Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | a disintegrin and metalloproteinase with | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Brugia malayi | ADAM-TS Spacer 1 family protein | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Schistosoma japonicum | ko:K08624 ADAM metallopeptidase with thrombospondin type 1 motif, 9, putative | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0482 | 0.0442 |
Onchocerca volvulus | 0.0045 | 0.0482 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0045 | 0.0482 | 0.0442 |
Echinococcus multilocularis | acetylcholinesterase | 0.0264 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0264 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0264 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0264 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0264 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0482 | 0.0442 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0045 | 0.0482 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.3284 | 0.3255 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0264 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0045 | 0.0482 | 0.0482 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0046 | 0.0526 | 0.0046 |
Brugia malayi | Carboxylesterase family protein | 0.0045 | 0.0482 | 0.0482 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0264 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0045 | 0.0482 | 0.0442 |
Echinococcus granulosus | carboxylesterase 5A | 0.0264 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0264 | 1 | 1 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0046 | 0.0526 | 0.0046 |
Onchocerca volvulus | 0.0045 | 0.0482 | 1 | |
Onchocerca volvulus | 0.0045 | 0.0482 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0482 | 0.0442 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0482 | 0.0442 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0045 | 0.0482 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0045 | 0.0482 | 0.0482 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0045 | 0.0482 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0482 | 0.0442 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0482 | 0.0442 |
Onchocerca volvulus | 0.0045 | 0.0482 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0482 | 0.0442 |
Echinococcus granulosus | acetylcholinesterase | 0.0264 | 1 | 1 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0046 | 0.0526 | 0.0046 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0109 | 0.3284 | 0.3284 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0045 | 0.0482 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0045 | 0.0482 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0045 | 0.0482 | 0.0482 |
Brugia malayi | Carboxylesterase family protein | 0.0045 | 0.0482 | 0.0482 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0045 | 0.0482 | 0.5 |
Onchocerca volvulus | 0.0045 | 0.0482 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.64 uM | Inhibition of ADAMTS5 by FRET assay | ChEMBL. | 17804234 |
IC50 (binding) | = 0.64 uM | Inhibition of ADAMTS5 by FRET assay | ChEMBL. | 17804234 |
IC50 (binding) | = 0.64 uM | Inhibition of ADAMTS5 | ChEMBL. | 18790648 |
IC50 (binding) | > 22 uM | Inhibition of ADAMTS4 | ChEMBL. | 17804234 |
IC50 (binding) | > 22 uM | Inhibition of MMP12 | ChEMBL. | 17804234 |
IC50 (binding) | > 22 uM | Inhibition of ADAMTS4 | ChEMBL. | 17804234 |
IC50 (binding) | > 22 uM | Inhibition of MMP12 | ChEMBL. | 17804234 |
IC50 (binding) | > 22 uM | Inhibition of MMP12 | ChEMBL. | 18790648 |
IC50 (binding) | > 22 uM | Inhibition of ADAMTS4 | ChEMBL. | 18790648 |
IC50 (binding) | > 100 uM | Inhibition of MMP13 | ChEMBL. | 17804234 |
IC50 (binding) | > 100 uM | Inhibition of MMP13 | ChEMBL. | 17804234 |
IC50 (binding) | > 100 uM | Inhibition of MMP13 | ChEMBL. | 18790648 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.