Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Schistosoma japonicum | ko:K08624 ADAM metallopeptidase with thrombospondin type 1 motif, 9, putative | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Brugia malayi | ADAM-TS Spacer 1 family protein | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0297 | 0.1521 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0297 | 0.1521 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.1521 | 0.1521 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.0622 | 0.0622 |
Brugia malayi | hypothetical protein | 0.0297 | 0.1521 | 0.1138 |
Loa Loa (eye worm) | carboxylesterase | 0.0297 | 0.1521 | 0.1521 |
Loa Loa (eye worm) | hypothetical protein | 0.1756 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.1521 | 0.1521 |
Echinococcus granulosus | neuroligin | 0.0297 | 0.1521 | 0.1468 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0297 | 0.1521 | 0.1468 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0297 | 0.1521 | 0.1468 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0297 | 0.1521 | 0.1468 |
Onchocerca volvulus | 0.0297 | 0.1521 | 1 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1756 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.1521 | 0.1521 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0473 | 0.2545 | 0.2499 |
Brugia malayi | Carboxylesterase family protein | 0.0297 | 0.1521 | 0.1138 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0297 | 0.1521 | 0.1468 |
Schistosoma mansoni | acetylcholinesterase | 0.0297 | 0.1521 | 0.1468 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0297 | 0.1521 | 0.1468 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.1521 | 0.1521 |
Echinococcus granulosus | carboxylesterase 5A | 0.1756 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0297 | 0.1521 | 0.1138 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0297 | 0.1521 | 0.1468 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0297 | 0.1521 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1756 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0297 | 0.1521 | 0.1468 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.1521 | 0.1521 |
Brugia malayi | Amyloid A4 extracellular domain containing protein | 0.0336 | 0.1746 | 0.1373 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0297 | 0.1521 | 0.5 |
Onchocerca volvulus | 0.0297 | 0.1521 | 1 | |
Echinococcus granulosus | acetylcholinesterase | 0.1756 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1756 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0209 | 0.0209 |
Echinococcus multilocularis | acetylcholinesterase | 0.1756 | 1 | 1 |
Echinococcus multilocularis | neuroligin | 0.0297 | 0.1521 | 0.1468 |
Echinococcus granulosus | acetylcholinesterase | 0.1756 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.1521 | 0.1521 |
Onchocerca volvulus | 0.0297 | 0.1521 | 1 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.1756 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.1333 | 0.1333 |
Schistosoma mansoni | gliotactin | 0.0297 | 0.1521 | 0.1468 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0297 | 0.1521 | 0.5 |
Schistosoma mansoni | alzheimer's disease beta-amyloid related | 0.0122 | 0.0507 | 0.0448 |
Loa Loa (eye worm) | carboxylesterase | 0.1756 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.1521 | 0.1521 |
Onchocerca volvulus | 0.0297 | 0.1521 | 1 | |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0297 | 0.1521 | 0.1468 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0297 | 0.1521 | 0.1468 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1756 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0297 | 0.1521 | 0.1138 |
Onchocerca volvulus | 0.0297 | 0.1521 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0297 | 0.1521 | 0.1468 |
Loa Loa (eye worm) | carboxylesterase | 0.0297 | 0.1521 | 0.1521 |
Loa Loa (eye worm) | hypothetical protein | 0.1756 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0432 | 0.0432 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0297 | 0.1521 | 0.1468 |
Brugia malayi | Carboxylesterase family protein | 0.0297 | 0.1521 | 0.1138 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0297 | 0.1521 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.