Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histone deacetylase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0064 | 0.5202 | 0.5202 |
Plasmodium falciparum | histone deacetylase 1 | 0.0077 | 0.6732 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0064 | 0.5202 | 0.5202 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.6732 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0064 | 0.5202 | 0.7727 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0077 | 0.6732 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0104 | 1 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0064 | 0.5202 | 0.7727 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0077 | 0.6732 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0077 | 0.6732 | 0.5 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0077 | 0.6732 | 0.707 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0064 | 0.5202 | 0.7727 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0077 | 0.6732 | 0.707 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0064 | 0.5202 | 0.5463 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0077 | 0.6732 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0064 | 0.5202 | 0.7727 |
Echinococcus granulosus | histone deacetylase 3 | 0.0077 | 0.6732 | 0.6732 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.6732 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0064 | 0.5202 | 0.7727 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0077 | 0.6732 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0077 | 0.6732 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.6732 | 0.5 |
Leishmania major | histone deacetylase, putative | 0.0077 | 0.6732 | 1 |
Brugia malayi | Histone deacetylase 1 | 0.0077 | 0.6732 | 1 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0022 | 0 | 0.5 |
Giardia lamblia | Histone deacetylase | 0.0077 | 0.6732 | 0.5 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0077 | 0.6732 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.6732 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0077 | 0.6732 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0077 | 0.6732 | 0.6732 |
Trypanosoma brucei | histone deacetylase 1 | 0.0077 | 0.6732 | 1 |
Leishmania major | histone deacetylase, putative | 0.0077 | 0.6732 | 1 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0037 | 0.1879 | 0.1974 |
Entamoeba histolytica | histone deacetylase, putative | 0.0077 | 0.6732 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0077 | 0.6732 | 0.6732 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.6732 | 0.5 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0077 | 0.6732 | 1 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0077 | 0.6732 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0064 | 0.5202 | 0.7727 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.01 | 0.9521 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.6732 | 0.5 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0037 | 0.1879 | 0.1879 |
Echinococcus granulosus | histone deacetylase 1 | 0.0077 | 0.6732 | 0.6732 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0077 | 0.6732 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.6732 | 0.5 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0077 | 0.6732 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 892 nM | Growth inhibition of HCT116 cells after 72 hrs | ChEMBL. | 17761416 |
GI50 (functional) | = 892 nM | Growth inhibition of HCT116 cells after 72 hrs | ChEMBL. | 17761416 |
IC50 (binding) | = 47 nM | Inhibition of recombinant HDAC1 | ChEMBL. | 17761416 |
IC50 (binding) | = 47 nM | Inhibition of recombinant HDAC1 | ChEMBL. | 17761416 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.