TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 318.411 | Formula: C18H26N2O3
H donors: 2 H acceptors: 3 LogP: 2.74 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: ONC(=O)CCCCCC1(C)Cc2c(C1=O)ccc(c2)N(C)C
InChi: 1S/C18H26N2O3/c1-18(10-6-4-5-7-16(21)19-23)12-13-11-14(20(2)3)8-9-15(13)17(18)22/h8-9,11,23H,4-7,10,12H2,1-3H3,(H,19,21)
InChiKey: GNRYAOCCSQWELU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	DNA polymerase eta, putative	0.0023	0.0062	0.0217
Schistosoma mansoni	amidase	0.0527	0.5489	1
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.0272	0.0495
Schistosoma mansoni	thyroid hormone receptor	0.0024	0.0074	0.0134
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0062	0.0217
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0024	0.0074	0.0134
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0024	0.0074	0.0134
Schistosoma mansoni	hypothetical protein	0.0048	0.0331	0.0604
Echinococcus multilocularis	sterol regulatory element binding protein	0.0049	0.035	0.035
Loa Loa (eye worm)	hypothetical protein	0.006	0.047	0.0856
Entamoeba histolytica	hypothetical protein	0.0042	0.0272	0.0945
Trypanosoma brucei	unspecified product	0.0023	0.0062	0.0217
Schistosoma mansoni	hypothetical protein	0.0048	0.0331	0.0604
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0024	0.0074	0.0129
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0062	0.0217
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.0446	0.0812
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0062	0.0113
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0024	0.0074	0.0134
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0062	0.0217
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0018	0.0033
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0284	0.2874	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0024	0.0074	0.0134
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0023	0.0062	0.0217
Schistosoma mansoni	fatty-acid amide hydrolase	0.0064	0.0504	0.0918
Schistosoma mansoni	hypothetical protein	0.0048	0.0331	0.0604
Echinococcus multilocularis	dna polymerase kappa	0.0023	0.0062	0.0062
Mycobacterium ulcerans	lysophospholipase	0.0284	0.2874	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0062	0.0217
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0284	0.2874	1
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0284	0.2874	1
Echinococcus granulosus	glutamyl tRNAGln amidotransferase subunit A	0.0064	0.0504	0.0878
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.0446	0.0812
Schistosoma mansoni	DNA polymerase eta	0.0023	0.0062	0.0113
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0064	0.0504	0.0878
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0024	0.0074	0.0134
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0023	0.0062	0.0109
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0024	0.0074	0.0134
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0024	0.0074	0.0074
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0024	0.0074	0.0129
Echinococcus granulosus	expressed conserved protein	0.0108	0.0981	0.171
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0024	0.0074	0.0134
Plasmodium falciparum	esterase, putative	0.0284	0.2874	1
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0023	0.0062	0.0113
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0023	0.0062	0.0113
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0062	0.0217
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0062	0.0113
Trypanosoma cruzi	DNA polymerase eta, putative	0.0023	0.0062	0.0217
Mycobacterium ulcerans	amidase	0.0064	0.0504	0.1753
Plasmodium vivax	PST-A protein	0.0284	0.2874	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0136	0.0475
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0024	0.0074	0.0134
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0284	0.2874	1
Schistosoma mansoni	hypothetical protein	0.0198	0.1947	0.3548
Plasmodium vivax	glutamyl-tRNA(Gln) amidotransferase subunit A, putative	0.0064	0.0504	0.1753
Loa Loa (eye worm)	hypothetical protein	0.004	0.0248	0.0452
Entamoeba histolytica	hypothetical protein	0.0042	0.0272	0.0945
Brugia malayi	amidase	0.0527	0.5489	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0062	0.0217
Echinococcus granulosus	Niemann Pick C1 protein	0.0115	0.1056	0.1841
Echinococcus granulosus	X box binding protein 1	0.0336	0.3437	0.5992
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0527	0.5489	0.5489
