TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 425.488 | Formula: C22H30F3N3O2
H donors: 1 H acceptors: 2 LogP: 3.16 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)[C@@H]1CC[C@H](CC1)[C@H](C(=O)N(C)C)[C@@H](C(=O)N1CCC(C1)(F)F)N
InChi: 1S/C22H30F3N3O2/c1-27(2)20(29)18(19(26)21(30)28-12-11-22(24,25)13-28)16-5-3-14(4-6-16)15-7-9-17(23)10-8-15/h7-10,14,16,18-19H,3-6,11-13,26H2,1-2H3/t14-,16-,18-,19-/m0/s1
InChiKey: ZVYHUXGREFPCKG-CBVHJVASSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	dipeptidyl-peptidase 4	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	dipeptidyl aminopeptidase B	Get druggable targets OG5_128614	All targets in OG5_128614
Brugia malayi	prolyl oligopeptidase family protein	Get druggable targets OG5_128614	All targets in OG5_128614
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	Get druggable targets OG5_128614	All targets in OG5_128614
Loa Loa (eye worm)	prolyl oligopeptidase	Get druggable targets OG5_128614	All targets in OG5_128614
Candida albicans	dipeptidyl aminopeptidase B	Get druggable targets OG5_128614	All targets in OG5_128614
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	Get druggable targets OG5_128614	All targets in OG5_128614
Schistosoma japonicum	ko:K01278 dipeptidyl-peptidase 4, putative	Get druggable targets OG5_128614	All targets in OG5_128614
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	Get druggable targets OG5_128614	All targets in OG5_128614
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	Get druggable targets OG5_128614	All targets in OG5_128614

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0054	0.0135	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0208	0.1132	0.1529
Brugia malayi	hypothetical protein	0.0053	0.013	0.0175
Trypanosoma cruzi	hypothetical protein, conserved	0.0033	0.0001	0.0001
Echinococcus granulosus	dro:myosuppressin receptor	0.0054	0.0135	0.0134
Brugia malayi	hypothetical protein	0.0054	0.0135	0.0181
Echinococcus multilocularis	neuropeptide receptor A26	0.0054	0.0135	0.0139
Brugia malayi	Melatonin receptor type 1A	0.0054	0.0135	0.0181
Echinococcus granulosus	neuropeptide receptor A26	0.0054	0.0135	0.0134
Echinococcus multilocularis	fmrfamide receptor	0.0054	0.0135	0.0139
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0054	0.0135	0.0134
Brugia malayi	hypothetical protein	0.0053	0.013	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Schistosoma mansoni	amine GPCR	0.0054	0.0135	0.0134
Brugia malayi	Nuclear hormone receptor E75	0.0053	0.013	0.0175
Echinococcus multilocularis	transcription factor Dp 1	0.0681	0.4195	0.4362
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0054	0.0135	0.0139
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0053	0.013	0.0129
Onchocerca volvulus		0.0054	0.0135	0.0838
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0208	0.1132	0.1131
Mycobacterium tuberculosis	Probable peptidase	0.0033	0.0001	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0097	0.0096
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.006	0.0171	0.0171
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0054	0.0135	0.0134
Loa Loa (eye worm)	hypothetical protein	0.01	0.0436	0.0588
Brugia malayi	nuclear receptor RXR	0.0053	0.013	0.0175
Schistosoma mansoni	hypothetical protein	0.0054	0.0135	0.0134
Schistosoma mansoni	biogenic amine receptor	0.0054	0.0135	0.0134
Leishmania major	DNA polymerase eta, putative	0.0047	0.009	0.0122
Echinococcus granulosus	FTZ F1 alpha	0.0113	0.0515	0.0515
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0113	0.0515	0.0515
Brugia malayi	Dopamine receptor	0.0054	0.0135	0.0181
Loa Loa (eye worm)	nuclear hormone receptor	0.0053	0.013	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0053	0.013	0.0175
Brugia malayi	G-protein coupled receptor	0.0054	0.0135	0.0181
Echinococcus granulosus	dna polymerase eta	0.0047	0.009	0.009
Brugia malayi	hypothetical protein	0.0038	0.0031	0.004
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0054	0.0135	0.0134
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0053	0.013	0.081
Brugia malayi	nuclear hormone receptor	0.0113	0.0515	0.0695
Onchocerca volvulus		0.0054	0.0135	0.0838
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0033	0.0001	0.0001
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.1518	0.9615	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0113	0.0515	0.0695
Echinococcus multilocularis	g protein coupled receptor	0.0054	0.0135	0.0139
Brugia malayi	Nuclear hormone receptor-like 1	0.0113	0.0515	0.0695
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0053	0.013	0.0134
Echinococcus granulosus	7TM GPCR rhodopsin	0.0054	0.0135	0.0134
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0113	0.0515	0.0695
