Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dipeptidyl-peptidase 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0194 | 0.8908 | 0.878 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0194 | 0.8908 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0194 | 0.8908 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0203 | 0.9494 | 0.9578 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.007 | 0.1052 | 0.5 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0112 | 0.372 | 0.2981 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0194 | 0.8908 | 0.9029 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0209 | 0.9866 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0211 | 1 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0194 | 0.8908 | 0.878 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0209 | 0.9866 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.007 | 0.1052 | 0.1067 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0112 | 0.372 | 0.3026 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0194 | 0.8908 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0194 | 0.8908 | 0.9029 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0194 | 0.8908 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0209 | 0.9866 | 0.985 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0209 | 0.9866 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0209 | 0.9866 | 0.985 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0194 | 0.8908 | 0.8913 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0209 | 0.9866 | 0.5 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0194 | 0.8908 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.038 uM | Inhibition of human DPP4 | ChEMBL. | 17851076 |
IC50 (binding) | = 0.038 uM | Inhibition of human DPP4 | ChEMBL. | 17851076 |
IC50 (binding) | = 0.12 uM | Inhibition of human DPP4 in presence of 50 % human serum | ChEMBL. | 17851076 |
IC50 (binding) | = 0.12 uM | Inhibition of human DPP4 in presence of 50 % human serum | ChEMBL. | 17851076 |
IC50 (binding) | = 22 uM | Inhibition of human DPP8 | ChEMBL. | 17851076 |
IC50 (binding) | = 22 uM | Inhibition of human DPP8 | ChEMBL. | 17851076 |
IC50 (binding) | > 100 uM | Inhibition of human DPP9 | ChEMBL. | 17851076 |
IC50 (binding) | > 100 uM | Inhibition of human DPP9 | ChEMBL. | 17851076 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.