Detailed information for compound 443915

Basic information

Technical information
  • TDR Targets ID: 443915
  • Name: 4-chloro-5-methyl-1H-pyrazole-3-carboxylic ac id
  • MW: 160.558 | Formula: C5H5ClN2O2
  • H donors: 2 H acceptors: 3 LogP: 1.1 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)c1n[nH]c(c1Cl)C
  • InChi: 1S/C5H5ClN2O2/c1-2-3(6)4(5(9)10)8-7-2/h1H3,(H,7,8)(H,9,10)
  • InChiKey: FWSYEYQXPSSQMV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxycarboxylic acid receptor 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis G-protein coupled receptor, putative hydroxycarboxylic acid receptor 2 363 aa 294 aa 20.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0009 0.0095 0.0218
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0118 0.0269
Loa Loa (eye worm) hypothetical protein 0.0049 0.1384 0.1375
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0118 0.0195
Schistosoma mansoni hypothetical protein 0.0017 0.0329 0.0752
Entamoeba histolytica recQ family helicase, putative 0.0013 0.023 0.0737
Schistosoma mansoni jumonji domain containing protein 0.0075 0.2206 0.504
Echinococcus granulosus phd:f box containing protein 0.0009 0.0095 0.0155
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0131 0.0121
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0118 0.0195
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0329 0.058
Brugia malayi hypothetical protein 0.0009 0.0097 0.0086
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0917 0.2096
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.001 0.0024
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0722 1
Schistosoma mansoni DNA helicase recq5 0.001 0.0131 0.03
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0118 0.0195
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0118 0.0107
Schistosoma mansoni phd/f-box containing protein 0.0009 0.0095 0.0218
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0118 0.0107
Schistosoma mansoni thyroid hormone receptor 0.001 0.0118 0.0269
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0118 0.0107
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0437 0.0998
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0097 0.0221
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0118 0.0195
Schistosoma mansoni coup transcription factor 0.001 0.0118 0.0269
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0118 0.0195
Schistosoma mansoni ras GTP exchange factor 0.0007 0.001 0.0024
Brugia malayi Bromodomain containing protein 0.0029 0.0722 0.0713
Echinococcus multilocularis GPCR, family 2 0.0017 0.0329 0.058
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0118 0.0195
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.023 0.0313
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0177 0.5507 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0118 0.0107
Loa Loa (eye worm) hypothetical protein 0.001 0.0118 0.0107
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0131 0.057
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.2986 1
Echinococcus multilocularis phd:f box containing protein 0.0009 0.0095 0.0155
Brugia malayi jmjC domain containing protein 0.0035 0.0917 0.0908
Loa Loa (eye worm) hypothetical protein 0.0009 0.0097 0.0086
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0118 0.0269
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0097 0.0157
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0118 0.0107
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0329 0.058
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0509 0.6591
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0009 0.0095 0.0155
Echinococcus multilocularis jumonji domain containing protein 0.004 0.1085 0.1955
Giardia lamblia PHD finger protein 15 0.0029 0.0722 0.2071
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.023 0.0464
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0097 0.0086
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0097 0.0157
Echinococcus granulosus jumonji domain containing protein 0.004 0.1085 0.1955
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0722 0.1295
Trypanosoma brucei RNA helicase, putative 0.0142 0.4376 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0095 0.0085
Schistosoma mansoni hypothetical protein 0.0036 0.0947 0.2164
Loa Loa (eye worm) hypothetical protein 0.0213 0.6657 0.6654
Toxoplasma gondii hypothetical protein 0.0009 0.0097 0.0018
Schistosoma mansoni hypothetical protein 0.0017 0.0329 0.0752
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.2986 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0329 0.0319
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0118 0.0107
Schistosoma mansoni hypothetical protein 0.0009 0.0099 0.0227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0118 0.0107
Echinococcus multilocularis jumonji domain containing 1A 0.0009 0.0095 0.0155
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.2986 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0118 0.0107
Brugia malayi nuclear hormone receptor 0.001 0.0118 0.0107
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.148 0.1471
Echinococcus granulosus peregrin 0.0029 0.0722 0.1295
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0607 0.2005
Schistosoma mansoni jumonji domain containing protein 0.0009 0.0095 0.0218
Brugia malayi DIX domain containing protein 0.0009 0.0097 0.0086
Loa Loa (eye worm) RecQ helicase 0.0025 0.0607 0.0597
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0177 0.5507 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0118 0.0107
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0099 0.2986 1
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0097 0.0086
Entamoeba histolytica serine/threonine protein kinase, putative 0.0099 0.2986 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0131 0.057
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0097 0.0157
Loa Loa (eye worm) hypothetical protein 0.0009 0.0095 0.0085
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0917 0.0908
