0.1044 0.153
Loa Loa (eye worm) hypothetical protein 0.0175 0.0639 0.0612
Loa Loa (eye worm) carboxylesterase 0.0271 0.1044 0.1018
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0035 0.004 0.0059
Loa Loa (eye worm) hypothetical protein 0.0175 0.0639 0.0612
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0167 0.0604 0.0577
Onchocerca volvulus 0.0044 0.008 0.0504
Brugia malayi G protein-coupled receptor F59B2.13 0.0044 0.008 0.0087
Chlamydia trachomatis protoporphyrinogen oxidase 0.0091 0.0278 1
Brugia malayi Doublecortin family protein 0.0099 0.0314 0.0437
Echinococcus granulosus g-protein coupled receptor 0.0044 0.008 0.0087
Brugia malayi Serotonin receptor 0.0044 0.008 0.0087
Schistosoma mansoni neuropeptide receptor 0.0044 0.008 0.0087
Onchocerca volvulus 0.0044 0.008 0.0504
Trichomonas vaginalis aldo-keto reductase, putative 0.0035 0.004 0.011
Schistosoma mansoni aldo-keto reductase 0.0035 0.004 0.0027
Leishmania major prostaglandin f synthase, putative 0.0035 0.004 0.0449
Onchocerca volvulus Dual oxidase homolog 0.0175 0.0639 0.6011
Loa Loa (eye worm) hypothetical protein 0.0175 0.0639 0.0612
Schistosoma mansoni hypothetical protein 0.0044 0.008 0.0087
Loa Loa (eye worm) carboxylesterase 0.0271 0.1044 0.1018
Onchocerca volvulus 0.0044 0.008 0.0504
Schistosoma mansoni peroxidasin 0.0175 0.0639 0.0924
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0035 0.004 0.0027
Trichomonas vaginalis aldo-keto reductase, putative 0.0035 0.004 0.011
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1195 0.4974 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0099 0.0314 0.0468
Onchocerca volvulus 0.0035 0.004 0.011
Schistosoma mansoni fatty acid binding protein 0.0187 0.0688 0.0997
Brugia malayi Dopamine receptor protein 2 0.0044 0.008 0.0087
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0035 0.004 0.0027
Schistosoma mansoni pyruvate kinase 0.0032 0.0029 0.0011
Onchocerca volvulus Peroxidase homolog 0.0175 0.0639 0.6011
Schistosoma mansoni hypothetical protein 0.0044 0.008 0.0087
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0044 0.008 0.0119
Echinococcus multilocularis 0.0091 0.0278 0.0414
Echinococcus granulosus pyruvate kinase 0.0032 0.0029 0.0011
Loa Loa (eye worm) hypothetical protein 0.0091 0.0278 0.025
Echinococcus multilocularis BC026374 protein (S09 family) 0.0271 0.1044 0.1557
Trichomonas vaginalis aldo-keto reductase, putative 0.0035 0.004 0.011
Echinococcus multilocularis disintegrin and metalloproteinase 0.0113 0.0372 0.0555
Echinococcus granulosus neuroligin 0.0271 0.1044 0.153
Schistosoma mansoni lipoxygenase 0.0592 0.241 0.3575
Brugia malayi ORL1-like opioid receptor 0.0044 0.008 0.0087
Brugia malayi neuropeptide F receptor 0.0044 0.008 0.0087
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0035 0.004 0.011
Loa Loa (eye worm) animal heme peroxidase 0.0175 0.0639 0.0612
Brugia malayi Peroxidasin 0.0175 0.0639 0.0924
Brugia malayi Carboxylesterase family protein 0.1602 0.6705 1
Echinococcus multilocularis sex peptide receptor 0.0044 0.008 0.0119
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Brugia malayi hypothetical protein 0.0044 0.008 0.0087
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1285 0.5359 1
Brugia malayi amine oxidase, flavin-containing family protein 0.0091 0.0278 0.0383
Trichomonas vaginalis aldo-keto reductase, putative 0.0035 0.004 0.011
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1602 0.6705 1
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0091 0.0278 0.8739
Brugia malayi ADAM-TS Spacer 1 family protein 0.0084 0.025 0.0341
Loa Loa (eye worm) hypothetical protein 0.0175 0.0639 0.0612
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0271 0.1044 1
Echinococcus granulosus aldo keto reductase 0.0035 0.004 0.0027
Echinococcus granulosus G protein coupled receptor 139 0.0044 0.008 0.0087
