TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 377.459 | Formula: C21H19N3O2S
H donors: 2 H acceptors: 3 LogP: 3.57 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1csc(n1)CC1(C)Cc2c(C1=O)cccc2)Nc1ccccc1N
InChi: 1S/C21H19N3O2S/c1-21(10-13-6-2-3-7-14(13)19(21)25)11-18-23-17(12-27-18)20(26)24-16-9-5-4-8-15(16)22/h2-9,12H,10-11,22H2,1H3,(H,24,26)
InChiKey: KWWRATGDZQZNQI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	PXA domain containing protein	0.0019	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.003	0.0155	0.0155
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0003	0.0003
Plasmodium vivax	PST-A protein	0.0285	0.3231	1
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0003	0.0003
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0848	1	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0155	0.0155
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0024	0.0085	0.0262
Echinococcus multilocularis	fmrfamide receptor	0.003	0.0155	0.0155
Schistosoma mansoni	histamine h1 receptor	0.003	0.0155	0.0155
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0155	0.0155
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0085	0.0818	0.0818
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.003	0.0155	0.0155
Loa Loa (eye worm)	TYRA-2 protein	0.003	0.0155	0.0155
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0155	0.0155
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0092	0.0905	0.0905
Echinococcus multilocularis	G-protein coupled receptor, putative	0.003	0.0155	0.0155
Echinococcus granulosus	tachykinin peptides receptor 99D	0.003	0.0155	0.0155
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Brugia malayi	putative amidase	0.0102	0.1028	0.1028
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0155	0.0155
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0028	0.0028
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.003	0.0155	0.0155
Echinococcus granulosus	tm gpcr rhodopsin	0.003	0.0155	0.0155
Plasmodium falciparum	lysophospholipase, putative	0.0285	0.3231	1
Echinococcus granulosus	7tm_1 domain containing protein	0.003	0.0155	0.0155
Trichomonas vaginalis	conserved hypothetical protein	0.0285	0.3231	1
Brugia malayi	hypothetical protein	0.003	0.0155	0.0155
Echinococcus granulosus	neuropeptide Y receptor	0.003	0.0155	0.0155
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0017	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0028	0.0028
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0024	0.0085	0.0562
Loa Loa (eye worm)	RGS-3 protein	0.0019	0.0032	0.0032
Entamoeba histolytica	hypothetical protein	0.0019	0.0032	0.0099
Schistosoma mansoni	growth hormone secretagogue receptor	0.003	0.0155	0.0155
Brugia malayi	sulfakinin receptor protein	0.003	0.0155	0.0155
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0059	0.0513	0.1587
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0028	0.0088
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0581	0.1797
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0019	0.0032	0.0032
Brugia malayi	G protein-coupled receptor F59B2.13	0.003	0.0155	0.0155
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.003	0.0155	0.0155
Onchocerca volvulus		0.003	0.0155	0.1683
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0003	0.0003
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0028	0.0088
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0028	0.0088
Echinococcus granulosus	neuropeptides capa receptor	0.003	0.0155	0.0155
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0032	0.0099
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0581	0.1797
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Echinococcus multilocularis	neuropeptide receptor	0.003	0.0155	0.0155
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0155	0.0155
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0028	0.0088
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.003	0.0155	0.0155
Echinococcus granulosus	g protein coupled receptor	0.003	0.0155	0.0155
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0019	0.0032	0.0032
Loa Loa (eye worm)	cysteine protease	0.0017	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0003	0.0003
Brugia malayi	neuropeptide F receptor	0.003	0.0155	0.0155
Brugia malayi	Dopamine receptor protein 1	0.003	0.0155	0.0155
Brugia malayi	RE15519p	0.003	0.0155	0.0155
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0019	0.0032	0.0099
Echinococcus multilocularis	sex peptide receptor	0.003	0.0155	0.0155
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0024	0.0085	0.0823
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0155	0.0155
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.003	0.0155	0.0155
