Detailed information for compound 444220

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 448.509 | Formula: C22H30F2N6O2
  • H donors: 1 H acceptors: 4 LogP: 1.89 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C([C@H]([C@@H](C(=O)N1CCC(C1)(F)F)N)[C@@H]1CC[C@H](CC1)c1ccc2n(c1)ncn2)N(C)C
  • InChi: 1S/C22H30F2N6O2/c1-28(2)20(31)18(19(25)21(32)29-10-9-22(23,24)12-29)15-5-3-14(4-6-15)16-7-8-17-26-13-27-30(17)11-16/h7-8,11,13-15,18-19H,3-6,9-10,12,25H2,1-2H3/t14-,15-,18-,19-/m0/s1
  • InChiKey: JNAZOMVWUGPITI-LNMJFAINSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dipeptidyl-peptidase 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) Get druggable targets OG5_128614 All targets in OG5_128614
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus granulosus dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Loa Loa (eye worm) prolyl oligopeptidase Get druggable targets OG5_128614 All targets in OG5_128614
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Brugia malayi prolyl oligopeptidase family protein Get druggable targets OG5_128614 All targets in OG5_128614
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma japonicum ko:K01278 dipeptidyl-peptidase 4, putative Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Dopamine receptor protein 1 0.0086 0.2357 0.3614
Echinococcus multilocularis g protein coupled receptor 0.0086 0.2357 0.2454
Plasmodium falciparum flap endonuclease 1 0.0025 0.0317 0.1602
Schistosoma mansoni histamine h1 receptor 0.0086 0.2357 0.2357
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.007 0.1836 0.4829
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0066 0.1702 0.2355
Brugia malayi prolyl oligopeptidase family protein 0.0209 0.6522 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0215 0.0297
Echinococcus granulosus transcription factor Dp 1 0.0074 0.1975 0.1975
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0024 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0024 0.0284 0.0403
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.2357 0.2357
Echinococcus multilocularis Glycoside hydrolase, family 27 0.01 0.2821 0.2938
Onchocerca volvulus 0.0086 0.2357 0.3239
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.01 0.2821 0.2938
Plasmodium falciparum glutathione reductase 0.0046 0.1013 0.5127
Schistosoma mansoni neuropeptide f receptor 76f 0.0086 0.2357 0.2357
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0086 0.2357 0.2357
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.2357 0.2454
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Loa Loa (eye worm) ACC-1 protein 0.0024 0.0284 0.0403
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0024 0.0284 0.0284
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0215 0.033
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Echinococcus multilocularis nAChR subunit 0.0024 0.0284 0.0296
Loa Loa (eye worm) hypothetical protein 0.0024 0.0284 0.0403
Brugia malayi Serotonin receptor 0.0086 0.2357 0.3614
Loa Loa (eye worm) hypothetical protein 0.0024 0.0284 0.0403
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.1013 0.2985
Loa Loa (eye worm) hypothetical protein 0.002 0.0124 0.0156
Brugia malayi steroid hormone receptor 0.0022 0.0215 0.033
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0965 0.1479
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.007 0.1836 0.1836
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Echinococcus granulosus g protein coupled receptor 0.0086 0.2357 0.2357
Leishmania major oligopeptidase b 0.0017 0.0022 0.0059
Echinococcus multilocularis neuropeptide receptor A26 0.0086 0.2357 0.2454
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0086 0.2357 0.2454
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.2357 0.2454
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0215 0.0215
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0024 0.0284 0.0403
Echinococcus granulosus 7tm_1 domain containing protein 0.0086 0.2357 0.2357
Echinococcus multilocularis g protein coupled receptor 0.0086 0.2357 0.2454
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0369 0.0511
Onchocerca volvulus 0.0086 0.2357 0.3239
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0086 0.2357 0.2357
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0215 0.033
Plasmodium vivax glutathione reductase, putative 0.0046 0.1013 0.5127
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0024 0.0284 0.0436
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.007 0.1836 0.4829
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.2821 0.2821
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0024 0.0284 0.0436
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0215 0.033
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Schistosoma mansoni biogenic amine receptor 0.0086 0.2357 0.2357
Brugia malayi Cation transporter family protein 0.0024 0.0284 0.0436
Schistosoma mansoni nAChR subunit 0.0024 0.0284 0.0284
Echinococcus multilocularis dro:myosuppressin receptor 0.0086 0.2357 0.2454
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0215 0.0224
Toxoplasma gondii prolyl endopeptidase 0.0017 0.0022 0.0079
Schistosoma mansoni hypothetical protein 0.0165 0.5027 0.5027
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0317 0.0778
Echinococcus granulosus neuropeptide s receptor 0.0086 0.2357 0.2357
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Brugia malayi Melatonin receptor type 1A 0.0086 0.2357 0.3614