Plasmodium vivax multidomain scavenger receptor, putative 0.0099 0.0314 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.008 0.0087
Echinococcus multilocularis aldo keto reductase 0.0035 0.004 0.0059
Onchocerca volvulus Peroxidasin homolog 0.0175 0.0639 0.6011
Schistosoma mansoni memapsin-2 (A01 family) 0.0474 0.191 0.2826
Loa Loa (eye worm) hypothetical protein 0.0084 0.025 0.0222
Toxoplasma gondii aldose reductase, putative 0.0035 0.004 0.0449
Echinococcus granulosus allatostatin A receptor 0.0044 0.008 0.0087
Schistosoma mansoni peroxidasin 0.0175 0.0639 0.0924
Brugia malayi sulfakinin receptor protein 0.0044 0.008 0.0087
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Brugia malayi Animal haem peroxidase family protein 0.0175 0.0639 0.0924
Onchocerca volvulus 0.0035 0.004 0.011
Loa Loa (eye worm) lipocalin/cytosolic fatty-acid binding protein family protein 0.1505 0.6291 0.628
Loa Loa (eye worm) carboxylesterase 0.1602 0.6705 0.6695
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0044 0.008 0.0051
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0079 0.0086
Brugia malayi Carboxylesterase family protein 0.0271 0.1044 0.153
Loa Loa (eye worm) hypothetical protein 0.0113 0.0372 0.0345
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0035 0.004 0.0059
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0271 0.1044 0.153
Schistosoma mansoni biogenic amine (5HT) receptor 0.0044 0.008 0.0087
Onchocerca volvulus Peroxidase homolog 0.0175 0.0639 0.6011
Schistosoma mansoni biogenic amine (5HT) receptor 0.0044 0.008 0.0087
Onchocerca volvulus 0.0099 0.0314 0.2809
Trypanosoma brucei Aph-1 protein, putative 0.0065 0.017 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.008 0.0087
Echinococcus multilocularis acetylcholinesterase 0.1602 0.6705 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0044 0.008 0.0051
Loa Loa (eye worm) hypothetical protein 0.0084 0.025 0.0222
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.0029 0.0011
Echinococcus granulosus tm gpcr rhodopsin 0.0044 0.008 0.0087
Brugia malayi hypothetical protein 0.0175 0.0639 0.0924
Loa Loa (eye worm) hypothetical protein 0.0175 0.0639 0.0612
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0079 0.0086
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0079 0.0118
Echinococcus granulosus Polycystic kidney disease protein 0.0099 0.0314 0.0437
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0113 0.0372 0.0525
Loa Loa (eye worm) hypothetical protein 0.0175 0.0639 0.0612
Echinococcus granulosus hypothetical protein 0.0044 0.008 0.0087
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0035 0.004 0.0027
Mycobacterium tuberculosis Probable oxidoreductase 0.0035 0.004 0.0023
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Schistosoma mansoni hypothetical protein 0.0099 0.0314 0.0437
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0044 0.008 0.0119
Brugia malayi Carboxylesterase family protein 0.0271 0.1044 0.153
Schistosoma mansoni lipoxygenase 0.0414 0.1653 0.2441
Echinococcus granulosus adam 0.0197 0.0729 0.1059
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.071 0.2911 0.4342
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0091 0.0278 0.8739
Echinococcus multilocularis neuropeptides capa receptor 0.0044 0.008 0.0119
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0035 0.004 0.0059
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0035 0.004 0.011
Echinococcus granulosus para nitrobenzyl esterase 0.0271 0.1044 0.153
Onchocerca volvulus Neuropeptide F receptor homolog 0.0044 0.008 0.0504
Brugia malayi Dopamine receptor 0.0044 0.008 0.0087
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0044 0.008 0.0087
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0079 0.0118
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.008 0.0087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.008 0.0087
Schistosoma mansoni adenoreceptor 0.0044 0.008 0.0087
