Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K08624 ADAM metallopeptidase with thrombospondin type 1 motif, 9, putative | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Brugia malayi | ADAM-TS Spacer 1 family protein | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0046 | 0.0134 | 0.0134 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0186 | 0.1446 | 0.1446 |
Schistosoma mansoni | acetylcholinesterase | 0.0186 | 0.1446 | 0.1446 |
Echinococcus granulosus | carboxylesterase 5A | 0.1103 | 1 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.004 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0034 | 0.0034 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0032 | 0.0006 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0186 | 0.1446 | 0.1446 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0926 | 0.0926 |
Loa Loa (eye worm) | hypothetical protein | 0.1103 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1103 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.1103 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1103 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1103 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0186 | 0.1446 | 0.1446 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0186 | 0.1446 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.004 | 0.004 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0186 | 0.1446 | 0.1446 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.1446 | 0.1446 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.004 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0186 | 0.1446 | 0.1446 |
Onchocerca volvulus | 0.0186 | 0.1446 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0186 | 0.1446 | 0.1446 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0186 | 0.1446 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1103 | 1 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.004 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.1446 | 0.1446 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0046 | 0.0134 | 0.0134 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.004 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.1446 | 0.1446 |
Onchocerca volvulus | 0.0186 | 0.1446 | 1 | |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.004 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0316 | 0.0316 |
Brugia malayi | hypothetical protein | 0.0186 | 0.1446 | 0.1446 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.1446 | 0.1446 |
Schistosoma mansoni | gliotactin | 0.0186 | 0.1446 | 0.1446 |
Onchocerca volvulus | 0.0186 | 0.1446 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.1103 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1103 | 1 | 1 |
Brugia malayi | Inositol-1 | 0.0036 | 0.004 | 0.004 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0186 | 0.1446 | 0.1446 |
Brugia malayi | Amyloid A4 extracellular domain containing protein | 0.0308 | 0.2587 | 0.2587 |
Loa Loa (eye worm) | hypothetical protein | 0.1103 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0186 | 0.1446 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.004 | 0.5 |
Brugia malayi | ADAMTS-like protease | 0.0034 | 0.002 | 0.002 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0186 | 0.1446 | 0.1446 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0046 | 0.0134 | 0.0134 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0186 | 0.1446 | 0.1446 |
Echinococcus multilocularis | acetylcholinesterase | 0.1103 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0186 | 0.1446 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.1446 | 0.1446 |
Brugia malayi | Carboxylesterase family protein | 0.0186 | 0.1446 | 0.1446 |
Brugia malayi | Carboxylesterase family protein | 0.0186 | 0.1446 | 0.1446 |
Echinococcus multilocularis | acetylcholinesterase | 0.1103 | 1 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.004 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0186 | 0.1446 | 0.1446 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0186 | 0.1446 | 1 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0435 | 0.3768 | 0.3768 |
Echinococcus multilocularis | neuroligin | 0.0186 | 0.1446 | 0.1446 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0186 | 0.1446 | 0.1446 |
Echinococcus granulosus | neuroligin | 0.0186 | 0.1446 | 0.1446 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0186 | 0.1446 | 0.1446 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.004 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0728 | 0.0728 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0186 | 0.1446 | 0.1446 |
Onchocerca volvulus | 0.0186 | 0.1446 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.1976 | 0.1976 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.004 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.004 | 0.5 |
Onchocerca volvulus | 0.0186 | 0.1446 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0186 | 0.1446 | 0.1446 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.004 | 0.004 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0186 | 0.1446 | 1 |
Brugia malayi | angiogenesis inhibito | 0.0034 | 0.002 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.1446 | 0.1446 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.1446 | 0.1446 |
Schistosoma mansoni | alzheimer's disease beta-amyloid related | 0.0112 | 0.0757 | 0.0757 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0109 | 0.0728 | 0.0728 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0186 | 0.1446 | 0.1446 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.