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.003	0.0155	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0905	0.0905
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.0285	0.3231	1
Mycobacterium ulcerans	amidase	0.0102	0.1028	0.3183
Brugia malayi	larval opioid receptor	0.003	0.0155	0.0155
Leishmania major	cysteine peptidase A (CPA)	0.0017	0.0003	0.001
Onchocerca volvulus		0.003	0.0155	0.1683
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0032	0.0032
Loa Loa (eye worm)	ShTK domain-containing protein	0.0092	0.0905	0.0905
Echinococcus granulosus	Regulator of G protein signaling 20	0.0019	0.0032	0.0032
Schistosoma mansoni	fatty-acid amide hydrolase	0.0848	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0581	0.1797
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0085	0.0818	0.0818
Trypanosoma cruzi	major cysteine proteinase, putative	0.0051	0.0413	0.1279
Onchocerca volvulus		0.003	0.0155	0.1683
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0024	0.0085	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.003	0.0155	0.0155
Schistosoma mansoni	biogenic amine receptor	0.003	0.0155	0.0155
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0085	0.0818	0.0818
Brugia malayi	Serotonin receptor	0.003	0.0155	0.0155
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Brugia malayi	hypothetical protein	0.0019	0.0032	0.0032
Trypanosoma cruzi	amidase, putative	0.0102	0.1028	0.3183
Brugia malayi	GnHR receptor homolog	0.003	0.0155	0.0155
Schistosoma mansoni	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0102	0.1028	0.1028
Mycobacterium tuberculosis	Probable amidase AmiC (aminohydrolase)	0.0102	0.1028	0.3183
Mycobacterium ulcerans	amidase	0.0102	0.1028	0.3183
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.003	0.0155	0.0155
Brugia malayi	Common central domain of tyrosinase family protein	0.0092	0.0905	0.0905
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0003	0.001
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0155	0.0155
Echinococcus granulosus	alpha 1A adrenergic receptor	0.003	0.0155	0.0155
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0003	0.001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0155	0.0155
Echinococcus multilocularis	cysteine protease	0.0017	0.0003	0.0003
Echinococcus multilocularis	neuropeptide receptor	0.003	0.0155	0.0155
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0017	0.0003	0.001
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Schistosoma mansoni	biogenic amine receptor	0.003	0.0155	0.0155
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.003	0.0155	0.0155
Brugia malayi	G protein-coupled receptor	0.003	0.0155	0.0155
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0285	0.3231	1
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0032	0.0099
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0019	0.0032	0.0032
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.0003	0.001
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0581	0.1797
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0003	0.001
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.003	0.0155	0.0155
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Echinococcus multilocularis	neuropeptide Y receptor	0.003	0.0155	0.0155
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.003	0.0155	0.0155
Echinococcus multilocularis	allatostatin A receptor	0.003	0.0155	0.0155
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0032	0.0032
Plasmodium falciparum	esterase, putative	0.0285	0.3231	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0032	0.0032
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.003	0.0155	0.0155
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0032	0.0099
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0102	0.1028	0.1028
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0155	0.0155
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.003	0.0155	0.0155
Leishmania major	cathepsin L-like protease	0.0017	0.0003	0.001
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Schistosoma mansoni	neuropeptide F-like receptor	0.003	0.0155	0.0155
Schistosoma mansoni	biogenic amine receptor	0.003	0.0155	0.0155
Echinococcus granulosus	neuropeptide receptor A26	0.003	0.0155	0.0155
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0581	0.1797
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0019	0.0032	0.0032
Brugia malayi	hypothetical protein	0.0019	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Mycobacterium tuberculosis	Probable amidase AmiD (acylamidase) (acylase)	0.0102	0.1028	0.3183
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0003	0.001
Echinococcus granulosus	regulator of G protein signaling 3	0.0019	0.0032	0.0032