Loa Loa (eye worm)	amidase	0.0064	0.0504	0.0918
Echinococcus granulosus	FTZ F1 alpha	0.0024	0.0074	0.0129
Mycobacterium tuberculosis	Probable amidase AmiC (aminohydrolase)	0.0064	0.0504	0.1753
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0023	0.0062	0.0062
Echinococcus multilocularis	expressed conserved protein	0.0108	0.0981	0.0981
Loa Loa (eye worm)	transcription factor SMAD2	0.0139	0.1319	0.2403
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0024	0.0074	0.0074
Brugia malayi	Amidase family protein	0.0064	0.0504	0.0918
Trichomonas vaginalis	DNA polymerase eta, putative	0.0023	0.0062	0.0217
Schistosoma mansoni	coup transcription factor	0.0024	0.0074	0.0134
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0284	0.2874	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.0446	0.0812
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0062	0.0113
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0527	0.5489	0.9569
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.0284	0.2874	1
Trichomonas vaginalis	conserved hypothetical protein	0.0284	0.2874	1
Schistosoma mansoni	patched 1	0.0049	0.035	0.0638
Echinococcus multilocularis	dna polymerase eta	0.0023	0.0062	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0074	0.0134
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0024	0.0074	0.0134
Brugia malayi	MH2 domain containing protein	0.0139	0.1319	0.2403
Entamoeba histolytica	hypothetical protein	0.0042	0.0272	0.0945
Schistosoma mansoni	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0064	0.0504	0.0918
Echinococcus multilocularis	ecdysone induced protein 78C	0.0024	0.0074	0.0074
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0023	0.0062	0.0217
Onchocerca volvulus	Huntingtin homolog	0.0143	0.1358	1
Mycobacterium tuberculosis	Probable amidase AmiB2 (aminohydrolase)	0.0064	0.0504	0.1753
Schistosoma mansoni	fatty-acid amide hydrolase	0.0527	0.5489	1
Brugia malayi	Steroid receptor seven-up type 2	0.0024	0.0074	0.0134
Giardia lamblia	DINP protein human, muc B family	0.0023	0.0062	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0024	0.0074	0.0134
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0024	0.0074	0.0134
Trypanosoma cruzi	monoglyceride lipase, putative	0.0284	0.2874	1
Onchocerca volvulus	Huntingtin homolog	0.0143	0.1358	1
Brugia malayi	steroid hormone receptor	0.0024	0.0074	0.0134
Trypanosoma cruzi	amidase, putative	0.0064	0.0504	0.1753
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0018	0.0033
Schistosoma mansoni	hypothetical protein	0.0018	0.0018	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0284	0.2874	1
Entamoeba histolytica	hypothetical protein	0.0042	0.0272	0.0945
Echinococcus multilocularis	neuropeptide receptor A26	0.055	0.5736	0.5736
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0064	0.0504	0.0504
Mycobacterium ulcerans	amidase	0.0064	0.0504	0.1753
Treponema pallidum	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0064	0.0504	0.5
Mycobacterium tuberculosis	Probable amidase AmiD (acylamidase) (acylase)	0.0064	0.0504	0.1753
Schistosoma mansoni	hypothetical protein	0.0048	0.0331	0.0604
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0024	0.0074	0.0134
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0024	0.0074	0.0134
Mycobacterium ulcerans	peptide amidase, GatA	0.0064	0.0504	0.1753
Brugia malayi	hypothetical protein	0.0029	0.0136	0.0249
Echinococcus multilocularis	X box binding protein 1	0.0336	0.3437	0.3437
Schistosoma mansoni	thyroid hormone receptor	0.0024	0.0074	0.0134
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.0272	0.0474
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0074	0.0134
Echinococcus granulosus	sterol regulatory element binding protein	0.0049	0.035	0.0611
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0018	0.0031
Schistosoma mansoni	hypothetical protein	0.0018	0.0018	0.0033
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0527	0.5489	0.5489
Mycobacterium tuberculosis	Probable amidase AmiA2 (aminohydrolase)	0.0064	0.0504	0.1753
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0024	0.0074	0.0134
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0062	0.0217
Echinococcus multilocularis	geminin	0.0198	0.1947	0.1947
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0018	0.0033
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0062	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0527	0.5489	1
Leishmania major	DNA polymerase kappa, putative	0.0023	0.0062	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0074	0.0134
