Detailed information for compound 44522

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 408.598 | Formula: C22H36N2O3S
  • H donors: 1 H acceptors: 3 LogP: 5.11 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCS(=O)(=O)N1CCCC1C(=O)NCCCc1ccccc1
  • InChi: 1S/C22H36N2O3S/c1-2-3-4-5-6-10-19-28(26,27)24-18-12-16-21(24)22(25)23-17-11-15-20-13-8-7-9-14-20/h7-9,13-14,21H,2-6,10-12,15-19H2,1H3,(H,23,25)
  • InChiKey: PWUZAHDIQBZHCE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens FK506 binding protein 1A, 12kDa Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis fk506-binding protein, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis immunophilin, putative Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes Get druggable targets OG5_126727 All targets in OG5_126727
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania infantum fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes Get druggable targets OG5_126727 All targets in OG5_126727
Plasmodium yoelii FK506-binding protein Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes Get druggable targets OG5_126727 All targets in OG5_126727
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis peptidylprolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_126727 All targets in OG5_126727
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus multilocularis fk506 binding protein Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A Get druggable targets OG5_126727 All targets in OG5_126727
Plasmodium knowlesi peptidyl-prolyl cis-trans isomerase FKBP35, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania donovani peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Plasmodium berghei peptidyl-prolyl cis-trans isomerase FKBP35, putative Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma mansoni immunophilin Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania mexicana fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans hypothetical protein Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma mansoni immunophilin Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania mexicana peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis peptidylprolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania major fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Neospora caninum Peptidylprolyl isomerase D (Cyclophilin D), related Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma congolense FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania infantum peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 Get druggable targets OG5_126727 All targets in OG5_126727
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) Get druggable targets OG5_126727 All targets in OG5_126727
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania major peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma brucei gambiense peptidylprolyl isomerase-like protein, putative Get druggable targets OG5_126727 All targets in OG5_126727
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania braziliensis peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania braziliensis fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma japonicum ko:K09571 FK506-binding protein 4/5, putative Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania donovani fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma japonicum FK506-binding protein 1A, putative Get druggable targets OG5_126727 All targets in OG5_126727
Loa Loa (eye worm) FKBP5 protein Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma mansoni immunophilin Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma japonicum ko:K09568 FK506-binding protein 1, putative Get druggable targets OG5_126727 All targets in OG5_126727
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative FK506 binding protein 1A, 12kDa 108 aa 107 aa 48.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Onchocerca volvulus 0.0055 0.0596 0.5
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0055 0.0596 0.0782
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0055 0.0596 0.0596
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0055 0.0596 0.0596
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0055 0.0596 0.0596
Echinococcus multilocularis Furin 1 0.0056 0.0625 0.082
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0101 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0101 0.0194
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0065 0.11 0.4808
Schistosoma mansoni immunophilin 0.0065 0.11 0.11
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0144 0.5186 0.5186
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Trichomonas vaginalis hypothetical protein 0.0046 0.0101 0.0194
Echinococcus multilocularis epidermal growth factor receptor 0.0056 0.0615 0.0806
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Schistosoma mansoni growth hormone secretagogue receptor 0.0055 0.0596 0.0596
Echinococcus granulosus g protein coupled receptor 0.0055 0.0596 0.0596
Schistosoma mansoni neuropeptide receptor 0.0055 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0596 0.0596
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0055 0.0596 0.0596
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0056 0.0625 0.0625
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.0596 0.0596
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0065 0.11 0.11
Echinococcus granulosus allatostatin A receptor 0.0055 0.0596 0.0596
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0055 0.0596 0.0596
Schistosoma mansoni amine GPCR 0.0055 0.0596 0.0596
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0065 0.11 1
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0101 0.0194
Schistosoma mansoni opsin-like receptor 0.0055 0.0596 0.0596
Echinococcus granulosus furin 0.0237 1 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0055 0.0596 0.0596
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0596 0.0596