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0097 0.0221
Loa Loa (eye worm) hypothetical protein 0.0036 0.0947 0.0938
Loa Loa (eye worm) hypothetical protein 0.001 0.0118 0.0107
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0097 0.0157
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0947 0.0938
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0118 0.0269
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0722 0.1295
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0097 0.0086
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0009 0.0095 0.0155
Loa Loa (eye worm) jmjC domain-containing protein 0.0009 0.0095 0.0085
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0118 0.0269
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0118 0.0107
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.2986 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0009 0.0095 0.0155
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0118 0.0269
Loa Loa (eye worm) hypothetical protein 0.0009 0.0099 0.0089
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0099 0.2986 0.2978
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.0131 0.057
Echinococcus granulosus jumonji domain containing 1A 0.0009 0.0095 0.0155
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0345 0.3974
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0329 0.0319
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0722 1
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.2986 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0189 0.5892 0.5887
Loa Loa (eye worm) hypothetical protein 0.0316 1 1
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0097 0.0157
Plasmodium falciparum phd finger protein, putative 0.0029 0.0722 1
Echinococcus multilocularis lysine specific demethylase 6a 0.0009 0.0095 0.0155
Schistosoma mansoni hypothetical protein 0.0017 0.0329 0.0752
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0917 0.165
Brugia malayi hypothetical protein 0.0009 0.0097 0.0086
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0118 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0118 0.0107
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0131 0.022
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0917 0.2096
Schistosoma mansoni phosphatidylserine receptor 0.0009 0.0095 0.0218
Brugia malayi jmjC domain containing protein 0.0009 0.0095 0.0085
Loa Loa (eye worm) hypothetical protein 0.001 0.0118 0.0107
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0118 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0118 0.0107
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0118 0.0269
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0097 0.0221
Plasmodium vivax hypothetical protein, conserved 0.0009 0.0099 0.006
Onchocerca volvulus 0.0316 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0118 0.0107
Loa Loa (eye worm) hypothetical protein 0.001 0.0131 0.0121
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0097 0.0157
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.001 0.0024
Loa Loa (eye worm) jmjC domain-containing protein 0.0009 0.0095 0.0085
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.2986 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.148 0.1471
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0099 0.0227
Echinococcus granulosus JmjC domain containing protein 4 0.0009 0.0095 0.0155
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0131 0.022
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0118 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0118 0.0107
Brugia malayi serine/threonine-protein kinase plk-2 0.0099 0.2986 0.2978
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0118 0.0107
Schistosoma mansoni kinase 0.005 0.1417 0.3239
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0118 0.0269
Brugia malayi jmjC domain containing protein 0.0009 0.0095 0.0085
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.2986 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0097 0.0086
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0009 0.0099 0.0009
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0118 0.0195
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0007 0.001 0.0024
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0009 0.0099 0.006
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0009 0.0099 0.0009
Echinococcus granulosus FTZ F1 alpha 0.001 0.0118 0.0195
Loa Loa (eye worm) hypothetical protein 0.001 0.0118 0.0107
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0118 0.0269
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0118 0.0107
Toxoplasma gondii PHD-finger domain-containing protein 0.0009 0.0099 0.006
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0131 0.0121
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0118 0.0107
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0097 0.0086
Schistosoma mansoni hypothetical protein 0.0029 0.0722 0.1651
Echinococcus multilocularis peregrin 0.0029 0.0722 0.1295
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0607 0.0597
Echinococcus granulosus bloom syndrome protein 0.0025 0.0607 0.1086
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0097 0.0157
Echinococcus granulosus GPCR family 2 0.0017 0.0329 0.058
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0131 0.022
Loa Loa (eye worm) jmjC domain-containing protein 0.0009 0.0095 0.0085
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0131 0.0121
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0099 0.0089
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0099 0.2986 0.5413
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0118 0.0107
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.2829 0.5128
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0118 0.0107
Brugia malayi AF-10 protein 0.0009 0.0099 0.0089
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.1375 0.4587
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0118 0.0195