Echinococcus multilocularis	neuropeptides capa receptor	0.0054	0.0135	0.0139
Plasmodium falciparum	peptidase, putative	0.0033	0.0001	0.5
Onchocerca volvulus		0.0054	0.0135	0.0838
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0054	0.0135	0.0181
Schistosoma mansoni	neuropeptide receptor	0.0054	0.0135	0.0134
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0054	0.0135	0.0181
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0113	0.0515	0.0695
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.028	0.1596	0.1659
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0054	0.0135	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Schistosoma mansoni	biogenic amine receptor	0.0054	0.0135	0.0134
Schistosoma mansoni	thyroid hormone receptor	0.0113	0.0515	0.0515
Onchocerca volvulus		0.0054	0.0135	0.0838
Brugia malayi	hypothetical protein	0.006	0.0171	0.023
Echinococcus multilocularis	neuropeptide receptor	0.0054	0.0135	0.0139
Echinococcus granulosus	neuropeptide s receptor	0.0054	0.0135	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0515	0.0695
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0054	0.0135	0.0134
Echinococcus granulosus	thyroid hormone receptor alpha	0.0053	0.013	0.0129
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0113	0.0515	0.0695
Echinococcus granulosus	somatostatin receptor	0.0054	0.0135	0.0134
Echinococcus multilocularis	tar DNA binding protein	0.0067	0.0217	0.0225
Echinococcus multilocularis	g protein coupled receptor	0.0054	0.0135	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0053	0.013	0.0175
Loa Loa (eye worm)	hypothetical protein	0.006	0.0171	0.023
Loa Loa (eye worm)	hypothetical protein	0.0053	0.013	0.0175
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0135	0.0134
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0113	0.0515	0.0535
Loa Loa (eye worm)	hypothetical protein	0.0053	0.013	0.0175
Brugia malayi	Steroid receptor seven-up type 2	0.0113	0.0515	0.0695
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0515	0.0695
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0054	0.0135	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0053	0.013	0.0175
Mycobacterium tuberculosis	Probable protease II PtrBb [second part] (oligopeptidase B)	0.0033	0.0001	0.5
Echinococcus multilocularis	somatostatin receptor	0.0054	0.0135	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Echinococcus granulosus	g protein coupled receptor	0.0054	0.0135	0.0134
Echinococcus granulosus	ecdysone induced protein 78C	0.0113	0.0515	0.0515
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0113	0.0515	0.0695
Loa Loa (eye worm)	G-protein coupled receptor	0.0054	0.0135	0.0181
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0113	0.0515	0.0515
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0113	0.0515	0.0695
Brugia malayi	ORL1-like opioid receptor	0.0054	0.0135	0.0181
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0054	0.0135	0.0181
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.1176	0.7402	1
Brugia malayi	steroid hormone receptor	0.0113	0.0515	0.0695
Onchocerca volvulus		0.0053	0.013	0.081
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0135	0.0134
Brugia malayi	larval opioid receptor	0.0054	0.0135	0.0181
Onchocerca volvulus		0.0054	0.0135	0.0838
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0135	0.0134
Entamoeba histolytica	hypothetical protein	0.0038	0.0031	0.004
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0097	0.0096
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0113	0.0515	0.0695
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.1176	0.7402	0.7402
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0135	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Schistosoma mansoni	hypothetical protein	0.0054	0.0135	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Brugia malayi	hypothetical protein	0.0054	0.0135	0.0181
Echinococcus multilocularis	G protein coupled receptor 139	0.0054	0.0135	0.0139
Schistosoma mansoni	growth hormone secretagogue receptor	0.0054	0.0135	0.0134
Echinococcus multilocularis	sex peptide receptor	0.0054	0.0135	0.0139
Echinococcus granulosus	nuclear receptor nhr 48	0.0053	0.013	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0053	0.013	0.0175
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0054	0.0135	0.0134
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0135	0.0134
Echinococcus granulosus	tm gpcr rhodopsin	0.0054	0.0135	0.0134
Brugia malayi	neuropeptide F receptor	0.0054	0.0135	0.0181
Onchocerca volvulus		0.0054	0.0135	0.0838
Loa Loa (eye worm)	hypothetical protein	0.0053	0.013	0.0175
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.028	0.1596	0.1595