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0056 0.0635 0.0635
Onchocerca volvulus Neuropeptide F receptor homolog 0.0055 0.0596 0.5
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0065 0.11 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Schistosoma mansoni myosin xvIII 0.0055 0.0596 0.0596
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.0625 0.1205
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.0625 0.1205
Brugia malayi larval opioid receptor 0.0055 0.0596 0.0596
Echinococcus multilocularis allatostatin A receptor 0.0055 0.0596 0.0782
Schistosoma mansoni furin-1 (S08 family) 0.0103 0.3065 0.3065
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.0596 0.0596
Onchocerca volvulus 0.0055 0.0596 0.5
Brugia malayi G protein-coupled receptor 0.0055 0.0596 0.0596
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0065 0.11 0.5
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.0596 0.0782
Onchocerca volvulus 0.0055 0.0596 0.5
Echinococcus granulosus Furin 1 0.0056 0.0625 0.0625
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Echinococcus granulosus neuropeptide s receptor 0.0055 0.0596 0.0596
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0596 0.0596
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0101 0.0194
Echinococcus granulosus hypothetical protein 0.0055 0.0596 0.0596
Brugia malayi hypothetical protein 0.0055 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Echinococcus granulosus peptide allatostatin:somatostatin 0.0055 0.0596 0.0596
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0596 0.0596
Schistosoma mansoni neuropeptide receptor 0.0055 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0237 1 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.0625 0.1205
Echinococcus granulosus tachykinin peptides receptor 99D 0.0055 0.0596 0.0596
Brugia malayi proprotein convertase 2 0.0149 0.5439 0.5439
Brugia malayi sulfakinin receptor protein 0.0055 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Schistosoma mansoni opsin-like receptor 0.0055 0.0596 0.0596
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0144 0.5186 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0055 0.0596 0.0596
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0055 0.0596 0.0782
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0055 0.0596 0.0596
Giardia lamblia High cysteine membrane protein Group 2 0.0088 0.2287 1
Echinococcus granulosus neuroendocrine convertase 2 0.0149 0.5439 0.5439
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0596 0.0782
Schistosoma mansoni neuropeptide receptor 0.0055 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Onchocerca volvulus 0.0055 0.0596 0.5
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Echinococcus granulosus neuropeptide receptor A26 0.0055 0.0596 0.0596
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0101 0.0194
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0065 0.11 0.2121
Brugia malayi neuropeptide F receptor 0.0055 0.0596 0.0596
Schistosoma mansoni amine GPCR 0.0055 0.0596 0.0596
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0055 0.0596 0.0596
Echinococcus multilocularis g-protein coupled receptor 0.0055 0.0596 0.0782
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0055 0.0596 0.0782
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0101 0.0194
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.0596 0.0782
Echinococcus multilocularis fk506 binding protein 0.0065 0.11 0.1442
Onchocerca volvulus 0.0055 0.0596 0.5
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0065 0.11 0.11
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.0596 0.0782
Brugia malayi hypothetical protein 0.0055 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Brugia malayi RE15519p 0.0055 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Loa Loa (eye worm) melatonin receptor type 1A 0.0055 0.0596 0.0596
Brugia malayi ORL1-like opioid receptor 0.0055 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0596 0.0782
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0065 0.11 0.4808
Brugia malayi Serotonin receptor 0.0055 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0596 0.0596
Loa Loa (eye worm) TK/EGFR protein kinase 0.0056 0.0615 0.0615
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0065 0.11 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0055 0.0596 0.0782
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.0596 0.0596
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0596 0.0782
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0055 0.0596 0.0596
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0101 0.0194
Brugia malayi hypothetical protein 0.0055 0.0596 0.0596
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0596 0.0596
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.0596 0.0596
Echinococcus multilocularis somatostatin receptor 0.0055 0.0596 0.0782
Schistosoma mansoni hypothetical protein 0.0055 0.0596 0.0596
Onchocerca volvulus 0.0055 0.0596 0.5
Echinococcus granulosus G protein coupled receptor 139 0.0055 0.0596 0.0596
Schistosoma mansoni amine GPCR 0.0055 0.0596 0.0596
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0055 0.0596 0.0596
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0596 0.0596
Echinococcus granulosus orexin receptor type 2 0.0055 0.0596 0.0596
Echinococcus granulosus somatostatin receptor 0.0055 0.0596 0.0596
Echinococcus granulosus biogenic amine 5HT receptor 0.0055 0.0596 0.0596
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0101 0.0194
Schistosoma mansoni neuropeptide receptor 0.0055 0.0596 0.0596
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.0596 0.0782
Echinococcus multilocularis neuroendocrine convertase 2 0.0149 0.5439 0.7133
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0065 0.11 1
Echinococcus granulosus fmrfamide receptor 0.0055 0.0596 0.0596
Schistosoma mansoni immunophilin 0.0065 0.11 0.11
Echinococcus multilocularis serotonin receptor 0.0055 0.0596 0.0782
