Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histone deacetylase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0077 | 0.0387 | 0.5 |
Onchocerca volvulus | 0.0038 | 0 | 0.5 | |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.1045 | 1 | 1 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0077 | 0.0387 | 0.0387 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0531 | 0.4894 | 0.4894 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0077 | 0.0387 | 0.0387 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0531 | 0.4894 | 0.4894 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0038 | 0 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.0387 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.0387 | 0.5 |
Brugia malayi | Histone deacetylase 1 | 0.0077 | 0.0387 | 0.0387 |
Schistosoma mansoni | histone deacetylase | 0.0077 | 0.0387 | 0.0387 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0077 | 0.0387 | 0.0387 |
Plasmodium falciparum | histone deacetylase 1 | 0.0077 | 0.0387 | 0.5 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.1045 | 1 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0077 | 0.0387 | 0.0387 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.1045 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.0387 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0077 | 0.0387 | 0.0387 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0077 | 0.0387 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0511 | 0.4695 | 0.4695 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0077 | 0.0387 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0387 | 0.0387 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.0387 | 0.5 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.1045 | 1 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.1045 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.1045 | 1 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.1045 | 1 | 1 |
Giardia lamblia | Histone deacetylase | 0.0077 | 0.0387 | 0.5 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0077 | 0.0387 | 0.5 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.1045 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0077 | 0.0387 | 0.0387 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.0387 | 0.5 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0077 | 0.0387 | 0.5 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.1045 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0038 | 0 | 0.5 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0605 | 0.563 | 0.563 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0077 | 0.0387 | 0.5 |
Echinococcus granulosus | histone deacetylase 3 | 0.0077 | 0.0387 | 0.0387 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0605 | 0.563 | 0.563 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0038 | 0 | 0.5 |
Echinococcus granulosus | histone deacetylase 1 | 0.0077 | 0.0387 | 0.0387 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0077 | 0.0387 | 0.0387 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.0387 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 902 nM | Growth inhibition of HCT116 cells after 72 hrs | ChEMBL. | 17761416 |
GI50 (functional) | = 902 nM | Growth inhibition of HCT116 cells after 72 hrs | ChEMBL. | 17761416 |
IC50 (binding) | = 47 nM | Inhibition of recombinant HDAC1 | ChEMBL. | 17761416 |
IC50 (binding) | = 47 nM | Inhibition of recombinant HDAC1 | ChEMBL. | 17761416 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.