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.1176	0.7402	0.7699
Echinococcus multilocularis	neuropeptide Y receptor	0.0054	0.0135	0.0139
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0113	0.0515	0.0535
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.1176	0.7402	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Onchocerca volvulus		0.0054	0.0135	0.0838
Mycobacterium ulcerans	protease II (oligopeptidase B), PtrB	0.0033	0.0001	0.5
Schistosoma mansoni	nuclear receptor nhr-48	0.0053	0.013	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Brugia malayi	nuclear receptor RXR	0.006	0.0171	0.023
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0135	0.0139
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0113	0.0515	0.0695
Brugia malayi	neuropeptide F receptor	0.0054	0.0135	0.0181
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.028	0.1596	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0054	0.0135	0.0134
Brugia malayi	nuclear receptor NHR-67	0.0053	0.013	0.0175
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0113	0.0515	0.0535
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Schistosoma mansoni	neuropeptide receptor	0.0054	0.0135	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0113	0.0515	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0482	0.065
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0113	0.0515	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0053	0.013	0.0175
Brugia malayi	G-protein coupled receptor	0.0054	0.0135	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Brugia malayi	hypothetical protein	0.0108	0.0482	0.065
Brugia malayi	GnHR receptor homolog	0.0054	0.0135	0.0181
Echinococcus granulosus	neuropeptides capa receptor	0.0054	0.0135	0.0134
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0054	0.0135	0.0139
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0208	0.1132	0.1131
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0053	0.013	0.0129
Brugia malayi	conserved hypotetical protein	0.0053	0.013	0.0175
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0113	0.0515	0.0515
Echinococcus granulosus	neuropeptide receptor	0.0054	0.0135	0.0134
Echinococcus multilocularis	neuropeptides capa receptor	0.0054	0.0135	0.0139
Onchocerca volvulus		0.0054	0.0135	0.0838
Schistosoma mansoni	thyroid hormone receptor	0.0113	0.0515	0.0515
Brugia malayi	hypothetical protein	0.0054	0.0135	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0054	0.0135	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Brugia malayi	ImpB/MucB/SamB family protein	0.0047	0.009	0.0121
Schistosoma mansoni	amine GPCR	0.0054	0.0135	0.0134
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0054	0.0135	0.0139
Echinococcus granulosus	tm gpcr rhodopsin	0.0054	0.0135	0.0134
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0054	0.0135	0.0139
Echinococcus granulosus	geminin	0.0178	0.0938	0.0937
Echinococcus granulosus	neuropeptide FF receptor 2	0.0054	0.0135	0.0134
Echinococcus multilocularis	neuropeptide s receptor	0.0054	0.0135	0.0139
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0135	0.0139
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0054	0.0135	0.0181
Brugia malayi	hypothetical protein	0.0054	0.0135	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0113	0.0515	0.0515
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0135	0.0139
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0031	0.003
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0033	0.0001	0.5
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0054	0.0135	0.0134
Schistosoma mansoni	amine GPCR	0.0054	0.0135	0.0134
Brugia malayi	nuclear hormone receptor	0.0053	0.013	0.0175
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0054	0.0135	0.0134
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0217	0.0216
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0054	0.0135	0.0181
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0113	0.0515	0.0695
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Loa Loa (eye worm)	TAR-binding protein	0.0067	0.0217	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0054	0.0135	0.0181
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0135	0.0134
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0033	0.0001	0.5
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0515	0.0695
Loa Loa (eye worm)	hypothetical protein	0.006	0.0171	0.023
Brugia malayi	hypothetical protein	0.0054	0.0135	0.0181
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0113	0.0515	0.3225
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0054	0.0135	0.0134
Echinococcus granulosus	neuropeptide Y receptor	0.0054	0.0135	0.0134