Echinococcus multilocularis	neuropeptide receptor A26	0.003	0.0155	0.0155
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	0.0285	0.3231	1
Plasmodium falciparum	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0102	0.1028	0.3183
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0155	0.0155
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.003	0.0155	0.0155
Schistosoma mansoni	fatty-acid amide hydrolase	0.0102	0.1028	0.1028
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.0032	0.0032
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0003	0.001
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0003	0.0003
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0024	0.0085	0.0562
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.0032	0.0032
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0003	0.001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0155	0.0155
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0003	0.0003
Loa Loa (eye worm)	fibroinase	0.0017	0.0003	0.0003
Schistosoma mansoni	opsin-like receptor	0.003	0.0155	0.0155
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.003	0.0155	0.0155
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0003	0.0003
Echinococcus multilocularis	regulator of G protein signaling	0.0019	0.0032	0.0032
Echinococcus multilocularis	G protein coupled receptor 139	0.003	0.0155	0.0155
Echinococcus multilocularis	neuropeptide Y receptor	0.003	0.0155	0.0155
Loa Loa (eye worm)	tyrosinase 1	0.0092	0.0905	0.0905
Leishmania major	cathepsin L-like protease	0.0065	0.0581	0.1797
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0581	0.1797
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Leishmania major	cathepsin L-like protease	0.0065	0.0581	0.1797
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0019	0.0032	0.0032
Toxoplasma gondii	exonuclease III APE	0.0019	0.0028	0.3363
Echinococcus granulosus	G protein coupled receptor 139	0.003	0.0155	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0032	0.0032
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0003	0.0003
Echinococcus granulosus	neuropeptide receptor	0.003	0.0155	0.0155
Loa Loa (eye worm)	neuropeptide F receptor	0.003	0.0155	0.0155
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.003	0.0155	0.0155
Onchocerca volvulus		0.003	0.0155	0.1683
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0581	0.1797
Brugia malayi	hypothetical protein	0.003	0.0155	0.0155
Schistosoma mansoni	neuropeptide receptor	0.003	0.0155	0.0155
Echinococcus granulosus	cathepsin l1	0.0017	0.0003	0.0003
Echinococcus multilocularis	regulator of G protein signaling 3	0.0019	0.0032	0.0032
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.003	0.0155	0.0155
Echinococcus granulosus	g protein coupled receptor	0.003	0.0155	0.0155
Brugia malayi	hypothetical protein	0.003	0.0155	0.0155
Brugia malayi	Melatonin receptor type 1A	0.003	0.0155	0.0155
Schistosoma mansoni	axis inhibition protein axin	0.0019	0.0032	0.0032
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Schistosoma mansoni	neuropeptide f receptor 76f	0.003	0.0155	0.0155
Schistosoma mansoni	myosin xvIII	0.003	0.0155	0.0155
Trypanosoma cruzi	cysteine peptidase, putative	0.0017	0.0003	0.001
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.003	0.0155	0.0155
Loa Loa (eye worm)	amidase	0.0102	0.1028	0.1028
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0581	0.1797
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0155	0.0155
Brugia malayi	hypothetical protein	0.003	0.0155	0.0155
Onchocerca volvulus		0.003	0.0155	0.1683
Mycobacterium leprae	PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A)	0.0102	0.1028	0.2999
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0155	0.0155
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0003	0.001
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0905	0.0905
Entamoeba histolytica	hypothetical protein	0.0019	0.0032	0.0099
Echinococcus granulosus	fmrfamide receptor	0.003	0.0155	0.0155
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0024	0.0085	0.0262
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0155	0.0155
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.0032	0.0032
Schistosoma mansoni	z-protein (S1r protein)	0.0019	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Onchocerca volvulus	Neuropeptide F receptor homolog	0.003	0.0155	0.1683
Echinococcus multilocularis	neuropeptide s receptor	0.003	0.0155	0.0155
Schistosoma mansoni	amidase	0.0848	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0065	0.0581	0.1797
Mycobacterium ulcerans	amidase	0.0102	0.1028	0.3183
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0024	0.0085	0.0262
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0848	1	1
