Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate [NMDA] receptor subunit epsilon 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | glutamate NMDA receptor subunit | Get druggable targets OG5_129290 | All targets in OG5_129290 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | Get druggable targets OG5_129290 | All targets in OG5_129290 |
Schistosoma japonicum | ko:K05314 glutamate receptor, ionotropic, N-methyl-D-aspartate 2, invertebrate, putative | Get druggable targets OG5_129290 | All targets in OG5_129290 |
Schistosoma mansoni | glutamate receptor NMDA | Get druggable targets OG5_129290 | All targets in OG5_129290 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0081 | 1 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0073 | 0.8294 | 0.8139 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.8294 | 0.8139 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.8294 | 0.8139 |
Echinococcus multilocularis | peroxidasin | 0.0073 | 0.8294 | 0.8294 |
Brugia malayi | Animal haem peroxidase family protein | 0.0073 | 0.8294 | 0.8139 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0081 | 1 | 0.5 |
Mycobacterium ulcerans | proteasome PrcB | 0.0081 | 1 | 0.5 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0081 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0073 | 0.8294 | 0.8294 |
Brugia malayi | Peroxidasin | 0.0073 | 0.8294 | 0.8139 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.8294 | 0.8139 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.8294 | 0.8139 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.8294 | 0.8139 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.8294 | 0.8139 |
Onchocerca volvulus | 0.0073 | 0.8294 | 0.5 | |
Brugia malayi | Blistered cuticle protein 3 | 0.0073 | 0.8294 | 0.8139 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.8294 | 0.8139 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0081 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0073 | 0.8294 | 0.5 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0036 | 0.0837 | 0.0837 |
Onchocerca volvulus | Dual oxidase homolog | 0.0073 | 0.8294 | 0.5 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0081 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0073 | 0.8294 | 0.8139 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.8294 | 0.8139 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0081 | 1 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0036 | 0.0837 | 0.0837 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0073 | 0.8294 | 0.8139 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0073 | 0.8294 | 0.8139 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0073 | 0.8294 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0073 | 0.8294 | 0.8139 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.8294 | 0.8139 |
Onchocerca volvulus | Peroxidase homolog | 0.0073 | 0.8294 | 0.5 |
Onchocerca volvulus | 0.0073 | 0.8294 | 0.5 | |
Schistosoma mansoni | peroxidasin | 0.0073 | 0.8294 | 0.8139 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0081 | 1 | 1 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0076 | 0.8899 | 0.8899 |
Onchocerca volvulus | Peroxidase homolog | 0.0073 | 0.8294 | 0.5 |
Echinococcus granulosus | proteasome prosome macropain | 0.0081 | 1 | 1 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0076 | 0.8899 | 0.8899 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.8294 | 0.8139 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.8294 | 0.8139 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.8294 | 0.8139 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0081 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0073 | 0.8294 | 0.8139 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0073 | 0.8294 | 0.8139 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0081 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0073 | 0.8294 | 0.8139 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.8294 | 0.8139 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0076 | 0.8899 | 0.8799 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.8294 | 0.8139 |
Schistosoma mansoni | peroxidasin | 0.0073 | 0.8294 | 0.8139 |
Brugia malayi | hypothetical protein | 0.0073 | 0.8294 | 0.8139 |
Onchocerca volvulus | Peroxidasin homolog | 0.0073 | 0.8294 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0073 | 0.8294 | 0.8139 |
Onchocerca volvulus | 0.0073 | 0.8294 | 0.5 | |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0081 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0081 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 85 nM | Displacement of [3H]CP101,606 from NR2B in rat forebrain P2 membrane | ChEMBL. | 17768047 |
IC50 (binding) | = 85 nM | Displacement of [3H]CP101,606 from NR2B in rat forebrain P2 membrane | ChEMBL. | 17768047 |
Solubility | = 69 ug ml-1 | Solubility at pH 6.5 | ChEMBL. | 17768047 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.