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Schistosoma mansoni chromobox protein 0.0068 0.1747 0.1747
Onchocerca volvulus 0.0086 0.2357 0.3239
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.1747 0.2653
Trichomonas vaginalis chromobox protein, putative 0.0041 0.084 0.1163
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0129 0.3802 0.583
Echinococcus granulosus glycine receptor subunit alpha 1 0.0024 0.0284 0.0284
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0086 0.2357 0.2454
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0017 0.0022 0.0059
Echinococcus granulosus g protein coupled receptor 0.0086 0.2357 0.2357
Loa Loa (eye worm) hypothetical protein 0.0024 0.0284 0.0403
Echinococcus granulosus neuropeptide receptor 0.0086 0.2357 0.2357
Loa Loa (eye worm) glutathione reductase 0.0046 0.1013 0.1524
Trichomonas vaginalis chromobox protein, putative 0.0041 0.084 0.1163
Echinococcus multilocularis orexin receptor type 2 0.0086 0.2357 0.2454
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0215 0.0215
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0074 0.1976 0.3029
Echinococcus granulosus chromobox protein 1 0.0068 0.1747 0.1747
Loa Loa (eye worm) hypothetical protein 0.0074 0.1976 0.3005
Echinococcus multilocularis somatostatin receptor 0.0086 0.2357 0.2454
Giardia lamblia Alanyl dipeptidyl peptidase 0.0017 0.0022 0.0082
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Echinococcus multilocularis neuropeptide Y receptor 0.0086 0.2357 0.2454
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0086 0.2357 0.2357
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0086 0.2357 0.2454
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0017 0.0022 0.0022
Trichomonas vaginalis 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, putative 0.0097 0.2738 0.3787
Echinococcus multilocularis sex peptide receptor 0.0086 0.2357 0.2454
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0317 0.033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.2357 0.2357
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0215 0.0224
Trypanosoma brucei oligopeptidase b 0.0017 0.0022 0.0059
Loa Loa (eye worm) melatonin receptor type 1A 0.0086 0.2357 0.3592
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0074 0.1976 0.5794
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0215 0.033
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0215 0.0215
Echinococcus multilocularis neuropeptide s receptor 0.0086 0.2357 0.2454
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.2357 0.2454
Trypanosoma cruzi oligopeptidase b 0.0017 0.0022 0.0059
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.2999 0.8837
Trypanosoma brucei prolyl endopeptidase 0.0017 0.0022 0.0059
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0066 0.1702 0.1702
Schistosoma mansoni opsin-like receptor 0.0086 0.2357 0.2357
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.2357 0.2357
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0024 0.0284 0.0436
Echinococcus granulosus tm gpcr rhodopsin 0.0086 0.2357 0.2357
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0215 0.0215
Schistosoma mansoni coup transcription factor 0.0022 0.0215 0.0215
Onchocerca volvulus 0.0086 0.2357 0.3239
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0086 0.2357 0.2357
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.1013 0.1013
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0129 0.3802 0.3802
Brugia malayi follicle stimulating hormone receptor 0.0086 0.2357 0.3614
Onchocerca volvulus 0.0024 0.0284 0.0363
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.11 0.1686
Onchocerca volvulus 0.0022 0.0215 0.0268
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Trypanosoma brucei trypanothione reductase 0.0046 0.1013 0.2664
Schistosoma mansoni neuropeptide receptor 0.0086 0.2357 0.2357
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0086 0.2357 0.3592
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0215 0.0215
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0215 0.0297
Brugia malayi hypothetical protein 0.0086 0.2357 0.3614
Trypanosoma cruzi oligopeptidase b 0.0017 0.0022 0.0059
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0215 0.0297
Loa Loa (eye worm) hypothetical protein 0.0022 0.0215 0.0297
Brugia malayi Dopamine receptor protein 2 0.0086 0.2357 0.3614
Schistosoma mansoni biogenic amine receptor 0.0086 0.2357 0.2357
Schistosoma mansoni growth hormone secretagogue receptor 0.0086 0.2357 0.2357
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0086 0.2357 0.2357
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0215 0.0297
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0024 0.0284 0.0403
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0024 0.0284 0.0284
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0209 0.6522 0.6522
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.01 0.2821 0.2821
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0017 0.0022 0.0031
Brugia malayi hypothetical protein 0.0086 0.2357 0.3614
Schistosoma mansoni biogenic amine (5HT) receptor 0.0086 0.2357 0.2357
Loa Loa (eye worm) hypothetical protein 0.0038 0.0743 0.1109
Onchocerca volvulus 0.0086 0.2357 0.3239
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.2357 0.2454
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0215 0.0215
