Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histone deacetylase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.1045 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.1045 | 1 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.1045 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 3 | 0.0077 | 0.0387 | 0.0387 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.1045 | 1 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.1045 | 1 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.1045 | 1 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.1045 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0077 | 0.0387 | 0.0387 |
Giardia lamblia | Histone deacetylase | 0.0077 | 0.0387 | 0.5 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Echinococcus granulosus | transcription factor Dp 1 | 0.0605 | 0.563 | 0.563 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0077 | 0.0387 | 0.0387 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.1045 | 1 | 1 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0605 | 0.563 | 0.563 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0038 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0038 | 0 | 0.5 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0077 | 0.0387 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.0387 | 0.5 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0077 | 0.0387 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0531 | 0.4894 | 0.4894 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0511 | 0.4695 | 0.4695 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0077 | 0.0387 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.0387 | 0.5 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.1045 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0387 | 0.0387 |
Echinococcus granulosus | histone deacetylase 1 | 0.0077 | 0.0387 | 0.0387 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0077 | 0.0387 | 0.5 |
Schistosoma mansoni | histone deacetylase | 0.0077 | 0.0387 | 0.0387 |
Plasmodium falciparum | histone deacetylase 1 | 0.0077 | 0.0387 | 0.5 |
Brugia malayi | Histone deacetylase 1 | 0.0077 | 0.0387 | 0.0387 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0077 | 0.0387 | 0.0387 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.0387 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.0387 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0077 | 0.0387 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.0387 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.0387 | 0.5 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0077 | 0.0387 | 0.0387 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0038 | 0 | 0.5 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0077 | 0.0387 | 0.5 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0077 | 0.0387 | 0.0387 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0531 | 0.4894 | 0.4894 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0077 | 0.0387 | 0.0387 |
Schistosoma mansoni | histone deacetylase | 0.0077 | 0.0387 | 0.0387 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 1925 nM | Growth inhibition of HCT116 cells after 72 hrs | ChEMBL. | 17761416 |
GI50 (functional) | = 1925 nM | Growth inhibition of HCT116 cells after 72 hrs | ChEMBL. | 17761416 |
IC50 (binding) | = 101 nM | Inhibition of recombinant HDAC1 | ChEMBL. | 17761416 |
IC50 (binding) | = 101 nM | Inhibition of recombinant HDAC1 | ChEMBL. | 17761416 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.