Onchocerca volvulus 0.0044 0.008 0.0504
Loa Loa (eye worm) hypothetical protein 0.0175 0.0639 0.0612
Echinococcus multilocularis neuropeptide receptor 0.0044 0.008 0.0119
Echinococcus multilocularis fatty acid binding protein FABP2 0.0187 0.0688 0.1026
Echinococcus multilocularis allatostatin A receptor 0.0044 0.008 0.0119
Onchocerca volvulus 0.0271 0.1044 1
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0534 0.2164 0.3206
Loa Loa (eye worm) hypothetical protein 0.0175 0.0639 0.0612
Echinococcus multilocularis fmrfamide receptor 0.0044 0.008 0.0119
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0091 0.0278 0.8739
Brugia malayi Animal haem peroxidase family protein 0.0175 0.0639 0.0924
Trypanosoma cruzi aldo/keto reductase, putative 0.0035 0.004 0.0449
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0091 0.0278 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.008 0.0087
Echinococcus multilocularis serotonin receptor 0.0044 0.008 0.0119
Echinococcus granulosus RUN 0.0099 0.0314 0.0437
Onchocerca volvulus 0.0044 0.008 0.0504
Echinococcus granulosus g protein coupled receptor 0.0044 0.008 0.0087
Echinococcus multilocularis g protein coupled receptor 0.0044 0.008 0.0119
Onchocerca volvulus 0.0044 0.008 0.0504
Onchocerca volvulus 0.0044 0.008 0.0504
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.008 0.0087
Onchocerca volvulus 0.0035 0.004 0.011
Brugia malayi Blistered cuticle protein 3 0.0175 0.0639 0.0924
Loa Loa (eye worm) hypothetical protein 0.0099 0.0314 0.0286
Echinococcus multilocularis serotonin receptor 0.0044 0.008 0.0119
Echinococcus granulosus aldo keto reductase 0.0035 0.004 0.0027
Echinococcus multilocularis neuroligin 0.0271 0.1044 0.1557
Onchocerca volvulus 0.0044 0.008 0.0504
Echinococcus multilocularis fatty acid binding protein FABP2 0.0187 0.0688 0.1026
Trypanosoma cruzi UDP-galactopyranose mutase 0.0091 0.0278 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0044 0.008 0.0119
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0271 0.1044 0.153
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0079 0.0086
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.008 0.0087
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.003 0.0021 0.0032
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0044 0.008 0.0087
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0044 0.008 0.0119
Brugia malayi Carboxylesterase family protein 0.1602 0.6705 1
Onchocerca volvulus 0.0175 0.0639 0.6011
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0044 0.008 0.0087
Echinococcus granulosus adam 17 protease 0.1244 0.5182 0.7722
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0197 0.0729 0.1059
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0044 0.008 0.0087
Echinococcus granulosus pyruvate kinase 0.0032 0.0029 0.0011
Schistosoma mansoni amine oxidase 0.0091 0.0278 0.0383
Echinococcus granulosus fatty acid binding protein FABP2 0.0187 0.0688 0.0997
Schistosoma mansoni amine GPCR 0.0044 0.008 0.0087
Brugia malayi GnHR receptor homolog 0.0044 0.008 0.0087
Brugia malayi Carboxylesterase family protein 0.0271 0.1044 0.153
Echinococcus granulosus neuropeptides capa receptor 0.0044 0.008 0.0087
Echinococcus granulosus neuropeptide Y receptor 0.0044 0.008 0.0087
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Echinococcus multilocularis G-protein coupled receptor, putative 0.0044 0.008 0.0119
Brugia malayi hypothetical protein 0.0044 0.008 0.0087
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0035 0.004 0.0027
Echinococcus granulosus hypothetical protein 0.0035 0.004 0.0027
Schistosoma mansoni alpha-1 adrenergic receptor 0.0044 0.008 0.0087
Mycobacterium ulcerans carboxylesterase, LipT 0.0271 0.1044 0.1905
Trichomonas vaginalis aldo-keto reductase, putative 0.0035 0.004 0.011
Echinococcus multilocularis peroxidasin 0.0175 0.0639 0.0953