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0022 0.0059
Loa Loa (eye worm) hypothetical protein 0.0022 0.0215 0.0297
Schistosoma mansoni hypothetical protein 0.0033 0.0582 0.0582
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.3394 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0284 0.0403
Trypanosoma brucei 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 0.0097 0.2738 0.72
Brugia malayi neuropeptide F receptor 0.0086 0.2357 0.3614
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0017 0.0022 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0215 0.033
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0965 0.145
Trichomonas vaginalis set domain proteins, putative 0.023 0.7229 1
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0124 0.019
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0024 0.0284 0.0284
Echinococcus multilocularis Dipeptidyl peptidase 9 0.007 0.1836 0.1912
Echinococcus granulosus tm gpcr rhodopsin 0.0086 0.2357 0.2357
Echinococcus granulosus glycine receptor subunit alpha 1 0.0024 0.0284 0.0284
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0317 0.1156
Schistosoma mansoni nAChR subunit 0.0024 0.0284 0.0284
Brugia malayi excitatory GABA receptor EXP-1A 0.0024 0.0284 0.0436
Loa Loa (eye worm) G-protein coupled receptor 0.0086 0.2357 0.3592
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0965 0.0965
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.2821 0.2821
Echinococcus granulosus neuropeptide receptor A26 0.0086 0.2357 0.2357
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.2999 0.8837
Brugia malayi hypothetical protein 0.0086 0.2357 0.3614
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Loa Loa (eye worm) LGC-31 protein 0.0024 0.0284 0.0403
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.004 0.0815 0.0815
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0024 0.0284 0.0436
Loa Loa (eye worm) hypothetical protein 0.0024 0.0284 0.0403
Echinococcus granulosus rhodopsin orphan GPCR 0.0086 0.2357 0.2357
Brugia malayi sulfakinin receptor protein 0.0086 0.2357 0.3614
Loa Loa (eye worm) hypothetical protein 0.0024 0.0284 0.0403
Echinococcus granulosus neuropeptide FF receptor 2 0.0086 0.2357 0.2357
Loa Loa (eye worm) hypothetical protein 0.0033 0.0582 0.0861
Echinococcus granulosus tachykinin peptides receptor 99D 0.0086 0.2357 0.2357
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0215 0.0297
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0215 0.0215
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0024 0.0284 0.0284
Echinococcus multilocularis neuropeptide receptor 0.0086 0.2357 0.2454
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0965 0.0965
Schistosoma mansoni amine GPCR 0.0086 0.2357 0.2357
Mycobacterium tuberculosis Probable peptidase 0.0017 0.0022 0.0066
Echinococcus granulosus acylamino acid releasing enzyme 0.0017 0.0022 0.0022
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0086 0.2357 0.3614
Trichomonas vaginalis chromobox protein, putative 0.0068 0.1747 0.2417
Loa Loa (eye worm) hypothetical protein 0.0024 0.0284 0.0403
Echinococcus granulosus neuropeptide Y receptor 0.0086 0.2357 0.2357
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0024 0.0284 0.0403
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0024 0.0284 0.0284
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0743 0.1028
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0215 0.0297
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0129 0.3802 0.396
Schistosoma mansoni nAChR subunit 0.0024 0.0284 0.0284
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0317 0.0833
Echinococcus granulosus peptide allatostatin:somatostatin 0.0086 0.2357 0.2357
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0209 0.6522 0.9019
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Schistosoma mansoni nAChR subunit 0.0024 0.0284 0.0284
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0441 0.046
Plasmodium falciparum thioredoxin reductase 0.0046 0.1013 0.5127
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0124 0.0364
Trypanosoma cruzi 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, putative 0.0097 0.2738 0.72
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0215 0.0297
Brugia malayi Melibiase family protein 0.0066 0.1702 0.261
Brugia malayi ecdysteroid receptor 0.0022 0.0215 0.033
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0215 0.033
Schistosoma mansoni opsin-like receptor 0.0086 0.2357 0.2357
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Loa Loa (eye worm) hypothetical protein 0.0049 0.11 0.1658
Echinococcus granulosus glycine receptor subunit beta 0.0024 0.0284 0.0284
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0215 0.0297
Echinococcus multilocularis neuropeptide receptor 0.0086 0.2357 0.2454
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Brugia malayi putative neuropeptide receptor NPR1 0.0086 0.2357 0.3614
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0024 0.0284 0.0296
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0024 0.0284 0.0284
Schistosoma mansoni adenoreceptor 0.0086 0.2357 0.2357
Brugia malayi Tachykinin-like peptides receptor 99D 0.0086 0.2357 0.3614
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0284 0.0436
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0074 0.1976 0.5822
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0024 0.0284 0.0284