Echinococcus multilocularis	glutamyl tRNA(Gln) amidotransferase subunit A	0.0102	0.1028	0.1028
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0155	0.0155
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0032	0.0032
Schistosoma mansoni	hypothetical protein	0.003	0.0155	0.0155
Brugia malayi	ShTK domain containing protein	0.0092	0.0905	0.0905
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0092	0.0905	0.0905
Brugia malayi	G-protein coupled receptor	0.003	0.0155	0.0155
Trypanosoma cruzi	cruzipain precursor, putative	0.0065	0.0581	0.1797
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0019	0.0032	0.0032
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0019	0.0032	0.0032
Onchocerca volvulus		0.0092	0.0905	1
Brugia malayi	regulator of G-protein signaling egl-10	0.0019	0.0032	0.0032
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0032	0.0099
Brugia malayi	putative neuropeptide receptor	0.003	0.0155	0.0155
Schistosoma mansoni	adenoreceptor	0.003	0.0155	0.0155
Trypanosoma brucei	monoglyceride lipase, putative	0.0285	0.3231	1
Echinococcus multilocularis	g protein coupled receptor	0.003	0.0155	0.0155
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0003	0.001
Loa Loa (eye worm)	G-protein coupled receptor	0.003	0.0155	0.0155
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Onchocerca volvulus		0.003	0.0155	0.1683
Brugia malayi	PXA domain containing protein	0.0019	0.0032	0.0032
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0019	0.0032	0.0032
Brugia malayi	G-protein coupled receptor	0.003	0.0155	0.0155
Onchocerca volvulus		0.003	0.0155	0.1683
Brugia malayi	Amidase family protein	0.0102	0.1028	0.1028
Leishmania major	hypothetical protein, conserved	0.0102	0.1028	0.3183
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0028	0.0088
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.003	0.0155	0.0155
Schistosoma mansoni	biogenic amine (5HT) receptor	0.003	0.0155	0.0155
Trichomonas vaginalis	conserved hypothetical protein	0.0285	0.3231	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Mycobacterium ulcerans	amidase	0.0102	0.1028	0.3183
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0285	0.3231	1
Loa Loa (eye worm)	ShTK domain-containing protein	0.0092	0.0905	0.0905
Brugia malayi	putative neuropeptide receptor NPR1	0.003	0.0155	0.0155
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0003	0.0003
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0028	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Brugia malayi	Dopamine receptor	0.003	0.0155	0.0155
Echinococcus multilocularis	g protein coupled receptor	0.003	0.0155	0.0155
Mycobacterium tuberculosis	Possible amidase (aminohydrolase)	0.0102	0.1028	0.3183
Schistosoma mansoni	amine GPCR	0.003	0.0155	0.0155
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0017	0.0003	0.0003
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0024	0.0085	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.003	0.0155	0.0155
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Onchocerca volvulus		0.0092	0.0905	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.003	0.0155	0.0155
Echinococcus multilocularis	neuropeptides capa receptor	0.003	0.0155	0.0155
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0003	0.001
Schistosoma mansoni	hypothetical protein	0.003	0.0155	0.0155
Echinococcus granulosus	allatostatin A receptor	0.003	0.0155	0.0155
Onchocerca volvulus		0.003	0.0155	0.1683
Brugia malayi	Dopamine receptor protein 2	0.003	0.0155	0.0155
Trypanosoma cruzi	amidase, putative	0.0102	0.1028	0.3183
Leishmania major	cathepsin L-like protease	0.0017	0.0003	0.001
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.003	0.0155	0.0155
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0028	0.0088
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0155	0.0155
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.003	0.0155	0.0155
Trypanosoma cruzi	monoglyceride lipase, putative	0.0285	0.3231	1
Echinococcus multilocularis	cysteine protease	0.0017	0.0003	0.0003
Leishmania major	cathepsin L-like protease	0.0017	0.0003	0.001
Schistosoma mansoni	axis inhibition protein axin	0.0019	0.0032	0.0032
Plasmodium falciparum	lysophospholipase, putative	0.0285	0.3231	1
Onchocerca volvulus		0.0092	0.0905	1
Mycobacterium tuberculosis	Possible lysophospholipase	0.0285	0.3231	1
Brugia malayi	AKH receptor	0.003	0.0155	0.0155
Schistosoma mansoni	amine GPCR	0.003	0.0155	0.0155
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0028	0.0028
Echinococcus multilocularis	g-protein coupled receptor	0.003	0.0155	0.0155
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.003	0.0155	0.0155
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0155	0.0155