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Schistosoma mansoni hypothetical protein 0.0044 0.008 0.0087
Loa Loa (eye worm) hypothetical protein 0.0271 0.1044 0.1018
Schistosoma mansoni neuroligin 3 (S09 family) 0.0271 0.1044 0.153
Toxoplasma gondii histone lysine-specific demethylase 0.0091 0.0278 1
Schistosoma mansoni fatty acid binding protein 0.0187 0.0688 0.0997
Brugia malayi Disintegrin family protein 0.0113 0.0372 0.0525
Schistosoma mansoni amine GPCR 0.0044 0.008 0.0087
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0044 0.008 0.0087
Echinococcus multilocularis aldo keto reductase 0.0035 0.004 0.0059
Echinococcus multilocularis g-protein coupled receptor 0.0044 0.008 0.0119
Brugia malayi Tachykinin-like peptides receptor 99D 0.0044 0.008 0.0087
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0044 0.008 0.0051
Brugia malayi putative neuropeptide receptor 0.0044 0.008 0.0087
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0044 0.008 0.0119
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.008 0.0087
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0035 0.004 0.0059
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0044 0.008 0.0119
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Schistosoma mansoni dihydroceramide desaturase 0.0113 0.0372 0.0525
Loa Loa (eye worm) G-protein coupled receptor 0.0044 0.008 0.0051
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0271 0.1044 0.153
Giardia lamblia Aldose reductase 0.0035 0.004 1
Echinococcus multilocularis g protein coupled receptor 0.0044 0.008 0.0119
Schistosoma mansoni gliotactin 0.0271 0.1044 0.153
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0044 0.008 0.0119
Echinococcus multilocularis neuropeptide Y receptor 0.0044 0.008 0.0119
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.008 0.0087
Loa Loa (eye worm) hypothetical protein 0.0084 0.025 0.0222
Brugia malayi G protein-coupled receptor 0.0044 0.008 0.0087
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0044 0.008 0.0087
Echinococcus granulosus neuropeptide Y receptor 0.0044 0.008 0.0087
Schistosoma mansoni neuropeptide F-like receptor 0.0044 0.008 0.0087
Echinococcus multilocularis para nitrobenzyl esterase 0.0271 0.1044 0.1557
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0044 0.008 0.0087
Onchocerca volvulus 0.0044 0.008 0.0504
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.008 0.0087
Echinococcus granulosus peptide allatostatin:somatostatin 0.0044 0.008 0.0087
Loa Loa (eye worm) hypothetical protein 0.0271 0.1044 0.1018
Brugia malayi G-protein coupled receptor 0.0044 0.008 0.0087
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0534 0.2164 0.3228
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0271 0.1044 0.2053
Brugia malayi hypothetical protein 0.0044 0.008 0.0087
Brugia malayi putative neuropeptide receptor NPR1 0.0044 0.008 0.0087
Trypanosoma cruzi aldo-keto reductase 0.0035 0.004 0.0449
Echinococcus granulosus dro:myosuppressin receptor 0.0044 0.008 0.0087
Echinococcus granulosus orexin receptor type 2 0.0044 0.008 0.0087
Loa Loa (eye worm) hypothetical protein 0.0175 0.0639 0.0612
Onchocerca volvulus 0.0044 0.008 0.0504
Loa Loa (eye worm) hypothetical protein 0.0044 0.008 0.0051
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0035 0.004 0.0027
Leishmania major aldo-keto reductase-like protein 0.0035 0.004 0.0449
Echinococcus granulosus neuropeptide s receptor 0.0044 0.008 0.0087
Onchocerca volvulus 0.0035 0.004 0.011
Brugia malayi hypothetical protein 0.0091 0.0278 0.0383

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 437 nM Inhibition of Tie2 kinase by autophosphorylation assay ChEMBL. 17618114
IC50 (functional) = 437 nM Inhibition of Tie2 kinase by autophosphorylation assay ChEMBL. 17618114
IC50 (binding) > 16000 nM Inhibition of P38 kinase ChEMBL. 17618114

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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