Echinococcus multilocularis serotonin receptor 0.0086 0.2357 0.2454
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0024 0.0284 0.0296
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0965 0.0965
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0215 0.033
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0022 0.0031
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0129 0.3802 1
Echinococcus multilocularis glycine receptor subunit beta 0.0024 0.0284 0.0296
Echinococcus granulosus rhodopsin orphan GPCR 0.0086 0.2357 0.2357
Schistosoma mansoni amine GPCR 0.0086 0.2357 0.2357
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0284 0.0436
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0024 0.0284 0.0284
Onchocerca volvulus 0.0086 0.2357 0.3239
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0086 0.2357 0.2454
Echinococcus granulosus tm gpcr rhodopsin 0.0086 0.2357 0.2357
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0215 0.0224
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0215 0.0215
Echinococcus granulosus nAChR subunit 0.0024 0.0284 0.0284
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0017 0.0022 0.0031
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0086 0.2357 0.3614
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0129 0.3802 1
Loa Loa (eye worm) ACC-1 protein 0.0024 0.0284 0.0403
Mycobacterium ulcerans hypothetical protein 0.002 0.0124 0.0626
Loa Loa (eye worm) hypothetical protein 0.003 0.0467 0.0683
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0024 0.0284 0.0296
Brugia malayi Flap endonuclease-1 0.0025 0.0317 0.0485
Echinococcus granulosus allatostatin A receptor 0.0086 0.2357 0.2357
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.007 0.1836 0.4829
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Echinococcus granulosus dro:myosuppressin receptor 0.0086 0.2357 0.2357
Brugia malayi larval opioid receptor 0.0086 0.2357 0.3614
Onchocerca volvulus 0.0024 0.0284 0.0363
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0024 0.0284 0.0296
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0017 0.0022 0.0079
Chlamydia trachomatis endonuclease IV 0.0074 0.1976 1
Onchocerca volvulus 0.003 0.0467 0.0616
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0215 0.033
Echinococcus multilocularis transcription factor Dp 1 0.0074 0.1975 0.2056
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0086 0.2357 0.2454
Onchocerca volvulus 0.0086 0.2357 0.3239
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0086 0.2357 0.2357
Brugia malayi Pre-SET motif family protein 0.0029 0.0441 0.0677
Onchocerca volvulus 0.0086 0.2357 0.3239
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0284 0.0436
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.3394 1
Mycobacterium ulcerans epimerase 0.002 0.0124 0.0626
Giardia lamblia Alanyl dipeptidyl peptidase 0.0017 0.0022 0.0082
Brugia malayi hypothetical protein 0.0086 0.2357 0.3614
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0024 0.0284 0.0296
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0024 0.0284 0.0296
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0086 0.2357 0.2357
Schistosoma mansoni hypothetical protein 0.0086 0.2357 0.2357
Brugia malayi hypothetical protein 0.0086 0.2357 0.3614
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.1013 0.1524
Echinococcus multilocularis neuropeptides capa receptor 0.0086 0.2357 0.2454
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0086 0.2357 0.3614
Echinococcus granulosus somatostatin receptor 0.0086 0.2357 0.2357
Schistosoma mansoni amine GPCR 0.0086 0.2357 0.2357
Echinococcus granulosus sex peptide receptor 0.0086 0.2357 0.2357
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0215 0.0224
Echinococcus granulosus g protein coupled receptor 0.0086 0.2357 0.2357
Loa Loa (eye worm) hypothetical protein 0.0066 0.1702 0.2584
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.3394 1
Brugia malayi Dopamine receptor 0.0086 0.2357 0.3614
Schistosoma mansoni myosin xvIII 0.0086 0.2357 0.2357
Echinococcus multilocularis neuropeptide FF receptor 2 0.0086 0.2357 0.2454
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.2999 0.8837
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.2999 0.8837
Schistosoma mansoni hypothetical protein 0.0086 0.2357 0.2357
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0066 0.1702 0.1702
Echinococcus multilocularis chromobox protein 1 0.0068 0.1747 0.1819
Schistosoma mansoni biogenic amine receptor 0.0086 0.2357 0.2357
Echinococcus multilocularis neuropeptide Y receptor 0.0086 0.2357 0.2454
Onchocerca volvulus Putative nachr subunit 0.0024 0.0284 0.0363
Echinococcus multilocularis fmrfamide receptor 0.0086 0.2357 0.2454
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0086 0.2357 0.2454
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0024 0.0284 0.0436
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.2357 0.2454
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0317 0.1122
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0215 0.0215
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0209 0.6522 0.6522
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Toxoplasma gondii thioredoxin reductase 0.0046 0.1013 0.3591
Brugia malayi nuclear hormone receptor 0.0022 0.0215 0.033
Onchocerca volvulus 0.004 0.0815 0.11
Schistosoma mansoni neuropeptide receptor 0.0086 0.2357 0.2357