Mycobacterium tuberculosis	Possible lysophospholipase	0.0284	0.2874	1
Brugia malayi	ecdysteroid receptor	0.0024	0.0074	0.0134
Leishmania major	hypothetical protein, conserved	0.0064	0.0504	0.1753
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0062	0.0217
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0284	0.2874	1
Plasmodium falciparum	lysophospholipase, putative	0.0284	0.2874	1
Schistosoma mansoni	hypothetical protein	0.0336	0.3437	0.6262
Brugia malayi	Amidase family protein	0.0064	0.0504	0.0918
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0115	0.1056	0.3675
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0062	0.0217
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0023	0.0062	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0446	0.0812
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0024	0.0074	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0074	0.0134
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0018	0.0031
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0024	0.0074	0.0134
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.035	0.1219
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0024	0.0074	0.0129
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0024	0.0074	0.0134
Loa Loa (eye worm)	MH2 domain-containing protein	0.0139	0.1319	0.2403
Schistosoma mansoni	hypothetical protein	0.004	0.0248	0.0452
Trypanosoma brucei	monoglyceride lipase, putative	0.0284	0.2874	1
Mycobacterium ulcerans	amidase	0.0064	0.0504	0.1753
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0024	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1056	0.1924
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0023	0.0062	0.0217
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0136	0.0475
Brugia malayi	hypothetical protein	0.0143	0.1358	0.2474
Brugia malayi	Niemann-Pick C1 protein precursor	0.0115	0.1056	0.1924
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0062	0.0217
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0062	0.0217
Schistosoma mansoni	hypothetical protein	0.0198	0.1947	0.3548
Mycobacterium ulcerans	amidase	0.0064	0.0504	0.1753
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0018	0.0018
Plasmodium falciparum	lysophospholipase, putative	0.0284	0.2874	1
Mycobacterium ulcerans	hypothetical protein	0.0284	0.2874	1
Echinococcus multilocularis	glutamyl tRNA(Gln) amidotransferase subunit A	0.0064	0.0504	0.0504
Echinococcus multilocularis	FTZ F1 alpha	0.0024	0.0074	0.0074
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0024	0.0074	0.0129
Echinococcus multilocularis	protein dispatched 1	0.0056	0.0425	0.0425
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0024	0.0074	0.0134
Leishmania major	hypothetical protein, conserved	0.0029	0.0136	0.0475
Brugia malayi	putative amidase	0.0064	0.0504	0.0918
Chlamydia trachomatis	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0064	0.0504	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0115	0.1056	0.1056
Brugia malayi	hypothetical protein	0.0042	0.0272	0.0495
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0018	0.0018
Brugia malayi	nuclear receptor NHR-88	0.0024	0.0074	0.0134
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0062	0.0217
Mycobacterium tuberculosis	Possible amidase (aminohydrolase)	0.0064	0.0504	0.1753
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	0.0284	0.2874	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0024	0.0074	0.0134
Brugia malayi	latrophilin 2 splice variant baaae	0.004	0.0248	0.0452
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0284	0.2874	1
Mycobacterium ulcerans	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0064	0.0504	0.1753
Plasmodium vivax	ataxin-2 like protein, putative	0.0029	0.0136	0.0475
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0024	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1358	0.2474
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0136	0.0475
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0024	0.0074	0.0134
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0136	0.0475
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0062	0.0217
Echinococcus granulosus	geminin	0.0198	0.1947	0.3395
Schistosoma mansoni	nuclear hormone receptor	0.0024	0.0074	0.0134
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0062	0.0217
Trypanosoma brucei	fatty-acid amide hydrolase, putative	0.0064	0.0504	0.1753
Brugia malayi	nuclear hormone receptor	0.0024	0.0074	0.0134