Schistosoma mansoni	opsin-like receptor	0.0054	0.0135	0.0134
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0113	0.0515	0.0515
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0113	0.0515	0.0695
Schistosoma mansoni	hypothetical protein	0.0054	0.0135	0.0134
Echinococcus granulosus	biogenic amine 5HT receptor	0.0054	0.0135	0.0134
Echinococcus granulosus	tm gpcr rhodopsin	0.0054	0.0135	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0047	0.009	0.0121
Echinococcus multilocularis	g protein coupled receptor	0.0054	0.0135	0.0139
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0217	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Brugia malayi	AKH receptor	0.0054	0.0135	0.0181
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0054	0.0135	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Echinococcus granulosus	g protein coupled receptor	0.0054	0.0135	0.0134
Onchocerca volvulus		0.0054	0.0135	0.0838
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0515	0.0695
Echinococcus granulosus	neuropeptide Y receptor	0.0054	0.0135	0.0134
Brugia malayi	hypothetical protein	0.006	0.0171	0.023
Loa Loa (eye worm)	hypothetical protein	0.0053	0.013	0.0175
Echinococcus granulosus	g-protein coupled receptor	0.0054	0.0135	0.0134
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0054	0.0135	0.0181
Trypanosoma cruzi	DNA polymerase eta, putative	0.0047	0.009	0.0122
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0208	0.1132	0.1529
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0054	0.0135	0.0134
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0054	0.0135	0.0134
Echinococcus granulosus	orexin receptor type 2	0.0054	0.0135	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0054	0.0135	0.0139
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0054	0.0135	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0515	0.0695
Brugia malayi	TAR-binding protein	0.0067	0.0217	0.0292
Onchocerca volvulus		0.0054	0.0135	0.0838
Schistosoma mansoni	DNA polymerase eta	0.0047	0.009	0.009
Onchocerca volvulus		0.0054	0.0135	0.0838
Schistosoma mansoni	RAR-like nuclear receptor	0.0113	0.0515	0.0515
Brugia malayi	hypothetical protein	0.0054	0.0135	0.0181
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0053	0.013	0.081
Toxoplasma gondii	hypothetical protein	0.0033	0.0001	0.0012
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0054	0.0135	0.0134
Echinococcus multilocularis	FTZ F1 alpha	0.0113	0.0515	0.0535
Brugia malayi	hypothetical protein	0.0054	0.0135	0.0181
Echinococcus multilocularis	dro:myosuppressin receptor	0.0054	0.0135	0.0139
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0054	0.0135	0.0139
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0113	0.0515	0.0535
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.1176	0.7402	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0135	0.0134
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0113	0.0515	0.0515
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0053	0.013	0.0129
Onchocerca volvulus		0.0054	0.0135	0.0838
Brugia malayi	prolyl oligopeptidase family protein	0.0208	0.1132	0.1529
Schistosoma mansoni	zinc finger protein	0.0053	0.013	0.0129
Leishmania major	oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein	0.0033	0.0001	0.0001
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.1176	0.7402	0.7402
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0135	0.0134
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0135	0.0134
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0113	0.0515	0.0515
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0033	0.0001	0.0001
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0031	0.0031
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0113	0.0515	0.0695
Echinococcus granulosus	hypothetical protein	0.0054	0.0135	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Schistosoma mansoni	opsin-like receptor	0.0054	0.0135	0.0134
Brugia malayi	Serotonin receptor	0.0054	0.0135	0.0181
Onchocerca volvulus		0.0054	0.0135	0.0838
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0135	0.0139
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0113	0.0515	0.0695
Trypanosoma brucei	DNA polymerase eta, putative	0.0047	0.009	0.0121
Loa Loa (eye worm)	prolyl oligopeptidase	0.028	0.1596	0.2155
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0054	0.0135	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Trypanosoma cruzi	oligopeptidase b	0.0033	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Brugia malayi	G protein-coupled receptor F59B2.13	0.0054	0.0135	0.0181
Brugia malayi	tailless protein	0.0053	0.013	0.0175
Onchocerca volvulus	Bile acid receptor homolog	0.0113	0.0515	0.3225