Mycobacterium ulcerans	lysophospholipase	0.0285	0.3231	1
Leishmania major	cathepsin L-like protease	0.0065	0.0581	0.1797
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0032	0.0099
Schistosoma mansoni	amine GPCR	0.003	0.0155	0.0155
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.003	0.0155	0.0155
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0003	0.001
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0581	0.1797
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0019	0.0032	0.0032
Echinococcus granulosus	sex peptide receptor	0.003	0.0155	0.0155
Brugia malayi	hypothetical protein	0.003	0.0155	0.0155
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.003	0.0155	0.0155
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0003	0.001
Schistosoma mansoni	opsin-like receptor	0.003	0.0155	0.0155
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0032	0.0099
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0019	0.0032	0.0032
Brugia malayi	Amidase family protein	0.0102	0.1028	0.1028
Schistosoma mansoni	ap endonuclease	0.0019	0.0028	0.0028
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0003	0.001
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0003	0.001
Brugia malayi	Tachykinin-like peptides receptor 99D	0.003	0.0155	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0848	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0032	0.0032
Onchocerca volvulus		0.003	0.0155	0.1683
Echinococcus granulosus	g-protein coupled receptor	0.003	0.0155	0.0155
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0285	0.3231	1
Schistosoma mansoni	amine GPCR	0.003	0.0155	0.0155
Plasmodium falciparum	lysophospholipase, putative	0.0285	0.3231	1
Mycobacterium ulcerans	hypothetical protein	0.0285	0.3231	1
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0818	0.0818
Schistosoma mansoni	tyrosinase precursor	0.0092	0.0905	0.0905
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0017	0.0003	0.0003
Echinococcus granulosus	peptide allatostatin:somatostatin	0.003	0.0155	0.0155
Echinococcus granulosus	tm gpcr rhodopsin	0.003	0.0155	0.0155
Echinococcus multilocularis	regulator of G protein signaling 3	0.0019	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Schistosoma mansoni	neuropeptide receptor	0.003	0.0155	0.0155
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.003	0.0155	0.0155
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0003	0.001
Schistosoma mansoni	amine GPCR	0.003	0.0155	0.0155
Trypanosoma cruzi	cysteine peptidase, putative	0.0065	0.0581	0.1797
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0017	0.0003	0.001
Trypanosoma brucei	monoglyceride lipase, putative	0.0285	0.3231	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Echinococcus multilocularis	serotonin receptor	0.003	0.0155	0.0155
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0028	0.0088
Echinococcus granulosus	7TM GPCR rhodopsin	0.003	0.0155	0.0155
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.0003	0.001
Brugia malayi	neuropeptide F receptor	0.003	0.0155	0.0155
Echinococcus granulosus	somatostatin receptor	0.003	0.0155	0.0155
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0032	0.0032
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.003	0.0155	0.0155
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0028	0.0028
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0017	0.0003	0.001
Echinococcus granulosus	expressed protein	0.0379	0.436	0.436
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0155	0.0155
Onchocerca volvulus		0.003	0.0155	0.1683
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Echinococcus multilocularis	orexin receptor type 2	0.003	0.0155	0.0155
Schistosoma mansoni	alpha-1 adrenergic receptor	0.003	0.0155	0.0155
Onchocerca volvulus		0.003	0.0155	0.1683
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0019	0.0032	0.0032
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0848	1	1
Entamoeba histolytica	hypothetical protein	0.0024	0.0085	0.0262
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0003	0.001
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0028	0.0088
Echinococcus granulosus	L aminoadipate semialdehyde	0.0085	0.0818	0.0818
Onchocerca volvulus		0.003	0.0155	0.1683
Treponema pallidum	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0102	0.1028	1
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0285	0.3231	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.003	0.0155	0.0155
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0003	0.001
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0017	0.0003	0.0003
Echinococcus granulosus	dro:myosuppressin receptor	0.003	0.0155	0.0155
Echinococcus granulosus	neuropeptide s receptor	0.003	0.0155	0.0155