Leishmania major 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 0.0097 0.2738 0.72
Loa Loa (eye worm) hypothetical protein 0.0024 0.0284 0.0403
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0086 0.2357 0.2454
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0086 0.2357 0.2357
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0024 0.0284 0.0284
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0024 0.0284 0.0403
Echinococcus granulosus neuropeptide receptor 0.0086 0.2357 0.2357
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Schistosoma mansoni alpha-1 adrenergic receptor 0.0086 0.2357 0.2357
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0024 0.0284 0.0436
Brugia malayi G protein-coupled receptor 0.0086 0.2357 0.3614
Onchocerca volvulus 0.0086 0.2357 0.3239
Echinococcus multilocularis fmrfamide receptor 0.0086 0.2357 0.2454
Brugia malayi nuclear receptor NHR-88 0.0022 0.0215 0.033
Echinococcus granulosus rhodopsin orphan GPCR 0.0086 0.2357 0.2357
Plasmodium falciparum peptidase, putative 0.0017 0.0022 0.0113
Onchocerca volvulus 0.0086 0.2357 0.3239
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0215 0.033
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.1013 0.2664
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0129 0.3802 1
Entamoeba histolytica 2,3-bisphosphoglycerate-independentphosphoglycerate mutase, putative 0.0053 0.1267 0.3292
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Loa Loa (eye worm) independent phosphoglycerate mutase isoform 2 0.0097 0.2738 0.4177
Schistosoma mansoni neuropeptide receptor 0.0086 0.2357 0.2357
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0965 0.1005
Loa Loa (eye worm) hypothetical protein 0.0022 0.0215 0.0297
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0301 0.9603 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Echinococcus multilocularis G protein coupled receptor 139 0.0086 0.2357 0.2454
Loa Loa (eye worm) hypothetical protein 0.0024 0.0284 0.0403
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0124 0.0141
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0441 0.0441
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0215 0.0215
Leishmania major trypanothione reductase 0.0046 0.1013 0.2664
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0284 0.0436
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0215 0.033
Brugia malayi Cation transporter family protein 0.0024 0.0284 0.0436
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0284 0.0436
Echinococcus granulosus serotonin receptor 0.0086 0.2357 0.2357
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0317 0.0833
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0215 0.0224
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0129 0.3802 0.3802
Echinococcus granulosus G protein coupled receptor 139 0.0086 0.2357 0.2357
Brugia malayi RE15519p 0.0086 0.2357 0.3614
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0215 0.0215
Plasmodium vivax SET domain protein, putative 0.0029 0.0441 0.2235
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0369 0.0511
Brugia malayi G-protein coupled receptor 0.0086 0.2357 0.3614
Brugia malayi hypothetical protein 0.0086 0.2357 0.3614
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0215 0.033
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0215 0.0215
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0215 0.0224
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0441 0.046
Loa Loa (eye worm) hypothetical protein 0.0022 0.0215 0.0297
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.11 0.1686
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0284 0.0436
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0965 0.0965
Onchocerca volvulus Neuropeptide F receptor homolog 0.0086 0.2357 0.3239
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0215 0.0268
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0086 0.2357 0.2357
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.2357 0.2454
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0215 0.033
Loa Loa (eye worm) hypothetical protein 0.0024 0.0284 0.0403
Echinococcus granulosus g-protein coupled receptor 0.0086 0.2357 0.2357
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Brugia malayi G protein-coupled receptor F59B2.13 0.0086 0.2357 0.3614
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0024 0.0284 0.0296
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.11 0.1658
Loa Loa (eye worm) neuropeptide F receptor 0.0086 0.2357 0.3592
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.2357 0.2357
Schistosoma mansoni flap endonuclease-1 0.0023 0.0235 0.0235
Schistosoma mansoni hypothetical protein 0.0086 0.2357 0.2357
Trichomonas vaginalis chromobox protein, putative 0.0068 0.1747 0.2417
Loa Loa (eye worm) hypothetical protein 0.0024 0.0284 0.0403
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Mycobacterium tuberculosis Probable reductase 0.0105 0.2999 0.8837
Brugia malayi glutathione reductase 0.0046 0.1013 0.1553
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0024 0.0284 0.0284
Brugia malayi hypothetical protein 0.0054 0.1277 0.1957
Echinococcus granulosus rhodopsin orphan GPCR 0.0086 0.2357 0.2357
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0215 0.0215
Brugia malayi chromobox protein homolog 3 0.0038 0.0743 0.114
Schistosoma mansoni chromobox protein 0.0068 0.1747 0.1747
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0074 0.1976 1