Schistosoma mansoni	biogenic amine receptor	0.0054	0.0135	0.0134
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0053	0.013	0.0129
Brugia malayi	RE15519p	0.0054	0.0135	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0054	0.0135	0.0838
Brugia malayi	follicle stimulating hormone receptor	0.0054	0.0135	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0113	0.0515	0.0695
Toxoplasma gondii	prolyl endopeptidase	0.0033	0.0001	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0135	0.0134
Schistosoma mansoni	coup transcription factor	0.0113	0.0515	0.0515
Entamoeba histolytica	hypothetical protein	0.0038	0.0031	0.004
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0097	0.01
Echinococcus granulosus	G protein coupled receptor 139	0.0054	0.0135	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Brugia malayi	Dopamine receptor protein 2	0.0054	0.0135	0.0181
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0031	0.003
Echinococcus granulosus	sex peptide receptor	0.0054	0.0135	0.0134
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0054	0.0135	0.0139
Schistosoma mansoni	opsin-like receptor	0.0054	0.0135	0.0134
Trichomonas vaginalis	Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase	0.0033	0.0001	0.5
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0515	0.0695
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0515	0.0695
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0053	0.013	0.0175
Loa Loa (eye worm)	neuropeptide F receptor	0.0054	0.0135	0.0181
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0135	0.0134
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0113	0.0515	0.0515
Echinococcus multilocularis	neuropeptide receptor	0.0054	0.0135	0.0139
Echinococcus granulosus	neuropeptide receptor	0.0054	0.0135	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0053	0.013	0.0175
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0135	0.0139
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0054	0.0135	0.0139
Trypanosoma cruzi	oligopeptidase b	0.0033	0.0001	0.0001
Schistosoma mansoni	nuclear hormone receptor	0.0053	0.013	0.0129
Loa Loa (eye worm)	melatonin receptor type 1A	0.0054	0.0135	0.0181
Brugia malayi	G protein-coupled receptor	0.0054	0.0135	0.0181
Brugia malayi	ecdysteroid receptor	0.0113	0.0515	0.0695
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0515	0.0695
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0113	0.0515	0.0695
Echinococcus multilocularis	fmrfamide receptor	0.0054	0.0135	0.0139
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0113	0.0515	0.0515
Schistosoma mansoni	hypothetical protein	0.0054	0.0135	0.0134
Echinococcus multilocularis	ecdysone induced protein 78C	0.0113	0.0515	0.0535
Echinococcus multilocularis	allatostatin A receptor	0.0054	0.0135	0.0139
Onchocerca volvulus		0.0113	0.0515	0.3225
Onchocerca volvulus		0.0054	0.0135	0.0838
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.1176	0.7402	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Echinococcus granulosus	neuropeptides capa receptor	0.0054	0.0135	0.0134
Brugia malayi	nuclear receptor NHR-88	0.0113	0.0515	0.0695
Brugia malayi	putative neuropeptide receptor NPR1	0.0054	0.0135	0.0181
Schistosoma mansoni	nuclear receptor	0.0053	0.013	0.0129
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0053	0.013	0.0175
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0135	0.0134
Brugia malayi	nuclear receptor NHR-88	0.0053	0.013	0.0175
Echinococcus multilocularis	dna polymerase eta	0.0047	0.009	0.0093
Loa Loa (eye worm)	steroid hormone receptor	0.0113	0.0515	0.0695
Brugia malayi	hypothetical protein	0.0054	0.0135	0.0181
Schistosoma mansoni	neuropeptide f receptor 76f	0.0054	0.0135	0.0134
Echinococcus granulosus	allatostatin A receptor	0.0054	0.0135	0.0134
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.006	0.0171	0.0171
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0054	0.0135	0.0134
Schistosoma mansoni	hypothetical protein	0.0178	0.0938	0.0937
Schistosoma mansoni	nuclear hormone receptor	0.0053	0.013	0.0129
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0054	0.0135	0.0139
Brugia malayi	photoreceptor-specific nuclear receptor	0.0113	0.0515	0.0695
Echinococcus granulosus	g protein coupled receptor	0.0054	0.0135	0.0134
Schistosoma mansoni	neuropeptide receptor	0.0054	0.0135	0.0134
Echinococcus granulosus	serotonin receptor	0.0054	0.0135	0.0134
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0113	0.0515	0.0535
Loa Loa (eye worm)	hypothetical protein	0.006	0.0171	0.023
Schistosoma mansoni	hypothetical protein	0.0178	0.0938	0.0937
Brugia malayi	RNA binding protein	0.0067	0.0217	0.0292
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0054	0.0135	0.0838
