Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histone deacetylase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | histone deacetylase 1 | 0.0077 | 0.1216 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0077 | 0.1216 | 0.5 |
Schistosoma mansoni | histone deacetylase | 0.0077 | 0.1216 | 0.1216 |
Echinococcus granulosus | histone deacetylase 1 | 0.0077 | 0.1216 | 0.1216 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0077 | 0.1216 | 0.2061 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0417 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.1216 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.1216 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.1216 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.1216 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1216 | 0.2061 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.1216 | 0.5 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0077 | 0.1216 | 0.1267 |
Brugia malayi | Histone deacetylase 1 | 0.0077 | 0.1216 | 0.2061 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0077 | 0.1216 | 0.1267 |
Echinococcus granulosus | transcription factor Dp 1 | 0.015 | 0.3091 | 0.3091 |
Schistosoma mansoni | histone deacetylase | 0.0077 | 0.1216 | 0.1216 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0077 | 0.1216 | 0.2061 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0077 | 0.1216 | 0.5 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0077 | 0.1216 | 0.2061 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0401 | 0.9594 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0258 | 0.59 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0258 | 0.59 | 1 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0258 | 0.59 | 0.615 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0258 | 0.59 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0258 | 0.59 | 0.59 |
Echinococcus granulosus | histone deacetylase 3 | 0.0077 | 0.1216 | 0.1216 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0077 | 0.1216 | 0.5 |
Giardia lamblia | Histone deacetylase | 0.0077 | 0.1216 | 0.5 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0258 | 0.59 | 0.59 |
Onchocerca volvulus | Bile acid receptor homolog | 0.003 | 0 | 0.5 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0077 | 0.1216 | 0.5 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0258 | 0.59 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.003 | 0 | 0.5 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0077 | 0.1216 | 0.2061 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0258 | 0.59 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0258 | 0.59 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0077 | 0.1216 | 0.5 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.015 | 0.3091 | 0.3222 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0258 | 0.59 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.1216 | 0.5 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0077 | 0.1216 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 916 nM | Growth inhibition of HCT116 cells after 72 hrs | ChEMBL. | 17761416 |
GI50 (functional) | = 916 nM | Growth inhibition of HCT116 cells after 72 hrs | ChEMBL. | 17761416 |
IC50 (binding) | = 39 nM | Inhibition of recombinant HDAC1 | ChEMBL. | 17761416 |
IC50 (binding) | = 39 nM | Inhibition of recombinant HDAC1 | ChEMBL. | 17761416 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.