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0596 0.0596
Onchocerca volvulus 0.0055 0.0596 0.5
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Schistosoma mansoni neuropeptide f receptor 76f 0.0055 0.0596 0.0596
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0055 0.0596 0.0782
Echinococcus multilocularis neuropeptide receptor A26 0.0055 0.0596 0.0782
Schistosoma mansoni biogenic amine receptor 0.0055 0.0596 0.0596
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0596 0.0782
Loa Loa (eye worm) endoprotease bli-4 0.0237 1 1
Loa Loa (eye worm) FKBP5 protein 0.0065 0.11 0.11
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0596 0.0596
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0065 0.11 0.2121
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0596 0.0782
Brugia malayi Tachykinin-like peptides receptor 99D 0.0055 0.0596 0.0596
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0065 0.11 1
Onchocerca volvulus 0.0055 0.0596 0.5
Echinococcus granulosus neuropeptide receptor 0.0055 0.0596 0.0596
Onchocerca volvulus 0.0055 0.0596 0.5
Brugia malayi hypothetical protein 0.0055 0.0596 0.0596
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0596 0.0596
Echinococcus granulosus sex peptide receptor 0.0055 0.0596 0.0596
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0055 0.0596 0.0782
Brugia malayi AKH receptor 0.0055 0.0596 0.0596
Brugia malayi hypothetical protein 0.0055 0.0596 0.0596
Brugia malayi hypothetical protein 0.0055 0.0596 0.0596
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0596 0.0782
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.0596 0.0596
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0596 0.0782
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0055 0.0596 0.5
Loa Loa (eye worm) proprotein convertase 2 0.0056 0.0625 0.0625
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.0625 0.1205
Echinococcus multilocularis G protein coupled receptor 139 0.0055 0.0596 0.0782
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0046 0.0101 0.0194
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0596 0.0782
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0055 0.0596 0.0596
Echinococcus granulosus g protein coupled receptor 0.0055 0.0596 0.0596
Onchocerca volvulus 0.0055 0.0596 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0055 0.0596 0.0596
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0065 0.11 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0055 0.0596 0.0782
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0055 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Loa Loa (eye worm) TYRA-2 protein 0.0055 0.0596 0.0596
Brugia malayi G protein-coupled receptor F59B2.13 0.0055 0.0596 0.0596
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0065 0.11 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Brugia malayi G-protein coupled receptor 0.0055 0.0596 0.0596
Brugia malayi GnHR receptor homolog 0.0055 0.0596 0.0596
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0101 0.0194
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0055 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Schistosoma mansoni hypothetical protein 0.0046 0.0101 0.0101
Brugia malayi celfurPC protein 0.0191 0.7626 0.7626
Schistosoma mansoni alpha-1 adrenergic receptor 0.0055 0.0596 0.0596
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0055 0.0596 0.0596
Schistosoma mansoni biogenic amine receptor 0.0055 0.0596 0.0596
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0101 0.0194
Schistosoma mansoni adenoreceptor 0.0055 0.0596 0.0596
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0144 0.5186 1
Echinococcus multilocularis fmrfamide receptor 0.0055 0.0596 0.0782
Schistosoma mansoni hypothetical protein 0.0055 0.0596 0.0596
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0055 0.0596 0.0596
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.0596 0.0596
Echinococcus multilocularis serotonin receptor 0.0055 0.0596 0.0782
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.0596 0.0596
Brugia malayi hypothetical protein 0.0055 0.0596 0.0596
Brugia malayi follicle stimulating hormone receptor 0.0055 0.0596 0.0596
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0596 0.0782
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.0596 0.0596
Brugia malayi hypothetical protein 0.0055 0.0596 0.0596
Echinococcus granulosus neuropeptide receptor 0.0055 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Brugia malayi hypothetical protein 0.0055 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Echinococcus multilocularis sex peptide receptor 0.0055 0.0596 0.0782
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0055 0.0596 0.0782
Onchocerca volvulus 0.0055 0.0596 0.5
Brugia malayi neuropeptide F receptor 0.0055 0.0596 0.0596
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0046 0.0101 0.0194
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0596 0.0596
Brugia malayi G-protein coupled receptor 0.0055 0.0596 0.0596
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0144 0.5186 0.68
Toxoplasma gondii beta-tubulin, putative 0.0044 0 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.0625 0.1205
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0065 0.11 0.11
Echinococcus granulosus biogenic amine 5HT receptor 0.0055 0.0596 0.0596
Onchocerca volvulus 0.0055 0.0596 0.5
Echinococcus granulosus dro:myosuppressin receptor 0.0055 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Echinococcus multilocularis neuropeptide receptor 0.0055 0.0596 0.0782
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0596 0.0596
Onchocerca volvulus 0.0055 0.0596 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0596 0.0596
Trichomonas vaginalis fk506-binding protein, putative 0.0065 0.11 0.2121
Onchocerca volvulus 0.0055 0.0596 0.5
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Echinococcus multilocularis orexin receptor type 2 0.0055 0.0596 0.0782
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0065 0.11 0.11