Trypanosoma brucei	fatty-acid amide hydrolase, putative	0.0102	0.1028	0.3183
Brugia malayi	hypothetical protein	0.003	0.0155	0.0155
Loa Loa (eye worm)	amidase	0.0102	0.1028	0.1028
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0003	0.001
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0285	0.3231	1
Schistosoma mansoni	neuropeptide receptor	0.003	0.0155	0.0155
Loa Loa (eye worm)	ctsf protein	0.0017	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Schistosoma mansoni	tyrosinase precursor	0.0092	0.0905	0.0905
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0003	0.001
Leishmania major	cathepsin L-like protease	0.0017	0.0003	0.001
Echinococcus multilocularis	expressed protein	0.0379	0.436	0.436
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0581	0.1797
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0003	0.001
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0155	0.0155
Echinococcus multilocularis	axis inhibition protein axin	0.0019	0.0032	0.0032
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0285	0.3231	1
Onchocerca volvulus		0.0092	0.0905	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.003	0.0155	0.0155
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.003	0.0155	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0032	0.0032
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.003	0.0155	0.0155
Echinococcus granulosus	tm gpcr rhodopsin	0.003	0.0155	0.0155
Brugia malayi	Serotonin receptor	0.003	0.0155	0.0155
Entamoeba histolytica	hypothetical protein	0.0019	0.0032	0.0099
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0003	0.0003
Echinococcus multilocularis	neuropeptides capa receptor	0.003	0.0155	0.0155
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0024	0.0085	0.0262
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Echinococcus multilocularis	dro:myosuppressin receptor	0.003	0.0155	0.0155
Echinococcus multilocularis	fmrfamide receptor	0.003	0.0155	0.0155
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Brugia malayi	A-kinase anchor protein 10, precursor	0.0019	0.0032	0.0032
Trypanosoma brucei	hypothetical protein, conserved	0.0024	0.0085	0.0262
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0024	0.0085	0.0262
Mycobacterium tuberculosis	Probable amidase AmiB2 (aminohydrolase)	0.0102	0.1028	0.3183
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Echinococcus granulosus	neuropeptides capa receptor	0.003	0.0155	0.0155
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0155	0.0155
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0285	0.3231	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.003	0.0155	0.0155
Brugia malayi	regulator of G-protein signaling rgs-7	0.0019	0.0032	0.0032
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.003	0.0155	0.0155
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0003	0.001
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.003	0.0155	0.0155
Brugia malayi	hypothetical protein	0.003	0.0155	0.0155
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0155	0.0155
Echinococcus granulosus	neuropeptide receptor	0.003	0.0155	0.0155
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.003	0.0155	0.0155
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0155	0.0155
Echinococcus multilocularis	axis inhibition protein axin	0.0019	0.0032	0.0032
Plasmodium vivax	glutamyl-tRNA(Gln) amidotransferase subunit A, putative	0.0102	0.1028	0.3183
Mycobacterium ulcerans	peptide amidase, GatA	0.0102	0.1028	0.3183
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.003	0.0155	0.0155
Plasmodium vivax	vivapain-2	0.0017	0.0003	0.001
Echinococcus granulosus	hypothetical protein	0.003	0.0155	0.0155
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0003	0.001
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.003	0.0155	0.0155
Loa Loa (eye worm)	neuropeptide F receptor	0.003	0.0155	0.0155
Echinococcus granulosus	glutamyl tRNAGln amidotransferase subunit A	0.0102	0.1028	0.1028
Leishmania major	monoglyceride lipase, putative	0.0285	0.3231	1
Brugia malayi	hypothetical protein	0.003	0.0155	0.0155
Schistosoma mansoni	neuropeptide F-like receptor	0.003	0.0155	0.0155
Echinococcus multilocularis	serotonin receptor	0.003	0.0155	0.0155
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.0092	0.0905	0.0905
Chlamydia trachomatis	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0102	0.1028	1
Brugia malayi	follicle stimulating hormone receptor	0.003	0.0155	0.0155
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0155	0.0155
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0032	0.0032
Echinococcus granulosus	neuropeptide FF receptor 2	0.003	0.0155	0.0155
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.003	0.0155	0.1683
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0019	0.0032	0.0032
