Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0131 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0131 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0131 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0131 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0131 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0131 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0131 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0131 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0131 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0131 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Efficacy (functional) | = 23 % | Activity at GABAB 1b/2 receptor expressed in CHO-K1 cells assessed as effect on glutamate-induced [35S]GTPgammaS binding at 2.5 uM | ChEMBL. | 17884493 |
Efficacy (functional) | = 23 % | Activity at GABAB 1b/2 receptor expressed in CHO-K1 cells assessed as effect on glutamate-induced [35S]GTPgammaS binding at 2.5 uM | ChEMBL. | 17884493 |
Efficacy (functional) | = 41 % | Activity at GABAB 1b/2 receptor expressed in CHO-K1 cells assessed as effect on glutamate-induced [35S]GTPgammaS binding at 25 uM | ChEMBL. | 17884493 |
Efficacy (functional) | = 41 % | Activity at GABAB 1b/2 receptor expressed in CHO-K1 cells assessed as effect on glutamate-induced [35S]GTPgammaS binding at 25 uM | ChEMBL. | 17884493 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.