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.0596 0.0596
Echinococcus granulosus g protein coupled receptor 0.0055 0.0596 0.0596
Brugia malayi putative neuropeptide receptor 0.0055 0.0596 0.0596
Echinococcus granulosus serotonin receptor 0.0055 0.0596 0.0596
Schistosoma mansoni amine GPCR 0.0055 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Trichomonas vaginalis immunophilin, putative 0.0065 0.11 0.2121
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0055 0.0596 0.0596
Echinococcus granulosus 7tm_1 domain containing protein 0.0055 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Schistosoma mansoni opsin-like receptor 0.0055 0.0596 0.0596
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0056 0.0625 0.1205
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.0596 0.0596
Echinococcus granulosus 7TM GPCR rhodopsin 0.0055 0.0596 0.0596
Brugia malayi Melatonin receptor type 1A 0.0055 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Brugia malayi hypothetical protein 0.0055 0.0596 0.0596
Echinococcus multilocularis neuropeptide s receptor 0.0055 0.0596 0.0782
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Echinococcus granulosus epidermal growth factor receptor 0.0056 0.0615 0.0615
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0055 0.0596 0.0782
Echinococcus granulosus neuropeptide FF receptor 2 0.0055 0.0596 0.0596
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0056 0.0635 0.0635
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0065 0.11 0.1442
Echinococcus multilocularis dro:myosuppressin receptor 0.0055 0.0596 0.0782
Brugia malayi Dopamine receptor 0.0055 0.0596 0.0596
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0065 0.11 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0055 0.0596 0.0596
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.0596 0.0596
Brugia malayi Dopamine receptor protein 2 0.0055 0.0596 0.0596
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0596 0.0782
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0596 0.0596
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0055 0.0596 0.0596
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0055 0.0596 0.0596
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0046 0.0101 0.0194
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Schistosoma mansoni hypothetical protein 0.0055 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.0596 0.0596
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0596 0.0782
Onchocerca volvulus 0.0055 0.0596 0.5
Loa Loa (eye worm) hypothetical protein 0.0093 0.2541 0.2541
Echinococcus multilocularis neuropeptide receptor 0.0055 0.0596 0.0782
Brugia malayi putative neuropeptide receptor NPR1 0.0055 0.0596 0.0596
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.0596 0.0596
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0596 0.0596
Echinococcus granulosus alpha 1A adrenergic receptor 0.0055 0.0596 0.0596
Leishmania major peptidylprolyl isomerase-like protein 0.0065 0.11 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0055 0.0596 0.0596
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.0596 0.0596
Leishmania major fk506-binding protein 1-like protein 0.0065 0.11 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0055 0.0596 0.0782
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0596 0.0782
Brugia malayi Furin-like cysteine rich region family protein 0.0056 0.0615 0.0615
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0065 0.11 0.11
Onchocerca volvulus 0.0055 0.0596 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0596 0.0596
Schistosoma mansoni immunophilin 0.0056 0.0635 0.0635
Brugia malayi Serotonin receptor 0.0055 0.0596 0.0596
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0596 0.0782
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0596 0.0782
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0065 0.11 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0596 0.0596
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0065 0.11 1
Onchocerca volvulus 0.0055 0.0596 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0596 0.0596
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0056 0.0635 0.0833
Toxoplasma gondii beta tubulin 0.0044 0 0.5
Echinococcus granulosus g-protein coupled receptor 0.0055 0.0596 0.0596
Brugia malayi Dopamine receptor protein 1 0.0055 0.0596 0.0596
Toxoplasma gondii beta-1 tubulin, putative 0.0044 0 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.0596 0.0782
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0596 0.0596
Schistosoma mansoni amine GPCR 0.0055 0.0596 0.0596
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0065 0.11 0.11
Brugia malayi neuroendocrine convertase 1 precursor 0.0149 0.5439 0.5439
Echinococcus multilocularis fmrfamide receptor 0.0055 0.0596 0.0782
Giardia lamblia Furin precursor putative serine protease 0.0046 0.0101 0.044
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.0596 0.0782
Loa Loa (eye worm) hypothetical protein 0.0237 1 1
Schistosoma mansoni hypothetical protein 0.0055 0.0596 0.0596
Schistosoma mansoni histamine h1 receptor 0.0055 0.0596 0.0596
Schistosoma mansoni biogenic amine receptor 0.0055 0.0596 0.0596
Echinococcus multilocularis 0.0191 0.7626 1
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0065 0.11 0.5
Echinococcus multilocularis G-protein coupled receptor, putative 0.0055 0.0596 0.0782
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.0596
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0101 0.0194
Schistosoma mansoni tyrosine kinase 0.0056 0.0615 0.0615

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 5400 nM Ability to inhibit peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12 ChEMBL. 11992791
Ki (binding) = 5400 nM Ability to inhibit peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12 ChEMBL. 11992791

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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