Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Homo sapiens | androgen receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Bile acid receptor homolog | 0.0027 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0027 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0027 | 0.5 | 0.5 | |
Schistosoma mansoni | nuclear hormone receptor | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0027 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0027 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0027 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 70 % | Agonist activity at glucocorticoid receptor in human A549 cells by MMTV transactivation assay relative to dexamethasone | ChEMBL. | 17616395 |
Activity (functional) | = 70 % | Agonist activity at glucocorticoid receptor in human A549 cells by MMTV transactivation assay relative to dexamethasone | ChEMBL. | 17616395 |
Activity (functional) | = 97 % | Agonist activity at glucocorticoid receptor in human A549 cells by NFkappaB transrepression assay relative to dexamethasone | ChEMBL. | 17616395 |
Activity (functional) | = 97 % | Agonist activity at glucocorticoid receptor in human A549 cells by NFkappaB transrepression assay relative to dexamethasone | ChEMBL. | 17616395 |
Activity (functional) | = 99 % | Agonist activity at glucocorticoid receptor in human A549 cells by MMTV transactivation assay relative to dexamethasone | ChEMBL. | 17616395 |
Activity (functional) | = 99 % | Agonist activity at glucocorticoid receptor in human A549 cells by MMTV transactivation assay relative to dexamethasone | ChEMBL. | 17616395 |
Activity (functional) | = 105 % | Agonist activity at glucocorticoid receptor in human A549 cells by NFkappaB transrepression assay relative to dexamethasone | ChEMBL. | 17616395 |
Activity (functional) | = 105 % | Agonist activity at glucocorticoid receptor in human A549 cells by NFkappaB transrepression assay relative to dexamethasone | ChEMBL. | 17616395 |
EC50 (functional) | = -8.92 | Agonist activity at glucocorticoid receptor in human A549 cells by MMTV transactivation assay | ChEMBL. | 17616395 |
EC50 (functional) | = -7.8 | Agonist activity at glucocorticoid receptor in human A549 cells by MMTV transactivation assay | ChEMBL. | 17616395 |
IC50 (functional) | = -9.34 | Agonist activity at glucocorticoid receptor in human A549 cells by NFkappaB transrepression assay | ChEMBL. | 17616395 |
IC50 (binding) | = -8.26 | Binding affinity to glucocorticoid receptor | ChEMBL. | 17616395 |
IC50 (binding) | = -8.17 | Binding affinity to glucocorticoid receptor | ChEMBL. | 17616395 |
IC50 (functional) | = -7.75 | Agonist activity at glucocorticoid receptor in human A549 cells by NFkappaB transrepression assay | ChEMBL. | 17616395 |
IC50 (functional) | < -6 | Antagonist activity at glucocorticoid receptor in human A549 cells transfected with MMTV luciferase reporter gene assessed as inhibition of dexamethasone-induced activation | ChEMBL. | 17616395 |
IC50 (binding) | < -6 | Binding affinity to progesterone receptor | ChEMBL. | 17616395 |
IC50 (binding) | < -6 | Binding affinity to androgen receptor | ChEMBL. | 17616395 |
Inhibition (functional) | = 4 % | Antagonist activity at glucocorticoid receptor in human A549 cells transfected with MMTV luciferase reporter gene assessed as inhibition of dexamethasone-induced activation | ChEMBL. | 17616395 |
Inhibition (functional) | = 4 % | Antagonist activity at glucocorticoid receptor in human A549 cells transfected with MMTV luciferase reporter gene assessed as inhibition of dexamethasone-induced activation | ChEMBL. | 17616395 |
Log EC50 (functional) | = 7.8 | Agonist activity at glucocorticoid receptor in human A549 cells by MMTV transactivation assay | ChEMBL. | 17616395 |
Log EC50 (functional) | = 8.92 | Agonist activity at glucocorticoid receptor in human A549 cells by MMTV transactivation assay | ChEMBL. | 17616395 |
Log IC50 (functional) | 0 | Antagonist activity at glucocorticoid receptor in human A549 cells transfected with MMTV luciferase reporter gene assessed as inhibition of dexamethasone-induced activation | ChEMBL. | 17616395 |
Log IC50 (functional) | < 6 | Antagonist activity at glucocorticoid receptor in human A549 cells transfected with MMTV luciferase reporter gene assessed as inhibition of dexamethasone-induced activation | ChEMBL. | 17616395 |
Log IC50 (binding) | < 6 | Binding affinity to progesterone receptor | ChEMBL. | 17616395 |
Log IC50 (binding) | < 6 | Binding affinity to androgen receptor | ChEMBL. | 17616395 |
Log IC50 (functional) | = 7.75 | Agonist activity at glucocorticoid receptor in human A549 cells by NFkappaB transrepression assay | ChEMBL. | 17616395 |
Log IC50 (binding) | = 8.17 | Binding affinity to glucocorticoid receptor | ChEMBL. | 17616395 |
Log IC50 (binding) | = 8.26 | Binding affinity to glucocorticoid receptor | ChEMBL. | 17616395 |
Log IC50 (functional) | = 9.34 | Agonist activity at glucocorticoid receptor in human A549 cells by NFkappaB transrepression assay | ChEMBL. | 17616395 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.