Plasmodium vivax hypothetical protein, conserved 0.0017 0.0022 0.0113
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0024 0.0284 0.0403
Loa Loa (eye worm) hypothetical protein 0.0024 0.0284 0.0403
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.2821 0.2821
Echinococcus multilocularis G-protein coupled receptor, putative 0.0086 0.2357 0.2454
Onchocerca volvulus 0.0086 0.2357 0.3239
Loa Loa (eye worm) hypothetical protein 0.0022 0.0215 0.0297
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0215 0.0224
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0215 0.0215
Brugia malayi Thioredoxin reductase 0.0046 0.1013 0.1553
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0086 0.2357 0.2357
Loa Loa (eye worm) hypothetical protein 0.0022 0.0215 0.0297
Brugia malayi GnHR receptor homolog 0.0086 0.2357 0.3614
Loa Loa (eye worm) hypothetical protein 0.0054 0.1277 0.193
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0441 0.0441
Brugia malayi Serotonin receptor 0.0086 0.2357 0.3614
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0017 0.0022 0.0059
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.2357 0.2454
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.007 0.1836 0.4829
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Echinococcus multilocularis glycine receptor subunit beta 0.0024 0.0284 0.0296
Trypanosoma brucei prolyl oligopeptidase, putative 0.0017 0.0022 0.0059
Loa Loa (eye worm) hypothetical protein 0.0024 0.0284 0.0403
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.2357 0.2357
Schistosoma mansoni opsin-like receptor 0.0086 0.2357 0.2357
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0017 0.0022 0.0059
Echinococcus multilocularis neuropeptides capa receptor 0.0086 0.2357 0.2454
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.2821 0.2821
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0441 0.1565
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0215 0.0297
Schistosoma mansoni hypothetical protein 0.0165 0.5027 0.5027
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0086 0.2357 0.2357
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0022 0.0059
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.0022 0.0034
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0086 0.2357 0.2357
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0024 0.0284 0.0436
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.2357 0.2454
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0215 0.0215
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0129 0.3802 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.6286 0.9637
Onchocerca volvulus 0.0024 0.0284 0.0363
Brugia malayi 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 0.0059 0.1469 0.2253
Onchocerca volvulus 0.0024 0.0284 0.0363
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0086 0.2357 0.3592
Loa Loa (eye worm) hypothetical protein 0.0022 0.0215 0.0297
Echinococcus granulosus glycine receptor subunit beta 0.0024 0.0284 0.0284
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0017 0.0022 0.0022
Echinococcus granulosus fmrfamide receptor 0.0086 0.2357 0.2357
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0017 0.0022 0.0022
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.1013 0.1055
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.007 0.1836 0.6509
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0074 0.1976 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0405 0.0405
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0317 0.0438
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0317 0.0833
Brugia malayi hypothetical protein 0.0086 0.2357 0.3614
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.0022 0.0034
Schistosoma mansoni amine GPCR 0.0086 0.2357 0.2357
Echinococcus multilocularis allatostatin A receptor 0.0086 0.2357 0.2454
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0086 0.2357 0.3239
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Loa Loa (eye worm) G-protein coupled receptor 0.0086 0.2357 0.3592
Toxoplasma gondii melibiase subfamily protein 0.01 0.2821 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0965 0.1005
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.2357 0.2357
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.2357 0.2357
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0086 0.2357 0.2357
Echinococcus multilocularis g protein coupled receptor 0.0086 0.2357 0.2454
Echinococcus multilocularis acylamino acid releasing enzyme 0.0017 0.0022 0.0023
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0024 0.0284 0.0284
Onchocerca volvulus 0.0086 0.2357 0.3239
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0317 0.0453
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0086 0.2357 0.2454
Loa Loa (eye worm) hypothetical protein 0.0024 0.0284 0.0403
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0086 0.2357 0.2357
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0086 0.2357 0.2454
Echinococcus granulosus glycine receptor subunit alpha 1 0.0024 0.0284 0.0284
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.007 0.1836 0.4829
Schistosoma mansoni hypothetical protein 0.0086 0.2357 0.2357
Schistosoma mansoni biogenic amine (5HT) receptor 0.0086 0.2357 0.2357
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.084 0.1135
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0215 0.0268