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0053	0.013	0.0175
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0054	0.0135	0.0134
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0208	0.1132	0.1529
Schistosoma mansoni	neuropeptide F-like receptor	0.0054	0.0135	0.0134
Loa Loa (eye worm)	hypothetical protein	0.006	0.0171	0.023
Loa Loa (eye worm)	hypothetical protein	0.006	0.0171	0.023
Schistosoma mansoni	neuropeptide receptor	0.0054	0.0135	0.0134
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.006	0.0171	0.023
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0113	0.0515	0.0515
Brugia malayi	hypothetical protein	0.0054	0.0135	0.0181
Schistosoma mansoni	nuclear hormone receptor	0.0113	0.0515	0.0515
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0113	0.0515	0.0535
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0054	0.0135	0.0134
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0054	0.0135	0.0139
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0053	0.013	0.0134
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0135	0.0139
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0135	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Leishmania major	oligopeptidase b	0.0033	0.0001	0.0001
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0113	0.0515	0.0695
Echinococcus granulosus	fmrfamide receptor	0.0054	0.0135	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Plasmodium vivax	hypothetical protein, conserved	0.0033	0.0001	0.5
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0054	0.0135	0.0134
Toxoplasma gondii	acylaminoacyl-peptidase, putative	0.0033	0.0001	0.0012
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0135	0.0134
Brugia malayi	Nuclear hormone receptor-like 1	0.006	0.0171	0.023
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.1176	0.7402	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0097	0.013
Brugia malayi	Nuclear hormone receptor E75	0.0053	0.013	0.0175
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0113	0.0515	0.0695
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0053	0.013	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0113	0.0515	0.0695
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0054	0.0135	0.0139
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0208	0.1132	0.1529
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0097	0.0096
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.1176	0.7402	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0208	0.1132	0.1177
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0033	0.0001	0.5
Schistosoma mansoni	nuclear receptor	0.0053	0.013	0.0129
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0033	0.0001	0.0001
Onchocerca volvulus		0.0053	0.013	0.081
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.1176	0.7402	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0113	0.0515	0.0515
Loa Loa (eye worm)	G-protein coupled receptor	0.0054	0.0135	0.0181
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0054	0.0135	0.0139
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0113	0.0515	0.0695
Onchocerca volvulus		0.0054	0.0135	0.0838
Schistosoma mansoni	amine GPCR	0.0054	0.0135	0.0134
Echinococcus granulosus	transcription factor Dp 1	0.0681	0.4195	0.4194
Echinococcus multilocularis	serotonin receptor	0.0054	0.0135	0.0139
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0053	0.013	0.0134
Brugia malayi	Serotonin receptor	0.0054	0.0135	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0053	0.013	0.0175
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0097	0.013
Brugia malayi	sulfakinin receptor protein	0.0054	0.0135	0.0181
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0053	0.013	0.0175
Onchocerca volvulus	Protein ultraspiracle homolog	0.0113	0.0515	0.3225
Echinococcus granulosus	tar DNA binding protein	0.0067	0.0217	0.0216
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0113	0.0515	0.0695
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0054	0.0135	0.0181
Echinococcus multilocularis	nuclear receptor nhr 48	0.0053	0.013	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0054	0.0135	0.0181
Echinococcus multilocularis	serotonin receptor	0.0054	0.0135	0.0139
Loa Loa (eye worm)	DR-78	0.0053	0.013	0.0175
Entamoeba histolytica	hypothetical protein	0.0038	0.0031	0.004
Brugia malayi	ecdysone receptor	0.0053	0.013	0.0175
Brugia malayi	nuclear hormone receptor family member odr-7	0.0053	0.013	0.0175
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0054	0.0135	0.0181
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.028	0.1596	0.1595
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0054	0.0135	0.0139
