Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histone deacetylase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0077 | 0.0088 | 0.5 |
Echinococcus granulosus | histone deacetylase 1 | 0.0077 | 0.0088 | 0.0088 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.0088 | 0.5 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.099 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0077 | 0.0088 | 0.5 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0077 | 0.0088 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0927 | 0.9309 | 0.9309 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0069 | 0 | 0.5 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0077 | 0.0088 | 0.0088 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0077 | 0.0088 | 0.0088 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0077 | 0.0088 | 0.5 |
Brugia malayi | Histone deacetylase 1 | 0.0077 | 0.0088 | 0.0088 |
Onchocerca volvulus | 0.0069 | 0 | 0.5 | |
Schistosoma mansoni | histone deacetylase | 0.0077 | 0.0088 | 0.0088 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0077 | 0.0088 | 0.0088 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.0088 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.0088 | 0.5 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0573 | 0.5474 | 0.5474 |
Echinococcus granulosus | histone deacetylase 3 | 0.0077 | 0.0088 | 0.0088 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.099 | 1 | 1 |
Giardia lamblia | Histone deacetylase | 0.0077 | 0.0088 | 0.5 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.099 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.099 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0077 | 0.0088 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0069 | 0 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.0088 | 0.5 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0077 | 0.0088 | 0.0088 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0077 | 0.0088 | 0.0088 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0069 | 0 | 0.5 |
Plasmodium falciparum | histone deacetylase 1 | 0.0077 | 0.0088 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0963 | 0.9703 | 0.9703 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0088 | 0.0088 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.099 | 1 | 1 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0573 | 0.5474 | 0.5474 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.099 | 1 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0077 | 0.0088 | 0.0088 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0963 | 0.9703 | 0.9703 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.099 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.099 | 1 | 1 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0077 | 0.0088 | 0.0088 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.099 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.0088 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.0088 | 0.5 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0077 | 0.0088 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 2262 nM | Growth inhibition of HCT116 cells after 72 hrs | ChEMBL. | 17761416 |
GI50 (functional) | = 2262 nM | Growth inhibition of HCT116 cells after 72 hrs | ChEMBL. | 17761416 |
IC50 (binding) | = 91 nM | Inhibition of recombinant HDAC1 | ChEMBL. | 17761416 |
IC50 (binding) | = 91 nM | Inhibition of recombinant HDAC1 | ChEMBL. | 17761416 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.