Schistosoma mansoni	retinoic acid receptor RXR	0.0024	0.0074	0.0134
Schistosoma mansoni	hypothetical protein	0.0018	0.0018	0.0033
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.0136	0.0475
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0074	0.0134
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0024	0.0074	0.0129
Echinococcus granulosus	dna polymerase kappa	0.0023	0.0062	0.0109
Echinococcus multilocularis	protein patched	0.0049	0.035	0.035
Schistosoma mansoni	RAR-like nuclear receptor	0.0024	0.0074	0.0134
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0024	0.0074	0.0134
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0527	0.5489	0.9569
Schistosoma mansoni	hypothetical protein	0.0042	0.0272	0.0495
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.0272	0.0272
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0024	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0136	0.0249
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0024	0.0074	0.0134
Toxoplasma gondii	LsmAD domain-containing protein	0.0029	0.0136	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0024	0.0074	0.0074
Trypanosoma brucei	DNA polymerase eta, putative	0.0023	0.0062	0.0217
Brugia malayi	hypothetical protein	0.0019	0.0024	0.0044
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0062	0.0217
Trypanosoma cruzi	amidase, putative	0.0064	0.0504	0.1753
Plasmodium falciparum	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0064	0.0504	0.1753
Echinococcus granulosus	neuropeptide s receptor	0.055	0.5736	1
Trypanosoma brucei	monoglyceride lipase, putative	0.0284	0.2874	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0018	0.0018
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0024	0.0074	0.0129
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0062	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1358	0.2474
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0062	0.0217
Brugia malayi	CHE-14 protein	0.0049	0.035	0.0638
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0024	0.0074	0.0074
Wolbachia endosymbiont of Brugia malayi	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0064	0.0504	0.5
Mycobacterium ulcerans	amidase	0.0064	0.0504	0.1753
Echinococcus granulosus	dna polymerase eta	0.0023	0.0062	0.0109
Leishmania major	monoglyceride lipase, putative	0.0284	0.2874	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0164	0.1586	0.1586
Echinococcus granulosus	ecdysone induced protein 78C	0.0024	0.0074	0.0129
Loa Loa (eye worm)	steroid hormone receptor	0.0024	0.0074	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0074	0.0134
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0024	0.0074	0.0134
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0024	0.0074	0.0134
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0024	0.0074	0.0134
Echinococcus granulosus	Protein patched homolog 1	0.0049	0.035	0.0611
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0024	0.0074	0.0134
Loa Loa (eye worm)	amidase	0.0064	0.0504	0.0918
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0023	0.0062	0.0217
Schistosoma mansoni	hypothetical protein	0.0018	0.0018	0.0033
Echinococcus multilocularis	neuropeptide s receptor	0.055	0.5736	0.5736
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0024	0.0074	0.0134
Echinococcus granulosus	neuropeptide receptor A26	0.055	0.5736	1
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0049	0.035	0.0638
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0023	0.0062	0.0217
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0117	0.1075	0.1959
Brugia malayi	photoreceptor-specific nuclear receptor	0.0024	0.0074	0.0134
Echinococcus granulosus	Niemann Pick C1 protein	0.0164	0.1586	0.2766
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0018	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0049	0.035	0.0638
Echinococcus granulosus	GPCR family 2	0.0018	0.0018	0.0031
Plasmodium falciparum	lysophospholipase, putative	0.0284	0.2874	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0074	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0074	0.0134
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0024	0.0074	0.0129
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0062	0.0217
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0024	0.0074	0.0134

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	0	Antiproliferative activity against H661 cells at 25 uM after 48 hrs	ChEMBL.	17897824

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 443867