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0217	0.0216
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0217	0.0216
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0001	0.5
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.006	0.0171	0.0177
Echinococcus multilocularis	geminin	0.0178	0.0938	0.0975
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0053	0.013	0.0129
Schistosoma mansoni	hypothetical protein	0.0038	0.0031	0.003
Schistosoma mansoni	myosin xvIII	0.0054	0.0135	0.0134
Echinococcus granulosus	biogenic amine 5HT receptor	0.0054	0.0135	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Onchocerca volvulus		0.0054	0.0135	0.0838
Mycobacterium leprae	PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)	0.0033	0.0001	0.5
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Schistosoma mansoni	amine GPCR	0.0054	0.0135	0.0134
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0097	0.0096
Echinococcus multilocularis	neuropeptide Y receptor	0.0054	0.0135	0.0139
Brugia malayi	RNA recognition motif domain containing protein	0.0067	0.0217	0.0292
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0135	0.0134
Echinococcus multilocularis	orexin receptor type 2	0.0054	0.0135	0.0139
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.006	0.0171	0.0171
Schistosoma mansoni	adenoreceptor	0.0054	0.0135	0.0134
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0097	0.01
Brugia malayi	prolyl oligopeptidase family protein	0.028	0.1596	0.2155
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0054	0.0135	0.0134
Loa Loa (eye worm)	neuropeptide F receptor	0.0054	0.0135	0.0181
Loa Loa (eye worm)	TYRA-2 protein	0.0054	0.0135	0.0181
Brugia malayi	Dopamine receptor protein 1	0.0054	0.0135	0.0181
Schistosoma mansoni	retinoic acid receptor RXR	0.1578	1	1
Onchocerca volvulus		0.0054	0.0135	0.0838
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0067	0.0217	0.0292
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0054	0.0135	0.0139
Brugia malayi	orphan nuclear receptor NR2E1	0.0053	0.013	0.0175
Echinococcus granulosus	7tm_1 domain containing protein	0.0054	0.0135	0.0134
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0097	0.0096
Echinococcus multilocularis	g-protein coupled receptor	0.0054	0.0135	0.0139
Trypanosoma cruzi	prolyl endopeptidase	0.0033	0.0001	0.0001
Trypanosoma cruzi	hypothetical protein, conserved	0.0033	0.0001	0.0001
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0135	0.0139
Brugia malayi	putative neuropeptide receptor	0.0054	0.0135	0.0181
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0208	0.1132	0.1529
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0054	0.0135	0.0139
Schistosoma mansoni	neuropeptide F-like receptor	0.0054	0.0135	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0135	0.0134
Entamoeba histolytica	hypothetical protein	0.0038	0.0031	0.004
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0141	0.0697	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0135	0.0181
Loa Loa (eye worm)	RNA binding protein	0.0067	0.0217	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0053	0.013	0.0175
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0053	0.013	0.0129
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0054	0.0135	0.0134
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0054	0.0135	0.0134
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0217	0.0216
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0054	0.0135	0.0139
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0053	0.013	0.0175
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0054	0.0135	0.0134
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0113	0.0515	0.0535
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0135	0.0134
Schistosoma mansoni	histamine h1 receptor	0.0054	0.0135	0.0134
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0113	0.0515	0.0695
Brugia malayi	Nuclear hormone receptor-like 1	0.006	0.0171	0.023

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.011 uM	Inhibition of human DPP4	ChEMBL.	17851076
IC50 (binding)	= 0.011 uM	Inhibition of human DPP4	ChEMBL.	17851076
IC50 (binding)	= 0.29 uM	Inhibition of human DPP4 in presence of 50 % human serum	ChEMBL.	17851076
IC50 (binding)	= 0.29 uM	Inhibition of human DPP4 in presence of 50 % human serum	ChEMBL.	17851076
IC50 (binding)	= 21 uM	Inhibition of human DPP9	ChEMBL.	17851076
IC50 (binding)	= 21 uM	Inhibition of human DPP9	ChEMBL.	17851076
IC50 (binding)	= 41 uM	Inhibition of human DPP8	ChEMBL.	17851076
IC50 (binding)	= 41 uM	Inhibition of human DPP8	ChEMBL.	17851076

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL238190

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 444214