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0118 0.0195
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0099 0.2986 0.5413
Schistosoma mansoni thyroid hormone receptor 0.001 0.0118 0.0269
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0118 0.0107
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0131 0.022
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.023 0.0737
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0722 0.0713
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0118 0.0107
Brugia malayi PHD-finger family protein 0.0029 0.0722 0.0713
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0118 0.0195
Schistosoma mansoni dishevelled 0.0009 0.0097 0.0221
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0118 0.0195
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0722 0.1651
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0118 0.0107
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0213 0.6657 0.6654
Loa Loa (eye worm) hypothetical protein 0.001 0.0118 0.0107
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.1708 0.17
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.2986 1
Brugia malayi N-terminal motif family protein 0.0189 0.5892 0.5887
Loa Loa (eye worm) hypothetical protein 0.0126 0.3876 0.387
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.2829 0.5128
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.1375 0.4587
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0009 0.0099 0.006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0118 0.0195
Schistosoma mansoni DNA helicase recq1 0.001 0.0131 0.03
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0118 0.0195
Schistosoma mansoni dep domain containing protein 0.0009 0.0097 0.0221
Brugia malayi jmjC domain containing protein 0.0009 0.0095 0.0085
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0097 0.0157
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0338 0.3871
Schistosoma mansoni dishevelled 0.0009 0.0097 0.0221
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0118 0.0195
Loa Loa (eye worm) hypothetical protein 0.0029 0.0722 0.0713
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0329 0.0319
Onchocerca volvulus Alhambra homolog 0.0029 0.0722 0.0713
Schistosoma mansoni hypothetical protein 0.0017 0.0329 0.0752
Onchocerca volvulus Serine\/threonine kinase homolog 0.0099 0.2986 0.2978
Loa Loa (eye worm) hypothetical protein 0.001 0.0118 0.0107
Loa Loa (eye worm) hypothetical protein 0.001 0.0118 0.0107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0118 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0118 0.0107
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0118 0.0195
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.001 0.0024
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.023 0.0737
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0118 0.0195
Brugia malayi steroid hormone receptor 0.001 0.0118 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0118 0.0107
Brugia malayi nuclear receptor NHR-88 0.001 0.0118 0.0107
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0009 0.0095 0.0286
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0097 0.0157
Brugia malayi jmjC domain containing protein 0.0094 0.2829 0.2821
Giardia lamblia Kinase, PLK 0.0099 0.2986 1
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0097 0.0157
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0118 0.0269
Onchocerca volvulus 0.0009 0.0097 0.0086
Trypanosoma brucei polo-like protein kinase 0.0099 0.2986 0.6752
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0097 0.0086
Brugia malayi ecdysteroid receptor 0.001 0.0118 0.0107
Onchocerca volvulus 0.001 0.0118 0.0107
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0607 0.2005
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0009 0.0095 0.0286
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.2986 0.6822
Schistosoma mansoni hypothetical protein 0.0142 0.4376 1
Schistosoma mansoni nuclear hormone receptor 0.001 0.0118 0.0269
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.2986 1
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0097 0.0086
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0329 0.0319
Loa Loa (eye worm) hypothetical protein 0.0189 0.5892 0.5887
Echinococcus granulosus lysine specific demethylase 6a 0.0009 0.0095 0.0155
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0607 0.1086
Loa Loa (eye worm) hypothetical protein 0.0009 0.0097 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0118 0.0107
Brugia malayi jmjC domain containing protein 0.0009 0.0095 0.0085
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0917 0.165
Schistosoma mansoni protein phosphatase 2C 0.0009 0.0095 0.0218
Brugia malayi PHD-finger family protein 0.0009 0.0099 0.0089
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0722 1

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay ChEMBL. 17804224
Activity (functional) Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level upto 50 uM by HTRF assay ChEMBL. 17804224
Activity (functional) 0 Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay ChEMBL. 17804224
Activity (functional) 0 Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level upto 50 uM by HTRF assay ChEMBL. 17804224
EC50 (functional) = -5.6 Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay ChEMBL. 17804224
EC50 (functional) > 1 uM Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay ChEMBL. 17804224
EC50 (functional) > 1 uM Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay ChEMBL. 17804224
Efficacy (functional) = 95 % Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay in relative to niacin ChEMBL. 17804224
Efficacy (functional) = 95 % Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay in relative to niacin ChEMBL. 17804224
Log EC50 (functional) = 5.6 Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay ChEMBL. 17804224

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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