Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | androgen receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0063 | 0 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0936 | 1 | 0.5 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0936 | 1 | 0.5 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0936 | 1 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0936 | 1 | 0.5 |
Echinococcus multilocularis | traf and tnf receptor associated protein | 0.0367 | 0.3486 | 0.3486 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0936 | 1 | 0.5 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0936 | 1 | 1 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0936 | 1 | 1 |
Brugia malayi | Endonuclease/Exonuclease/phosphatase family protein | 0.0367 | 0.3486 | 0.3486 |
Onchocerca volvulus | 0.0063 | 0 | 0.5 | |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0063 | 0 | 0.5 |
Loa Loa (eye worm) | endonuclease/Exonuclease/phosphatase | 0.0362 | 0.3423 | 0.3423 |
Toxoplasma gondii | endonuclease/exonuclease/phosphatase family protein | 0.0357 | 0.3363 | 0.5 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0936 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0063 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0762 | 0.8009 | 0.8009 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0936 | 1 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0762 | 0.8009 | 0.8009 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0542 | 0.5485 | 0.5485 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0542 | 0.5485 | 0.5485 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0729 | 0.7628 | 0.7628 |
Echinococcus granulosus | traf and tnf receptor associated protein | 0.0367 | 0.3486 | 0.3486 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
FI5 (functional) | = 2500 nM | Agonist activity at human androgen receptor expressed in HeLa cells assessed as five times increase in transcriptional activity by reporter gene assay | ChEMBL. | 17804229 |
FI5 (functional) | = 2500 nM | Agonist activity at human androgen receptor expressed in HeLa cells assessed as five times increase in transcriptional activity by reporter gene assay | ChEMBL. | 17804229 |
IC50 (functional) | = 170 nM | Antagonist activity at human androgen receptor expressed in HeLa cells assessed as inhibition of dihydrotestosterone induced transcriptional activity by reporter gene assay | ChEMBL. | 17804229 |
IC50 (functional) | = 170 nM | Antagonist activity at human androgen receptor expressed in HeLa cells assessed as inhibition of dihydrotestosterone induced transcriptional activity by reporter gene assay | ChEMBL. | 17804229 |
IC50 (binding) | = 300 nM | Displacement of [3H]mibolerone from human androgen receptor expressed in CHOK1 cells | ChEMBL. | 17804229 |
IC50 (binding) | = 300 nM | Displacement of [3H]mibolerone from human androgen receptor expressed in CHOK1 cells | ChEMBL. | 17804229 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.