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0086 0.2357 0.3614
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0317 0.1602
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0086 0.2357 0.2357
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0024 0.0284 0.0436
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0965 0.0965
Schistosoma mansoni nAChR subunit 0.0024 0.0284 0.0284
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0017 0.0022 0.0113
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0017 0.0022 0.0059
Echinococcus granulosus rhodopsin orphan GPCR 0.0086 0.2357 0.2357
Echinococcus multilocularis geminin 0.0165 0.5027 0.5235
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Loa Loa (eye worm) hypothetical protein 0.0024 0.0284 0.0403
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0086 0.2357 0.2454
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0086 0.2357 0.3592
Brugia malayi hypothetical protein 0.0086 0.2357 0.3614
Entamoeba histolytica 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, putative 0.0097 0.2738 0.7183
Echinococcus granulosus biogenic amine 5HT receptor 0.0086 0.2357 0.2357
Echinococcus multilocularis prolyl endopeptidase 0.0017 0.0022 0.0023
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.0022 0.0034
Loa Loa (eye worm) neuropeptide F receptor 0.0086 0.2357 0.3592
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0209 0.6522 0.6792
Onchocerca volvulus 0.0024 0.0284 0.0363
Onchocerca volvulus 0.0086 0.2357 0.3239
Mycobacterium leprae conserved hypothetical protein 0.002 0.0124 0.0301
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0743 0.1028
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0215 0.033
Echinococcus granulosus biogenic amine 5HT receptor 0.0086 0.2357 0.2357
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0215 0.0268
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0086 0.2357 0.2454
Echinococcus granulosus chromobox protein 1 0.0068 0.1747 0.1747
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0017 0.0022 0.0059
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0215 0.0215
Echinococcus granulosus neuropeptides capa receptor 0.0086 0.2357 0.2357
Onchocerca volvulus 0.0086 0.2357 0.3239
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0215 0.033
Echinococcus multilocularis g-protein coupled receptor 0.0086 0.2357 0.2454
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0024 0.0284 0.0436
Loa Loa (eye worm) TYRA-2 protein 0.0086 0.2357 0.3592
Giardia lamblia 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 0.0097 0.2738 1
Echinococcus granulosus neuropeptides capa receptor 0.0086 0.2357 0.2357
Echinococcus multilocularis chromobox protein 1 0.0068 0.1747 0.1819
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0129 0.3802 0.5815
Echinococcus granulosus 7TM GPCR rhodopsin 0.0086 0.2357 0.2357
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0582 0.0892
Echinococcus granulosus rhodopsin orphan GPCR 0.0086 0.2357 0.2357
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.1013 0.5127
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0215 0.0224
Echinococcus granulosus orexin receptor type 2 0.0086 0.2357 0.2357
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0024 0.0284 0.0296
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0215 0.0215
Echinococcus granulosus rhodopsin orphan GPCR 0.0086 0.2357 0.2357
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.2999 0.883
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0024 0.0284 0.0296
Schistosoma mansoni neuropeptide receptor 0.0086 0.2357 0.2357
Onchocerca volvulus 0.0086 0.2357 0.3239
Schistosoma mansoni neuropeptide F-like receptor 0.0086 0.2357 0.2357
Loa Loa (eye worm) hypothetical protein 0.0024 0.0284 0.0403
Loa Loa (eye worm) hypothetical protein 0.0024 0.0284 0.0403
Brugia malayi AKH receptor 0.0086 0.2357 0.3614
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0743 0.1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.3394 1
Brugia malayi hypothetical protein 0.0086 0.2357 0.3614
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0441 0.0441
Onchocerca volvulus 0.0086 0.2357 0.3239
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0215 0.0215
Echinococcus granulosus Dipeptidyl peptidase 9 0.007 0.1836 0.1836
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0086 0.2357 0.2454
Echinococcus granulosus neuropeptide Y receptor 0.0086 0.2357 0.2357
Schistosoma mansoni retinoic acid receptor RXR 0.0312 1 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Toxoplasma gondii endonuclease IV APN 0.0074 0.1976 0.7004
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0215 0.033
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0086 0.2357 0.2454
Mycobacterium ulcerans endonuclease IV 0.0074 0.1976 1
Brugia malayi G-protein coupled receptor 0.0086 0.2357 0.3614
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0086 0.2357 0.3614
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Echinococcus granulosus hypothetical protein 0.0086 0.2357 0.2357
Brugia malayi putative neuropeptide receptor 0.0086 0.2357 0.3614
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0017 0.0022 0.0022
Brugia malayi Heterochromatin protein 1 0.0068 0.1747 0.2679
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.2999 0.8837
Onchocerca volvulus 0.0024 0.0284 0.0363
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0024 0.0284 0.0284
