Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | thymidine kinase, putative | 0.0104819 | 0.5 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.0223 | 0.5805 | 0.9051 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.035 | 0.432 |
Toxoplasma gondii | ribonuclease HI protein | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0133 | 0.3201 | 0.5128 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0123 | 0.2915 | 0.467 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0811 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0027 | 0.0146 | 0.0228 |
Schistosoma mansoni | hypothetical protein | 0.0223 | 0.5805 | 0.9298 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0104819 | 0.5 | 0.5 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0022 | 0 | 0.5 |
Giardia lamblia | Thymidine kinase | 0.0104819 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0811 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0691 | 0.1107 |
Schistosoma mansoni | thyroid hormone receptor | 0.0133 | 0.3201 | 0.5128 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0691 | 0.7395 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0691 | 0.1107 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0244 | 0.6413 | 1 |
Echinococcus multilocularis | thymidine kinase | 0.0238 | 0.6243 | 1 |
Echinococcus granulosus | thymidine kinase | 0.0238 | 0.6243 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0818 | 0.131 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0123 | 0.2915 | 0.467 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0104819 | 0.5 | 0.5 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0104819 | 0.5 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0027 | 0.0146 | 0.0228 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0691 | 0.1107 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.035 | 0.0561 |
Schistosoma mansoni | hypothetical protein | 0.0123 | 0.2915 | 0.467 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0691 | 0.1107 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0133 | 0.3201 | 0.5128 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0027 | 0.0146 | 0.0228 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0811 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0244 | 0.6413 | 1 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0027 | 0.0146 | 0.0228 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0691 | 0.852 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0022 | 0 | 0.5 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0244 | 0.6413 | 1 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0022 | 0 | 0.5 |
Leishmania major | thymidine kinase, putative | 0.0244 | 0.6413 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0244 | 0.6413 | 1 |
Trypanosoma brucei | thymidine kinase | 0.0244 | 0.6413 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0244 | 0.6413 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0811 | 1 |
Giardia lamblia | Thymidine kinase | 0.0244 | 0.6413 | 0.6413 |
Trypanosoma brucei | thymidine kinase | 0.0104819 | 0.5 | 0.5 |
Echinococcus granulosus | thymidine kinase | 0.0238 | 0.6243 | 1 |
Echinococcus granulosus | Thymidine kinase 2 mitochondrial | 0.0238 | 0.6243 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0104819 | 0.5 | 0.5 |
Echinococcus multilocularis | transfer RNA-Ile | 0.0238 | 0.6243 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0691 | 0.1107 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0027 | 0.0146 | 0.0228 |
Leishmania major | thymidine kinase, putative | 0.0104819 | 0.5 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0691 | 0.1107 |
Schistosoma mansoni | thymidine kinase | 0.0238 | 0.6243 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0691 | 0.1107 |
Entamoeba histolytica | thymidine kinase, putative | 0.0104819 | 0.5 | 0.5 |
Entamoeba histolytica | thymidine kinase, putative | 0.0244 | 0.6413 | 0.5 |
Echinococcus multilocularis | thymidine kinase | 0.0238 | 0.6243 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.0084 uM | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 | ChEMBL. | 17644333 |
IC50 (functional) | = 0.0084 uM | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 | ChEMBL. | 17644333 |
IC50 (functional) | = 0.23 uM | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 | ChEMBL. | 17644333 |
IC50 (functional) | = 0.23 uM | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 | ChEMBL. | 17644333 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 17644333 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.