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0028	0.0088
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.003	0.0155	0.0155
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0581	0.1797
Loa Loa (eye worm)	PXA domain-containing protein	0.0019	0.0032	0.0032
Onchocerca volvulus		0.003	0.0155	0.1683
Mycobacterium ulcerans	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0102	0.1028	0.3183
Wolbachia endosymbiont of Brugia malayi	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0102	0.1028	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.003	0.0155	0.0155
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0102	0.1028	0.1028
Loa Loa (eye worm)	melatonin receptor type 1A	0.003	0.0155	0.0155
Onchocerca volvulus		0.0085	0.0818	0.904
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0003	0.0003
Echinococcus granulosus	neuropeptide Y receptor	0.003	0.0155	0.0155
Plasmodium vivax	vivapain-2	0.0017	0.0003	0.001
Mycobacterium tuberculosis	Probable amidase AmiA2 (aminohydrolase)	0.0102	0.1028	0.3183
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0003	0.001
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.003	0.0155	0.0155
Schistosoma mansoni	ap endonuclease	0.0019	0.0028	0.0028
Echinococcus granulosus	g protein coupled receptor	0.003	0.0155	0.0155
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Onchocerca volvulus		0.003	0.0155	0.1683
Leishmania major	cathepsin L-like protease	0.0017	0.0003	0.001
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0019	0.0032	0.0032
Mycobacterium leprae	PROBABLE AMIDASE AMIC (AMINOHYDROLASE)	0.0102	0.1028	0.2999
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0028	0.0088
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0155	0.0155
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Echinococcus multilocularis	g protein coupled receptor	0.003	0.0155	0.0155
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0003	0.001
Trypanosoma cruzi	cysteine peptidase, putative	0.0065	0.0581	0.1797
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.003	0.0155	0.0155
Brugia malayi	hypothetical protein	0.003	0.0155	0.0155
Echinococcus multilocularis	neuropeptide FF receptor 2	0.003	0.0155	0.0155
Echinococcus granulosus	axis inhibition protein axin	0.0019	0.0032	0.0032
Echinococcus granulosus	axis inhibition protein axin	0.0019	0.0032	0.0032
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0092	0.0905	0.0905
Leishmania major	phosphopantetheinyl transferase-like protein	0.0024	0.0085	0.0262
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0003	0.001
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.0032	0.0032
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.003	0.0155	0.0155
Echinococcus granulosus	serotonin receptor	0.003	0.0155	0.0155
Echinococcus granulosus	orexin receptor type 2	0.003	0.0155	0.0155
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0032	0.0032
Echinococcus multilocularis	somatostatin receptor	0.003	0.0155	0.0155
Schistosoma mansoni	hypothetical protein	0.003	0.0155	0.0155
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0019	0.0032	0.0032
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0032	0.0032
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0848	1	1
Onchocerca volvulus		0.003	0.0155	0.1683
Brugia malayi	hypothetical protein	0.003	0.0155	0.0155
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Schistosoma mansoni	opsin-like receptor	0.003	0.0155	0.0155
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0028	0.0088
Loa Loa (eye worm)	G-protein coupled receptor	0.003	0.0155	0.0155
Mycobacterium ulcerans	amidase	0.0102	0.1028	0.3183
Echinococcus granulosus	regulator of G protein signaling 3	0.0019	0.0032	0.0032
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0032	0.0032
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0003	0.001
Schistosoma mansoni	neuropeptide receptor	0.003	0.0155	0.0155
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.003	0.0155	0.0155
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0003	0.001
Onchocerca volvulus		0.003	0.0155	0.1683
Brugia malayi	ORL1-like opioid receptor	0.003	0.0155	0.0155
Echinococcus granulosus	biogenic amine 5HT receptor	0.003	0.0155	0.0155
Onchocerca volvulus		0.003	0.0155	0.1683
Schistosoma mansoni	hypothetical protein	0.003	0.0155	0.0155
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0003	0.0003
Toxoplasma gondii	cathepsin CPL	0.0017	0.0003	0.0372
Loa Loa (eye worm)	hypothetical protein	0.003	0.0155	0.0155

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	0	Antiproliferative activity against H661 cells at 25 uM after 48 hrs	ChEMBL.	17897824

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 443866