Echinococcus granulosus alpha 1A adrenergic receptor 0.0086 0.2357 0.2357
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.2357 0.2357
Trypanosoma cruzi prolyl endopeptidase 0.0017 0.0022 0.0059
Echinococcus granulosus prolyl endopeptidase 0.0017 0.0022 0.0022
Echinococcus multilocularis serotonin receptor 0.0086 0.2357 0.2454
Treponema pallidum NADH oxidase 0.0016 0 0.5
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0086 0.2357 0.2357
Brugia malayi Cation transporter family protein 0.0024 0.0284 0.0436
Toxoplasma gondii hypothetical protein 0.0017 0.0022 0.0079
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0086 0.2357 0.3592
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0024 0.0284 0.0296
Brugia malayi ORL1-like opioid receptor 0.0086 0.2357 0.3614
Echinococcus granulosus geminin 0.0165 0.5027 0.5027
Wolbachia endosymbiont of Brugia malayi phosphoglyceromutase 0.0097 0.2738 1
Loa Loa (eye worm) prolyl oligopeptidase 0.0209 0.6522 1
Schistosoma mansoni amine GPCR 0.0086 0.2357 0.2357
Brugia malayi neuropeptide F receptor 0.0086 0.2357 0.3614
Schistosoma mansoni nAChR subunit 0.0024 0.0284 0.0284
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0024 0.0284 0.0284
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0129 0.3802 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0086 0.2357 0.3592
Brugia malayi Pre-SET motif family protein 0.0202 0.6286 0.9638
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0024 0.0284 0.0436
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.2357 0.2357
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0086 0.2357 0.2357
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0017 0.0022 0.0066
Loa Loa (eye worm) hypothetical protein 0.0029 0.0441 0.0645
Brugia malayi prolyl oligopeptidase family protein 0.007 0.1836 0.2815
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0024 0.0284 0.0403
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Onchocerca volvulus 0.023 0.7229 1
Schistosoma mansoni nAChR subunit 0.0024 0.0284 0.0284
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0024 0.0284 0.0403
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0441 0.0441
Brugia malayi hypothetical protein 0.0086 0.2357 0.3614
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0086 0.2357 0.2454
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0215 0.0224
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Schistosoma mansoni neuropeptide F-like receptor 0.0086 0.2357 0.2357
Loa Loa (eye worm) hypothetical protein 0.0086 0.2357 0.3592
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0086 0.2357 0.2357
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0086 0.2357 0.2357
Onchocerca volvulus 0.0086 0.2357 0.3239
Echinococcus granulosus flap endonuclease 1 0.0025 0.0317 0.0317
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0215 0.033
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0124 0.0626

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 23 % Reduction in glucose excursion in mouse at 0.03 mg/kg, po administered 60 mins prior to dextrose challenge by oral glucose tolerance test ChEMBL. 17851076
Activity (functional) = 23 % Reduction in glucose excursion in mouse at 0.03 mg/kg, po administered 60 mins prior to dextrose challenge by oral glucose tolerance test ChEMBL. 17851076
AUC (ADMET) = 4.4 uM.hr AUC in rat at 2 mg/kg, po ChEMBL. 17851076
AUC (ADMET) = 6.5 uM.hr AUC in rhesus monkey at 2 mg/kg, po ChEMBL. 17851076
AUC (ADMET) = 46 uM.hr AUC in dog at 0.5 mg/kg, po ChEMBL. 17851076
CL (ADMET) = 0.94 ml/min.Kg Plasma clearance in dog at 0.5 mg/kg, po ChEMBL. 17851076
CL (ADMET) = 5.3 ml/min.Kg Plasma clearance in rat at 1 mg/kg, iv or 2 mg/kg, po ChEMBL. 17851076
CL (ADMET) = 5.6 ml/min.Kg Plasma clearance in rhesus monkey at 1 mg/kg, iv or 2 mg/kg, po ChEMBL. 17851076
Cmax (ADMET) = 2.8 uM Cmax in rhesus monkey at 1 mg/kg, iv or 2 mg/kg, po ChEMBL. 17851076
Cmax (ADMET) = 3.3 uM Cmax in rat at 1 mg/kg, iv or 2 mg/kg, po ChEMBL. 17851076
Cmax (ADMET) = 16 uM Cmax in dog at 0.5 mg/kg, po ChEMBL. 17851076
F (ADMET) = 63 % Oral bioavailability in rat at 2 mg/kg ChEMBL. 17851076
F (ADMET) = 97 % Oral bioavailability in rhesus monkey at 2 mg/kg ChEMBL. 17851076
F (ADMET) = 100 % Oral bioavailability in dog at 0.5 mg/kg ChEMBL. 17851076
IC50 (binding) = 0.0048 uM Inhibition of human DPP4 ChEMBL. 17851076
IC50 (binding) = 0.0048 uM Inhibition of human DPP4 ChEMBL. 17851076
IC50 (binding) = 0.13 uM Inhibition of human DPP4 in presence of 50 % human serum ChEMBL. 17851076
IC50 (binding) = 0.13 uM Inhibition of human DPP4 in presence of 50 % human serum ChEMBL. 17851076
IC50 (binding) = 30 uM Inhibition of human DPP8 ChEMBL. 17851076
IC50 (binding) = 30 uM Inhibition of human DPP8 ChEMBL. 17851076
IC50 (binding) = 38 uM Inhibition of human DPP9 ChEMBL. 17851076
IC50 (binding) = 38 uM Inhibition of human DPP9 ChEMBL. 17851076
IC50 (binding) > 90 uM Inhibition of human ERG ChEMBL. 17851076
IC50 (binding) > 90 uM Inhibition of human ERG ChEMBL. 17851076
t1/2 (ADMET) = 3.9 hr Half life in dog at 0.5 mg/kg, po ChEMBL. 17851076
t1/2 (ADMET) = 4.1 hr Half life in rat at 1 mg/kg, iv or 2 mg/kg, po ChEMBL. 17851076
t1/2 (ADMET) = 4.1 hr Half life in rhesus monkey at 1 mg/kg, iv or 2 mg/kg, po ChEMBL. 17851076

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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